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  1. Content type: Research article

    Oedema, characterized by accumulation of extracellular water (ECW), is one of the major clinical manifestations in children suffering from nephrotic syndrome (NS).

    Authors: Steven Brantlov, Lars Jødal, René Frydensbjerg Andersen, Aksel Lange, Søren Rittig and Leigh C. Ward

    Citation: BMC Nephrology 2019 20:331

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  2. Content type: Case report

    Proteinuria is a common clinical presentation, the diagnostic workup for which involves many non-invasive and invasive investigations. We report on two siblings that highlight the clinically relevant functiona...

    Authors: Kushani Jayasinghe, Susan M. White, Peter G. Kerr, Duncan MacGregor, Zornitza Stark, Ella Wilkins, Cas Simons, Andrew Mallett and Catherine Quinlan

    Citation: BMC Nephrology 2019 20:330

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  3. Content type: Research article

    A survival advantage associated with obesity has often been described in dialysis patients. The association of higher body mass index (BMI) with mortality and renal replacement therapy (RRT) in preterminal chr...

    Authors: Zaimin Wang, Jianzhen Zhang, Samuel Chan, Anne Cameron, Helen G. Healy, Sree K. Venuthurupalli, Ken-Soon Tan and Wendy E. Hoy

    Citation: BMC Nephrology 2019 20:329

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  4. Content type: Research article

    Focal segmental lesions (FSLs) are not uncommon in idiopathic membranous nephropathy (IMN). The reported percentage of IMN patients with focal segmental glomerulosclerosis (FSGS) lesions varies widely between ...

    Authors: Hong-Guang He, Chao-Qing Wu, Kun Ye, Chun Zeng, Yi-Yun Huang, Shu-Wen Luo, Wu Yin, Qiu-Rong Ye and Xiao-Mei Peng

    Citation: BMC Nephrology 2019 20:328

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  5. Content type: Case report

    Podocyte infolding glomerulopathy (PIG) is a rare histopathologic finding with global infolding of the podocytes into the glomerular basement membrane (GBM), accompanied by microstructures underneath. Describe...

    Authors: Fabian Wöstmann, Roman-Ulrich Müller, Heike Göbel, Thomas Benzing, Jan U. Becker and Malte P. Bartram

    Citation: BMC Nephrology 2019 20:326

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  6. Content type: Research article

    Patients with cardiovascular disease are at an increased risk of chronic kidney disease (CKD). However, data on incident CKD in patients with multiple vascular comorbidities are insufficient. In this study, we...

    Authors: Saif Al-Shamsi, Abderrahim Oulhaj, Dybesh Regmi and Romona D. Govender

    Citation: BMC Nephrology 2019 20:325

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  7. Content type: Research article

    Patients with autosomal dominant polycystic kidney disease (ADPKD) have an increased risk of cardiovascular morbidity and mortality. Impaired left ventricular (LV) global longitudinal strain (GLS) can be a sig...

    Authors: Mats C. H. Lassen, Atif N. Qasim, Tor Biering-Sørensen, Jacob L. T. Reeh, Terry Watnick, Stephen L. Seliger, Huanwen Chen, Mariem A. Sawan, Daniel Nguyen, Yongfang Li, Susie N. Hong and Meyeon Park

    Citation: BMC Nephrology 2019 20:324

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  8. Content type: Research article

    Patients with end-stage renal disease (ESRD) under hemodialysis (HD) are at greater risks of infectious spondylitis (IS), but there is no reliable predictor that facilitate early detection of this relatively r...

    Authors: Kun-Lin Lu, Wen-Hung Huang, Yueh-An Lu, Chan-Yu Lin, Hsin-Hsu Wu, Ching-Wei Hsu, Cheng-Hao Weng, Chao-Yi Wu, I-Wen Wu, Meng-Yu Wu, Tzung-Hai Yen and Huang-Yu Yang

    Citation: BMC Nephrology 2019 20:323

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  9. Content type: Case report

    Glomerulopathy with fibronectin deposits is an autosomal dominant disease associated with proteinuria, hematuria, hypertension and renal function decline. Forty percent of the cases are caused by mutations in FN1

    Authors: Maria Luíza Gonçalves dos Reis Monteiro, Fabiano Bichuette Custódio, Precil Diego Miranda de Menezes Neves, Frederico Moraes Ferreira, Elieser Hitoshi Watanabe, Antônio Marcondes Lerário, Liliane Silvano de Araújo, Bruno Eduardo Pedroso Balbo, Vívian Christine Dourado Pinto, Lívia Maria Gruli Barbosa, Vilmar de Paiva Marques, Juliana Reis Machado, Marlene Antônia Reis and Luiz Fernando Onuchic

    Citation: BMC Nephrology 2019 20:322

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  10. Content type: Research article

    Cardiovascular disease (CVD) events are the main cause of death in long-term hemodialysis (HD) patients. Macrophage colony- stimulating factor (M-CSF) is actively involved in the formation of atherosclerosis a...

