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  1. A bundle of preventive measures can be taken to avoid acute kidney injury (AKI) or progression of AKI. We performed a systematic review and meta-analysis to evaluate the compliance to AKI care bundles in hospi...

    Authors: Hannah A. I. Schaubroeck, Diana Vargas, Wim Vandenberghe and Eric A. J. Hoste
    Citation: BMC Nephrology 2021 22:335
  2. Monitoring Health Related Quality of Life (HRQoL) in different stages of chronic kidney disease is advised by all nephrology societies. We aimed to study the relation between quality of life and dialysis adequ...

    Authors: Lamia M. Hasan, Dina A. H. Shaheen, Ghada A. H. El Kannishy, Nagy A. H. Sayed-Ahmed and Ahmed M. Abd El Wahab
    Citation: BMC Nephrology 2021 22:334
  3. The transition from chronic kidney disease stage 5 to initiation of hemodialysis has gained increased attention in recent years as this period is one of high risk for patients with an annual mortality rate exc...

    Authors: Maciej Drozdz, João Frazão, Fatima Silva, Partha Das, Werner Kleophas, Wisam Al Badr, Szymon Brzosko and Stefan H. Jacobson
    Citation: BMC Nephrology 2021 22:333
  4. Clinical pathways aim to improve patient care. We sought to determine whether an online chronic kidney disease (CKD) clinical pathway was associated with improvements in CKD management.

    Authors: Maoliosa Donald, Michelle D. Smekal, Meghan J. Elliott, Kerry McBrien, Robert G. Weaver, Braden J. Manns, Marcello Tonelli, Aminu Bello, Sharon E. Straus, Nairne Scott-Douglas, Kailash Jindal and Brenda R. Hemmelgarn
    Citation: BMC Nephrology 2021 22:332
  5. Reference intervals (RIs) for clinical chemistry test parameters are specific to the method of measurement and population under service. However, there has been no locally available dry chemistry based RIs for...

    Authors: Goma Kathayat, Daya Ram Pokharel, Naval Kishor Yadav and Manoj Sigdel
    Citation: BMC Nephrology 2021 22:331
  6. It has been shown that individuals with obesity have a higher risk for chronic kidney disease (CKD). However, it is unclear which measure of obesity is most useful for prediction of CKD in the general populati...

    Authors: Ensieh Memarian, Peter M. Nilsson, Isac Zia, Anders Christensson and Gunnar Engström
    Citation: BMC Nephrology 2021 22:330
  7. Fibroblast growth factor23 (FGF23) is elevated in CKD and has been associated with outcomes such as death, cardiovascular (CV) events and progression to Renal Replacement therapy (RRT). The majority of studies...

    Authors: Helen V. Alderson, Rajkumar Chinnadurai, Sara T. Ibrahim, Ozgur Asar, James P. Ritchie, Rachel Middleton, Anders Larsson, Peter J. Diggle, Tobias E. Larsson and Philip A. Kalra
    Citation: BMC Nephrology 2021 22:329
  8. Some studies have suggested mizoribine (MZR) could inhibit the replication of BK polyomavirus (BKPyV). The purpose of this study was to explore whether conversion from mycophenolate mofetil (MMF) to MZR in the...

    Authors: Ping Li, Dongrui Cheng, Jiqiu Wen, Xuefeng Ni, Kenan Xie, Xue Li and Jinsong Chen
    Citation: BMC Nephrology 2021 22:328
  9. The vasoconstricting peptide endothelin-1 (ET-1) is associated with endothelial dysfunction. The aim of this paper was to investigate whether circulating ET-1 levels predicts chronic kidney disease (CKD) in a ...

    Authors: Margareta I. Hellgren, Per-Anders Jansson, Hormoz Alayar, Ulf Lindblad and Bledar Daka
    Citation: BMC Nephrology 2021 22:327
  10. Hypertension (HT) is associated with adverse outcomes in kidney transplant (KTX) recipients. Blunting of physiological decrease in nighttime compared to daytime blood pressure (non-dipping status) is frequent ...

