Variable | ESRD | Composite endpoint | ||
---|---|---|---|---|
Hazard Ratio (95%CI) | p-value | Hazard Ratio (95%CI) | p-value | |
Univariate analysis | ||||
Age (for 1 y) | 1.003 (0.98–1.02) | 0.76 | 1.01 (0.99–1.03) | 0.33 |
Sex (male vs. female) | 1.02 (0.56–1.84) | 0.94 | 1.07 (0.62–1.86) | 0.79 |
MAP (for 1 mmHg) | 1.02 (1.009–1.04) | 0.003 | 1.02 (1.01–1.04) | 0.001 |
eGFR (for 1 ml/min/1.73m2) | 0.91 (0.89–0.93) | < 0.001 | 0.93 (0.91–0.95) | < 0.001 |
Proteinuria (for 1 g/day) | 1.16 (1.06–1.26) | 0.001 | 1.14 (1.06–1.24) | 0.001 |
Oxford Classification | ||||
• M1 vs. M0 | 1.48 (0.69–3.14) | 0.31 | 1.36 (0.69–2.68) | 0.37 |
• E1 vs. E0 | 1.34 (0.75–2.38) | 0.32 | 1.15 (0.66-2) | 0.6 |
• S1 vs. S0 | 1.18 (0.67–2.06) | 0.55 | 1.31 (0.78–2.2) | 0.31 |
• T1 vs. T0 | 2.82 (1.42–5.62) | 0.003 | 2.97 (1.59–5.55) | 0.001 |
• T2 vs. T0 | 8.38 (4.27–16.4) | < 0.001 | 7.85 (4.18–14.7) | < 0.001 |
• C1 vs. C0 | 2.71 (1.44–5.11) | 0.002 | 2.4 (1.31–4.37) | 0.004 |
• C2 vs. C0 | 5.68 (2.58–12.5) | < 0.001 | 5.18 (2.47–10.8) | < 0.001 |
Decreased serum C3 (vs. no decreased) | 2.85 (1.32–6.14) | 0.007 | 2.13 (1.02–4.47) | 0.04 |
Intense C3 deposition (vs. no intense) | 1.72 (0.87–3.41) | 0.11 | 1.43 (0.78–2.59) | 0.24 |
IgA co-deposition (vs. IgA alone) | - | - | - | - |
• IgG + IgA | 1.01 (0.36–2.83) | 0.97 | 0.68 (0.28–1.62) | 0.38 |
• IgM + IgA | 2.01 (0.76–5.33) | 0.15 | 1.49 (0.67–3.31) | 3.31 |
LM pattern (vs. mesangioproliferative) | - | - | - | - |
• Proliferative/necrotizing | 2.91 (1.32–6.42) | 0.008 | 1.96 (0.97–3.97) | 0.06 |
• Crescentic | 6.38 (1.99–20.4) | 0.002 | 5.31 (1.92–14.6) | 0.001 |
• Sclerosing | 5.74 (2.72–12.1) | < 0.001 | 4.4 (2.32–8.34) | < 0.001 |
Multivariate analysis | ||||
A) Light microscopy model 1 | ||||
eGFR (for 1 ml/min/1.73m2) | 0.92 (0.89–0.94) | < 0.001 | 0.93 (0.92–0.95) | < 0.001 |
Proteinuria (for 1 g/day) | 1.04 (0.92–1.17) | 0.53 | 1.04 (0.92–1.16) | 0.48 |
LM pattern (vs. mesangioproliferative) | - | - | - | - |
• Proliferative/necrotizing | 1.08 (0.43–2.73) | 0.85 | 0.83 (0.36–1.91) | 0.65 |
• Crescentic | 3.77 (0.98–14.5) | 0.05 | 3.64 (1.07–12.3) | 0.03 |
• Sclerosing | 2.7 (1.26–5.79) | 0.01 | 2.17 (1.13–4.19) | 0.02 |
B) Light microscopy model 2 | ||||
eGFR (for 1 ml/min/1.73m2) | 0.92 (0.9–0.95) | < 0.001 | 0.94 (0.92–0.96) | < 0.001 |
Proteinuria (for 1 g/day) | 1.03 (0.91–1.18) | 0.61 | 1.03 (0.92–1.16) | 0.56 |
Oxford Classification | - | - | - | - |
• M1 vs. M0 | 0.77 (0.32–1.83) | 0.56 | 0.81 (0.37–1.73) | 0.58 |
• E1 vs. E0 | 0.85 (0.39–1.82) | 0.68 | 0.79 (0.38–1.6) | 0.51 |
• S1 vs. S0 | 0.81 (0.42–1.53) | 0.51 | 0.95 (0.53–1.7) | 0.88 |
• T1 vs. T0 | 1.33 (0.56–3.13) | 0.51 | 1.57 (0.73–3.35) | 0.24 |
• T2 vs. T0 | 1.84 (0.82–4.11) | 0.13 | 2.13 (1.01–4.47) | 0.04 |
• C1 vs. C0 | 1.08 (0.46–2.51) | 0.85 | 1.04 (0.48–2.24) | 0.91 |
• C2 vs. C0 | 2.61 (0.87–7.82) | 0.08 | 3.17 (1.16–8.7) | 0.02 |
C) Immunofluorescence model | ||||
eGFR (for 1 ml/min/1.73m2) | 0.9 (0.86–0.94) | < 0.001 | 0.92 (0.89–0.95) | < 0.001 |
Proteinuria (for 1 g/day) | 1.31 (1.1–1.55) | 0.002 | 1.26 (1.1–1.24) | 0.001 |
Decreased serum C3 (vs. no decreased) | 8.05 (2.7-24.04) | < 0.001 | 4.83 (1.85–12.6) | 0.001 |
Intense C3 deposition (vs. no intense) | 3.33 (1.21–9.2) | 0.02 | 2.28 (1.008–5.18) | 0.04 |
IgA co-deposition (vs. IgA alone) | - | - | - | - |
• IgG + IgA | 1.02 (0.27–3.91) | 0.96 | 0.74 (0.24–2.19) | 0.58 |
• IgM + IgA | 1.03 (0.31–3.44) | 0.95 | 0.97 (0.38–2.49) | 0.96 |