    Authors: Xuan Deng, Qian Yang, Yuxi Wang, Yi Yang, Guangchang Pei, Han Zhu, Jianliang Wu, Meng Wang, Zhi Zhao, Huzi Xu, Cheng Zhou, Yi Guo, Ying Yao, Zhiguo Zhang, Wenhui Liao and Rui Zeng

    Citation: BMC Nephrology 2019 20:321

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  11. Content type: Research article

    The challenges in diagnosis of rare renal conditions can negatively impact patient prognosis, quality of life and result in significant healthcare costs. Differential methylation is emerging as an important bi...

    Authors: Katie Kerr, Helen McAneney, Cheryl Flanagan, Alexander P. Maxwell and Amy Jayne McKnight

    Citation: BMC Nephrology 2019 20:320

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  12. Content type: Research article

    Chronic kidney disease (CKD) has been considered as a major health problem in the world. Increasing uric acid (UA) could induce vascular endothelial injury, which is closely related to microinflammation, oxida...

    Authors: Wei Yin, Qiao-Ling Zhou, Sha-Xi OuYang, Ying Chen, Yu-Ting Gong and Yu-Mei Liang

    Citation: BMC Nephrology 2019 20:319

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  13. Content type: Research article

    No study has specifically investigated the duration of continuous renal replacement therapy (CRRT) in patients who experienced acute kidney injury during extracorporeal membrane oxygenation (ECMO) support. How...

    Authors: George Kuo, Shao-Wei Chen, Pei-Chun Fan, Victor Chien-Chia Wu, An-Hsun Chou, Cheng-Chia Lee, Pao-Hsien Chu, Feng-Chun Tsai, Ya-Chung Tian and Chih-Hsiang Chang

    Citation: BMC Nephrology 2019 20:318

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  14. Content type: Research article

    Patients treated with conventional hemodialysis have poor physical performance, explained by insufficient metabolic clearance and shortage of time by time-consuming dialysis. Nocturnal hemodialysis improves me...

    Authors: Manouk Dam, Peter J. M. Weijs, Frans J. van Ittersum and Brigit C. van Jaarsveld

    Citation: BMC Nephrology 2019 20:317

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  15. Content type: Research article

    It is known that one of the leading causes of morbidity in chronic kidney disease (CKD) is the anemic syndrome. Although the pathogenic mechanisms of anemia are multiple, erythropoietin deficiency appears as t...

    Authors: Ailema González-Ortiz, Ricardo Correa-Rotter, Armando Vázquez-Rangel, Olynka Vega-Vega and Ángeles Espinosa-Cuevas

    Citation: BMC Nephrology 2019 20:316

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  16. Content type: Research article

    Performing a kidney biopsy is necessary to accurately diagnose diseases such as glomerulonephritis and tubulointerstitial nephritis, among other such conditions. These conditions predispose patients to chronic...

    Authors: Henrique Pinheiro Konigsfeld, Tatiana Garcia Viana, Suzy Cristine Pereira, Thais Oliveira Claizoni Dos Santos, Gianna Mastroianni Kirsztajn, Agostinho Tavares and Marcelino de Souza Durão Junior

    Citation: BMC Nephrology 2019 20:315

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  17. Content type: Research article

    In kidney transplantation, immunotherapy with thymoglobulin (rATG) has been used to down-regulate the patient immune system. rATG is a powerful immunobiologic drug used to deplete lymphocytes to prevent early ...

    Authors: Marcus Faria Lasmar, Rodrigo Santana Dutra, José Augusto Nogueira-Machado, Raquel A. Fabreti-Oliveira, Raquel Gomes Siqueira and Evaldo Nascimento

    Citation: BMC Nephrology 2019 20:314

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  18. Content type: Research article

    Complement activation plays a substantial role in the pathogenesis of primary membranous nephropathy (pMN). C5b-9, C3c, MBL, and factor B have been documented in the subepithelial immune deposits. However, the...

