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  1. Content type: Research article

    Alport syndrome is a clinically heterogeneous nephropathy characterized by severe symptomatology at kidney level due to ultrastructural lesions of the glomerular basement membrane (GBM) as consequence of mutat...

    Authors: S. Daga, C. Fallerini, S. Furini, C. Pecoraro, F. Scolari, F. Ariani, M. Bruttini, M. A. Mencarelli, F. Mari, A. Renieri and A. M. Pinto

    Citation: BMC Nephrology 2019 20:70

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  2. Content type: Case report

    Genvoya® (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) is a recent single regimen for the treatment of Human Immunodeficiency Virus (HIV). However, because of its complexity, it is difficult to...

    Authors: Rita Godinho, Serge Bugnon, Terezija Gracin and James Tataw

    Citation: BMC Nephrology 2019 20:69

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  3. Content type: Research article

    Infections are the second leading cause of death and hospitalisation among haemodialysis (HD) patients. Rates of access-related bloodstream infections (AR-BSI) are influenced by patient characteristics and loc...

    Authors: Husham Mohamed, Alaa Ali, Leonard D. Browne, Nuala H. O’Connell, Liam Casserly, Austin G. Stack and Wael F. Hussein

    Citation: BMC Nephrology 2019 20:68

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  4. Content type: Research article

    Epidemiologic data of acute kidney injury (AKI) during pregnancy is lacking in China. This study aims to determine the effect of pregnancy on the risk of AKI among hospitalized women of childbearing age, and t...

    Authors: Diankun Liu, Wenjuan He, Yanqin Li, Mengqi Xiong, Long Wang, Jingxin Huang, Ling Jia, Shuling Yuan and Sheng Nie

    Citation: BMC Nephrology 2019 20:67

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  5. Content type: Research article

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is characterized by gradual cyst growth and expansion, increase in kidney volume with an ultimate decline i...

    Authors: Kyoungmi Kim, Josephine F. Trott, Guimin Gao, Arlene Chapman and Robert H. Weiss

    Citation: BMC Nephrology 2019 20:66

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  6. Content type: Research article

    Annual influenza vaccination is recommended for all children with idiopathic nephrotic syndrome (INS) in France. Consequently, the Social Security automatically sends prescriptions to all patients suffering fr...

    Authors: Roman Klifa, Julie Toubiana, Alizée Michel, Nathalie Biebuyck, Marina Charbit, Laurence Heidet, Saoussen Krid, Pauline Krug, Rémi Salomon and Olivia Boyer

    Citation: BMC Nephrology 2019 20:65

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  7. Content type: Case report

    Renal artery stenosis is one of the secondary causes of pediatric hypertension. Cases with critical unilateral renal artery stenosis manifesting with the hyponatremic hypertensive syndrome are rare and a compr...

    Authors: Jhao-Jhuang Ding, Shih-Hua Lin, Jin-Yao Lai, Tai-Wei Wu, Jing-Long Huang, Hung-Tao Chung and Min-Hua Tseng

    Citation: BMC Nephrology 2019 20:64

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  8. Content type: Research article

    Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk fac...

    Authors: Honglan Wei, Hua Li, Xiaohong Song, Xingguo Du, Yuan Cai, Chengxu Li, Liping Dong and Junwu Dong

    Citation: BMC Nephrology 2019 20:63

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  9. Content type: Research article

    Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we exa...

    Authors: Xue Bao, Yan Borné, Iram Faqir Muhammad, Christina-Alexandra Schulz, Margaretha Persson, Marju Orho-Melander, Kaijun Niu, Anders Christensson and Gunnar Engström

    Citation: BMC Nephrology 2019 20:61

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  10. Content type: Research article

    Insulin resistance contributes to the metabolic syndrome, which is associated with the development of kidney disease. However, it is unclear if insulin resistance independently contributes to an increased risk...

    Authors: Sarah J. Schrauben, Christopher Jepson, Jesse Y. Hsu, F. Perry Wilson, Xiaoming Zhang, James P. Lash, Bruce M. Robinson, Raymond R. Townsend, Jing Chen, Leon Fogelfeld, Patricia Kao, J. Richard Landis, Daniel J. Rader, L. Lee Hamm, Amanda H. Anderson and Harold I. Feldman

    Citation: BMC Nephrology 2019 20:60

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  11. Content type: Research article

    Risk of cardiac events and cardiovascular disease (CVD) in end-stage renal disease (ESRD) patients are predicted by coronary artery calcification (CAC) independently. It is not clear to what extent low bone mi...

    Authors: Zhimin Chen, Abdul Rashid Qureshi, Torkel B. Brismar, Jonaz Ripsweden, Mathias Haarhaus, Peter Barany, Olof Heimburger, Bengt Lindholm and Peter Stenvinkel

    Citation: BMC Nephrology 2019 20:59

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  12. Content type: Research article

    Intravenous pulse methylprednisolone (MP) is commonly included in the management of severe ANCA associated vasculitis (AAV) despite limited evidence of benefit. We aimed to evaluate outcomes in patients who ha...

