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  1. PKHD1 is the main genetic cause of autosomal recessive polycystic kidney disease (ARPKD), a hereditary hepato-renal fibrocystic disorder which is the most important cause of end-stage renal disease during early c...

    Authors: Elisa Molinari, Shalabh Srivastava, Rebecca M. Dewhurst and John A. Sayer

    Citation: BMC Nephrology 2020 21:435

    Content type: Research article

    Published on:

  2. Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy affecting the peripheral nervous system. This neurological disorder has been previously reported in bone marrow transplant recipients but is uncomm...

    Authors: Izabela Zakrocka, Iwona Baranowicz-Gąszczyk, Agnieszka Korolczuk and Wojciech Załuska

    Citation: BMC Nephrology 2020 21:434

    Content type: Case report

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  3. Very less is known about health-related quality of life (HRQOL) among patients with kidney diseases in Nepal. This study examined HRQOL among haemodialysis and kidney transplant recipients in Nepal.

    Authors: Kamal Ranabhat, Pratik Khanal, Shiva Raj Mishra, Anu Khanal, Sangita Tripathi and Mahesh Raj Sigdel

    Citation: BMC Nephrology 2020 21:433

    Content type: Research article

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  4. There is limited evidence on the association between short-term changes in mineral and bone disorder parameters and survival in maintenance hemodialysis patients.

    Authors: Chihiro Kato, Naohiko Fujii, Chisato Miyakoshi, Shinji Asada, Yoshihiro Onishi, Shingo Fukuma, Takanobu Nomura, Michihito Wada, Masafumi Fukagawa, Shunichi Fukuhara and Tadao Akizawa

    Citation: BMC Nephrology 2020 21:432

    Content type: Research article

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  5. Idiopathic membranous nephropathy (MN) is one of the major glomerulonephritis that cause nephrotic syndrome. The phospholipase A2 receptor (PLA2R) has recently been identified as an endogenous antigen of idiopath...

    Authors: Rei Iio, Shin’ichi Akiyama, Kensuke Mitsumoto, Yukimasa Iwata, Hiroki Okushima, Karin Shimada, Naomi Ota, Kodo Tomida, Hiroaki Fushimi, Tatsuya Shoji, Masanori Matsumoto and Terumasa Hayashi

    Citation: BMC Nephrology 2020 21:431

    Content type: Case report

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  6. Medullary sponge kidney (MSK) is a rare disease characterized by cystic dilatation of papillary collecting ducts. Intravenous urography is still considered the gold standard for diagnosis. We identified a coho...

    Authors: Isabella Pisani, Roberto Giacosa, Sara Giuliotti, Dario Moretto, Giuseppe Regolisti, Chiara Cantarelli, Augusto Vaglio, Enrico Fiaccadori and Lucio Manenti

    Citation: BMC Nephrology 2020 21:430

    Content type: Research article

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  7. Anti-glomerular basement membrane disease (GBM) is an autoimmune disease caused by the deposition of circulating anti-GBM antibodies. Non-collagen region of α3 chain of type IV collagen (α3(IV)NC1) is one of t...

    Authors: Wen-jing Wang, Xiao-yu Jia, Zhao Cui, Yan Chen, Wei Wang, Jin-li Lou, Ming-hui Zhao and Sun Ying

    Citation: BMC Nephrology 2020 21:429

    Content type: Research article

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  9. Fluctuations in serum phosphate levels increased mortality in end-stage renal disease patients. However, the impacts of serum phosphate changes in hospitalized patients remain unclear. This study aimed to test...

    Authors: Charat Thongprayoon, Wisit Cheungpasitporn, Panupong Hansrivijit, Sorkko Thirunavukkarasu, Api Chewcharat, Juan Medaura, Michael A. Mao and Kianoush B. Kashani

    Citation: BMC Nephrology 2020 21:427

    Content type: Research article

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  10. Bladder cancer is the most common malignant tumor of the urinary system. One of the biological characteristics of NMIBC is the high recurrence rate after surgery. The implementation of this project aimed to in...

    Authors: Zhenlong Wang, Hui Tang, Yuquan Xue, Li Xue, Hongliang Li and Tie Chong

    Citation: BMC Nephrology 2020 21:426

    Content type: Research article

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  11. Chronic kidney disease has become a major health problem around the world. It displays no symptoms until the later stages. Therefore, its early detection is crucial, and a suitable intervention is necessary to...