    Authors: Mu-fan Zhang, Jing Huang, Yi-miao Zhang, Zhen Qu, Xin Wang, Fang Wang, Li-qiang Meng, Xu-yang Cheng, Zhao Cui, Gang Liu and Ming-hui Zhao

    Citation: BMC Nephrology 2019 20:313

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  20. Content type: Research article

    Patients suffering from acute kidney injury (AKI) were associated with impaired sodium and potassium homeostasis. We aimed to investigate how admission serum sodium and potassium independently and jointly modi...

    Authors: Xu-ping Gao, Chen-fei Zheng, Min-qi Liao, Hong He, Yan-hua Liu, Chun-xia Jing, Fang-fang Zeng and Qing-shan Chen

    Citation: BMC Nephrology 2019 20:311

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  21. Content type: Case report

    Lysozyme amyloidosis is a rare hereditary systemic amyloidosis with amyloid deposits in various tissues leading to progressive organ failure. It has been mainly reported in developed countries since 1993. Here...

    Authors: Zhenyu Li, Hui Xu, Dan Liu, Danyang Li, Gang Liu and Su-xia Wang

    Citation: BMC Nephrology 2019 20:310

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  22. Content type: Research article

    The benefits and risks of antiplatelet therapy for patients with chronic kidney disease (CKD) remain controversial. We undertook a systematic review and meta-analysis to investigate the effects of antiplatelet...

    Authors: Xiaole Su, Bingjuan Yan, Lihua Wang, Jicheng Lv, Hong Cheng and Yipu Chen

    Citation: BMC Nephrology 2019 20:309

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  23. Content type: Research article

    The Southern Community Cohort Study is a prospective study of low socioeconomic status (SES) blacks and whites from the southeastern US, where the burden of end-stage renal disease (ESRD) and its risk factors ...

    Authors: Fabian Bock, Thomas G. Stewart, Cassianne Robinson-Cohen, Jennifer Morse, Edmond K. Kabagambe, Kerri L. Cavanaugh, Kelly A. Birdwell, Adriana M. Hung, Khaled Abdel-Kader, Edward D. Siew, Elvis A. Akwo, William J. Blot, T. Alp Ikizler and Loren Lipworth

    Citation: BMC Nephrology 2019 20:308

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  24. Content type: Case report

    Atypical hemolytic uremic syndrome (aHUS) is a disorder of the microvasculature with hemolytic anemia, thrombocytopenia and acute kidney injury. Nowadays, aHUS is successfully treated with eculizumab, a humani...

    Authors: Subagini Nagarajah, Martin Tepel, Christian Nielsen, Kristian Assing, Yaseelan Palarasah, Lise Lotte Torvin Andersen, Lotte Borg Lange and Claus Bistrup

    Citation: BMC Nephrology 2019 20:307

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  25. Content type: Research article

    Proteinuria is known to be associated with both kidney function deterioration and cardiovascular diseases. While proteinuria estimation from 24-h urine samples has traditionally been considered as the standard...

    Authors: Seiji Kobayashi, Hoichi Amano, Hiroyuki Terawaki, Makoto Ogura, Yoshindo Kawaguchi and Takashi Yokoo

    Citation: BMC Nephrology 2019 20:306

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  27. Content type: Research article

    Chronic Kidney Disease (CKD) is a growing public health problem. Many risk factors were identified and interventions were applied accordingly, but the incidence of end-stage renal disease continued increasing....

    Authors: Chung-Yen Lu, Yin-Cheng Chen, Yu-Wen Lu, Chih-Hsin Muo and Ray-E Chang

    Citation: BMC Nephrology 2019 20:304

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  28. Content type: Research article

    New non-invasive biomarkers are demanded to identify renal damage in various autoimmune-associated kidney diseases. Glomerular podocyte damage mediated by systemic lupus erythematosus (SLE) plays an important ...

    Authors: Jian Lu, Ze Bo Hu, Pei Pei Chen, Chen Chen Lu, Jia Xiu Zhang, Xue Qi Li, Ben Yin Yuan, Si Jia Huang and Kun Ling Ma

    Citation: BMC Nephrology 2019 20:303

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  29. Content type: Research article

    Chromium is an essential trace metal that reduces oxidative stress and inflammation. In patients undergoing maintenance hemodialysis (MHD), a correlation among chromium exposure, inflammation, and malnutrition...

    Authors: Ching-Wei Hsu, Cheng-Hao Weng, Cheng-Chia Lee, Tzung-Hai Yen and Wen-Hung Huang

    Citation: BMC Nephrology 2019 20:302

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  30. Content type: Research article

    Impaired T cell immune function exists in end-stage renal disease (ESRD) patients. Dialysis treatment may lead to changes in T cell subsets. In the present study, we aimed to identify alterations of T cell phe...

