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  1. Lupus nephritis (LN) is an inflammation of the kidneys and is a major cause of mortality in systemic lupus erythaematosus (SLE) patients. In addition, Th17/Treg balance is one of the most important factors tha...

    Authors: Dongdong Fu, Soulixay Senouthai, Junjie Wang and Yanwu You
    Citation: BMC Nephrology 2019 20:350
    Content type: Research article Published on:

  3. High blood pressure is the most significant risk factor for the development and progression of chronic kidney disease (CKD). Lowering blood pressure is a goal to prevent CKD progression. This study of adults w...

    Authors: Jianzhen Zhang, Helen G. Healy, Sree Krishna Venuthurupalli, Ken-Soon Tan, Zaimin Wang, Anne Cameron and Wendy E. Hoy
    Citation: BMC Nephrology 2019 20:348
    Content type: Research article Published on:

  4. Intradialytic blood pressure (BP) measurement is currently the main parameter used for monitoring hemodynamics during hemodialysis (HD). Since BP is dependent on cardiac output and total peripheral resistance,...

    Authors: Keren Doenyas-Barak, Marcia H. F. G. de Abreu, Lucas E. Borges, Helcio A. Tavares Filho, Feng Yunlin, Zou Yurong, Nathan W. Levin, Allen M. Kaufman, Shay Efrati, David Pereg, Ilya Litovchik, Shmuel Fuchs and Sa’ar Minha
    Citation: BMC Nephrology 2019 20:347
    Content type: Research article Published on:

  5. Kidney transplantation is the optimal treatment in end stage renal disease but the allograft survival is still hampered by immune reactions against the allograft. This process is driven by the recognition of a...

    Authors: Constantin Aschauer, Kira Jelencsics, Karin Hu, Andreas Heinzel, Julia Vetter, Thomas Fraunhofer, Susanne Schaller, Stephan Winkler, Lisabeth Pimenov, Guido A. Gualdoni, Michael Eder, Alexander Kainz, Heinz Regele, Roman Reindl-Schwaighofer and Rainer Oberbauer
    Citation: BMC Nephrology 2019 20:346
    Content type: Study protocol Published on:

  6. Patients with end-stage renal disease have a higher risk of death from cardiovascular events, which can be mainly attributed to coronary artery calcification (CAC). Wnt signaling is involved in vascular develo...

    Authors: Tzung-Yo Ho, Nai-Ching Chen, Chih-Yang Hsu, Chien-Wei Huang, Po-Tsang Lee, Kang-Ju Chou, Hua-Chang Fang and Chien-Liang Chen
    Citation: BMC Nephrology 2019 20:345
    Content type: Research article Published on:

  7. Patient-reported outcome measures (PROMs) are becoming increasingly important in healthcare. In nephrology, there is no agreement on which chronic kidney disease (CKD) symptom questionnaire to use. Therefore, ...

    Authors: Esmee M. van der Willik, Yvette Meuleman, Karen Prantl, Giel van Rijn, Willem Jan W. Bos, Frans J. van Ittersum, Hans A. J. Bart, Marc H. Hemmelder and Friedo W. Dekker
    Citation: BMC Nephrology 2019 20:344
    Content type: Research article Published on:

  8. Neighborhood racial mix is associated with dialysis facility performance metrics and mortality outcomes in patients on hemodialysis. We explored the association of neighborhood racial mix with emergency depart...

    Authors: Ladan Golestaneh, Atessa Farzami, Chikeluba Madu, Tanya Johns, Michal L. Melamed and Keith C. Norris
    Citation: BMC Nephrology 2019 20:343
    Content type: Research article Published on:

  9. Approximately 4–6% of incident end stage renal disease (ESRD) patients in the U.S. recover enough kidney function to discontinue dialysis but there is considerable geographic variation. We undertook this study...

    Authors: Zijin Chen, Benjamin J. Lee, Charles E. McCulloch, Nilka Ríos Burrows, Michael Heung, Raymond K. Hsu, Meda E. Pavkov, Neil R. Powe, Rajiv Saran, Vahakn Shahinian and Chi-yuan Hsu
    Citation: BMC Nephrology 2019 20:342
    Content type: Research article Published on:

  11. Kidney transplantation is the treatment of choice in end-stage renal disease due to Alport syndrome (AS). However, the chances of finding an adequate living-related donor in AS are much worse compared to non-h...

    Authors: Friederike Petzold, Anette Bachmann, Carsten Bergmann, Udo Helmchen and Jan Halbritter
    Citation: BMC Nephrology 2019 20:340
    Content type: Case report Published on:

  12. Microscopic polyangiitis (MPA) is a systemic autoimmune disease, and renal involvement is frequently present in MPA. MPA patients with renal involvement may have a worse prognosis. In this study, we aimed to e...

