Table 1 Baseline characteristics of septic patients classified by AKI
Variables | All patients n = 2175 | Non-AKI n = 833 | AKI n = 1342 | p-value |
|---|---|---|---|---|
Male gender | 1388 (63.8%) | 538 (64.6%) | 850 (63.3%) | 0.556 |
Age (years) | 64 (50–76) | 64 (49–76) | 64 (50–77) | 0.795 |
BMI (kg/m2) | 23.3 (20.9–25.3) | 22.9 (20.8–24.8) | 23.4 (21.3–25.4) | < 0.001 |
Chronic comorbidities | ||||
COPD/asthma | 167 (7.7%) | 64 (7.7%) | 103 (7.7%) | 0.995 |
Cardiovascular disease | 320 (14.7%) | 108 (13.0%) | 212 (15.8%) | 0.070 |
Hypertension | 687 (31.6%) | 238 (28.6%) | 449 (33.5%) | 0.017 |
Diabetes | 397 (18.3%) | 147 (17.6%) | 250 (18.6%) | 0.564 |
Cancer | 224 (10.3%) | 86 (10.3%) | 138 (10.3%) | 0.976 |
Chronic liver disease | 40 (1.8%) | 11 (1.3%) | 29 (2.2%) | 0.156 |
Admission type | ||||
Medical | 1213 (55.8%) | 441 (52.9%) | 772 (57.5%) | 0.051 |
Surgical | 470 (21.6%) | 201 (24.1%) | 269 (20.0%) | |
Emergency | 492 (22.6%) | 191 (22.9%) | 301 (22.4%) | |
APACHE II score | 19 (14–25) | 18 (13–23) | 20 (14–26) | < 0.001 |
Non-renal SOFA score | 7 (4–10) | 6 (4–9) | 8 (5–11) | < 0.001 |
Mechanical ventilation | 1707 (78.5%) | 626 (75.2%) | 1081 (80.6%) | 0.003 |
Baseline creatinine | 77 (66–88) | 75 (62–86) | 79 (69–89) | < 0.001 |
Use of nephrotoxic drugs | 166 (7.6%) | 64 (7.7%) | 102 (7.6%) | 0.944 |
Septic shock | 1067 (49.1%) | 312 (37.5%) | 755 (56.3%) | < 0.001 |
MAP (mmHg) | 75 (60–90) | 79 (66–94) | 72 (60–87) | < 0.001 |
Outcomes | ||||
ICU LOS (days) | 8 (4–17) | 7 (3–16) | 9 (5–17) | < 0.001 |
Hospital LOS (days) | 18 (10–28) | 18 (10–28) | 18 (10–28) | 0.679 |
ICU mortality | 337 (15.5%) | 78 (9.4%) | 259 (19.3%) | < 0.001 |
30-day mortality | 590 (27.1%) | 173 (20.8%) | 417 (31.1%) | < 0.001 |
Hospital mortality | 788 (36.2%) | 244 (29.3%) | 544 (40.5%) | < 0.001 |