    Authors: Jiao Xiaoyan, Chen Rongyi, Cao Xuesen, Zou Jianzhou, Ji Jun, Ding Xiaoqiang and Yu Xiaofang

    Citation: BMC Nephrology 2019 20:301

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  31. Content type: Research article

    A chronic inflammatory state is a prominent feature in patients with end-stage renal disease (ESRD). Nuclear factor-kappa B (NF-κB) is a transcription factor that regulates the expression of genes involved in ...

    Authors: Jia-Hwa Yang, Wei-Teing Chen, Meng-Chang Lee, Wen-Hui Fang, Yu-Juei Hsu, Chin-Lin, Hsiang-Cheng Chen, Hsueh-Lu Chang, Chien-Fu Chen, Min-Yu Tu, Chien-Wei Kuo, Yuan-Hau Lin, Po-Jen Hsiao and Sui-Lung Su

    Citation: BMC Nephrology 2019 20:300

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  32. Content type: Research article

    Haemodialysis is capable of prolonging life in patients with end stage renal disease, however this therapy comes with significant negative impact on quality of life. For patients requiring haemodialysis, the n...

    Authors: M. Field, A.Z Khawaja, J. Ellis, T. Nieto, J. Hodson and N. Inston

    Citation: BMC Nephrology 2019 20:299

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  33. Content type: Research article

    Chronic Kidney Disease in certain part of Sri Lanka and increasing burden of CKD in some other countries is a global public health problem. While the underlying causes of majority of cases are unknown, effecti...

    Authors: Nalaka Herath, Rajeewa Dassanayake, Manjula Dissanayake, Chamara Janitha, Kosala Weerakoon, Chalaka Kumarasinghe, Terence Gamini de Silva and Suneth Agampodi

    Citation: BMC Nephrology 2019 20:298

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  34. Content type: Research article

    Hydroxychloroquine (HCQ), a well-known immunomodulator, has recently been found to be a promising and safe anti-proteinuric agent for treating IgA nephropathy (IgAN). We aimed to compare the efficacy and safet...

    Authors: Ya-zi Yang, Pei Chen, Li-Jun Liu, Qing-Qing Cai, Su-Fang Shi, Yu-Qing Chen, Ji-Cheng Lv and Hong Zhang

    Citation: BMC Nephrology 2019 20:297

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  35. Content type: Case report

    Transplant failure requires the consideration of numerous potential causes including rejection, acute tubular necrosis, infection, and recurrence of the original kidney disease. Kidney biopsy is generally requ...

    Authors: Linus A. Völker, Katharina Burkert, Niklas Scholten, Franziska Grundmann, Christine Kurschat, Thomas Benzing, Jürgen Hampl, Jan Ulrich Becker and Roman-Ulrich Müller

    Citation: BMC Nephrology 2019 20:296

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  36. Content type: Research article

    Short-term hemoglobin (Hb) variability related to volume status is observed in chronic kidney disease (CKD) patients receiving hemodialysis (HD). Given the lack of studies regarding outcomes according to the d...

    Authors: Soo Ya Bae, Jae Wan Jeon, Seong Hoon Kim, Chung Hee Baek, Jai Won Jang, Won Seok Yang, Soon Bae Kim, Su-Kil Park, Sang Koo Lee and Hyosang Kim

    Citation: BMC Nephrology 2019 20:295

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  37. Content type: Research article

    Although hemodialysis is a highly effective treatment for diffusive clearance of low molecular weight uremic toxins, its effect on circulating extracellular vesicles and submicron particles is less clear. The ...

    Authors: Marcel Ruzicka, Fengxia Xiao, Hussein Abujrad, Yasamin Al-Rewashdy, Vera A. Tang, Marc-André Langlois, Alexander Sorisky, Teik Chye Ooi and Dylan Burger

    Citation: BMC Nephrology 2019 20:294

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  38. Content type: Study protocol

    Eighty percent of children with idiopathic nephrotic syndrome respond well to steroid therapy, but up to 50% of patients with steroid-sensitive nephrotic syndrome exhibit frequently relapsing (FRNS) or steroid...

    Authors: China Nagano, Mayumi Sako, Koichi Kamei, Kenji Ishikura, Hidefumi Nakamura, Koichi Nakanishi, Takashi Omori, Kandai Nozu and Kazumoto Iijima

    Citation: BMC Nephrology 2019 20:293

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  39. Content type: Research article

    Renal proximal tubular sodium and glucose reabsorption are regulated by the sodium-glucose cotransporter (SGLT2). Changes in this transporter can play a role in hyperglycaemia and reactive oxygen species (ROS)...

