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  1. Evidence supports high prevalence of periodontitis in patients with chronic kidney disease. Several renal factors have been proposed as possible modifiers of periodontitis pathogenesis in this population. In t...

    Authors: Michel V. Furtado Araújo, Bo-Young Hong, Philip L. Fava, Shiza Khan, Joseph A. Burleson, George Fares, Wilner Samson, Linda D. Strausbaugh, Patricia I. Diaz and Effie Ioannidou
    Citation: BMC Nephrology 2015 16:80
    Content type: Research article Published on:

  2. In patients undergoing maintenance hemodialysis (HD), hyporesponsiveness to erythropoiesis stimulating agents (ESAs) is associated with adverse clinical outcomes. Systemic inflammation is highly prevalent in H...

    Authors: Matthew B. Rivara, T. Alp Ikizler, Charles D. Ellis, Rajnish Mehrotra and Jonathan Himmelfarb
    Citation: BMC Nephrology 2015 16:79
    Content type: Research article Published on:

  3. The objective of the study was to determine the relationship between common carotid artery intima-media thickness (CCA-IMT) and histologically assessed calcification of radial artery in relation to clinical fe...

    Authors: Katarzyna Janda, Marcin Krzanowski, Mariusz Gajda, Paulina Dumnicka, Danuta Fedak, Grzegorz J. Lis, Piotr Jaśkowski, Agata Pietrzycka, Jan A. Litwin and Władysław Sułowicz
    Citation: BMC Nephrology 2015 16:78
    Content type: Research article Published on:

  4. We studied the association of inflammatory biomarkers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) with chronic kidney disease (CKD).

    Authors: Belinda T. Lee, Faheemuddin A. Ahmed, L. Lee Hamm, Federico J. Teran, Chung-Shiuan Chen, Yanxi Liu, Kamal Shah, Nader Rifai, Vecihi Batuman, Eric E. Simon, Jiang He and Jing Chen
    Citation: BMC Nephrology 2015 16:77
    Content type: Research article Published on:

  5. Adult cardiac surgery is significantly associated with the development of acute kidney injury (AKI). Still, the incidence and outcomes of AKI vary according to its definition. Our retrospective monocentric stu...

    Authors: Marc-Gilbert Lagny, François Jouret, Jean-Noël Koch, Francine Blaffart, Anne-Françoise Donneau, Adelin Albert, Laurence Roediger, Jean-Marie Krzesinski and Jean-Olivier Defraigne
    Citation: BMC Nephrology 2015 16:76
    Content type: Research article Published on:

  6. Renal involvement in sickle cell disease (SCD) contributes significantly to morbidity and mortality. The aim of this study was to determine the prevalence of chronic kidney disease (CKD) amongst SCD patients, ...

    Authors: Richard Kobina Dadzie Ephraim, Derick Nii Mensah Osakunor, Obed Cudjoe, Enos Amoako Oduro, Lyudmila Asante-Asamani, Juliana Mitchell, Hope Agbodzakey and Prince Adoba
    Citation: BMC Nephrology 2015 16:75
    Content type: Research article Published on:

  8. Streptococcus uberis, the most frequent cause of mastitis in lactating cows, is considered non-pathogenic for humans. Only a few case reports have described human infections with this microorganism, which is noto...

    Authors: Christine Valentiny, Harald Dirschmid and Karl Lhotta
    Citation: BMC Nephrology 2015 16:73
    Content type: Case report Published on:

  10. Mutations in several genes expressed in podocytes, including Cd2ap, have been associated with focal segmental glomerulosclerosis in humans. Mutant mouse models provide an opportunity to better understand the mole...

    Authors: Eric W. Brunskill and S. Steven Potter
    Citation: BMC Nephrology 2015 16:71
    Content type: Research article Published on:

  11. The main short-term advantages of haemodiafiltration (HDF) are supposedly better removal of Beta2-microglobulin (ß2-m) and phosphate, and better haemodynamic stability. The main disadvantage is higher costs. T...

    Authors: Guillaume Jean, Jean-Marc Hurot, Patrik Deleaval, Brice Mayor and Christie Lorriaux
    Citation: BMC Nephrology 2015 16:70
    Content type: Research article Published on:

  12. Chronic Kidney Disease (CKD) is a public health problem and there is a scarcity of type 2 CKD translational research that incorporates educational tools. Patient navigators have been shown to be effective at r...

