Fig. 4

Differentiation antagonizing non-protein coding ribonucleic acid (RNA) (DANCR) promotes renal tubular injury by suppressing microRNA (miR)-214-5p. A. The level of miR-214-5p was detected after transfection with a miR-214-5p inhibitor in high glucose (HG)-induced and knocked-down DANCR in human kidney 2 (HK-2) cells. Cell Counting Kit-8 (B) and flow cytometry (C) were conducted to explore the proliferation and apoptosis of HK-2 cells after miR-214-5p suppression. Inflammatory factor secretion (D), reactive oxygen species production (E), and malondialdehyde components (F) were examined in HK-2 cells that inhibited miR-214-5p. ### P < 0.001 vs. HG + small interfering-negative control; & P < 0.05, && P < 0.01, &&& P < 0.001