Fig. 1

Reverse transcription-qPCR detection of hsa_circ_0005519 as a biomarker in AKI patient serum samples and control subjects. (A) Significant differences were observed between AKI patients (n = 72) and controls (n = 72) for hsa_circ_0005519. The figure reported the 5–95 percentile data of the normalized expression of hsa_circ_0005519. (B) Significant differences were observed between recovery (n = 48) and non-recovery (n = 24). The figure reported the 5–95 percentile data of the normalized expression of hsa_circ_0005519. (C) Receiver operating characteristic (ROC) curve comparing all AKI patients with controls for hsa_circ_0005519 gave an area under the curve (AUC) of 0.85. (D) ROC curve comparing recovery AKI patients with non-recovery AKI patients for hsa_circ_0005519 gave an AUC of 0.88. Statistical analysis comparing two groups was by Mann-Whitney U test. Data were presented as median and 5–95 percentile; **p < 0.01, ***p < 0.001. AKI, acute kidney injury