    Authors: Stacey E Jolly, Sankar D Navaneethan, Jesse D Schold, Susana Arrigain, Victoria Konig, Yvette K Burrucker, Jennifer Hyland, Priscilla Dann, Barbara H Tucky, John W Sharp and Joseph V Nally
    Citation: BMC Nephrology 2015 16:69
    Content type: Research article Published on:

  13. Fructose acutely raises serum uric acid in normal subjects, but the effect in subjects with metabolic syndrome or subjects with chronic kidney disease is unknown. The aim of the study was to evaluate changes i...

    Authors: Rafał Donderski, Ilona Miśkowiec-Wiśniewska, Marek Kretowicz, Magdalena Grajewska, Jacek Manitius, Anna Kamińska, Roman Junik, Joanna Siódmiak, Anna Stefańska, Grażyna Odrowąż-Sypniewska, Agnieszka Pluta, Miguel Lanaspa and Richard J Johnson
    Citation: BMC Nephrology 2015 16:68
    Content type: Research article Published on:

  14. The aim of the US dialysis Prospective Payment System bundle, launched in January 2011, was reduction and more accurate prediction of costs of services, whilst maintaining or improving patient care. Dialysis f...

    Authors: Keri L Monda, Parveen Nedra Joseph, Peter J Neumann, Brian D Bradbury and Robert J Rubin
    Citation: BMC Nephrology 2015 16:67
    Content type: Research article Published on:

  15. Chronic kidney disease is strongly linked to neurocognitive deficits in adults and children, but the pathophysiologic processes leading to these deficits remain poorly understood. The NiCK study (Neurocognitiv...

    Authors: Erum A Hartung, Nina Laney, Ji Young Kim, Rebecca L Ruebner, John A Detre, Hua-Shan Liu, Christos Davatzikos, Guray Erus, Jimit J Doshi, Robert T Schultz, John D Herrington, Abbas F Jawad, Divya G Moodalbail, Ruben C Gur, Allison M Port, Jerilynn Radcliffe…
    Citation: BMC Nephrology 2015 16:66
    Content type: Study protocol Published on:

  16. Reliable estimates of the impacts of chronic kidney disease (CKD) stage, with and without cardiovascular disease, on hospital costs are needed to inform health policy.

    Authors: Seamus Kent, Iryna Schlackow, Jingky Lozano-Kühne, Christina Reith, Jonathan Emberson, Richard Haynes, Alastair Gray, Alan Cass, Colin Baigent, Martin J Landray, William Herrington and Borislava Mihaylova
    Citation: BMC Nephrology 2015 16:65
    Content type: Research article Published on:

  17. Amyloidosis leads to deposition of abnormal protein with beta-pleated sheet structure in specific compartments of the affected organs. The histological localization of these amyloid deposits determines the ove...

    Authors: Ekaterina Castano, Matthew B Palmer, Christine Vigneault, Randy Luciano, Serena Wong and Gilbert Moeckel
    Citation: BMC Nephrology 2015 16:64
    Content type: Research article Published on:

  18. Sudden cardiac death occurs commonly in the end-stage renal disease population receiving dialysis, with 25% dying of sudden cardiac death over 5 years. Despite this high risk, surprisingly few prospective stud...

    Authors: Rulan S Parekh, Lucy A Meoni, Bernard G Jaar, Stephen M Sozio, Tariq Shafi, Gordon F Tomaselli, Joao A Lima, Larisa G Tereshchenko, Michelle M Estrella and W H Linda Kao
    Citation: BMC Nephrology 2015 16:63
    Content type: Study protocol Published on:

  19. Chronic kidney disease (CKD) accelerates vascular stiffening related to age. Arterial stiffness may be evaluated measuring the carotid-femoral pulse wave velocity (PWV) or more simply, as recommended by KDOQI,...

    Authors: Igor Salvadé, Sibylle Schätti-Stählin, Eleonora Violetti, Carlo Schönholzer, Claudio Cereghetti, Hugo Zwahlen, Lorenzo Berwert, Michel Burnier and Luca Gabutti
    Citation: BMC Nephrology 2015 16:62
    Content type: Research article Published on:

  20. Chronic kidney disease (CKD) and systemic inflammation are risk factors for sepsis. While often viewed as a marker of chronic kidney disease, Cystatin C (Cyst-C) may also reflect systemic inflammation. We soug...

