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  1. Content type: Research article

    Chronic kidney disease (CKD) is often asymptomatic in its early stages but is indicated and is diagnosed with an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2. Certain sociodemographic groups are...

    Authors: Irene Ma, Maggie Guo, Daniel Muruve, Hallgrimur Benediktsson and Christopher Naugler

    Citation: BMC Nephrology 2018 19:198

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  2. Content type: Research article

    Dialysis is often initiated in the hospital during episodes of acute kidney injury and critical illness. Little is known about how patients or their surrogate decision makers feel about dialysis initiation in ...

    Authors: Amar D. Bansal, Nina R. O’Connor and David J. Casarett

    Citation: BMC Nephrology 2018 19:197

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  3. Content type: Research article

    Exercise improves functional outcomes and quality of life of older patients with end-stage renal disease undergoing hemodialysis. Yet exercise is not promoted as part of routine care. Health care providers and...

    Authors: Pia Kontos, Alisa Grigorovich, Romeo Colobong, Karen-Lee Miller, Gihad E. Nesrallah, Malcolm A. Binns, Shabbir M. H. Alibhai, Trisha Parsons, Sarbjit Vanita Jassal, Alison Thomas and Gary Naglie

    Citation: BMC Nephrology 2018 19:195

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  4. Content type: Research article

    While there is a great deal of research updating methods for estimating renal function, many of these methods are being developed in either adults with CKD or younger children. Currently, there is limited unde...

    Authors: Michael Webster-Clark, Byron Jaeger, Yi Zhong, Guido Filler, Ana Alvarez-Elias, Nora Franceschini and Maria E. Díaz-González de Ferris

    Citation: BMC Nephrology 2018 19:194

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  5. Content type: Research article

    Genitourinary tuberculosis (GUTB) is a type of extrapulmonary TB that exerts a deleterious effect on renal function by promoting renal calcification and ureteric stricture. Therefore, we investigated the risk ...

    Authors: Eun Jin Kim, Woonji Lee, Woo Yong Jeong, Hen Choi, In Young Jung, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Young Hwa Choi, Young Goo Song and June Myung Kim

    Citation: BMC Nephrology 2018 19:193

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  6. Content type: Research article

    Increased plasma level of lipoprotein(a) (Lpa) is a risk factor of cardiovascular diseases. This study aimed to explore the role of Lpa in the progression of atherosclerosis in patients with end-stage renal di...

    Authors: Kun Ling Ma, Tie Kai Gong, Ze Bo Hu, Yang Zhang, Gui Hua Wang, Liang Liu, Pei Pei Chen, Jian Lu, Chen Chen Lu and Bi Cheng Liu

    Citation: BMC Nephrology 2018 19:192

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  7. Content type: Research article

    Soluble urokinase-type plasminogen activator receptor (suPAR) has emerged as a new sepsis biomarker. It is not known whether suPAR has a role in critically ill patients with severe acute kidney injury (AKI).

    Authors: Anna Hall, Siobhan Crichton, Matt Varrier, Danielle E. Bear and Marlies Ostermann

    Citation: BMC Nephrology 2018 19:191

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  8. Content type: Research article

    Kidney transplantation (KTx) is the best therapeutic approach for chronic kidney diseases leading to irreversible kidney failure. Considering the origin of the graft, several studies have reported differences ...

    Authors: S. Inés Lozano-Ramos, Ioana Bancu, Laura Carreras-Planella, Marta Monguió-Tortajada, Laura Cañas, Javier Juega, Josep Bonet, M. Pilar Armengol, Ricardo Lauzurica and Francesc E. Borràs

    Citation: BMC Nephrology 2018 19:189

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  9. Content type: Research article

    Investigations on the role of the time-mean serum uric acid (SUA) value in determining the risk of chronic kidney disease (CKD) are limited. We investigated whether the time-mean SUA value indicates the risk o...

    Authors: Meiyu Ye, Kang Hu, Juan Jin, Diandian Wu, Peiying Hu and Qiang He

    Citation: BMC Nephrology 2018 19:190

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  10. Content type: Research article

    Ongoing efforts are focused on shortening ischemia intervals as much as possible during partial nephrectomy to preserve renal function. Off-clamp partial nephrectomy (off-PN) has been a common strategy for to ...

