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  1. Gastrointestinal (GI) symptoms are common in end-stage kidney disease. Mounting evidence indicates that the intestine plays an important role in the pathogenesis of IgA nephropathy (IgAN). However, no studies ...

    Authors: Jussi T. Pohjonen, Katri M. Kaukinen, Martti J. Metso, Rakel KK. Nurmi, Heini SA. Huhtala, Ilkka H. Pörsti, Jukka T. Mustonen and Satu M. Mäkelä
    Citation: BMC Nephrology 2022 23:395
    Content type: Research Published on:

  2. Social inequalities in health are responsible for disparities in access to the kidney transplant waiting list (KTWL). The perception of disparities by nephrologists has consequences for the registration on the...

    Authors: Lucile Paris, Eve Calvar, Rémy Morello, Angélique Lecouf, Mathilde Beaumier, Thierry Lobbedez and Valérie Châtelet
    Citation: BMC Nephrology 2022 23:394
    Content type: Research Published on:

  3. Hemodialysis (HD) is the most important renal replacement therapy for patients with end-stage kidney disease (ESKD). Systemic inflammation is a risk factor of mortality in HD patients. Neutrophil-to-lymphocyte...

    Authors: Jiaxian Liao, Dongyan Wei, Chenghui Sun, Yuqi Yang, Yinxia Wei and Xinhui Liu
    Citation: BMC Nephrology 2022 23:393
    Content type: Research article Published on:

  4. Acute kidney injury (AKI) in critically ill patients has poor renal outcome with high mortality. Changes in intra-renal microcirculation and tissue oxygenation are currently considered essential pathophysiolog...

    Authors: Xiangyu Wang, Luzeng Chen and Tao Su
    Citation: BMC Nephrology 2022 23:392
    Content type: Study protocol Published on:

  5. Disordered Treg counts and function have been observed in patients with SARS-Cov-2 and are thought to contribute to disease severity. In hemodialysis patients, scarce data are available on the Treg response to...

    Authors: Emad Samaan, Marwa O Elmaria, Doaa Khedr, Tamer Gaber, Ahmed G Elsayed, Ragy N Shenouda, Hend Gamal, Doaa Shahin, Nashwa K Abousamra and Rasha Shemies
    Citation: BMC Nephrology 2022 23:391
    Content type: Research Published on:

  6. Hepatitis C virus (HCV) may play a pathogenic role in several forms of immune complex glomerulonephritis (GN). We present a patient whose initial clinical presentation instilled suspicion of HCV-related renal ...

    Authors: Anna Zito, Antonio De Pascalis, Vincenzo Montinaro, Paolo Ria, Maria Caterina Carbonara, Emiliana Ferramosca and Marcello Napoli
    Citation: BMC Nephrology 2022 23:390
    Content type: Case report Published on:

  7. Observational studies have shown home hemodialysis (HHD) to be associated with better survival than facility hemodialysis (HD) and peritoneal dialysis (PD). Patients on HHD have reported higher quality of life...

    Authors: Zhaohui Ni, Yijun Zhou, Renhua Lu, Jianxiao Shen, Leyi Gu, Shan Mou, Li Zhao, Haifen Zhang, Bin Zhang, Yan Fang, Wei Fang, Qin Wang, Weiming Zhang, Jidong Zhang and Weiping Li
    Citation: BMC Nephrology 2022 23:389
    Content type: Research Published on:

  8. Adult studies have demonstrated potential harm from resuscitation with 0.9% sodium chloride (0.9%NaCl), resulting in increased utilization of balanced crystalloids like lactated ringers (LR). The sodium and po...

    Authors: Natalja L. Stanski, Katja M. Gist, Kaci Pickett, John T. Brinton, Jennifer Sadlowski, Hector R. Wong, Peter Mourani, Danielle E. Soranno, Jessica Kendrick and Erin K. Stenson
    Citation: BMC Nephrology 2022 23:388
    Content type: Research Published on:

  9. The prevalence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) is increasing continuously as a result of the dramatic growth in the prevalence of two main causes of ESKD which are diabetes ...

    Authors: Noha H. Helmy, Amal Hussein, Marwa Kamal, Osama El Minshawy and Engy A. Wahsh
    Citation: BMC Nephrology 2022 23:387
    Content type: Research Published on:

  10. Pulmonary arterial hypertension (PAH) in the setting of end-stage renal disease (ESRD) has important prognostic and therapeutic consequences. We estimated the prevalence of PAH among patients with ESRD treated...