    Authors: Thomas Clark Powell, John P Donnelly, Orlando M Gutiérrez, Russell L Griffin, Monika M Safford and Henry E Wang
    Citation: BMC Nephrology 2015 16:61
    Content type: Research article Published on:

  22. Data regarding the epidemiology of end-stage renal disease (ESRD) and dialysis in sub-Saharan Africa are scarce and knowledge about the spectrum renal disease is very limited. This study is on the profile of p...

    Authors: Marie P Halle, Christian Takongue, Andre P Kengne, François F Kaze and Kathleen B Ngu
    Citation: BMC Nephrology 2015 16:59
    Content type: Research article Published on:

  23. Hyperuricemia may contribute to renal injury. We do not know whether use of treatments that lower urate reduce the progression of chronic kidney disease (CKD) and cardiovascular disease. We performed a systema...

    Authors: Tahir Kanji, Mandark Gandhi, Catherine M Clase and Robert Yang
    Citation: BMC Nephrology 2015 16:58
    Content type: Research article Published on:

  24. Multipass hemodialysis (MPHD) is a recently described dialysis modality, involving the use of small volumes of dialysate which are repetitively recycled. Dialysis regimes of 8 hours for six days a week using t...

    Authors: Sunny Eloot, Wim Van Biesen, Mette Axelsen, Griet Glorieux, Robert Smith Pedersen and James Goya Heaf
    Citation: BMC Nephrology 2015 16:57
    Content type: Research article Published on:

  25. Primary care providers do not routinely follow guidelines for the care of patients with chronic kidney disease (CKD). Multidisciplinary efforts may improve care for patients with chronic disease. Pharmacist ba...

    Authors: Danielle Cooney, Helen Moon, Yang Liu, Richard Tyler Miller, Adam Perzynski, Brook Watts and Paul E Drawz
    Citation: BMC Nephrology 2015 16:56
    Content type: Research article Published on:

  26. Small non-coding RNA molecules (miRNAs) play a pivotal role in regulating gene expression in development. miRNAs regulate key processes at the cellular level and thereby influence organismal and tissue develop...

    Authors: Malte P Bartram, Claudia Dafinger, Sandra Habbig, Thomas Benzing, Bernhard Schermer and Roman-Ulrich Müller
    Citation: BMC Nephrology 2015 16:55
    Content type: Research article Published on:

  27. In western Nicaragua and El Salvador, chronic kidney disease (CKD) is highly prevalent and generally affects young, male, agricultural (usually sugar cane) workers without the established CKD risk factors. It ...

    Authors: Timothy S Laux, Joaquin Barnoya, Douglas R Guerrero and Marcos Rothstein
    Citation: BMC Nephrology 2015 16:54
    Content type: Research article Published on:

  28. The last decade has witnessed considerable improvement in dialysis technology and changes in clinical management of patients in peritoneal dialysis (PD) with a significant impact on long term clinical outcomes...

    Authors: Gianluigi Zaza, Carlo Rugiu, Alessandra Trubian, Simona Granata, Albino Poli and Antonio Lupo
    Citation: BMC Nephrology 2015 16:53
    Content type: Research article Published on:

  29. People with kidney failure are often deficient in zinc and selenium, but little is known about the optimal way to correct such deficiency.

    Authors: Marcello Tonelli, Natasha Wiebe, Stephanie Thompson, David Kinniburgh, Scott W Klarenbach, Michael Walsh, Aminu K Bello, Labib Faruque, Catherine Field, Braden J Manns and Brenda R Hemmelgarn
    Citation: BMC Nephrology 2015 16:52
    Content type: Research article Published on:

  30. Hyperlipidemia is thought to be a major risk factor for the progression of renal diseases in diabetes. Recent studies have shown that lipid profiles are commonly abnormal early on type 2 diabetes mellitus (T2D...

    Authors: Liang He, Lili Hao, Xin Fu, Mingshu Huang and Rui Li
    Citation: BMC Nephrology 2015 16:51
    Content type: Research article Published on:

  31. In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that a...

    Authors: Renata P Assis, Juliana FA Castro, Vânia O Gutierres, Carlos A Arcaro, Renata S Brotto, Olga MMF Oliveira, Amanda M Baviera and Iguatemy L Brunetti
    Citation: BMC Nephrology 2015 16:50
    Content type: Research article Published on:

  32. Disparities in access to kidney transplantation (KT) remain inadequately understood and addressed. Detailed descriptions of patient attitudes may provide insight into mechanisms of disparity. The aims of this ...