    Authors: Wen Deng, Xiaoqiang Liu, Jieping Hu, Luyao Chen and Bin Fu

    Citation: BMC Nephrology 2018 19:188

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  11. Content type: Research article

    Both dialysis facilities and hospitals are accountable for 30-day hospital readmissions among U.S. hemodialysis patients. We examined the association of post-hospitalization processes of care at hemodialysis f...

    Authors: Laura C. Plantinga, Tahsin Masud, Janice P. Lea, John M. Burkart, Christopher M. O’Donnell and Bernard G. Jaar

    Citation: BMC Nephrology 2018 19:186

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  12. Content type: Research article

    Neutrophil to lymphocyte ratio (NLR) was introduced to predict poor prognosis in various diseases, but not all variants of ANCA-associated vasculitis (AAV). In this study, we aimed to investigate whether NLR a...

    Authors: Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

    Citation: BMC Nephrology 2018 19:187

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  13. Content type: Research article

    End stage renal disease (ESRD) is on the rise globally. Varicella infection among adult patients with ESRD has been reported to lead to multiple complications and even death. While varicella vaccination has be...

    Authors: Chong Yau Ong, Sher Guan Low, Farhad Fakhrudin Vasanwala, Shashidhar Baikunje and Lian Leng Low

    Citation: BMC Nephrology 2018 19:185

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  14. Content type: Research article

    Knowing how chronic kidney disease (CKD) patients talk about their encounters with providers (i.e., their discourse) can inform the important clinical goal of engaging patients in their chronic disease self-ma...

    Authors: Ann E. Vandenberg, Katharina V. Echt, Theodore M. Johnson II and C. Barrett Bowling

    Citation: BMC Nephrology 2018 19:183

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  15. Content type: Research article

    Idiopathic membranous nephropathy (IMN) is one of the most common adult nephrotic syndromes. Some patients with this disorder require immunosuppressive therapy. This retrospective case series was performed to ...

    Authors: Shun-Lai Shang, Guang-Yan Cai, Shu-wei Duan, Ping Li, Qing-Gang Li and Xiang-Mei Chen

    Citation: BMC Nephrology 2018 19:182

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  16. Content type: Research article

    Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have r...

    Authors: Tamara Milagres, Fernando E. García-Arroyo, Miguel A. Lanaspa, Gabriela Garcia, Takuji Ishimoto, Ana Andres-Hernando, Masanari Kuwabara, Thomas Jensen, Yuka Sato, Jason Glaser, Laura G. Sánchez-Lozada, Richard J. Johnson and Carlos Roncal-Jimenez

    Citation: BMC Nephrology 2018 19:180

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  17. Content type: Research article

    Angiotensin II (Ang II) contributes to the progression of renal diseases associated with proteinuria and glomerulosclerosis mainly by inducing podocyte apoptosis. In the present study, we investigated whether ...

    Authors: Vanessa Gerolde Cardoso, Guilherme Lopes Gonçalves, Juliana Martins Costa-Pessoa, Karina Thieme, Bruna Bezerra Lins, Fernando Augusto Malavazzi Casare, Mariana Charleaux de Ponte, Niels Olsen Saraiva Camara and Maria Oliveira-Souza

    Citation: BMC Nephrology 2018 19:179

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  18. Content type: Research article

    Renal impairment (RI) is common in multiple myeloma (MM) and is associated with poor survival. This study reports the associations between renal function and disease characteristics including serum free light ...

    Authors: Punit Yadav, Paul Cockwell, Mark Cook, Jennifer Pinney, Hannah Giles, Yu Sandar Aung, David Cairns, Roger G. Owen, Faith E. Davies, Graham H. Jackson, J. Anthony Child, Gareth J. Morgan and Mark T. Drayson

    Citation: BMC Nephrology 2018 19:178

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  19. Content type: Study protocol

    Graft survival after kidney transplantation has significantly improved within the last decades but there is a substantial number of patients with declining transplant function and graft loss. Over the past yea...

