Fig. 3
From: Circular RNA hsa_circ_0005519 contributes to acute kidney injury via sponging microRNA-98-5p
Hsa_circ_0005519 contributed to LPS-induced inflammatory response and oxidative stress in HK-2 cells. HK-2 cells were transfected with hsa_circ_0005519 siRNA (anti-CIRC), followed by culture in LPS. (A) Effect of hsa_circ_0005519 siRNA on the concentration of IL-6, TNF-α, and IL-1β was measured by ELISA. Effect of hsa_circ_0005519 siRNA on MPO activity (B) and MDA (C) content was detected using commercialized detection kits. Statistical analysis comparing two groups was by Mann-Whitney U test. ***p < 0.001, vs. blank. ##p < 0.01, ###p < 0.001,vs. LPS + anti-NC. LPS, lipopolysaccharide; MPO, myeloperoxidase; MDA, malondialdehyde; ELISA, enzyme-linked immunosorbent assay