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  1. Thrombotic microangiopathy (TMA), a rare but serious complication of systemic lupus erythematosus (SLE), is associated with poor outcomes to conventional immunosuppressive therapy. Recently, eculizumab, a huma...

    Authors: Mi Jung Kim, Haekyung Lee, Yon Hee Kim, So Young Jin, Hee-Jin Kim, Doyeun Oh and Jin Seok Jeon
    Citation: BMC Nephrology 2021 22:86
    Content type: Case report Published on:

  2. Physical frailty has previously been associated with adverse clinical outcomes in patients with end-stage renal disease (ESRD). This study aimed to determine whether impaired physical performance at baseline i...

    Authors: Hee-won Jung, In Young Choi, Dong Wook Shin, Kyungdo Han, Jung Eun Yoo, Sohyun Chun and Yongjin Yi
    Citation: BMC Nephrology 2021 22:85
    Content type: Research article Published on:

  3. Primary hyperoxaluria(PH)is a rare autosomal recessive genetic disease that contains three subtypes (PH1, PH2 and PH3). Approximately 80% of PH patients has been reported as subtype PH1, this subtype of PH has...

    Authors: Chang Bao Xu, Xu Dong Zhou, Hong En Xu, Yong Li Zhao, Xing Hua Zhao, Dan Hua Liu, Yong An Tian, Xin Xin Hu, Jing Yuan Guan, Jian Cheng Guo, Wen Xue Tang and Xia Xue
    Citation: BMC Nephrology 2021 22:83
    Content type: Case report Published on:

  4. Patients with rapidly declining renal function face the dual threat of end-stage renal disease (ESRD) and mortality prior to ESRD. What is less well characterised is whether the pattern of the renal trajectory...

    Authors: Ibrahim Ali, Rajkumar Chinnadurai, Sara T. Ibrahim and Philip A. Kalra
    Citation: BMC Nephrology 2021 22:82
    Content type: Research article Published on:

  5. Emory Dialysis serves an urban and predominantly African American population at its four outpatient dialysis facilities. We describe COVID-19 infection control measures implemented and clinical characteristics...

    Authors: Ibironke W. Apata, Jason Cobb, Jose Navarrete, John Burkart, Laura Plantinga and Janice P. Lea
    Citation: BMC Nephrology 2021 22:81
    Content type: Research article Published on:

  7. Whilst there are a number of publications comparing the relationship between body mass index (BMI) of kidney transplant recipients and graft/patient survival, no study has assessed this for a French patient co...

    Authors: Y. Foucher, M. Lorent, L. Albano, S. Roux, V. Pernin, M. Le Quintrec, C. Legendre, F. Buron, E. Morelon, S. Girerd, M. Ladrière, D. Glotz, C. Lefaucher, C. Kerleau, J. Dantal, J. Branchereau…
    Citation: BMC Nephrology 2021 22:79
    Content type: Research article Published on:

  9. Chronic kidney disease as well as acute kidney injury are associated with adverse outcomes after transcatheter aortic valve replacement (TAVR). However, little is known about the prognostic implications of an ...

    Authors: Dominik Kylies, Sandra Freitag-Wolf, Florian Fulisch, Hatim Seoudy, Christian Kuhn, Lars Philipp Kihm, Thomas Pühler, Georg Lutter, Astrid Dempfle, Norbert Frey, Thorsten Feldkamp and Derk Frank
    Citation: BMC Nephrology 2021 22:77
    Content type: Research article Published on:

  10. A growing body of evidence supports the potential role of social determinants of health on health outcomes. However, few studies have examined the cumulative effect of social determinants of health on health o...

    Authors: Mukoso N. Ozieh, Emma Garacci, Rebekah J. Walker, Anna Palatnik and Leonard E. Egede
    Citation: BMC Nephrology 2021 22:76
    Content type: Research article Published on:

  11. Anti-glomerular basement membrane disease (GBM) disease is a rare autoimmune disease causing rapidly progressive glomerulonephritis and pulmonary haemorrhage. Recently, an association between COVID-19 and anti...

    Authors: Alexander Winkler, Emanuel Zitt, Hannelore Sprenger-Mähr, Afschin Soleiman, Manfred Cejna and Karl Lhotta
    Citation: BMC Nephrology 2021 22:75
    Content type: Case report Published on:

  12. Lately, monoclonal gammopathy of renal significance (MGRS) has been defined as a group of renal disorders that are strongly associated with monoclonal protein, including amyloid immunoglobulin light chain (AL)...