    Authors: Anna Wiegand, Alexander Ritter, Nicole Graf, Spyridon Arampatzis, Daniel Sidler, Karine Hadaya, Thomas F. Müller, Carsten A. Wagner, Rudolf P. Wüthrich and Nilufar Mohebbi

    Citation: BMC Nephrology 2018 19:177

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  20. Content type: Case report

    Sixty mutations of claudin 16 coding gene have been reported in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients. Recent investigations revealed that a highly conserved glycine...

    Authors: Jingru Lu, Xiangzhong Zhao, Alessandro Paiardini, Yanhua Lang, Irene Bottillo and Leping Shao

    Citation: BMC Nephrology 2018 19:181

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  21. Content type: Research article

    Echocardiographic characteristics across the spectrum of chronic kidney disease (CKD) have not been well described. We assessed the echocardiographic characteristics of patients with preserved renal function a...

    Authors: Thomas A. Mavrakanas, Aisha Khattak, Karandeep Singh and David M. Charytan

    Citation: BMC Nephrology 2018 19:176

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  22. Content type: Research article

    The management of proliferative lupus nephritis (LN) comprises timely and coordinated immunosuppressive therapy. This study aimed to evaluate and compare the effectiveness and safety profile of low dose mycoph...

    Authors: Arun Sedhain, Rajani Hada, Rajendra K. Agrawal, Gandhi R. Bhattarai and Anil Baral

    Citation: BMC Nephrology 2018 19:175

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  23. Content type: Research article

    Current guidelines regarding plasma-sampling techniques for glomerular filtration rate (GFR) determination are inconsistent. Single-sample methods are commonly believed not to be precise enough to meet clinica...

    Authors: Yong Zhang, Zhun Sui, Ze Yu, Tai Feng Li, Wan Yu Feng and Li Zuo

    Citation: BMC Nephrology 2018 19:174

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  24. Content type: Research article

    Nephrolithiasis is a risk factor for Osteopenia and osteoporosis. Receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) regulate bone remodeling and osteoclastogenesis. This stud...

    Authors: Asieh Mansour, Maryam Aboeerad, Mostafa Qorbani, Amir Pejman Hashemi Taheri, Mohamad Pajouhi, Abbas Ali Keshtkar, Bagher Larijani, Mohammad Reza Mohajeri-Tehrani and Mohammad Reza Ganji

    Citation: BMC Nephrology 2018 19:172

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  25. Content type: Research article

    We present a case series of 5 patients with proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) of renal allografts to better define its natural history, presenting characteristics, patholog...

    Authors: Jiqiu Wen, Wei Wang, Feng Xu, Jinsong Chen, Mingchao Zhang, Dongrui Cheng, Xuefeng Ni, Xue Li and Zhihong Liu

    Citation: BMC Nephrology 2018 19:173

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  26. Content type: Research article

    Chronic kidney disease (CKD) poses a substantial health burden in sub-Saharan Africa, with risk factors ranging from communicable to non-communicable diseases. Hyperuricemia has been recently identified as a f...

    Authors: Marie Doualla, Marie Patrice Halle, Jude Moutchia, Steve Tegang and Gloria Ashuntantang

    Citation: BMC Nephrology 2018 19:169

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  27. Content type: Research article

    Choice of dialysis is context sensitive, explored for PD and extracorporeal dialysis, but less studied for haemodialysis (HD) and hemodiafiltration (HDF), both widely employed in Italy and France; reasons of c...

    Authors: Giorgina Barbara Piccoli, Gianfranca Cabiddu, Maria Rita Moio, Antioco Fois, Riccardo Cao, Ida Molfino, Ana Kaniassi, Francoise Lippi, Ludivine Froger, Antonello Pani and Marilisa Biolcati

    Citation: BMC Nephrology 2018 19:171

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  28. Content type: Case report

    Recurrence of glomerulonephritis is an important risk factor for renal graft dysfunction. Cryoglobulinemia is known as a relatively rare cause of renal failure, and doctors are usually hesitant to perform tran...

