Fig. 1

Light microscopic and immunohistochemical changes in patients with RPGN: (A) the glomerulus showed cellular crescent (circle) and fibrinoid necrosis (PAS, ×200). (B) the glomerulus showed fibrocellular crescent (circle) and endocapillary proliferation with leucocytic infiltrate that surrounded by lymphocytes. Arteriole showed fibrin thrombus (arrow) (H&E, ×200). (C) the glomerulus showed fibrous crescent (asterisk) with shrunken tuft (circle) and surrounded by mild lymphocytic infiltrate (arrow) (H&E, ×200). (D) arteriole showed endothelial swelling, endothelialitis (arrow) and fibrinoid necrosis (asterisk) (H&E, ×400). (E) the interstitium showed moderate lymphocytic infiltrate (arrow) (H&E, ×400). (F) the interstitium showed marked IFTA (masson trichrome, ×400). (G) the glomerular basement membranes and mesangium showed marked diffuse deposits of IgG (asterisk) and no deposits in the crescent (arrow) (IHC, ×400). (H) the glomerular basement membranes and mesangium showed moderate diffuse deposits of C3 (asterisk) and no deposits in the crescent (arrow) (IHC, ×200)