    Authors: David A. Jaques, Patrick Saudan, Chantal Martinez, Axel Andres, Pierre-Yves Martin, Antoinette Pechere-Bertschi and Belen Ponte
    Citation: BMC Nephrology 2021 22:325
  11. Chronic kidney disease (CKD) is a common health challenge. There are some risk models predicting CKD adverse outcomes, but seldom focus on the Mongoloid population in East Asian. So, we developed a simple but ...

    Authors: Huizhen Ye, Youyuan Chen, Peiyi Ye, Yu Zhang, Xiaoyi Liu, Guanqing Xiao, Zhe Zhang, Yaozhong Kong and Gehao Liang
    Citation: BMC Nephrology 2021 22:322
  12. The current study investigated the performance of intravoxel incoherent motion diffusion (IVIM) technology in monitoring early renal injury in streptozotocin rats.

    Authors: You-Zhen Feng, Xiao-Qiao Chen, Zhong-Yuan Cheng, Qi-Ting Lin, Ping-Kang Chen, Ding-Kun Si-Tu, Rui Cao, Long Qian, Baoli Heng and Xiang-Ran Cai
    Citation: BMC Nephrology 2021 22:321
  13. Focal and segmental glomerulosclerosis (FSGS) is a histologic pattern of injury that characterizes a wide spectrum of diseases. Many genetic causes have been identified in FSGS but even in families with compre...

    Authors: Poornima Vijayan, Saidah Hack, Tony Yao, Mohammad Azfar Qureshi, Andrew D. Paterson, Rohan John, Bernard Davenport, Rachel Lennon, York Pei and Moumita Barua
    Citation: BMC Nephrology 2021 22:320
  14. Progression of renal anemia has been shown to be associated with advanced renal tubulointerstitial lesions. This retrospective study investigated the impact of lower hemoglobin (Hb) levels and renal interstiti...

    Authors: Miho Shimizu, Kengo Furuichi, Shinji Kitajima, Tadashi Toyama, Megumi Oshima, Hisayuki Ogura, Koichi Sato, Shiori Nakagawa, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Hitoshi Yokoyama…
    Citation: BMC Nephrology 2021 22:319
  15. People living with chronic kidney disease (CKD) require complex medical management and may be frequently hospitalized. Patient safety incidents during hospitalization can result in serious complications which ...

    Authors: Lucia New, Donna Goodridge, Joanne Kappel, Joshua Lawson, Roy Dobson, Erika Penz, Gary Groot and John Gjevre
    Citation: BMC Nephrology 2021 22:318
  16. HIV subjects have several kidney pathologies, like HIV-associated nephropathy or antiretroviral therapy injury, among others. The global prevalence of Chronic Kidney Disease (CKD) is 8–16%; however, in HIV sub...

    Authors: Verónica Valdivia-Cerda, Monserrat Alvarez-Zavala, Karina Sánchez-Reyes, Rodolfo I. Cabrera-Silva, Vida V. Ruiz-Herrera, Aldo D. Loza-Salazar, Pedro Martínez-Ayala, Juan C. Vázquez-Limón, Guillermo García-García, Jaime F. Andrade-Villanueva and Luz A. González-Hernández
    Citation: BMC Nephrology 2021 22:317
  17. The low-density lipoprotein receptor (LDLR) plays a significant role in maintaining the cellular cholesterol homeostasis. Mutations in the LDLR gene can lead to a significant rise in plasma LDL levels that may re...

    Authors: Monika Buraczynska, Jerry Jacob, Karolina Gwiazda-Tyndel and Andrzej Ksiazek
    Citation: BMC Nephrology 2021 22:316
  18. Medication nonadherence is common among patients with hemodialysis, leading to poorer patient outcomes. Health care professionals have an important role in assessing risk of nonadherence and intervening to sup...