    Authors: Tomomichi Kasagi, Hironobu Nobata, Kaori Ikeda, Shogo Banno and Yasuhiko Ito

    Citation: BMC Nephrology 2018 19:170

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  29. Content type: Research article

    Substrate reduction therapy with analogs reduces the accumulation of substrates by inhibiting the metabolic pathways involved in their biosynthesis, providing new treatment options for patients with primary hy...

    Authors: Huan Yang, Musa Male, Yang Li, Ning Wang, Chenming Zhao, Shan Jin, Juncheng Hu, Zhiqiang Chen, Zhangqun Ye and Hua Xu

    Citation: BMC Nephrology 2018 19:167

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  30. Content type: Research article

    There are conflicting reports on the impact of HIV in the era of combined antiretroviral (c-ART) on survival of patient with ESKD. We aimed to compare the one-year survival of HIV positive patients to that of ...

    Authors: Marie Patrice Halle, Anais Mfoula Edjomo, Hermine Fouda, Hilaire Djantio, Noel Essomba and Gloria Enow Ashuntantang

    Citation: BMC Nephrology 2018 19:166

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  31. Content type: Research article

    Organ donation after brain death (DBD) is the standard strategy for organ transplantation; however, the concept of brain death is not universally accepted due to cultural beliefs and barriers amongst billions ...

    Authors: Qipeng Sun, Honglan Zhou, Ronghua Cao, Minzhuan Lin, Xuefeng Hua, Liangqing Hong, Zhengyu Huang, Ning Na, Ruiming Cai, Gang Wang, Fanhang Meng and Qiquan Sun

    Citation: BMC Nephrology 2018 19:164

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  32. Content type: Case report

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder, leading to end stage renal failure and kidney transplantation in its most serious form. The severity of the di...

    Authors: Veronika Elisakova, Miroslav Merta, Jana Reiterova, Alica Baxova, Jaroslav Kotlas, Katerina Hirschfeldova, Lena Obeidova, Vladimir Tesar and Jitka Stekrova

    Citation: BMC Nephrology 2018 19:163

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  33. Content type: Case report

    While the majority of adult-onset minimal change nephrotic syndrome (MCNS) is a primary or an idiopathic form of disease, it can also occur as a secondary form. Reports on the spontaneous remission of MCNS are...

    Authors: Ayumi Haruki, Eiji Ishikawa, Kan Katayama, Takayasu Ito, Takuya Hiramoto, Mika Fujimoto, Tomohiro Murata and Masaaki Ito

    Citation: BMC Nephrology 2018 19:162

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  34. Content type: Case report

    Gallbladder perforation is a rare but lethal condition and its diagnosis is usually difficult and delayed. Frequently, gallbladder rupture is associated with cholecystitis, but spontaneous perforation was ever...

    Authors: Yueh-Lin Wu, Yi-Sheng Lin, Thomas Yu-Ren Hsueh, Wen-Ching Lo, Kuo-Chou Peng and Mu-Jung Kao

    Citation: BMC Nephrology 2018 19:165

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  35. Content type: Research article

    Acute kidney injury (AKI) following cardiac surgery is a frequent complication and several risk factors increasing its incidence have already been characterized. This study evaluates the influence of preoperat...

    Authors: T. Kaufeld, K. A. Foerster, T. Schilling, J. T. Kielstein, J. Kaufeld, M. Shrestha, H. G. Haller, A. Haverich and B. M. W. Schmidt

    Citation: BMC Nephrology 2018 19:161

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  36. Content type: Case report

    Hypokalemia is one of the most common clinical electrolyte imbalance problems, and thyrotoxic periodic paralysis (TPP) is a leading cause of presentation to the emergency department. Low renal potassium secret...

    Authors: Mei-Lan Tu, Yu-Wei Fang, Jyh-Gang Leu and Ming-Hsien Tsai

    Citation: BMC Nephrology 2018 19:160

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  37. Content type: Research article

    According to the literature the three stone diseases, sialolithiasis (SL), urolithiasis (UL) and cholelithiasis (CL) share comorbidities. We assess familial and spouse risks between these stone disease and com...