    Authors: Haryati Anuar, Shamsul Azhar Shah, Abdul Halim Abdul Gafor and Mohd Ihsani Mahmood

    Citation: BMC Nephrology 2020 21:425

    Content type: Research article

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  12. Kidney disease accounts for more than 49 billion dollars in healthcare expenditures annually. Early detection and intervention may reduce the burden of disease. We describe a quality improvement project to dev...

    Authors: Melissa L. Swee, M. Lee Sanders, Kantima Phisitkul, George Bailey, Angie Thumann, Nikki Neuzil, Bharat Kumar, Amy M. J. O’Shea and Bradley S. Dixon

    Citation: BMC Nephrology 2020 21:424

    Content type: Research article

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  13. A series of policy changes in 2011 altered reimbursement arrangements and guidance on use of erythropoiesis-stimulating agents for end-stage renal disease (ESRD) patients with anaemia in the US. While the poli...

    Authors: Nga TQ. Nguyen, Alexander P. Maxwell, Michael Donnelly and Ciaran O’Neill

    Citation: BMC Nephrology 2020 21:423

    Content type: Research article

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  14. Early kidney transplantation (KT) is the best option for patients with end-stage kidney disease, but little is known about dialysis access strategy in this context. We studied practice patterns of dialysis acc...

    Authors: Raphaëlle Sylvestre, Natalia Alencar de Pinho, Ziad A. Massy, Christian Jacquelinet, Mathilde Prezelin-Reydit, Roula Galland, Bénédicte Stengel and Raphael Coscas

    Citation: BMC Nephrology 2020 21:422

    Content type: Research article

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  15. Patients with end-stage kidney disease, receiving haemodialysis rely increasingly on informal carers to help manage their debilitating chronic disease. Informal carers may experience a negative impact on their...

    Authors: Michael Matthews, Joanne Reid, Clare McKeaveney, Robert Mullan, Stephanie Bolton, Christopher Hill and Helen Noble

    Citation: BMC Nephrology 2020 21:421

    Content type: Study protocol

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  16. People with end-stage kidney disease have an increased risk of active tuberculosis (TB). Previous systematic reviews have demonstrated that patients with chronic kidney disease (CKD) have increased risk of sev...

    Authors: Judith Ruzangi, Masao Iwagami, Liam Smeeth, Punam Mangtani and Dorothea Nitsch

    Citation: BMC Nephrology 2020 21:420

    Content type: Research article

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  17. Infection with the severe acute respiratory coronavirus 2 (SARS-CoV-2) has led to a worldwide pandemic with coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, overwhelming healthcare system...

    Authors: Samira Bell, Jacqueline Campbell, Jackie McDonald, Martin O’Neill, Chrissie Watters, Katharine Buck, Zoe Cousland, Mark Findlay, Nazir I. Lone, Wendy Metcalfe, Shona Methven, Robert Peel, Alison Almond, Vinod Sanu, Elaine Spalding, Peter C. Thomson…

    Citation: BMC Nephrology 2020 21:419

    Content type: Research article

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  18. The causes of anaemia in patients with end-stage renal disease include a relative deficiency in erythropoietin production and complex clinical conditions. We aimed to investigate the underlying mechanisms of a...

    Authors: Koichiro Matsumura, Toshika Okumiya, Tetsuro Sugiura, Nobuyuki Takahashi, Yoshihiro Yamamoto, Sanae Kikuchi, Kenichi Fujii, Munemitsu Otagaki and Ichiro Shiojima

    Citation: BMC Nephrology 2020 21:418

    Content type: Research article

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  19. Acute kidney injury (AKI) is increasingly recognized as a consequential clinical complication in children with severe malaria. However, approaches to estimate baseline creatinine (bSCr) are not standardized in...

    Authors: Anthony Batte, Michelle C. Starr, Andrew L. Schwaderer, Robert O. Opoka, Ruth Namazzi, Erika S. Phelps Nishiguchi, John M. Ssenkusu, Chandy C. John and Andrea L. Conroy

    Citation: BMC Nephrology 2020 21:417

    Content type: Research article

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  20. Minimal change disease (MCD) is one of the causes of idiopathic nephrotic syndrome in adults. The pathogenesis of proteinuria in MCD has not been fully understood. Recently, it has been reported that the recep...

    Authors: Keisuke Horikoshi, Norihiko Sakai, Naoki Yamamoto, Hisayuki Ogura, Koichi Sato, Taro Miyagawa, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Miho Shimizu, Kengo Furuichi and Takashi Wada

    Citation: BMC Nephrology 2020 21:416

    Content type: Case report

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  21. Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and it is associated with poor clinical outcomes and quality of life. It is not clear if growth differentiation factor-15...