    Authors: Humberto Reyes-Pardo, Rocío Bautista, Hilda Vargas-Robles, Amelia Rios, Daniel Sánchez and Bruno Escalante

    Citation: BMC Nephrology 2019 20:292

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  40. Content type: Research article

    Neutrophil gelatinase-assoicated lipocalin (NGAL) appears to be a promising proximal tubular injury biomarker for early prediction of delayed graft function (DGF) in kidney transplant recipients. However, its ...

    Authors: Ya Mei Li, Yi Li, Lin Yan, Han Wang, Xiao Juan Wu, Jiang Tao Tang, Lan Lan Wang and Yun Ying Shi

    Citation: BMC Nephrology 2019 20:291

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  41. Content type: Research article

    Microparticles (MPs) are biomarkers and mediators of disease through their expression of surface receptors, reflecting activation or stress in their parent cells. Endothelial markers, ICAM-1 and VCAM-1, are im...

    Authors: Kristina Lundwall, Josefin Mörtberg, Fariborz Mobarrez, Stefan H. Jacobson, Gun Jörneskog and Jonas Spaak

    Citation: BMC Nephrology 2019 20:290

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  42. Content type: Research article

    Despite significant advances in surgical techniques, immunosuppression protocols, follow up periods and antimicrobial stewardship in modern medicine; post-renal transplantation urinary tract infection remained...

    Authors: Teklehaimanot Kiros, Daniel Asrat, Zeleke Ayenew and Estifanos Tsige

    Citation: BMC Nephrology 2019 20:289

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  43. Content type: Research article

    The reactive hyperemia index (RHI), measured by peripheral arterial tonometry (PAT), is a novel measurement of endothelial function and has been proven to be valuable in cardiovascular risk stratification in s...

    Authors: Lulu Wang, Xiaoqin Huang, Weichun He, Wenjin Liu and Junwei Yang

    Citation: BMC Nephrology 2019 20:288

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  44. Content type: Research article

    Many patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) need dialysis at disease onset due to severe kidney injury. Determining whether they can become dialysis independent i...

    Authors: Peng-cheng Xu, Tong Chen, Si-jing Wu, Xia Yang, Shan Gao, Shui-yi Hu, Li Wei and Tie-kun Yan

    Citation: BMC Nephrology 2019 20:287

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  46. Content type: Research article

    Readmission within 30 days of hospital discharge is common and costly among end-stage renal disease (ESRD) patients. Little is known about long-term outcomes after readmission. We estimated the association bet...

    Authors: Katherine H. Ross, Bernard G. Jaar, Janice P. Lea, Tahsin Masud, Rachel E. Patzer and Laura C. Plantinga

    Citation: BMC Nephrology 2019 20:285

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  47. Content type: Research article

    Disagreements between clinic and ambulatory blood pressure (BP) measurements are well-described in the general population. Though hypertension is frequent in renal transplant recipients, only a few studies add...

    Authors: Eitan Gluskin, Keren Tzukert, Irit Mor-Yosef Levi, Olga Gotsman, Itamar Sagiv, Roy Abel, Aharon Bloch, Dvorah Rubinger, Michal Aharon, Michal Dranitzki Elhalel and Iddo Z. Ben-Dov

    Citation: BMC Nephrology 2019 20:284

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  48. Content type: Research article

    Compensation of contralateral kidney function after living-donor kidney donation is well known, and many predictive factors have been proposed. However, no prediction model has been proposed. This study was pe...

    Authors: Kenji Okumura, Shigeyoshi Yamanaga, Kosuke Tanaka, Kohei Kinoshita, Akari Kaba, Mika Fujii, Masatomo Ogata, Yuji Hidaka, Mariko Toyoda, Soichi Uekihara, Akira Miyata, Akito Inadome and Hiroshi Yokomizo

    Citation: BMC Nephrology 2019 20:283

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  49. Content type: Research article

    Acute kidney injury (AKI) is a major global health problem. We aim to evaluate the epidemiology, risk factors and outcomes of AKI episodes in our single centre.

    Authors: Su Hooi Teo, Kian-Guan Lee, Riece Koniman, Alvin Ren Kwang Tng, Zhong Hong Liew, Thin Thiri Naing, Huihua Li, Ru Yu Tan, Han Khim Tan, Hui Lin Choong, W. Y. Marjorie Foo and Manish Kaushik

    Citation: BMC Nephrology 2019 20:282

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