    Authors: Trine Mechta Nielsen, Nina Schjerning, Gudrun Kaldan, Mads Hornum, Bo Feldt-Rasmussen and Thordis Thomsen
    Citation: BMC Nephrology 2021 22:315
  19. SARS-CoV-2 can remain transiently viable on surfaces. We examined if use of shared chairs in outpatient hemodialysis associates with a risk for indirect patient-to-patient transmission of SARS-CoV-2.

    Authors: Ravi Thadhani, Joanna Willetts, Catherine Wang, John Larkin, Hanjie Zhang, Lemuel Rivera Fuentes, Len Usvyat, Kathleen Belmonte, Yuedong Wang, Robert Kossmann, Jeffrey Hymes, Peter Kotanko and Franklin Maddux
    Citation: BMC Nephrology 2021 22:313
  20. Authors: Jan Dudley, Martin Christian, Alice Andrews, Nicola Andrews, Julie Baker, Sheila Boyle, Mairead Convery, Fiona Gamston, Martin Garcia, Shuman Haq, Shivaram Hegde, Richard Holt, Helen Jones, Shakeeb Khan, Jennifer McCaughan, David Milford…
    Citation: BMC Nephrology 2021 22:312
  21. Recent studies have shown that the serum uric acid/creatinine ratio (SUA/SCr) is a better predictor of chronic kidney disease (CKD) than serum uric acid (SUA) isolated. The aim of the present study was to eval...

    Authors: Nathalia Rabello Silva, Camila Evangelista Torres Gonçalves, Danilo Lemes Naves Gonçalves, Rosângela Minardi Mitre Cotta and Luciana Saraiva da Silva
    Citation: BMC Nephrology 2021 22:311
  22. Post-translational modifications (PTMs) are at the heart of many cellular signaling events, which changes the function of protein. Crotonylation, one of the most important and common PTMs, plays a crucial role...

    Authors: Jiahuang Huang, Donge Tang, Fengping Zheng, Huixuan Xu and Yong Dai
    Citation: BMC Nephrology 2021 22:310
  23. Explore priorities related to outcomes and barriers of adults with chronic kidney disease (CKD) regarding person centred care and care planning.

    Authors: Ype de Jong, Esmee M. van der Willik, Jet Milders, Yvette Meuleman, Rachael L. Morton, Friedo W. Dekker and Merel van Diepen
    Citation: BMC Nephrology 2021 22:309
  24. To prevent infection and thrombosis of central venous catheters (CVCs) in hemodialysis patients, different CVC lock solutions are available. Taurolidine-based solutions and citrate in different concentrations ...

    Authors: Sonja van Roeden, Mathijs van Oevelen, Alferso C. Abrahams, Friedo W. Dekker, Joris I. Rotmans and Sabine C. A. Meijvis
    Citation: BMC Nephrology 2021 22:308
  25. Patients with stage 5 chronic kidney disease (CKD5) collaborate with their clinicians when choosing their future treatment modality. Most elderly patients with CKD5 may only have two treatment options: dialysi...

    Authors: Louise Engelbrecht Buur, Jens Kristian Madsen, Inge Eidemak, Elizabeth Krarup, Thomas Guldager Lauridsen, Lena Helbo Taasti and Jeanette Finderup
    Citation: BMC Nephrology 2021 22:307

    The Correction to this article has been published in BMC Nephrology 2022 23:352

  26. Decreased kidney function is commonly caused by hypovolemia. When hypovolemic, the kidney reabsorbs water resulting in concentrated urine. Osmolality is a measure of urine concentration which is more objective...

    Authors: Boonsong K. Kitiwan, Sarinnapha M. Vasunilashorn, Heather J. Baer, Kenneth Mukamal and Stephen P. Juraschek
    Citation: BMC Nephrology 2021 22:306
  27. Albumin is the primary body protein, which can predict the poor prognosis of several critical diseases. However, there are a few scientific studies on the relationship between albumin and the prognosis of dial...