    Authors: Aishatu M. Nalado, Gbenga Olorunfemi, Therese Dix-Peek, Caroline Dickens, Lungile Khambule, Tracy Snyman, Graham Paget, Johnny Mahlangu, Raquel Duarte, Jaya George and Saraladevi Naicker

    Citation: BMC Nephrology 2020 21:415

    Content type: Research article

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  22. Chronic kidney disease (CKD) patients, especially those with end stage renal disease (ESRD) undergoing hemodialysis (HD), exhibit high prevalence of periodontitis. This cross-sectional study aimed to investiga...

    Authors: Xiaobo Duan, Xiaolei Chen, Megha Gupta, Dutmanee Seriwatanachai, Hanxiao Xue, Qiuchan Xiong, Tong Xu, Dan Li, Anchun Mo, Xi Tang, Xuedong Zhou, Yuqing Li and Quan Yuan

    Citation: BMC Nephrology 2020 21:414

    Content type: Research article

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  23. Cardiovascular disease is the most common cause of death in patients with end-stage kidney disease on haemodialysis. The potential clinical consequence of systematic echocardiographic assessment is however not...

    Authors: Anna Axelsson Raja, Peder E. Warming, Ture L. Nielsen, Louis L. Plesner, Mads Ersbøll, Morten Dalsgaard, Morten Schou, Casper Rydahl, Lisbet Brandi and Kasper Iversen

    Citation: BMC Nephrology 2020 21:413

    Content type: Research article

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  24. Acute kidney injury (AKI) is defined as a sudden event of kidney failure or kidney damage within a short period. Ischemia-reperfusion injury (IRI) is a critical factor associated with severe AKI and end-stage ...

    Authors: Meeyoung Park, Chae Hwa Kwon, Hong Koo Ha, Miyeun Han and Sang Heon Song

    Citation: BMC Nephrology 2020 21(Suppl 1):398

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

  25. The optimal choice of treatment, with hemodialysis (HD) or peritoneal dialysis (PD), for end-stage renal disease (ESRD) patients, is still controversial. Only a few studies comparing HD and PD have been conduc...

    Authors: Zhiren He, Haijing Hou, Difei Zhang, Yenan Mo, La Zhang, Guobin Su, Junjie Lin, Liming Lu, Jingyao Huang, Yewen Gu, Ying Zhang, Jingxia Lin, Fengling Yuan, Yu Peng, Hui Liang, Daixin Zhao…

    Citation: BMC Nephrology 2020 21:412

    Content type: Research article

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  26. Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in ...

    Authors: A. C. Nixon, T. J. Wilkinson, H.M.L. Young, M. W. Taal, N. Pendleton, S. Mitra, M. E. Brady, A. P. Dhaygude and A. C. Smith

    Citation: BMC Nephrology 2020 21:411

    Content type: Research article

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  27. Concurrent type 1 diabetes mellitus (T1DM) and idiopathic nephrotic syndrome is rare, and most previously reported cases were in children. We report the case of an adult woman who developed T1DM and minimal ch...

    Authors: Ryuzoh Nishizono, Hiroki Kogou, Yuri Ishizaki, Akihiro Minakawa, Masao Kikuchi, Hiroko Inagaki, Yuji Sato and Shouichi Fujimoto

    Citation: BMC Nephrology 2020 21:410

    Content type: Case report

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  28. This scoping review sought to summarize available data on the prevalence, associated factors, etiology, comorbidities, treatment, cost and mortality of chronic kidney disease (CKD) in Cameroon.

    Authors: Jerry Brown Aseneh, Ben-Lawrence A. Kemah, Stephane Mabouna, Mbeng Emmanuel Njang, Domin Sone Majunda Ekane and Valirie Ndip Agbor

    Citation: BMC Nephrology 2020 21:409

    Content type: Review

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  29. Autosomal dominant polycystic kidney disease (ADPKD), the predominant type of inherited kidney disorder, occurs due to PKD1 and PKD2 gene mutations. ADPKD diagnosis is made primarily by kidney imaging. However, m...

    Authors: Fatemeh Khadangi, Adam Torkamanzehi and Mohammad Amin Kerachian

    Citation: BMC Nephrology 2020 21:408

    Content type: Research article

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  30. The epidemiology of dialysis patients has been little studied in developing countries and economies in transition. We examined the prevalence, incidence and mortality rate of dialysis patients in Kazakhstan, v...