    Authors: Erina Ono, Akira Ishii, Yoshiaki Higashi, Natsuko Koita, Takashi Ayaki, Katsuya Tanigaki, Shunsuke Takayanagi, Naoya Kondo, Kaoru Sakai, Shuichiro Endo, Hideki Yokoi, Takeshi Matsubara, Sachiko Minamiguchi, Ichizo Nishino, Ryosuke Takahashi and Motoko Yanagita
    Citation: BMC Nephrology 2021 22:74
    Content type: Case report Published on:

  13. Hemodialysis patients with COVID-19 have been reported to be at higher risk for death than the general population. Several prognostic factors have been identified in the studies from Asian, European or America...

    Authors: Mabel Aoun, Rabab Khalil, Walid Mahfoud, Haytham Fatfat, Line Bou Khalil, Rashad Alameddine, Nabil Afiouni, Issam Ibrahim, Mohamad Hassan, Haytham Zarzour, Ali Jebai, Nina Mourad Khalil, Luay Tawil, Zeina Mechref, Zuhair El Imad, Fadia Chamma…
    Citation: BMC Nephrology 2021 22:73
    Content type: Research article Published on:

  14. Associations between microvascular variation and chronic kidney disease (CKD) have been reported previously. Non-invasive retinal fundus imaging enables evaluation of the microvascular network and may offer in...

    Authors: Euan N. Paterson, Chris Cardwell, Thomas J. MacGillivray, Emanuele Trucco, Alexander S. Doney, Paul Foster, Alexander P. Maxwell and Gareth J. McKay
    Citation: BMC Nephrology 2021 22:72
    Content type: Research article Published on:

  15. Higher plasma magnesium concentrations are associated with reduced cardiovascular disease risk in chronic kidney disease (CKD) patients. The importance of plasma magnesium concentration for vascular calcificat...

    Authors: Anique D. ter Braake, Larissa P. Govers, Mieke J. Peeters, Arjan D. van Zuilen, Jack F. M. Wetzels, Peter J. Blankenstijn, Joost G. J. Hoenderop, Jeroen H. F. de Baaij and Jan A. J. G. van den Brand
    Citation: BMC Nephrology 2021 22:71
    Content type: Research article Published on:

  16. Due to a critical shortage of available kidney grafts, most patients with Stage 5 Chronic Kidney Disease (CKD5) require bridging dialysis support. It remains unclear whether treatment by different dialysis mod...

    Authors: Robin W. M. Vernooij, Way Law, Sanne A. E. Peters, Bernard Canaud, Andrew Davenport, Muriel P. C. Grooteman, Fatih Kircelli, Francesco Locatelli, Francisco Maduell, Marion Morena, Menso J. Nubé, Ercan Ok, Ferran Torres, Mark Woodward, Peter J. Blankestijn and Michiel L. Bots
    Citation: BMC Nephrology 2021 22:70
    Content type: Research article Published on:

  17. It is unclear whether faster progression of atherosclerosis explains the higher risk of cardiovascular events in CKD. The objectives of this study were to 1. Characterize the associations of CKD with presence ...

    Authors: Srinivasan Beddhu, Robert E. Boucher, Jie Sun, Niranjan Balu, Michel Chonchol, Sankar Navaneethan, Glenn M. Chertow, Raymond Townsend, William Haley, Alfred K. Cheung, Molly B. Conroy, Dominic S. Raj, Dongxiang Xu, Thomas George, Reem Yunis, Guo Wei…
    Citation: BMC Nephrology 2021 22:69
    Content type: Research article Published on:

  18. Diabetic nephropathy, a major complication of diabetes, is the primary risk factor for dialysis, cardiovascular diseases, and mortality. Dietary fatty acids (FAs) have been revealed to be related with cardiova...

    Authors: Takuro Okamura, Hanako Nakajima, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Hiroshi Takakuwa and Michiaki Fukui
    Citation: BMC Nephrology 2021 22:68
    Content type: Research article Published on:

  19. Shared decision making (SDM) is recognized as the gold standard for patient-centered care. This study aimed to assess and compare the SDM among patients undergoing hemodialysis and peritoneal dialysis for choo...

    Authors: Sepide Ghodsian, Mansour Ghafourifard and Akram Ghahramanian
    Citation: BMC Nephrology 2021 22:67
    Content type: Research article Published on:

  20. Sulfation of tyrosine, yielding O-sulfotyrosine, is a common but fixed post-translational modification in eukaryotes. Patients with increased circulating O-sulfotyrosine levels experience a faster decline in r...