    Authors: Megan L Salter, Komal Kumar, Andrew H Law, Natasha Gupta, Kathryn Marks, Kamna Balhara, Mara A McAdams-DeMarco, Laura A Taylor and Dorry L Segev
    Citation: BMC Nephrology 2015 16:49
    Content type: Research article Published on:

  33. Peritoneal fibrosis is a common complication in patients treated with long-term peritoneal dialysis. The aim of this study was to identify the microRNAs (miRNAs) involved in regulation of peritoneal fibrosis i...

    Authors: Fan Lin, Xu Wu, Huidi Zhang, Xiaohan You, Zhoucang Zhang, Rongrong Shao and Chaoxing Huang
    Citation: BMC Nephrology 2015 16:48
    Content type: Research article Published on:

  34. Uremic pruritus is a common and deleterious condition among hemodialysis (HD) patients. Central gating of μ/κ opiate circuitry plays an important role in mediating and countering pruritogenic sensation. The ob...

    Authors: Amale Hawi, Harry Alcorn Jr, Jolene Berg, Carey Hines, Howard Hait and Thomas Sciascia
    Citation: BMC Nephrology 2015 16:47
    Content type: Research article Published on:

  35. Urinary density (UD) has been routinely used for decades as a surrogate marker for urine osmolality (Uosm). We asked if UD can accurately estimate Uosm both in healthy subjects and in different clinical scenarios...

    Authors: Ana Carolina P Souza, Roberto Zatz, Rodrigo B de Oliveira, Mirela A R Santinho, Marcia Ribalta, João E Romão Jr and Rosilene M Elias
    Citation: BMC Nephrology 2015 16:46
    Content type: Research article Published on:

  36. We examined whether renal resistive index (RI), a simple index of renal vascular resistance, is associated with the presence and severity of anemia, and can predict the future development of anemia in patients...

    Authors: Muneyoshi Tanimura, Kaoru Dohi, Masumi Matsuda, Yuichi Sato, Emiyo Sugiura, Naoto Kumagai, Shiro Nakamori, Tomomi Yamada, Naoki Fujimoto, Takashi Tanigawa, Norikazu Yamada, Mashio Nakamura and Masaaki Ito
    Citation: BMC Nephrology 2015 16:45
    Content type: Research article Published on:

  37. Diabetic nephropathy (DN) is a major cause of Chronic Kidney Disease and End-Stage Renal Disease throughout the world; however, the reversibility of diabetic nephropathy remains controversial. Endoplasmic reti...

    Authors: Zeng Si Wang, Fei Xiong, Xiao Hang Xie, Dan Chen, Jian Hua Pan and Li Cheng
    Citation: BMC Nephrology 2015 16:44
    Content type: Research article Published on:

  38. Screening for renal diseases should be performed at the time of diagnosis of human immunodeficiency virus (HIV) infection. Despite the high prevalence of HIV/AIDS in Northern Uganda, little is known about the ...

    Authors: Pancras Odongo, Ronald Wanyama, James Henry Obol, Paska Apiyo and Pauline Byakika-Kibwika
    Citation: BMC Nephrology 2015 16:43
    Content type: Research article Published on:

  39. Reducing dietary sodium has potential to benefit patients with chronic kidney disease (CKD). Little research is available defining dietary sodium knowledge gaps in patients with pre-dialysis CKD. We designed a...

    Authors: Julie A Wright Nunes, Cheryl A M Anderson, Jane H Greene, Talat Alp Ikizler and Kerri L Cavanaugh
    Citation: BMC Nephrology 2015 16:42
    Content type: Research article Published on:

  40. Cinacalcet reduces parathyroid hormone (PTH) levels in patients receiving hemodialysis, but no non-experimental studies have evaluated the association between changes in PTH levels following cinacalcet initiat...

    Authors: Wendy L St. Peter, Akeem A Yusuf, Thy Do, Kimberly A Lowe, Jiannong Liu, Kimberly M Nieman, Brian D Bradbury and Allan J Collins
    Citation: BMC Nephrology 2015 16:41
    Content type: Research article Published on:

  41. Glomerulonephritis is one of the most severe complications of lupus, a systemic disease with multi-organ involvement, with tissue damage produced mainly by complement activation. As a result of this activation...