    Authors: Dimitrios Chanouzas, Julie Anne G. McGregor, Peter Nightingale, Alan D. Salama, Wladimir M. Szpirt, Neil Basu, Matthew David Morgan, Caroline J. Poulton, Juliana Bordignon Draibe, Elizabeth Krarup, Paula Dospinescu, Jessica Anne Dale, William Franklin Pendergraft, Keegan Lee, Martin Egfjord, Susan L. Hogan…

    Citation: BMC Nephrology 2019 20:58

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  13. Content type: Research article

    Protein-bound uremic toxins are associated with poor outcomes in patients with chronic kidney disease. The aim of this study is to investigate the relationship between indoxyl sulfate (IS), a protein-bound sol...

    Authors: Wenji Wang, Guihua Hao, Yu Pan, Shuai Ma, Tianye Yang, Peng Shi, Qiuyu Zhu, Yingxin Xie, Shaojun Ma, Qi Zhang, Hong Ruan and Feng Ding

    Citation: BMC Nephrology 2019 20:57

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  14. Content type: Research article

    The incidence of Acute Kidney Injury (AKI) continues to increase in the UK, with associated mortality rates remaining significant. Approximately one fifth of hospital admissions are associated with AKI and app...

    Authors: Anastasios Argyropoulos, Stuart Townley, Paul M. Upton, Stephen Dickinson and Adam S. Pollard

    Citation: BMC Nephrology 2019 20:56

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  15. Content type: Research article

    Sarcopenia, defined as low muscle mass and strength, is highly prevalent in patients undergoing chronic hemodialysis (HD). However, muscle function and muscle mass do not share the same clinical relevance. In ...

    Authors: Yu-Li Lin, Shu-Yuan Chen, Yu-Hsien Lai, Chih-Hsien Wang, Chiu-Huang Kuo, Hung-Hsiang Liou and Bang-Gee Hsu

    Citation: BMC Nephrology 2019 20:54

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  16. Content type: Case report

    Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of “Monoclonal gammopathy-related kidney diseases”, and can recur after transplant. Clinic...

    Authors: Jon Von Visger, Clarissa Cassol, Uday Nori, Gerardo Franco-Ahumada, Tibor Nadasdy and Anjali A. Satoskar

    Citation: BMC Nephrology 2019 20:53

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  17. Content type: Research article

    The survival rate for dialysis patients is poor. Previous studies have shown improved survival with home hemodialysis (HHD), but this could be due to patient selection, since HHD patients tend to be younger an...

    Authors: Helena Rydell, Kerstin Ivarsson, Martin Almquist, Mårten Segelmark and Naomi Clyne

    Citation: BMC Nephrology 2019 20:52

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  18. Content type: Research article

    Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased mortality. However, the effect of the severity of an...

    Authors: Amir Schechter, Anat Gafter-Gvili, Daniel Shepshelovich, Ruth Rahamimov, Uzi Gafter, Eytan Mor, Avry Chagnac and Benaya Rozen-Zvi

    Citation: BMC Nephrology 2019 20:51

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  19. Content type: Correction

    Following publication of the original article [1], it was reported that, due to a typesetting mistake, the three tables and two figures for this article were included as an Additional file instead of in the bo...

    Authors: Ziyong Tang, Yue Wang, Liyuan Tao, Yanhong Guo, Yimu Zheng and Danxia Zheng

    Citation: BMC Nephrology 2019 20:50

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    The original article was published in BMC Nephrology 2018 19:357

  20. Content type: Research article

    Magnesium lithospermate B (MLB) can promote renal microcirculation. The aim of the current project was to study whether MLB improves renal hemodynamics, oxygen consumption and subsequently attenuates hypoxia i...

    Authors: Pinglan Lin, Ming Wu, Junyan Qin, Jing Yang, Chaoyang Ye and Chen Wang

    Citation: BMC Nephrology 2019 20:49

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  21. Content type: Research article

    Adherence to the diet prescription for chronic kidney disease is suboptimal. Interventions to improve dietary adherence suggest that improving communication between the patient and the health professional is f...

    Authors: Kelly Lambert, Tsz Kwan Lau, Sarah Davison, Holly Mitchell, Alex Harman and Mandy Carrie

    Citation: BMC Nephrology 2019 20:48

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  22. Content type: Research article

    Volume overload and depletion both lead to high morbidity and mortality. Achieving euvolemia is a challenge in patients with end stage kidney disease on hemodialysis (HD). Blood volume analysis (BVA) uses radi...