    Authors: Shuai Chen, Yong-Hua Liu, Dao-Peng Dai, Zheng-Bin Zhu, Yang Dai, Zhi-Ming Wu, Li-Ping Zhang, Zhi-Feng Duan, Lin Lu, Feng-Hua Ding, Jin-Zhou Zhu and Rui-Yan Zhang
    Citation: BMC Nephrology 2021 22:66
    Content type: Research article Published on:

  21. Individuals undergoing hemodialysis in the United States frequently report pain and receive three-fold more opioid prescriptions than the general population. While opioid use is appropriate for select patients...

    Authors: Matthew Daubresse, G. Caleb Alexander, Deidra C. Crews, Dorry L. Segev, Krista L. Lentine and Mara A. McAdams-DeMarco
    Citation: BMC Nephrology 2021 22:65
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:133

  22. Anemia is one of the common complications in patients with chronic kidney disease (CKD). However, there is no systematic investigation on the prevalence of anemia in CKD patients and its relationship with the ...

    Authors: Yan Shen, Jinwei Wang, Jing Yuan, Li Yang, Fangfang Yu, Xiaolei Wang, Ming-Hui Zhao, Luxia Zhang and Yan Zha
    Citation: BMC Nephrology 2021 22:64
    Content type: Research article Published on:

  23. Acute kidney injury is common in the surgical intensive care unit (ICU). It is associated with poor patient outcomes and high healthcare resource usage. This study’s primary objective is to help identify which...

    Authors: Wen En Joseph Wong, Siew Pang Chan, Juin Keith Yong, Yen Yu Sherlyn Tham, Jie Rui Gerald Lim, Ming Ann Sim, Chai Rick Soh, Lian Kah Ti and Tsong Huey Sophia Chew
    Citation: BMC Nephrology 2021 22:63
    Content type: Research article Published on:

  24. Renal resistive index (RI) predicts mortality in renal transplant recipients (RTR). However, its predictive value may be different according to the time of measurement. We analysed RI changes between 1 month a...

    Authors: Jean-Baptiste de Freminville, Louis-Marie Vernier, Jérome Roumy, Frédéric Patat, Philippe Gatault, Bénédicte Sautenet, Christelle Barbet, Hélène Longuet, Elodie Merieau, Matthias Buchler and Jean-Michel Halimi
    Citation: BMC Nephrology 2021 22:62
    Content type: Research article Published on:

  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Karine Moreau, Aurélie Desseix, Christine Germain, Pierre Merville, Lionel Couzi, Rodolphe Thiébaut and Philippe Chauveau
    Citation: BMC Nephrology 2021 22:61
    Content type: Correction Published on:

    The original article was published in BMC Nephrology 2021 22:31

  26. While catheters are often thought the result of emergency hemodialysis (HD) initiation among patients with little or no pre-dialysis nephrology care, the role of patient level of engagement in care and modalit...

    Authors: Vanessa Grubbs, Bernard G. Jaar, Kerri L. Cavanaugh, Patti L. Ephraim, Jessica M. Ameling, Courtney Cook, Raquel C. Greer and L. Ebony Boulware
    Citation: BMC Nephrology 2021 22:60
    Content type: Research article Published on:

  27. Living-donor transplantation is the best treatment option in patients with chronic kidney failure. Global data show that women are less likely to be kidney recipients than men but are more likely to become liv...

    Authors: Laura Rota-Musoll, Serena Brigidi, Esmeralda Molina-Robles, Ester Oriol-Vila, Laureano Perez-Oller and Mireia Subirana-Casacuberta
    Citation: BMC Nephrology 2021 22:59
    Content type: Research article Published on:

  28. For individuals in need of dialysis, patient participation is important when determining care goals and in decision making regarding dialysis modality. Nephrologists hold a key role in delivering evidence-base...

    Authors: Tone Andersen-Hollekim, Bodil J. Landstad, Marit Solbjør, Marit Kvangarsnes and Torstein Hole
    Citation: BMC Nephrology 2021 22:58
    Content type: Research article Published on:

  29. There is emerging evidence that the 4-variable Kidney Failure Risk Equation (KFRE) can be used for risk prediction of graft failure in transplant recipients. However, geographical validation of the 4-variable ...

    Authors: Ibrahim Ali and Philip A. Kalra
    Citation: BMC Nephrology 2021 22:57
    Content type: Research article Published on:

  30. Chronic kidney disease is a systemic disease affecting not only renal function, but also endocrine, cardiovascular, and skeletal muscle systems, with broad impact on functionality. Therefore, the assessment of...

    Authors: Camila Porto Brito, Igor Gutierrez Moraes, Cláudio Luders, Christina May Moran de Brito and Wellington Pereira Yamaguti
    Citation: BMC Nephrology 2021 22:56
    Content type: Research article Published on:

  31. The association of hypertension with congenital renal hypoplasia has been established. We report a case of an infant who underwent nephrectomy for hypertension.