    Authors: Pilar Nozal, Sofía Garrido, Jorge Martínez-Ara, María Luz Picazo, Laura Yébenes, Rita Álvarez-Doforno, Sheila Pinto, Santiago Rodríguez de Córdoba and Margarita López-Trascasa
    Citation: BMC Nephrology 2015 16:40
    Content type: Case report Published on:

  42. Patients with end-stage renal disease (ESRD) due to lupus nephritis (LN-ESRD) may be followed by multiple providers (nephrologists and rheumatologists) and have greater opportunities to receive recommended ESR...

    Authors: Laura C Plantinga, Rachel E Patzer, Cristina Drenkard, Stephen O Pastan, Jason Cobb, William McClellan and Sung Sam Lim
    Citation: BMC Nephrology 2015 16:39
    Content type: Research article Published on:

  43. Podocyte detachment and apoptosis are two risk factors causing podocyte loss, F-actin rearrangement is involved in detachment and apoptosis. However, the nature of events that promote detachment and apoptosis ...

    Authors: Rufeng Dai, Yi Lin, Haimei Liu, Jia Rao, Yihui Zhai, Xiliang Zha, Xiaoyan Fang and Hong Xu
    Citation: BMC Nephrology 2015 16:38
    Content type: Research article Published on:

  44. Early preparation for renal replacement therapy (RRT) is recommended for patients with advanced chronic kidney disease (CKD), yet many patients initiate RRT urgently and/or are inadequately prepared.

    Authors: Raquel C Greer, Jessica M Ameling, Kerri L Cavanaugh, Bernard G Jaar, Vanessa Grubbs, Carrie E Andrews, Patti Ephraim, Neil R Powe, Julia Lewis, Ebele Umeukeje, Luis Gimenez, Sam James and L Ebony Boulware
    Citation: BMC Nephrology 2015 16:37
    Content type: Research article Published on:

  45. Symptom burden in chronic kidney disease (CKD) is poorly understood. To date, the majority of research focuses on single symptoms and there is a lack of suitable multidimensional symptom measures. The purpose ...

    Authors: Hayfa Almutary, Ann Bonner and Clint Douglas
    Citation: BMC Nephrology 2015 16:36
    Content type: Research article Published on:

  46. Recent studies suggest a causal role for increased plasma uric acid in the progression of chronic renal insufficiency (CRI). However, uric acid also functions as an antioxidant with possible beneficial effects.

    Authors: Venla Kurra, Tuija Vehmas, Arttu Eräranta, Jarkko Jokihaara, Päivi Pirttiniemi, Heikki Ruskoaho, Heikki Tokola, Onni Niemelä, Jukka Mustonen and Ilkka Pörsti
    Citation: BMC Nephrology 2015 16:35
    Content type: Research article Published on:

  47. It is unknown whether variability of estimated Glomerular Filtration Rate (eGFR) is a risk factor for dialysis or death in patients with chronic kidney disease (CKD). This study aimed to evaluate variability o...

    Authors: Chin-Lin Tseng, Jean-Philippe Lafrance, Shou-En Lu, Orysya Soroka, Donald R Miller, Miriam Maney and Leonard M Pogach
    Citation: BMC Nephrology 2015 16:34
    Content type: Research article Published on:

  48. Socioeconomic characteristics may affect the outcomes of patients treated with peritoneal dialysis (PD). There are two major medical insurances in China: the New Cooperative Medical Scheme (NCMS), mainly for r...

    Authors: Zengsi Wang, Yanmin Zhang, Fei Xiong, Hongbo Li, Yanqiong Ding, Yihua Gao, Li Zhao and Sheng Wan
    Citation: BMC Nephrology 2015 16:33
    Content type: Research article Published on:

  49. The usage of nursing home (NH) services is a marker of frailty among older adults. Although the Centers for Medicare & Medicaid Services (CMS) revised the Medical Evidence Report Form CMS-2728 in 2005 to inclu...

    Authors: C Barrett Bowling, Rebecca Zhang, Harold Franch, Yijian Huang, Anna Mirk, William M McClellan, Theodore M Johnson II and Nancy G Kutner
    Citation: BMC Nephrology 2015 16:32
    Content type: Research article Published on:

  50. Acute kidney injury (AKI) is common among intensive care unit (ICU) patients and is associated with high mortality. Type of ICU, category of admission diagnosis, and socioeconomic characteristics of the region...

    Authors: Paulo Roberto Santos and Diego Levi Silveira Monteiro
    Citation: BMC Nephrology 2015 16:30
    Content type: Research article Published on:
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BMC Nephrology

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