Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p

Table 1 Comparison of the baseline data of the subject

Variables	HVs (n = 50)	DM (n = 55)	DN (n = 68)	P value
Age (year)	51.92 ± 12.94	55.56 ± 10.59	53.88 ± 12.50	0.305
Gender, male (%)	29 (58.00)	30 (54.55)	41 (60.29)	0.813
BMI (kg/m²)	26.86 ± 3.44	25.64 ± 4.23	25.92 ± 4.68	0.302
Smoking (%)	33 (66.00)	29 (52.73)	38 (55.89)	0.357
Alcohol (%)	28 (56.00)	33 (60.00)	38 (55.89)	0.881
Hypertension
SBP (mmHg)	121.08 ± 20.74	126.80 ± 12.42	121.38 ± 16.65	0.132
DBP (mmHg)	75.49 ± 7.74	77.48 ± 7.62	78.81 ± 7.20	0.062
Lipid profiles
TC (mg/dL)	180.81 ± 21.76	170.31 ± 46.25	181.96 ± 49.74	0.271
LDL cheolesterol (mg/dL)	109.72 ± 27.59	110.37 ± 18.47	112.51 ± 16.41	0.838
HDL cheolesterol (mg/dL)	50.92 ± 8.26	48.76 ± 8.45	48.90 ± 8.14	0.323
Glucose metabolism
FBG (mmol/L)	5.21 ± 1.41	8.76 ± 0.81	6.70 ± 0.77	< 0.001
HbA1c (%)	5.76 ± 0.87	9.95 ± 2.34	9.67 ± 2.28	< 0.001
Laboratory values
Hemoglobin (g/dL)	13.30 ± 3.49	13.94 ± 1.62	13.97 ± 1.91	0.489
BUN (mg/dL)	11.34 ± 2.67	15.08 ± 3.84	17.76 ± 6.88	< 0.001
Creatinine (mg/dL)	62.75 ± 3.67	62.87 ± 4.07	378.13 ± 60.67	< 0.001
eGFR (mL/min/1.73m²)	85.85 ± 13.45	86.09 ± 14.14	56.19 ± 16.04	< 0.001
Albuminuria (mg/24 h)	2.70 ± 0.74	7.45 ± 2.42	580.88 ± 333.04	< 0.001
hs-CRP (g/L)	0.58 ± 0.15	5.17 ± 1.69	130.58 ± 55.38	< 0.001

Note: HVs, healthy individuals; DM, T2DM patients; DN, Diabetic nephropathy patients
BMI: body mass index; SBP: systolic blood pressure; DBP: Diastolic blood pressure; TC: total cholesterol; LDL: Low-density lipoprotein; HDL: high density lipoprotein; FBG: fasting blood glucose; HbA1c: glycated hemoglobin A1c; BUN: blood urea nitrogen; hs-CRP: high-sensitivity C-reactive protein; eGFR: estimated glomerular filtration rate

ISSN: 1471-2369