    Authors: Keisuke Sugimoto, Takuji Enya, Kensuke Joh, Kohei Miyazaki, Tomoki Miyazawa, Rina Ohshima, Satoshi Marutani, Takemura Tsukasa and Mitsuru Okada
    Citation: BMC Nephrology 2021 22:55
    Content type: Case report Published on:

  32. Recent trials have suggested use of balanced crystalloids may decrease the incidence of major adverse kidney events compared to saline in critically ill adults. The effect of crystalloid composition on biomark...

    Authors: Blake E. Funke, Karen E. Jackson, Wesley H. Self, Sean P. Collins, Christina T. Saunders, Li Wang, Jeffrey D. Blume, Nancy Wickersham, Ryan M. Brown, Jonathan D. Casey, Gordon R. Bernard, Todd W. Rice, Edward D. Siew and Matthew W. Semler
    Citation: BMC Nephrology 2021 22:54
    Content type: Research article Published on:

  33. Anti-glomerular basement membrane (anti-GBM) disease is an organ-specific autoimmune disease that involves the lung and kidneys and leads to rapid glomerulonephritis progression, with or without diffuse alveol...

    Authors: Na Guo, Qinghua Yin, Song Lei, Yanjun He and Ping Fu
    Citation: BMC Nephrology 2021 22:53
    Content type: Case report Published on:

  34. Acute kidney injury (AKI) occurs among patients with coronavirus disease-19 (COVID-19) and has also been indicated to be associated with in-hospital mortality. Remdesivir has been authorized for the treatment ...

    Authors: Zhenjian Xu, Ying Tang, Qiuyan Huang, Sha Fu, Xiaomei Li, Baojuan Lin, Anping Xu and Junzhe Chen
    Citation: BMC Nephrology 2021 22:52
    Content type: Research article Published on:

  35. Heterozygous mutations in the inverted formin 2 (INF2) gene are related to secondary focal segmental glomerulosclerosis (FSGS), a rare secondary disease associated with rapidly progressive renal failure.

    Authors: Wenbo Zhao, Xinxin Ma, Xiaohao Zhang, Dan Luo, Jun Zhang, Ming Li, Zengchun Ye and Hui Peng
    Citation: BMC Nephrology 2021 22:51
    Content type: Case report Published on:

  36. Cardiac biomarkers Troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (proBNP) and abdominal aortic calcification score (AAC) are associated with cardiovascular events and mortality in patients wit...

    Authors: Roosa Lankinen, Markus Hakamäki, Kaj Metsärinne, Niina Koivuviita, Jussi P. Pärkkä, Maria Saarenhovi, Tapio Hellman and Mikko J. Järvisalo
    Citation: BMC Nephrology 2021 22:50
    Content type: Research article Published on:

  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Anja Gäckler, Ulf Schönermarck, Vladimir Dobronravov, Gaetano La Manna, Andrew Denker, Peng Liu, Maria Vinogradova, Sung-Soo Yoon and Manuel Praga
    Citation: BMC Nephrology 2021 22:49
    Content type: Correction Published on:

    The original article was published in BMC Nephrology 2021 22:5

  38. The festival of Ramadan is a month of spiritual reflection for Muslims worldwide. During Ramadan, Muslims are required to refrain from eating and drinking during daylight hours. Although exempted from fasting,...

    Authors: Nurul Iman Hafizah Adanan, Wan Ahmad Hafiz Wan Md Adnan, Pramod Khosla, Tilakavati Karupaiah and Zulfitri Azuan Mat Daud
    Citation: BMC Nephrology 2021 22:48
    Content type: Research article Published on:

  39. Tuberous Sclerosis Complex (TSC) is a genetic disorder, with renal manifestations like angiomyolipoma (AML) occurring in 70–80% of patients. AML usually cause more complications in TCS patients than in non-TSC...

    Authors: Kathrin Bausch, Christian Wetterauer, Julian Diethelm, Jan Ebbing, Daniel T. Boll, Patricia Dill, Cyrill A. Rentsch and Hans-H. Seifert
    Citation: BMC Nephrology 2021 22:47
    Content type: Research article Published on:

  40. Ankylosing spondylitis (AS) is an insidiously progressive and debilitating form of arthritis involving the axial skeleton, characterized by chronic back pain and progressive spinal stiffness, and lessening of ...

