Management of kidney transplant recipients for primary care practitioners

BMC Nephrology

Table 1 Adverse Effects of Immunosuppressive Agents. MPA: mycophenolic acid; mTOR: mammalian target of rapamycin

	Tacrolimus	Cyclosporine	MPA Derivatives	Azathioprine	mTOR Inhibitors
Neurologic (tremor, headache, paresthesia)	+++	+
Hypertension	++	+++
Angioedema					+
Interstitial pneumonitis					+
Dyslipidemia or Hypertriglyceridemia	+	++			++
Leukopenia			++	+++
Anemia			+	+	+
Thrombocytopenia			+	++
Hyperuricemia	+	++
Posttransplant diabetes mellitus	+++	+			+
Gastrointestinal (dyspepsia, nausea, vomiting, diarrhea)	+	+	+++	++	+
Hyperkalemia, metabolic acidosis, hypomagnesemia	++	++
Acute and Chronic nephrotoxicity	++	++			+
Proteinuria					+
Alopecia	+
Hirsutism		+
Gingival hyperplasia		+
Aphthous ulcers/mucositis			+		++
Peripheral edema					+
Delayed wound healing					++
Teratogenicity			+++		+++
Azoospermia and oligospermia					+++

ISSN: 1471-2369