Table 2 Reports describing the association of MN and sarcoidosis
Year | Reference | Age /Gender | Clinical/laboratory features | Renal pathology | Sequence of onset of sarcoidosis and MN | PLA2R Ab | Therapy | Outcome |
|---|---|---|---|---|---|---|---|---|
1978 | Mariani AF et al. (14) | 25/F 19/M | NS | MN | Sarcoidosis preceded the onset of MN by 6 months in the 25-year-old female patient and presented simultaneously with MN in the 19-year-old male patient. | NA | prednisone, CTX | resolution of proteinuria, stabilization of renal function |
1979 | Talyor TK et al. (15) | 57/M | NS, elevated Scr | MN with epithelial crescents | Sarcoidosis preceded the onset of MN by 10 years with progression of sarcoidosis. | NA | NA | NA |
1989 | Jones B et al. (16) | 32/F | proteinuria | MN | Sarcoidosis preceded the onset of MN by 5 years and recurred at the onset of MN. | NA | prednisone | resolution of proteinuria, relapse after ceasing prednisone |
1994 | Khan IH et al. (17) | 56/F | NS | MN and granulomatous interstitial nephritis | Simultaneously | NA | prednisone | decrease in proteinuria, stabilization of renal function |
1999 | Toda T et al. (18) | 49/F | Hypercalcemia, elevated Scr | MN and interstitial nephritis | Simultaneously | NA | prednisone | recovery of renal function and hypercalcemia |
1999 | Dimitriades C et al. (19) | 13/F | NS | MN | Sarcoidosis preceded the onset of MN by 1 year, and recurred at the onset of MN. | NA | prednisone, CTX | stabilization of sarcoidosis, resolution of proteinuria, normal renal function |
2011 | Knehtl M et al. (20) | 29/M | NS | MN and granulomatous tubulointerstitial nephritis | MN preceded the onset of sarcoidosis by 5 months. | seropositive for anti-PLA2R Ab and positive for PLA2R in renal biopsy | prednisone | resolution of nephrotic syndrome, stabilization of renal function |
2013 | Stehle T et al. (5,10) | Total of 11 patients, 3 females and 8 males | seven of the 11 patients were NS | MN, 2 with GTIN | Three patients exhibited glomerular lesions simultaneously with sarcoidosis. MN preceded the onset of sarcoidosis in 5 patients (mean delay of 4.5 years). In 3 other patients, MN was diagnosed after sarcoidosis (mean delay of 12.6 years). | data available for 9 patients: 3 seropositive for anti-PLA2R Ab, 5 positive for PLA2R on renal biopsy | supportive care in 5 patients, prednisone in 6 patients | 2 patients progressed to ESRD, and 1 patient died. |