    Authors: Jia Shi, Qing Shen, Xue-Mei Chen and Xiao-Gang Du
    Citation: BMC Nephrology 2019 20:339
    Content type: Research article Published on:

  13. Sleep disturbance is common among chronic haemodialysis patients, which leads to poor quality of life, in addition to increased instances of morbidity and mortality. Hypervolemia has been linked to sleep probl...

    Authors: Sethanant Sethakarun, Sutachard Bijaphala, Chagriya Kitiyakara, Sarinya Boongird, Pariya Phanachet, Sirimon Reutrakul, Kwanchai Pirojsakul and Arkom Nongnuch
    Citation: BMC Nephrology 2019 20:211
    Content type: Research article Published on:

  14. Chronic Kidney Disease (CKD) of uncertain origin (CKDu) has affected North Central Province (Anuradhapura and Polonnaruwa districts) of Sri Lanka. The cause is still unknown. The objective of this study was to...

    Authors: Asanga Venura Ranasinghe, Gardiye Weligamage Gamini Priyantha Kumara, Ranamuka Henayage Karunarathna, Ambepitiyawaduge Pubudu De Silva, Korale Gedara Dilini Sachintani, Jayaprakara Mudiyanselage Chathurika Nayani Gunawardena, Sembu Kuttige Champika Ruwan Kumari, Mohamed Shali Fathima Sarjana, Janaka Sri Chandraguptha and Mannikawadumesthri Vipula Chandu De Silva
    Citation: BMC Nephrology 2019 20:338
    Content type: Research article Published on:

  15. Autosomal dominant polycystic kidney disease (ADPKD) may manifest non-nephrotic range proteinuria, but is rarely complicated with nephrotic syndrome. Limited number of reports describe the histology of ADPKD w...

    Authors: Yasuhiro Oda, Naoki Sawa, Eiko Hasegawa, Hiroki Mizuno, Masahiro Kawada, Akinari Sekine, Rikako Hiramatsu, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Kenmei Takaichi, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii and Yoshifumi Ubara
    Citation: BMC Nephrology 2019 20:337
    Content type: Case report Published on:

  16. Though the roles of microRNAs (miRNAs) in renal diseases have been extensively investigated, a thorough screening and comparison of miRNAs among different types of chronic kidney disease (CKD) has never been p...

    Authors: Jianwen Yu, Chaolun Yu, Boya Feng, Xiaojiang Zhan, Ning Luo, Xueqing Yu and Qin Zhou
    Citation: BMC Nephrology 2019 20:336
    Content type: Research article Published on:

  17. The nature of immunoglobulin M (IgM) nephropathy has been controversial for a long time, but it is now considered an independent disease like immunoglobulin A nephropathy. IgM nephropathy has been known to hav...

    Authors: Kyoung Sook Park, Ea Wha Kang and Jeong Hae Kie
    Citation: BMC Nephrology 2019 20:335
    Content type: Case report Published on:

  18. The value of ANCA positivity in the setting of systemic lupus erythematous and their pathogenicity remains uncertain.

    Authors: Marie Lemerle, Anne-Sophie Garnier, Anne Croue, Alain Chevailler, Jean-Paul Saint-André, Jean-François Subra, Jean-François Augusto and Julien Demiselle
    Citation: BMC Nephrology 2019 20:334
    Content type: Case report Published on:

  19. Immunosuppressive agents have been widely used in the treatment of IgA nephropathy (IgAN), but the efficacy and safety remain controversial. The recent STOP-IgAN and TESTING studies have again focused attentio...

    Authors: Zheng Zhang, Yue Yang, Shi-min Jiang and Wen-ge Li
    Citation: BMC Nephrology 2019 20:333
    Content type: Research article Published on:

  20. Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies....

    Authors: Li Xian, Dandan Dong, Jiamei Luo, Ling Zhuo, Ke Li, Ping Zhang, Wei Wang, Ying Xu, Gang Xu, Li Wang and Guisen Li
    Citation: BMC Nephrology 2019 20:332
    Content type: Research article Published on:

  21. Oedema, characterized by accumulation of extracellular water (ECW), is one of the major clinical manifestations in children suffering from nephrotic syndrome (NS).

    Authors: Steven Brantlov, Lars Jødal, René Frydensbjerg Andersen, Aksel Lange, Søren Rittig and Leigh C. Ward
    Citation: BMC Nephrology 2019 20:331
    Content type: Research article Published on:

  22. Proteinuria is a common clinical presentation, the diagnostic workup for which involves many non-invasive and invasive investigations. We report on two siblings that highlight the clinically relevant functiona...