    Authors: Kari Hemminki, Otto Hemminki, Anni I. M. Koskinen, Asta Försti, Kristina Sundquist, Jan Sundquist and Xinjun Li

    Citation: BMC Nephrology 2018 19:158

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  38. Content type: Research article

    Left ventricular hypertrophy (LVH) increases the risk of death in chronic kidney disease (CKD). The transcription factor Kruppel-like factor 15 (KLF15) is expressed in the heart and regulates cardiac remodelli...

    Authors: Sheila K. Patel, Elena Velkoska, Daniel Gayed, Jay Ramchand, Jessica Lesmana and Louise M. Burrell

    Citation: BMC Nephrology 2018 19:159

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  39. Content type: Case report

    Currently, the vasopressin V2 receptor antagonist tolvaptan is the only available treatment for autosomal dominant polycystic kidney disease (ADPKD), but there are tolerability issues due to aquaretic side-eff...

    Authors: Bart J. Kramers, Maatje D. A. van Gastel, Esther Meijer and Ron T. Gansevoort

    Citation: BMC Nephrology 2018 19:157

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  40. Content type: Case report

    Although fatigue is common in dialysis patients, polypharmacy is seldom listed among its causes. In this report, we describe a dialysis patient who developed severe fatigue due to pharmacological interaction b...

    Authors: Emanuela Cataldo, Valeria Columbano, Louise Nielsen, Lurlynis Gendrot, Bianca Covella and Giorgina Barbara Piccoli

    Citation: BMC Nephrology 2018 19:155

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  41. Content type: Research article

    For patients with end-stage renal failure (ESFR), thrice-weekly hemodialysis is a standard care. Once-weekly hemodialysis combined with low-protein and low-salt dietary treatment (OWHD-DT) have been rarely stu...

    Authors: Toshiyuki Nakao, Yoshie Kanazawa and Toshimasa Takahashi

    Citation: BMC Nephrology 2018 19:151

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  42. Content type: Research article

    Conversion from calcineurin inhibitor (CNI) therapy to everolimus within 6 months after kidney transplantation improves long-term graft function but can increase the risk of mild biopsy-proven acute cellular r...

    Authors: Ute Eisenberger, Klemens Budde, Frank Lehner, Claudia Sommerer, Petra Reinke, Oliver Witzke, Rudolf P. Wüthrich, Rolf Stahl, Katharina Heller, Barbara Suwelack, Anja Mühlfeld, Ingeborg A. Hauser, Silvio Nadalin, Martina Porstner and Wolfgang Arns

    Citation: BMC Nephrology 2018 19:154

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  43. Content type: Case report

    Peritonitis secondary to bowel perforation is a rare and potentially fatal complication in peritoneal dialysis (PD) patients. However, the early diagnosis of bowel perforation is difficult in PD patients becau...

    Authors: Kentaro Fujii, Naoki Washida, Eri Arai, Masashi Tsuruta, Shu Wakino and Hiroshi Itoh

    Citation: BMC Nephrology 2018 19:153

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  44. Content type: Research article

    Hematuria is associated with chronic kidney disease (CKD), but has rarely been examined as a risk factor for CKD progression. We explored whether individuals with hematuria had worse outcomes compared to those...

    Authors: Paula F. Orlandi, Naohiko Fujii, Jason Roy, Hsiang-Yu Chen, L. Lee Hamm, James H. Sondheimer, Jiang He, Michael J. Fischer, Hernan Rincon-Choles, Geetha Krishnan, Raymond Townsend, Tariq Shafi, Chi-yuan Hsu, John W. Kusek, John T. Daugirdas and Harold I. Feldman

    Citation: BMC Nephrology 2018 19:150

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  45. Content type: Case report

    It has been suggested that C3 glomerulonephritis (C3GN) and atypical hemolytic-uremic syndrome (a stereotypical phenotype of thrombotic microangiopathy), two rare entities caused by complement alternative path...

    Authors: Jiqiu Wen, Wei Wang, Feng Xu, Jun Sun, Jinsong Chen and Xuefeng Ni

    Citation: BMC Nephrology 2018 19:148

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