    Authors: Lang Jing Zheng, Weiming Jiang, Lingling Pan and Jingye Pan
    Citation: BMC Nephrology 2021 22:305
  28. Diabetic nephropathy (DN) is one of the most important clinical complications of diabetes mellitus (DM) and is the most common cause of end-stage renal disease. Currently, there is no highly effective medicine...

    Authors: Hua-Bin Guo, Jia-Qing Peng, Xuan Wang, Ke-Kai Zhang, Guang-Zhi Zhong, Wei-Hong Chen and Gui-Xin Shi
    Citation: BMC Nephrology 2021 22:304
  29. Thymomas have been associated with a broad spectrum of autoimmune diseases. Minimal change disease (MCD) is the most frequent pathological lesion reported. Pathophysiological mechanisms involved in secondary M...

    Authors: Zhour El Ouafi, Clovis Mugnier, Robin Jeannet, Clément Danthu, Marion Duval, Valère Belle Mbou and Fatouma Touré
    Citation: BMC Nephrology 2021 22:303
  30. Previous studies have shown an association between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD), but it is unclear whether the association is independent of metabolic syndrome.

    Authors: Celestin Missikpode, Holly Kramer, Scott J. Cotler, Ramon Durazo-Arvizu, James P. Lash, Eric Kallwitz, Jianwen Cai, Mark H. Kuniholm, Sylvia E. Rosas, Ana C. Ricardo, Gregory A. Talavera, Leopoldo Raij, Amber Pirzada and Martha L. Daviglus
    Citation: BMC Nephrology 2021 22:302
  31. Globally, renal healthcare practitioners provide intensive and protracted support to a highly complex multi-morbid patient population however knowledge about the impact of COVID-19 on these practitioners is ex...

    Authors: Clare Mc Keaveney, Joanne Reid, Claire Carswell, Ann Bonner, Ilaria de Barbieri, William Johnston, Alexander P. Maxwell, Julien O’Riordan, Veronica Strini, Ian Walsh and Helen Noble
    Citation: BMC Nephrology 2021 22:301
  32. Acute kidney injury is a common complication of percutaneous coronary intervention and has been associated with an increased risk of death and progressive chronic kidney disease. However, whether the timing of...

    Authors: Alan S. Go, Thida C. Tan, Rishi V. Parikh, Andrew P. Ambrosy, Leonid V. Pravoverov, Sijie Zheng and Thomas K. Leong
    Citation: BMC Nephrology 2021 22:300
  33. We tested the hypotheses that: 1) early exposure to increasing episodes of clinically relevant intermittent hypoxia (IH) is detrimental to the developing kidneys; and 2) there is a critical number of daily IH ...

    Authors: Anano Zangaladze, Charles L. Cai, Matthew Marcelino, Jacob V. Aranda and Kay D. Beharry
    Citation: BMC Nephrology 2021 22:299
  34. No publications have reported on osteomalacia in patients receiving intermittent cyclical therapy with etidronate (a bisphosphonate) and undergoing long-term hemodialysis (HD).

    Authors: Masaki Hatano, Izuru Kitajima, Seizo Yamamoto, Masaki Nakamura, Kazuya Isawa, Yutaka Hirota, Junichi Hoshino, Naoki Sawa and Yoshifumi Ubara
    Citation: BMC Nephrology 2021 22:298
  35. Kidney disease and renal failure are associated with hospital deaths in patients with COVID − 19. We aimed to test if contrast enhancement affects short-term renal function in hospitalized COVID − 19 patients.

    Authors: Anna Kistner, Chen Tamm, Ann Mari Svensson, Mats O. Beckman, Fredrik Strand, Magnus Sköld and Sven Nyrén
    Citation: BMC Nephrology 2021 22:297

    The Correction to this article has been published in BMC Nephrology 2021 22:326

  36. Novel urine biomarkers have enabled the characterization of kidney tubular dysfunction and injury among persons living with HIV, a population at an increased risk of kidney disease. Even though several urine b...