    Authors: Kushani Jayasinghe, Susan M. White, Peter G. Kerr, Duncan MacGregor, Zornitza Stark, Ella Wilkins, Cas Simons, Andrew Mallett and Catherine Quinlan
    Citation: BMC Nephrology 2019 20:330
    Content type: Case report Published on:

  23. A survival advantage associated with obesity has often been described in dialysis patients. The association of higher body mass index (BMI) with mortality and renal replacement therapy (RRT) in preterminal chr...

    Authors: Zaimin Wang, Jianzhen Zhang, Samuel Chan, Anne Cameron, Helen G. Healy, Sree K. Venuthurupalli, Ken-Soon Tan and Wendy E. Hoy
    Citation: BMC Nephrology 2019 20:329
    Content type: Research article Published on:

  24. Focal segmental lesions (FSLs) are not uncommon in idiopathic membranous nephropathy (IMN). The reported percentage of IMN patients with focal segmental glomerulosclerosis (FSGS) lesions varies widely between ...

    Authors: Hong-Guang He, Chao-Qing Wu, Kun Ye, Chun Zeng, Yi-Yun Huang, Shu-Wen Luo, Wu Yin, Qiu-Rong Ye and Xiao-Mei Peng
    Citation: BMC Nephrology 2019 20:328
    Content type: Research article Published on:

  25. Studies have reported conflicting findings on the infection risk posed by intravenous iron supplementation among hemodialysis (HD) patients. We used a novel study design to assess associations between intraven...

    Authors: Chieh-Li Yen, Yu-Sheng Lin, Yueh-An Lu, Hsin-Fu Lee, Cheng-Chia Lee, Ying-Chang Tung, George Kuo, Lung-Sheng Wu, Ya-Chung Tian and Pao-Hsien Chu
    Citation: BMC Nephrology 2019 20:327
    Content type: Research article Published on:

  26. Podocyte infolding glomerulopathy (PIG) is a rare histopathologic finding with global infolding of the podocytes into the glomerular basement membrane (GBM), accompanied by microstructures underneath. Describe...

    Authors: Fabian Wöstmann, Roman-Ulrich Müller, Heike Göbel, Thomas Benzing, Jan U. Becker and Malte P. Bartram
    Citation: BMC Nephrology 2019 20:326
    Content type: Case report Published on:

  27. Patients with cardiovascular disease are at an increased risk of chronic kidney disease (CKD). However, data on incident CKD in patients with multiple vascular comorbidities are insufficient. In this study, we...

    Authors: Saif Al-Shamsi, Abderrahim Oulhaj, Dybesh Regmi and Romona D. Govender
    Citation: BMC Nephrology 2019 20:325
    Content type: Research article Published on:

  28. Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased risk of cardiovascular morbidity and mortality. Impaired left ventricular (LV) global longitudinal strain (GLS) can be a sig...

    Authors: Mats C. H. Lassen, Atif N. Qasim, Tor Biering-Sørensen, Jacob L. T. Reeh, Terry Watnick, Stephen L. Seliger, Huanwen Chen, Mariem A. Sawan, Daniel Nguyen, Yongfang Li, Susie N. Hong and Meyeon Park
    Citation: BMC Nephrology 2019 20:324
    Content type: Research article Published on:

  29. Patients with end-stage renal disease (ESRD) under hemodialysis (HD) are at greater risks of infectious spondylitis (IS), but there is no reliable predictor that facilitate early detection of this relatively r...

    Authors: Kun-Lin Lu, Wen-Hung Huang, Yueh-An Lu, Chan-Yu Lin, Hsin-Hsu Wu, Ching-Wei Hsu, Cheng-Hao Weng, Chao-Yi Wu, I-Wen Wu, Meng-Yu Wu, Tzung-Hai Yen and Huang-Yu Yang
    Citation: BMC Nephrology 2019 20:323
    Content type: Research article Published on:

  30. Glomerulopathy with fibronectin deposits is an autosomal dominant disease associated with proteinuria, hematuria, hypertension and renal function decline. Forty percent of the cases are caused by mutations in FN1

    Authors: Maria Luíza Gonçalves dos Reis Monteiro, Fabiano Bichuette Custódio, Precil Diego Miranda de Menezes Neves, Frederico Moraes Ferreira, Elieser Hitoshi Watanabe, Antônio Marcondes Lerário, Liliane Silvano de Araújo, Bruno Eduardo Pedroso Balbo, Vívian Christine Dourado Pinto, Lívia Maria Gruli Barbosa, Vilmar de Paiva Marques, Juliana Reis Machado, Marlene Antônia Reis and Luiz Fernando Onuchic
    Citation: BMC Nephrology 2019 20:322
    Content type: Case report Published on:

  31. Cardiovascular disease (CVD) events are the main cause of death in long-term hemodialysis (HD) patients. Macrophage colony- stimulating factor (M-CSF) is actively involved in the formation of atherosclerosis a...