    Authors: Anna Zawiasa-Bryszewska, Olga Brzezińska, Ilona Kurnatowska and Joanna Makowska
    Citation: BMC Nephrology 2021 22:46
    Content type: Case report Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:78

  41. To evaluate the transmembrane clearance (CLTM) of apixaban during modeled in vitro continuous renal replacement therapy (CRRT), assess protein binding and circuit adsorption, and provide initial dosing recommenda...

    Authors: Lauren Andrews, Scott Benken, Xing Tan and Eric Wenzler
    Citation: BMC Nephrology 2021 22:45
    Content type: Research article Published on:

  42. Serum parathyroid hormone (PTH) levels have been reported to be associated with infectious mortality in peritoneal dialysis (PD) patients. Peritonitis is the most common and fatal infectious complication, resu...

    Authors: Yuqi Yang, Jingjing Da, Yi Jiang, Jing Yuan and Yan Zha
    Citation: BMC Nephrology 2021 22:44
    Content type: Research article Published on:

  43. Immunoglobulin A nephropathy (IgAN) is identified as mesangial IgA deposition and is usually accompanied by other immunofluorescence deposits. The impact of immunofluorescent features in IgAN patients, however...

    Authors: Lingzhi Wu, Di Liu, Ming Xia, Guochun Chen, Yu Liu, Xuejing Zhu and Hong Liu
    Citation: BMC Nephrology 2021 22:43
    Content type: Research article Published on:

  44. Light chain cast nephropathy (LCCN) is the most common renal disease caused by multiple myeloma (MM). In addition to ordinary light chain protein casts, there are a few rare casts with unique shapes, including...

    Authors: Li-Jun Sun, Hong-Rui Dong, Xiao-Yi Xu, Guo-Qin Wang, Hong Cheng and Yi-Pu Chen
    Citation: BMC Nephrology 2021 22:42
    Content type: Case report Published on:

  45. The study aim was to establish if substitution of citrate with rt-PA for catheter lock once weekly can reduce the incidence of catheter-related blood stream infections (CR-BSI) or improve patency of tunneled h...

    Authors: Pavlina Richtrova, Jan Mares, Lukas Kielberger, Jan Klaboch, Jaromir Eiselt and Tomas Reischig
    Citation: BMC Nephrology 2021 22:41
    Content type: Research article Published on:

  46. IgD multiple myeloma (MM) is a rare subtype of MM and light chain deposition disease (LCDD) outside the kidney is also a rare and has scarcely been reported. We report herein the details of the first reported ...

    Authors: Takafumi Tsushima, Tomo Suzuki, Toshiki Terao, Daisuke Miura, Kentaro Narita, Masami Takeuchi, Akira Shimuzu and Kosei Matsue
    Citation: BMC Nephrology 2021 22:40
    Content type: Case report Published on:

  47. The incidence and prevalence of older patients with kidney failure who are dependent on dialysis is increasing. However, observational studies showed limited or no benefit of dialysis on mortality in subgroups...

    Authors: Mathijs van Oevelen, Alferso C. Abrahams, Willem Jan W. Bos, Mariëlle H. Emmelot-Vonk, Simon P. Mooijaart, Merel van Diepen, Brigit C. van Jaarsveld, Anita van Eck van der Sluijs, Carlijn G. N. Voorend and Marjolijn van Buren
    Citation: BMC Nephrology 2021 22:39
    Content type: Study protocol Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:113

  48. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Rui Huang, Haifen Zhang, Yan Yang, Nina Fang, Qian Liu, Jun Ma, Min Wang, Ling Shi and Xingjuan Tao
    Citation: BMC Nephrology 2021 22:38
    Content type: Correction Published on:

    The original article was published in BMC Nephrology 2021 22:17

  49. This study estimated the prevalence and risk factors for decreased estimated glomerular filtration rate (eGFR) in those without known hypertension, type 2 diabetes mellitus, or heavy proteinuria as a surrogate...

    Authors: Andrea Ruiz-Alejos, Ben Caplin, J. Jaime Miranda, Neil Pearce and Antonio Bernabé-Ortiz
    Citation: BMC Nephrology 2021 22:37
    Content type: Research article Published on:

  50. Dry weight assessment in hemodialysis (HD) remains a challenge. The aim of the study was to investigate the prevalence of subclinical pulmonary congestion using lung ultrasound (LUS) in maintenance HD patients...

    Authors: Domenico Giannese, Alessandro Puntoni, Adamasco Cupisti, Riccardo Morganti, Enrico Varricchio, Claudia D’Alessandro, Claudia Mannucci, Piera Serio and Maria Francesca Egidi
    Citation: BMC Nephrology 2021 22:36
    Content type: Research article Published on:
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BMC Nephrology

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