    Authors: Anthony N. Muiru, Rebecca Scherzer, Simon B. Ascher, Vasantha Jotwani, Carl Grunfeld, Judy Shigenaga, Kimberly A. Spaulding, Derek K. Ng, Deborah Gustafson, Amanda B. Spence, Anjali Sharma, Mardge H. Cohen, Chirag R. Parikh, Joachim H. Ix, Michelle M. Estrella and Michael G. Shlipak
    Citation: BMC Nephrology 2021 22:296
  37. In typical cases of Bartter syndrome (BS), assessing response to diuretics (furosemide and thiazide), hereinafter referred to as diuretic loading test, may be used to diagnose the type by detecting which part ...

    Authors: Jumpei Kuroda, Ryoko Harada, Riku Hamada, Yusuke Okuda, Yasuhiro Yoshida, Hiroshi Hataya, Kandai Nozu, Kazumoto Iijima, Masataka Honda and Kenji Ishikura
    Citation: BMC Nephrology 2021 22:295
  38. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis usually induces rapidly progressive glomerulonephritis, including pauci-immune necrotizing crescentic glomerulonephritis. Acute tubulointerstiti...

    Authors: Keita Morimoto, Go Kanzaki, Takahito Niikura, Kentaro Koike, Nanae Matsuo, Yukio Maruyama, Nobuo Tsuboi and Takashi Yokoo
    Citation: BMC Nephrology 2021 22:294
  39. KDIGO (Kidney Disease: Improving Global Outcomes) provides two sets of criteria to identify and classify acute kidney injury (AKI): serum creatinine (SCr) and urine output (UO). Inconsistencies in the applicat...

    Authors: Dafna Willner, Aliza Goldman, Hagar Azran, Tal Stern, Dvora Kirshenbom and Guy Rosenthal
    Citation: BMC Nephrology 2021 22:293
  40. Chronic kidney disease (CKD) has become a global public health problem. Accumulating evidence suggested that vitamins play important roles in the progression of CKD.

    Authors: Yong Wang, Ying Zheng, Pu Chen, Shuang Liang, Pengfei He, Xiaolei Shao, Guangyan Cai and Xiangmei Chen
    Citation: BMC Nephrology 2021 22:292
  41. Percutaneous kidney biopsy is the gold standard investigation for the diagnosis of kidney diseases. The associated risks of the procedure depend on the skill and experience of the proceduralist as well as the ...

    Authors: J. P Burke, T Pham, S May, S Okano, S. K Ratanjee, Z Thet, J. K.W Wong, S Venuthurupalli and D Ranganathan
    Citation: BMC Nephrology 2021 22:291
  42. The aim of the study was to assess the correlation of commonly used laboratory tests with clinical activity, degree of kidney involvement and treatment of systemic small-vessel vasculitis with the presence of ...

    Authors: Magdalena Mosakowska, Dorota Brodowska Kania, Katarzyna Szamotulska, Aleksandra Rymarz and Stanisław Niemczyk
    Citation: BMC Nephrology 2021 22:290
  43. Acute kidney injury (AKI) newly-emerged in intensive care unit (ICU), has not been thoroughly studied in previous researches, is likely to differ from AKI developed before ICU admission. This study aimed to ev...

    Authors: Yi-Jia Jiang, Xiu-Ming Xi, Hui-Miao Jia, Xi Zheng, Mei-Ping Wang, Wen Li and Wen-Xiong Li
    Citation: BMC Nephrology 2021 22:289
  44. Long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) is increased under the condition of ischemia. This study intended to identify the mechanism of TUG1 in renal ischemia-reperfusion (I/R).

    Authors: Zhiquan Xu, Xiaoyan Huang, Qiuyu Lin and Wei Xiang
    Citation: BMC Nephrology 2021 22:288
  45. Crescentic glomerulonephritis is a disease characterized by severe glomerular injuries that is classified into five different pathological types. Patients with type V disease have pauci-immune crescentic glome...

    Authors: Ling Hou, Lu Yin, Yubin Wu, Chengguang Zhao and Yue Du
    Citation: BMC Nephrology 2021 22:285

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