    Authors: Abdullah K. Alhwiesh, Ibrahiem Saeed Abdul-Rahman, Abdullah Alshehri, Amani Alhwiesh, Mahmoud Elnokeety, Syed Essam, Mohamad Sakr, Nadia Al-Oudah, Abdulla Abdulrahman, Abdelgalil Moaz Mohammed, Hany Mansour, Tamer El-Salamoni, Nehad Al-Oudah, Lamees Alayoobi, Hend Aljenaidi, Ali Al-Harbi…
    Citation: BMC Nephrology 2022 23:386
    Content type: Research article Published on:

  11. Royal Darwin Hospital (RDH) is the main tertiary hospital that has performed more than 600 biopsies since its establishment. Although Indigenous people in Australia’s Northern Territory (NT) has the highest ra...

    Authors: Kim Ling Goh, Asanga Abeyaratne, Shahid Ullah, Chris Rissel and Kelum Priyadarshana
    Citation: BMC Nephrology 2022 23:385
    Content type: Research Published on:

  12. There is growing evidence that self‐management behaviour can improve outcomes for patients with chronic kidney disease (CKD). However, no measures are available in Malay to effectively assess the self-manageme...

    Authors: Ayat Ali Al Sawad, Soo Kun Lim, Li Yoong Tang, Aneesa Abdul Rashid and Boon-How Chew
    Citation: BMC Nephrology 2022 23:384
    Content type: Research Published on:

  13. Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal disorders such as peptic ulcer disease and dyspepsia. However, several studies have suggested that PPI use increases the risk...

    Authors: Keiko Ikuta, Shunsaku Nakagawa, Chinami Yamawaki, Kotaro Itohara, Daiki Hira, Satoshi Imai, Atsushi Yonezawa, Takayuki Nakagawa, Minoru Sakuragi, Noriaki Sato, Eiichiro Uchino, Motoko Yanagita and Tomohiro Terada
    Citation: BMC Nephrology 2022 23:383
    Content type: Research Published on:

  14. Fibronectin glomerulopathy is a rare, familial glomerular disease characterized by mesangial fibronectin deposition in the glomeruli. It is caused by the genetic defect in fibronectin and does not involve the ...

    Authors: Xiaoli Li, Xueting Qi, Zhigang Ma and Wenhui Huang
    Citation: BMC Nephrology 2022 23:382
    Content type: Case report Published on:

  15. Lupus nephropathy (LN) occurs in approximately 50% of patients with systemic lupus erythematosus (SLE), and 20% of them will eventually progress into end-stage renal disease (ESRD). A clinical tool predicting ...

    Authors: Jakub Stojanowski, Andrzej Konieczny, Klaudia Rydzyńska, Izabela Kasenberg, Aleksandra Mikołajczak, Tomasz Gołębiowski, Magdalena Krajewska and Mariusz Kusztal
    Citation: BMC Nephrology 2022 23:381
    Content type: Research Published on:

  17. Changes in renal perfusion may play a pathophysiological role in hypertension and kidney disease, however to date, no method for renal blood flow (RBF) determination in humans has been implemented in clinical ...

    Authors: Stine Sundgaard Langaa, Frank Holden Mose, Claire Anne Fynbo, Jørn Theil and Jesper Nørgaard Bech
    Citation: BMC Nephrology 2022 23:379
    Content type: Research Published on:

  18. Chronic kidney disease (CKD), which affects about 10% of global population, has become a global public health crisis in recent decades. It is well recognized that health information dissemination could change ...

    Authors: Lan Yao, Yubao Li, Qinglou Lian, Junjun Sun, Shuyin Zhao and Pei Wang
    Citation: BMC Nephrology 2022 23:378
    Content type: Research Published on:

  19. The utility of dipstick proteinuria for predicting microalbuminuria in non-diabetic lifestyle-related diseases compared with the urine protein-to-creatinine ratio (uPCR) and the effect of dipstick proteinuria ...

    Authors: Makoto Ogi, Takuya Seto and Yoshinori Wakabayashi
    Citation: BMC Nephrology 2022 23:377
    Content type: Research article Published on:

  20. Chronic Kidney Disease (CKD), Type 2 Diabetes (T2D) and Hypertension (HTN) are frequently associated with adverse outcomes. We aimed to estimate the impact of a prior diagnosis of T2D and/or HTN on clinical ch...