    Authors: Xuan Deng, Qian Yang, Yuxi Wang, Yi Yang, Guangchang Pei, Han Zhu, Jianliang Wu, Meng Wang, Zhi Zhao, Huzi Xu, Cheng Zhou, Yi Guo, Ying Yao, Zhiguo Zhang, Wenhui Liao and Rui Zeng
    Citation: BMC Nephrology 2019 20:321
    Content type: Research article Published on:

  32. The challenges in diagnosis of rare renal conditions can negatively impact patient prognosis, quality of life and result in significant healthcare costs. Differential methylation is emerging as an important bi...

    Authors: Katie Kerr, Helen McAneney, Cheryl Flanagan, Alexander P. Maxwell and Amy Jayne McKnight
    Citation: BMC Nephrology 2019 20:320
    Content type: Research article Published on:

  33. Chronic kidney disease (CKD) has been considered as a major health problem in the world. Increasing uric acid (UA) could induce vascular endothelial injury, which is closely related to microinflammation, oxida...

    Authors: Wei Yin, Qiao-Ling Zhou, Sha-Xi OuYang, Ying Chen, Yu-Ting Gong and Yu-Mei Liang
    Citation: BMC Nephrology 2019 20:319
    Content type: Research article Published on:

  34. No study has specifically investigated the duration of continuous renal replacement therapy (CRRT) in patients who experienced acute kidney injury during extracorporeal membrane oxygenation (ECMO) support. How...

    Authors: George Kuo, Shao-Wei Chen, Pei-Chun Fan, Victor Chien-Chia Wu, An-Hsun Chou, Cheng-Chia Lee, Pao-Hsien Chu, Feng-Chun Tsai, Ya-Chung Tian and Chih-Hsiang Chang
    Citation: BMC Nephrology 2019 20:318
    Content type: Research article Published on:

  35. Patients treated with conventional hemodialysis have poor physical performance, explained by insufficient metabolic clearance and shortage of time by time-consuming dialysis. Nocturnal hemodialysis improves me...

    Authors: Manouk Dam, Peter J. M. Weijs, Frans J. van Ittersum and Brigit C. van Jaarsveld
    Citation: BMC Nephrology 2019 20:317
    Content type: Research article Published on:

  36. It is known that one of the leading causes of morbidity in chronic kidney disease (CKD) is the anemic syndrome. Although the pathogenic mechanisms of anemia are multiple, erythropoietin deficiency appears as t...

    Authors: Ailema González-Ortiz, Ricardo Correa-Rotter, Armando Vázquez-Rangel, Olynka Vega-Vega and Ángeles Espinosa-Cuevas
    Citation: BMC Nephrology 2019 20:316
    Content type: Research article Published on:

  37. Performing a kidney biopsy is necessary to accurately diagnose diseases such as glomerulonephritis and tubulointerstitial nephritis, among other such conditions. These conditions predispose patients to chronic...

    Authors: Henrique Pinheiro Konigsfeld, Tatiana Garcia Viana, Suzy Cristine Pereira, Thais Oliveira Claizoni Dos Santos, Gianna Mastroianni Kirsztajn, Agostinho Tavares and Marcelino de Souza Durão Junior
    Citation: BMC Nephrology 2019 20:315
    Content type: Research article Published on:

  38. In kidney transplantation, immunotherapy with thymoglobulin (rATG) has been used to down-regulate the patient immune system. rATG is a powerful immunobiologic drug used to deplete lymphocytes to prevent early ...

    Authors: Marcus Faria Lasmar, Rodrigo Santana Dutra, José Augusto Nogueira-Machado, Raquel A. Fabreti-Oliveira, Raquel Gomes Siqueira and Evaldo Nascimento
    Citation: BMC Nephrology 2019 20:314
    Content type: Research article Published on:

  39. Complement activation plays a substantial role in the pathogenesis of primary membranous nephropathy (pMN). C5b-9, C3c, MBL, and factor B have been documented in the subepithelial immune deposits. However, the...