    Authors: Abduzhappar Gaipov, Alpamys Issanov, Kainar Kadyrzhanuly, Dinara Galiyeva, Marina Khvan, Mohamad Aljofan, Miklos Z. Molnar and Csaba P. Kovesdy

    Citation: BMC Nephrology 2020 21:407

    Content type: Research article

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  31. Herein, a 3-year-old boy presented with hidden-onset isolated proteinuria was reported. The disease was induced by COQ8B (previously termed ADCK4) compound heterozygous variants, including c.[271C > T] and c.[737...

    Authors: Shu-bo Zhai, Li Zhang, Bai-chao Sun, Yan Zhang and Qing-shan Ma

    Citation: BMC Nephrology 2020 21:406

    Content type: Case report

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  32. We here report on the first observation of a C3 mutation that is related to atypical hemolytic and uremic syndrome (aHUS), which occurred in a pancreatic islet transplant patient. Immunosuppressive treatments,...

    Authors: Thibault Bahougne, Jérome Olagne, Marion Munch, Laura Braun-Parvez, Marie-Pierrette Chenard, Véronique Frémeaux-Bacchi, Sophie Caillard, Philippe Baltzinger, Michel Greget, Laurence Kessler and Bruno Moulin

    Citation: BMC Nephrology 2020 21:405

    Content type: Case report

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  33. Peritoneal dialysis (PD)-related peritonitis is a rare but serious complication and is associated with increased morbidity and mortality rates. It is most commonly caused by Staphylococcus aureus or Staphylococcu...

    Authors: Kristina Boss, Ina Wiegard-Szramek, Jan Dziobaka, Andreas Kribben and Sebastian Dolff

    Citation: BMC Nephrology 2020 21:404

    Content type: Case report

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  34. Calciphylaxis is a rare condition usually seen in patients with end-stage renal disease. Pain is a hallmark of this condition and can be extremely difficult to control. Anecdotal data suggests that pain manage...

    Authors: Rajkumar Chinnadurai, Smeeta Sinha, Aoife C Lowney and Mary Miller

    Citation: BMC Nephrology 2020 21:403

    Content type: Research article

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  35. Dipeptidyl peptidase-4 (DPP-4) is a serine protease that inhibits the degradation of glucagon-like peptide 1. DPP-4 inhibitors are used worldwide to treat type 2 diabetes mellitus and were recently shown to ha...

    Authors: Ayano Kubo, Teruo Hidaka, Maiko Nakayama, Yu Sasaki, Miyuki Takagi, Hitoshi Suzuki and Yusuke Suzuki

    Citation: BMC Nephrology 2020 21:402

    Content type: Research article

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  36. Membranous nephropathy (MN) has been recognized to occur in patients with human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. The prevalence of phospholipase A2 receptor (PLA2...

    Authors: Vivek Charu, Nicole Andeen, Vighnesh Walavalkar, Jessica Lapasia, Jin-Yon Kim, Andrew Lin, Richard Sibley, John Higgins, Megan Troxell and Neeraja Kambham

    Citation: BMC Nephrology 2020 21:401

    Content type: Research article

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  37. C3-glomerulonephritis can lead to progressive renal impairment from complement-mediated glomerular injury. Incidence and outcomes of C3-glomerulonephritis are not known in the New Zealand population.

    Authors: Luke J. Sutherland and Hari Talreja

    Citation: BMC Nephrology 2020 21:399

    Content type: Research article

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  38. Fungal peritonitis (FP) is an infrequent but serious complication in children undergoing peritoneal dialysis (PD). This study aimed to explore the risk factors, clinical manifestations, causative organisms, fu...

    Authors: Mohammed Alsuhaibani, Egab Aldosari, Khawla A. Rahim, Saeed Alzabli and Dayel Alshahrani

    Citation: BMC Nephrology 2020 21:400

    Content type: Research article

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  39. We aimed to examine the risk factors for chronic kidney disease (CKD) stage 3 among adults with ASK from unilateral nephrectomy.

    Authors: Wen-Jun Zhang, Zi-Yi Wang, Wei-Xing Zhou, Ning-Qiang Yang, Ya Wang, Ya Tang, Xiao-Chun Zhou, Jie-Cao Dao, Yan-Ru Ma, Yan-Ping He, Xiao-Ling Wang, Wen-Ge Wang and Li Yang

    Citation: BMC Nephrology 2020 21:397

    Content type: Research article

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  40. Minimal change disease (MCD) is one of the major causes of nephrotic syndrome (NS). A confirmed MCD diagnosis mainly depends on renal biopsy at present, which is an invasive procedure with many potential risks...

