Skip to main content

Table 4 Association between CKD (eGFR < 60 ml/min/1.73m2) and CSVD, stratified by hypertension

From: Chronic kidney disease and its association with cerebral small vessel disease in the general older hypertensive population

Participants with hypertension (n = 206)

Participants with no hypertension (n = 184)

Association between CKD and CSVD, not adjusted for covariates

 

Odds ratio

CI

p-value

 

Odds ratio

CI

p-value

WMHs1

1.22

0.68–2.18

0.501

WMHs1

1.64

0.59–4.58

0.346

Lacunar infarcts2

0.96

0.39–2.39

0.93

Lacunar infarcts2

2.46

0.48–12.75

0.284

CMBs3

1.96

1.07–3.58

0.029

CMBs3

0.59

0.16–2.10

0.412

Cortical atrophy 4

2.59

1.43–4.66

0.002

Cortical atrophy 4

0.61

0.24–1.56

0.297

Composite CSVD 5

1.58

0.88–2.86

0.127

Composite CSVD 5

1.19

0.47–3.02

0.722

Modified STRIVE 6

1.86

0.82–4.20

0.137

Modified STRIVE 6

0.97

0.33–2.83

0.952

Association between CKD and CSVD, adjusted for age and sex

WMHs1

1.15

0.64–2.08

0.633

WMHs1

1.28

0.45–3.70

0.643

Lacunar infarcts2

1.11

0.44–2.82

0.825

Lacunar infarcts2

1.93

0.36–10.47

0.447

CMBs3

1.93

1.04–3.59

0.037

CMBs3

0.54

0.14–2.03

0.359

Cortical atrophy 4

2.45

1.34–4.48

0.004

Cortical atrophy 4

0.63

0.24–1.69

0.36

Composite CSVD 5

1.5

0.82–2.73

0.186

Composite CSVD 5

0.97

0.36–2.63

0.951

Modified STRIVE 6

1.56

0.67–3.60

0.301

Modified STRIVE 6

1.05

0.33–3.39

0.935

  1. eGFR calculated from creatinine and cystatin C in non-underweight participants and on cystatin C in underweight participants (BMI < 23) using the CKD-EPI formula
  2. eGFR ≥ 60 ml/min/1.73m2 as reference
  3. Binary logistic regression models were used to examine the association between CKD (eGFR < 60 ml/min/1.73m2) and WMHs, lacunar infarcts, CMBs, cortical atrophy, CSVD composite, and modified STRIVE.
  4. Covariates: Age, sex
  5. Abbreviation BMI = Body mass index, CKD = Chronic kidney disease, CKD-EPI = chronic kidney disease epidemiology collaboration, CMBs = Cerebral microbleeds, CSVD = Cerebral small vessel disease, eGFR = estimated glomerular filtration rate, GCA = Global cortical atrophy, MRI = Magnetic resonance imaging, SD = Standard deviation, STRIVE = Standards for reporting vascular changes on neuroimaging, WMHs = White matter hyperintensities
  6. 1 WMHs defined as Fazekas scale ≥ 2
  7. 2 Lacunar infarcts defined as presence of ≥ 1 lacunar infarct
  8. 3 CMBs defined as presence of ≥ 1 CMB
  9. 4 Cortical atrophy defined as GCA ≥ 1 and/or Koedam score ≥ 1 and/or ≥ 1 frontal/frontotemporal/temporal atrophy
  10. 5 Presence of CSVD according to the composite CSVD variable was defined as Fazekas scale ≥ 2 and/or presence of ≥ 1 lacunar infarct and/or ≥ 1 CMB
  11. 6 Presence of CSVD according to the modified STRIVE variable was defined as Fazekas scale ≥ 2 and/or presence of ≥ 1 lacunar infarct and/or presence of ≥ 1 CMB and/or presence of cortical atrophy and/or presence of central atrophy
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us