    Authors: Mu-fan Zhang, Jing Huang, Yi-miao Zhang, Zhen Qu, Xin Wang, Fang Wang, Li-qiang Meng, Xu-yang Cheng, Zhao Cui, Gang Liu and Ming-hui Zhao
    Citation: BMC Nephrology 2019 20:313
    Content type: Research article Published on:

  41. Patients suffering from acute kidney injury (AKI) were associated with impaired sodium and potassium homeostasis. We aimed to investigate how admission serum sodium and potassium independently and jointly modi...

    Authors: Xu-ping Gao, Chen-fei Zheng, Min-qi Liao, Hong He, Yan-hua Liu, Chun-xia Jing, Fang-fang Zeng and Qing-shan Chen
    Citation: BMC Nephrology 2019 20:311
    Content type: Research article Published on:

  42. Lysozyme amyloidosis is a rare hereditary systemic amyloidosis with amyloid deposits in various tissues leading to progressive organ failure. It has been mainly reported in developed countries since 1993. Here...

    Authors: Zhenyu Li, Hui Xu, Dan Liu, Danyang Li, Gang Liu and Su-xia Wang
    Citation: BMC Nephrology 2019 20:310
    Content type: Case report Published on:

  43. The benefits and risks of antiplatelet therapy for patients with chronic kidney disease (CKD) remain controversial. We undertook a systematic review and meta-analysis to investigate the effects of antiplatelet...

    Authors: Xiaole Su, Bingjuan Yan, Lihua Wang, Jicheng Lv, Hong Cheng and Yipu Chen
    Citation: BMC Nephrology 2019 20:309
    Content type: Research article Published on:

  44. The Southern Community Cohort Study is a prospective study of low socioeconomic status (SES) blacks and whites from the southeastern US, where the burden of end-stage renal disease (ESRD) and its risk factors ...

    Authors: Fabian Bock, Thomas G. Stewart, Cassianne Robinson-Cohen, Jennifer Morse, Edmond K. Kabagambe, Kerri L. Cavanaugh, Kelly A. Birdwell, Adriana M. Hung, Khaled Abdel-Kader, Edward D. Siew, Elvis A. Akwo, William J. Blot, T. Alp Ikizler and Loren Lipworth
    Citation: BMC Nephrology 2019 20:308
    Content type: Research article Published on:

  45. Atypical hemolytic uremic syndrome (aHUS) is a disorder of the microvasculature with hemolytic anemia, thrombocytopenia and acute kidney injury. Nowadays, aHUS is successfully treated with eculizumab, a humani...

    Authors: Subagini Nagarajah, Martin Tepel, Christian Nielsen, Kristian Assing, Yaseelan Palarasah, Lise Lotte Torvin Andersen, Lotte Borg Lange and Claus Bistrup
    Citation: BMC Nephrology 2019 20:307
    Content type: Case report Published on:

  46. Proteinuria is known to be associated with both kidney function deterioration and cardiovascular diseases. While proteinuria estimation from 24-h urine samples has traditionally been considered as the standard...

    Authors: Seiji Kobayashi, Hoichi Amano, Hiroyuki Terawaki, Makoto Ogura, Yoshindo Kawaguchi and Takashi Yokoo
    Citation: BMC Nephrology 2019 20:306
    Content type: Research article Published on:

  48. New non-invasive biomarkers are demanded to identify renal damage in various autoimmune-associated kidney diseases. Glomerular podocyte damage mediated by systemic lupus erythematosus (SLE) plays an important ...

    Authors: Jian Lu, Ze Bo Hu, Pei Pei Chen, Chen Chen Lu, Jia Xiu Zhang, Xue Qi Li, Ben Yin Yuan, Si Jia Huang and Kun Ling Ma
    Citation: BMC Nephrology 2019 20:303
    Content type: Research article Published on:

  49. Impaired T cell immune function exists in end-stage renal disease (ESRD) patients. Dialysis treatment may lead to changes in T cell subsets. In the present study, we aimed to identify alterations of T cell phe...

    Authors: Jiao Xiaoyan, Chen Rongyi, Cao Xuesen, Zou Jianzhou, Ji Jun, Ding Xiaoqiang and Yu Xiaofang
    Citation: BMC Nephrology 2019 20:301
    Content type: Research article Published on:

  50. Chronic Kidney Disease in certain part of Sri Lanka and increasing burden of CKD in some other countries is a global public health problem. While the underlying causes of majority of cases are unknown, effecti...

    Authors: Nalaka Herath, Rajeewa Dassanayake, Manjula Dissanayake, Chamara Janitha, Kosala Weerakoon, Chalaka Kumarasinghe, Terence Gamini de Silva and Suneth Agampodi
    Citation: BMC Nephrology 2019 20:298
    Content type: Research article Published on:
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