    Authors: Oriol Cunillera-Puértolas, David Vizcaya, M. Jesús Cerain-Herrero, Neus Gil-Terrón, Silvia Cobo-Guerrero and Betlem Salvador-González
    Citation: BMC Nephrology 2022 23:376
    Content type: Research Published on:

  22. Vascular calcification (VC) is suggested to be associated with serum klotho levels in patients with maintenance hemodialysis (MHD), whereas there is a lack of reports on the associations of VC status in whole ...

    Authors: Yan Lin, Jiayuan Huang, Meiyang Zhou, Cuiping Pan, Aiqin Shan and Canxin Zhou
    Citation: BMC Nephrology 2022 23:374
    Content type: Research Published on:

  23. Anti-glomerular basement membrane (anti-GBM) disease is characterized by crescentic necrotizing glomerulonephritis, with linear deposits of immunoglobulin G (IgG) in the GBM. Classic anti-GBM disease is clinic...

    Authors: Ryo Tamura, Toshiki Doi, Shuma Hirashio, Kensuke Sasaki, Yukinari Masuda, Akira Shimizu and Takao Masaki
    Citation: BMC Nephrology 2022 23:373
    Content type: Case report Published on:

  24. A functioning vascular access (VA) is crucial to providing adequate hemodialysis (HD) and considered a critically important outcome by patients and healthcare professionals. A validated, patient-important outc...

    Authors: Andrea K. Viecelli, Armando Teixeira-Pinto, Andrea Valks, Richard Baer, Roy Cherian, Pietro E. Cippà, Jonathan C. Craig, Ranil DeSilva, Allison Jaure, David W. Johnson, Charani Kiriwandeniya, Pascal Kopperschmidt, Wen-J Liu, Timmy Lee, Charmaine Lok, Krishan Madhan…
    Citation: BMC Nephrology 2022 23:372
    Content type: Study protocol Published on:

  25. SARS-CoV-2 viral infection is associated with a rapid and vigorous systemic inflammatory response syndrome. Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel biomarker, both indicative o...

    Authors: Vaidas Vicka, Elija Januskeviciute, Ieva Bartuševiciene, Donata Ringaitiene, Aiste Aleknaviciene, Mindaugas Serpytis, Laurynas Rimsevicius, Marius Miglinas, Ligita Jancoriene and Jurate Sipylaite
    Citation: BMC Nephrology 2022 23:371
    Content type: Research Published on:

  26. Multiple myeloma (MM) is a malignant neoplasm associated with kidney involvement in nearly half of the patients. Cast nephropathy, monoclonal immunoglobulin deposition disease (MIDD), and light chain (AL) amyl...

    Authors: Samantha Innocenti, Beatrice Bacchi, Marco Allinovi, Federico Perfetto, Elisabetta Antonioli, Niccolo’ Marchionni, Carlo Di Mario, Leonardo Caroti, Francesco Cappelli and Pierluigi Stefàno
    Citation: BMC Nephrology 2022 23:370
    Content type: Case report Published on:

  27. Acute kidney replacement therapy (KRT) is delivered to acutely ill patients to support organ function and life in the Intensive Care Unit (ICU). Implementing standardized acute KRT pathways can ensure its safe...

    Authors: Dawn Opgenorth, Sean M. Bagshaw, Vincent Lau, Michelle M. Graham, Nancy Fraser, Scott Klarenbach, Louise Morrin, Colleen Norris, Neesh Pannu, Selvi Sinnadurai, Shelley Valaire, Xiaoming Wang and Oleksa G. Rewa
    Citation: BMC Nephrology 2022 23:369
    Content type: Study protocol Published on:

  28. March hemoglobinuria is caused by a hemolytic mechanism due to transient hematuria after physical exercise which, although rare, may lead to acute kidney injury. We report a case of a patient with march hemogl...

    Authors: Maiko Yoshida, Hitoshi Suzuki, Sho Hamaguchi, Masako Iwasaki, Hiromitsu Fukuda, Hisatsugu Takahara, Shigeki Tomita and Yusuke Suzuki
    Citation: BMC Nephrology 2022 23:368
    Content type: Case report Published on:

  29. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential inhibitory regulator of immune activation. CTLA-4 haploinsufficiency is known to be associated with dysregulation of FOXP3+ regulatory T cells, hyperactiv...

    Authors: Kaori Kohatsu, Tomo Suzuki, Madoka Takimoto, Katsuomi Matsui, Akinori Hashiguchi, Junki Koike and Sayuri Shirai
    Citation: BMC Nephrology 2022 23:367
    Content type: Case report Published on:

  30. IgA nephropathy in children has various clinical manifestations. Kidney biopsy is a gold standard for diagnosis by using Oxford classification 2016 with few studies about the correlation between clinical and p...

