The association of low serum uric acid with mortality in older people is modified by kidney function: National Health and Nutrition Examination Survey (NHANES) 1999–2018

Table 2 The association between SUA with all-cause and CV mortality

SUA, mg/dL	Follow-up, years	All-cause mortality			CV mortality
SUA, mg/dL	Follow-up, years	Events (incidence rate)	Adjusted HR (95% CI)^a	P value	Events (incidence rate)	Adjusted HR (95% CI)^a	P value
2 to < 5	8.4 (0.1)	1458 (28.2)	1.11 (1.03, 1.21)	0.01	445 (8.3)	1.14 (1.00, 1.30)	0.05
5 to < 7	8.3( 0.1)	2307 (28.6)	Reference	-	763 (9.4)	Reference	-
≥ 7	7.9 (0.2)	1087 (41.9)	1.25 (1.13, 1.38)	< 0.001	394 (15.1)	1.25 (1.08, 1.44)	0.003

Abbreviations: CV cardiovascular, SUA serum uric acid, HR hazard ratio, CI confidence interval, ASCVD atherosclerotic cardiovascular disease, CCI Charlson Comorbidity Index
^aAdjusted for age, sex, race, education, smoke status, BMI, WBC count, hemoglobin, serum albumin, total cholesterol, triglycerides, urine albumin to creatinine ratio, eGFR, ASCVD risk, comorbidities (hypertension, diabetes, CV disease, CCI), and co-medications (anti-hypertension, lipid-lowering drugs, hypoglycemic, urate-lowing agents)

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