Table 3 Common CYP3A4/5 Inducers. Empiric dose adjustments are suggested for tacrolimus. Cyclosporine and mTOR inhibitors have similar interactions given the overlap in metabolism
From: Management of kidney transplant recipients for primary care practitioners
Weak Inducers | Weak/Moderate Inducers | Moderate/Strong Inducers | Very Strong Inducers |
|---|---|---|---|
Monitoring levels without empiric adjustment | Dose increases of up to 1.5-fold may be required | Dose increases of 1.5- to 5-fold may be required | Avoid use (dose increases 5-10-fold may be required) |
Dexamethasone | Armodafanil | Carbamazepine | Rifampin |
Oxcarbazepine | Modafanil | Phenobarbital | Â |
Etravirine | Nafcillin | Phenytoin | Â |
Efavirenz | St. John’s Wort | Primidone |  |
| Â | Â | Rifabutin | Â |
| Â | Â | Rifapentine | Â |