    Authors: Karnchanit Sausukpaiboon, Sunee Panombualert, Suwannee Wisanuyotin, Anucha Puapairoj, Piyanan Suparattanagool, Leelawadee Techasatian and Nattakarn Tantawarak
    Citation: BMC Nephrology 2022 23:366
    Content type: Research Published on:

  31. Peritoneal dialysis (PD) is an effective and successful renal replacement therapy. The baseline peritoneal solute transfer rate (PSTR) is related to local membrane inflammation and may be partially genetically...

    Authors: Yue Qian, Li Ding, Liou Cao, Zanzhe Yu, Xinghua Shao, Ling Wang, Minfang Zhang, Qin Wang, Xiajing Che, Na Jiang, Hao Yan, Wei Fang, Yan Jin, Jiaying Huang, Aiping Gu and Zhaohui Ni
    Citation: BMC Nephrology 2022 23:365
    Content type: Research Published on:

  32. Acute kidney injury (AKI) is an under-recognized disorder, which is associated with a high risk for mortality, development of chronic kidney disease (CKD).

    Authors: Teuwafeu Denis Georges, Halle Marie-Patrice, Tonou Sorel Ingrid, Ronald Gobina Mbua, Fouda Menye Hermine and Ashuntantang Gloria
    Citation: BMC Nephrology 2022 23:364
    Content type: Research Published on:

  33. Subjective cognitive complaints refer to self-experienced difficulties with everyday cognitive tasks. Although there has been a fair amount of research on cognitive impairments and cognitive complaints in end-...

    Authors: Frederick H. F. Chan, Stanton Newman, Behram A. Khan and Konstadina Griva
    Citation: BMC Nephrology 2022 23:363
    Content type: Research Published on:

  34. Extended-release calcifediol (ERC), active vitamin D hormones and analogs (AVD) and nutritional vitamin D (NVD) are commonly used therapies for treating secondary hyperparathyroidism (SHPT) in adults with stag...

    Authors: Michael J. Germain, Subir K. Paul, George Fadda, Varshasb Broumand, Andy Nguyen, November H. McGarvey, Matthew D. Gitlin, Charles W. Bishop, Philipp Csomor, Stephen Strugnell and Akhtar Ashfaq
    Citation: BMC Nephrology 2022 23:362
    Content type: Research Published on:

  35. Sun-protective strategies focusing on skin cancer awareness are needed in immunosuppressed patients at risk of skin cancers. The study aims to determine the effect of an integrated skin cancer education progra...

    Authors: Zaw Thet, Alfred King-yin Lam, Shu-Kay Ng, Soe Yu Aung, Thin Han, Dwarakanathan Ranganathan, Stephanie Newsham, Jennifer Borg, Christine Pepito and Tien K. Khoo
    Citation: BMC Nephrology 2022 23:361
    Content type: Research Published on:

  36. Carbapenem-induced neurotoxicity is an unusual side effect, with seizure being the most commonly reported symptom. Among the carbapenems, imipenem-cilastin is classically associated with the most severe neurot...

    Authors: Shamira Shahar, Durga A. Arimuthu and Sadanah Aqashiah Mazlan
    Citation: BMC Nephrology 2022 23:360
    Content type: Case report Published on:

  37. Predicting allograft survival is vital for efficient transplant success. With dynamic changes in patient conditions, clinical indicators may change longitudinally, and doctors’ judgments may be highly variable...

    Authors: Baoyi Huang, Mingli Huang, Chengfeng Zhang, Zhiyin Yu, Yawen Hou, Yun Miao and Zheng Chen
    Citation: BMC Nephrology 2022 23:359
    Content type: Research Published on:

  38. Membranoproliferative glomerulonephritis (MPGN), a rare glomerulonephritis that causes nephrotic syndrome in children, is often difficult to treat. Typical immunofluorescence findings include strong C3 stainin...

    Authors: Yuko Hidaka, Hiroshi Tamura, Keishiro Furuie, Shohei Kuraoka, Hiroko Nagata and Hitoshi Nakazato
    Citation: BMC Nephrology 2022 23:358
    Content type: Case report Published on:

  39. Subclinical inflammation, including borderline lesions (BL), is very common (30–40%) after kidney transplantation (KT), even in low immunological risk patients, and can lead to interstitial fibrosis/tubular at...

