Table 3 Frequency of events and hazard ratio for the primary outcome in sensitivity analyses

Main analysis

 Non-MDC group

679

4,575

5,005,934

1.36 (1.26–1.46)

Ref

 MDC group

150

1,039

921,928

1.63 (1.38–1.91)

1.18 (0.99–1.41)

Changing the definition of censoring

 Non-MDC group

630

4,575

4,778,767

1.32 (1.22–1.43)

Ref

 MDC group

150

1,039

921,928

1.63 (1.38–1.91)

1.21 (1.01–1.44)

Changing the definition of the MDC and non-MDC groups

 Non-MDC group

511

3,349

3,665,556

1.39 (1.28–1.52)

Ref

 MDC group

95

689

590,790

1.61 (1.30–1.97)

1.18 (0.95–1.47)

Setting an upper limit for the observation period of 3 years

 Non-MDC group

519

4,575

3,513,034

1.48 (1.35–1.61)

Ref

 MDC group

123

1,039

735,007

1.67 (1.39–2.00)

1.14 (0.94–1.39)

Changing the definition of landmark time to 2 years

 Non-MDC group

440

3,661

3,700,736

1.19 (1.08–1.31)

Ref

 MDC group

114

821

663,891

1.72 (1.42–2.06)

1.41 (1.14–1.73)

IPTW

 Non-MDC group

1,258

8,758

9,635,373

1.31 (1.23–1.38)

Ref

 MDC group

151

1,046

925,496

1.63 (1.38–1.91)

1.24 (1.00–1.53)

Overlap weighting

 Non-MDC group

1,258

8,758

9,635,373

1.31 (1.23–1.38)

Ref

 MDC group

151

1,046

925,496

1.63 (1.38–1.91)

1.13 (0.94–1.35)