    Authors: Gaofei Yan, Guanzhi Liu, Xuefei Tian, Lifang Tian, Hao Wang, Peiyao Ren, Xiaotao Ma, Rongguo Fu and Zhao Chen

    Citation: BMC Nephrology 2020 21:396

    Content type: Technical advance

    Published on:

  41. Cryoglobulinemic glomerulonephritis (CryoGn) caused by hepatitis B virus (HBV) infection was rarely reported. Our study aimed to investigate the clinical features, renal pathology findings, and prognosis in pa...

    Authors: Chao Li, Hang Li, Wei Su, Yu-bing Wen, Wei Ye, Wen-ling Ye, Jian-fang Cai, Xu-zhen Qin, Xue-mei Li and Xue-wang Li

    Citation: BMC Nephrology 2020 21:395

    Content type: Research article

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  42. Platelet activation is an important side effect of dialysis, resulted in a subsequent release of arachidonic acid (AA) from activated platelets. AA is involved in many pathologic conditions, such as inflammati...

    Authors: Elżbieta Cecerska-Heryć, Rafał Heryć, Magda Wiśniewska, Natalia Serwin, Bartłomiej Grygorcewicz and Barbara Dołęgowska

    Citation: BMC Nephrology 2020 21:394

    Content type: Research article

    Published on:

  43. Hyponatremia is known to be associated with a worse patient outcome in heart failure. In cardiorenal syndrome (CRS), the prognostic role of concomitant hyponatremia is unclear. We sought to evaluate potential ...

    Authors: Rainer U. Pliquett, Katrin Schlump, Andreas Wienke, Babett Bartling, Michel Noutsias, Alexander Tamm and Matthias Girndt

    Citation: BMC Nephrology 2020 21:393

    Content type: Research article

    Published on:

  45. Immune checkpoint inhibitors (ICI) have become the standard of care in many oncological conditions but are associated with a spectrum of renal immune-related adverse events (IrAEs). We aimed to describe the sp...

    Authors: Sebastian Hultin, Kazi Nahar, Alexander M. Menzies, Georgina V. Long, Suran L. Fernando, Victoria Atkinson, Jonathan Cebon and Muh Geot Wong

    Citation: BMC Nephrology 2020 21:391

    Content type: Research article

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  47. Serum neutrophil gelatinase-associated lipocalin (NGAL) could be used as a predictive marker of acute kidney injury (AKI) in patients with return of spontaneous circulation (ROSC) after out-of-hospital cardiac...

    Authors: Yoon Hee Choi, Dong Hoon Lee and Jae Hee Lee

    Citation: BMC Nephrology 2020 21:389

    Content type: Research article

    Published on:

  48. New-onset diabetes after transplantation (NODAT) is associated with reduced patient and graft survival. This study examined the clinical and selected genetic factors associated with NODAT among renal-transplan...

    Authors: Rhanye Mac Guad, Andrew W. Taylor-Robinson, Yuan Seng Wu, Siew Hua Gan, Nur Lisa Zaharan, Roma Choudhury Basu, Constance Sat Lin Liew and Wan Ahmad Hafiz Wan Md Adnan

    Citation: BMC Nephrology 2020 21:388

    Content type: Research article

    Published on:

  49. An epidemic of chronic kidney disease of unknown cause (CKDu) is occurring in rural communities in tropical regions of low-and middle-income countries in South America and India. Little information is availabl...

    Authors: Sophie A. Hamilton, Wisdom P. Nakanga, Josephine E. Prynn, Amelia C. Crampin, Daniela Fecht, Paolo Vineis, Ben Caplin, Neil Pearce and Moffat J. Nyirenda

    Citation: BMC Nephrology 2020 21:387

    Content type: Research article

    Published on:

  50. The association between lower serum sodium levels and the clinical outcomes of insomnia patients remains unclear. We explored whether lower serum sodium is associated with poor clinical outcomes in patients wi...

    Authors: Eunjin Bae, Tae Won Lee, Ha Nee Jang, Hyun Seop Cho, Sehyun Jung, Seunghye Lee, Se-Ho Chang and Dong Jun Park

    Citation: BMC Nephrology 2020 21:386

    Content type: Research article

    Published on:

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