    Authors: Domingo Hernández, Teresa Vázquez-Sánchez, Eugenia Sola, Veronica Lopez, Pedro Ruiz-Esteban, Abelardo Caballero, Eduardo Salido, Myriam Leon, Aurelio Rodriguez, Nuria Serra, Consuelo Rodriguez, Carme Facundo, Manel Perello, Irene Silva, Domingo Marrero-Miranda, Ignacio Cidraque…
    Citation: BMC Nephrology 2022 23:357
    Content type: Study protocol Published on:

  40. To examine the association of the screening frequency of estimated glomerular filtration rate (eGFR) with the substantial reduction in eGFR (≥ 25%) among type 2 diabetes (T2D) patients with normal (eGFR≥60 ml/...

    Authors: Henry Sundqvist, Eveliina Heikkala, Jari Jokelainen, Giuseppina Russo, Ilona Mikkola and Maria Hagnäs
    Citation: BMC Nephrology 2022 23:356
    Content type: Research Published on:

  41. The atherosclerotic state of haemodialysis (HD) patients may be influenced by heavy metals. The purpose of our study was to assess the relationship between serum zinc (Zn) ankle brachial index (ABI) as a non-i...

    Authors: Maša Knehtl, Nejc Piko, Robert Ekart, Radovan Hojs and Sebastjan Bevc
    Citation: BMC Nephrology 2022 23:355
    Content type: Research Published on:

    The Correction to this article has been published in BMC Nephrology 2022 23:397

  43. The presence of acute kidney injury (AKI) in pre-eclampsia complicates treatment including; increasing length of hospital stay and a need to access services like dialysis which are largely expensive in resourc...

    Authors: Mariam Hassan, Roland Mayanja, Wasswa G.M Ssalongo, Natumanya Robert, Lugobe Henry Mark, Okello Samson and Rose Muhindo
    Citation: BMC Nephrology 2022 23:353
    Content type: Research Published on:

  45. Hyperkalemia increases the risk of mortality and cardiovascular-related hospitalizations in patients with hemodialysis. Predictors of hyperkalemia are yet to be identified. We aimed at developing a nomogram ab...

    Authors: Ziwei Mei, Jun Chen, Peipei Chen, Songmei Luo, Lie Jin and Limei Zhou
    Citation: BMC Nephrology 2022 23:351
    Content type: Research Published on:

  46. Muscle dysfunction is prevalent in dialysis patients. Gait speed and handgrip strength are simple and reliable methods of assessing muscle function. Numerous observational studies have linked 25-hydroxy vitami...

    Authors: Chen Fu, Fengqin Wu, Fang Chen, Enhong Han, Yuehua Gao and Yongxing Xu
    Citation: BMC Nephrology 2022 23:350
    Content type: Research Published on:

  47. Obesity is a major health problem worldwide and is associated with chronic kidney disease (CKD). Body mass index (BMI) is a common method of diagnosing obesity, but there are concerns about its accuracy and ab...

    Authors: Younghoon Song, Jeong Ah Hwang, Jaeun Shin, Eunjung Cho, Shin Young Ahn, Gang Jee Ko, Young Joo Kwon and Ji Eun Kim
    Citation: BMC Nephrology 2022 23:349
    Content type: Research Published on:

  48. Vascular endothelial growth factor inhibitors (VEGFIs) are used to treat malignant neoplasms and ocular diseases by inhibiting angiogenesis. Systemic use of VEGFIs has various side effects, including hypertens...

    Authors: Yawara Kikuchi, Yoshimi Odashima, Kazuhiro Yoshikawa, Tomoyasu Oda, Fumitaka Tanaka, Hiroki Oikawa, Yasushi Ishigaki and Koichi Asahi
    Citation: BMC Nephrology 2022 23:348
    Content type: Case report Published on:

    The Correction to this article has been published in BMC Nephrology 2022 23:380

  49. The factors associated with estimated glomerular filtrate rate (eGFR) decline in low risk adults remain relatively unknown. We hypothesized that a polygenic risk score (PRS) will be associated with eGFR decline.

    Authors: Farrukh M. Koraishy, Frank D. Mann, Monika A. Waszczuk, Pei-Fen Kuan, Katherine Jonas, Xiaohua Yang, Anna Docherty, Andrey Shabalin, Sean Clouston, Roman Kotov and Benjamin Luft
    Citation: BMC Nephrology 2022 23:347
    Content type: Research Published on:
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