    Authors: Line Malha, Hasan Fattah, Frank Modersitzki and David S. Goldfarb

    Citation: BMC Nephrology 2019 20:47

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  23. Content type: Research article

    The magnitude of renal function recovery after kidney donation differs in donors with a heterogeneous background. Preoperative assessment of candidates with potentially unfavorable renal functional compensatio...

    Authors: Kazunobu Shinoda, Shinya Morita, Hirotaka Akita, Satoshi Tamaki, Ryohei Takahashi, Hidaka Kono, Hiroshi Asanuma, Eiji Kikuchi, Masahiro Jinzaki, Ken Nakagawa and Mototsugu Oya

    Citation: BMC Nephrology 2019 20:46

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  24. Content type: Research article

    Nephrotic syndrome (NS) is one of the most frequent occurring chronic kidney diseases in childhood, despite its rarely occurrence in the general population. Detailed information about clinical data of NS (e.g....

    Authors: Ingo Franke, Malik Aydin, Lisa Kurylowicz, Corinna Elke Llamas Lopez, Rainer Ganschow, Michael J. Lentze and Mark Born

    Citation: BMC Nephrology 2019 20:45

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  25. Content type: Research article

    The aim of this study was to assess, the efficacy and safety of add-on corticosteroids to antiretroviral therapy [ART] in patients with biopsy proven HIV associated nephropathy.

    Authors: Nicola Wearne, Charles R. Swanepoel, Maureen S. Duffield, Bianca J. Davidson, Kathryn Manning, Nicki Tiffin, Andrew Boulle, Brian L. Rayner, Priyanka Naidu and Ikechi G. Okpechi

    Citation: BMC Nephrology 2019 20:44

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  26. Content type: Case report

    Thrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignan...

    Authors: Shinya Taguchi, Yoshiki Koshikawa, Shoya Ohyama, Hiroko Miyachi, Hiroaki Ozawa and Hiroaki Asada

    Citation: BMC Nephrology 2019 20:43

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  27. Content type: Research article

    Pruritus is a distressing, life-limiting symptom in chronic renal failure, affecting 40% of patients. This study aimed to determine uremic pruritus prevalence and investigate the multidimensional impact on hem...

    Authors: Nese Altınok Ersoy and İmatullah Akyar

    Citation: BMC Nephrology 2019 20:42

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  28. Content type: Research article

    Cystatin C (Cys C) used clinically for detecting early acute kidney injury (AKI) was reported to be associated with thyroid function. Therefore, whether the performance of Cys C is affected by thyroid hormones...

    Authors: Danqing Zhang, Lu Gao, Heng Ye, Ruibin Chi, Lin Wang, Linhui Hu, Xin Ouyang, Yating Hou, Yujun Deng, Yi Long, Weiping Xiong and Chunbo Chen

    Citation: BMC Nephrology 2019 20:41

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  29. Content type: Research article

    Nephron-sparing surgery (NSS) remains gold standard for the treatment of localised renal cell cancer (RCC), even in case of a normal contralateral kidney. Compared to radical nephrectomy, kidney failure and ca...

    Authors: Jan Ebbing, Felix Menzel, Paolo Frumento, Kurt Miller, Bernhard Ralla, Tom Florian Fuller, Jonas Busch, Justin William Collins, Christofer Adding, Hans Helge Seifert, Peter Ardelt, Christian Wetterauer, Timm Westhoff and Carsten Kempkensteffen

    Citation: BMC Nephrology 2019 20:40

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    The Correction to this article has been published in BMC Nephrology 2019 20:86

  30. Content type: Research article

    The problem of organ shortage is an important issue in kidney transplantation, but the effect of kidney donation on AKI is unclear. The aim of this study was to investigate the impact of acute kidney injury (A...

    Authors: Woo Yeong Park, Min-Seok Choi, Young Soo Kim, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Kyubok Jin, Seungyeup Han and Byung Ha Chung

    Citation: BMC Nephrology 2019 20:39

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  31. Content type: Research article

    Older people with advanced kidney disease require information and support from clinicians when deciding whether to have dialysis or conservative (non-dialysis) care. There is evidence that communication practi...

    Authors: Lucy Ellen Selman, Katherine Bristowe, Irene J. Higginson and Fliss E. M. Murtagh

    Citation: BMC Nephrology 2019 20:38

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  32. Content type: Research article

    Hyperphosphataemia in dialysis subjects is associated with increased mortality. However cause and effect has not been proven, and the ideal phosphate target range is unknown despite KDOQI’s call for studies ov...

    Authors: Ramya Bhargava, Philip A. Kalra, Mark Hann, Paul Brenchley, Helen Hurst and Alastair J. Hutchison

    Citation: BMC Nephrology 2019 20:37

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  33. Content type: Research article

    Only a few prospective trials exist regarding the use of novel direct-acting antiviral agents (DAAs) in kidney transplant recipients (KTR) with chronic hepatitis C virus (HCV) infection.

    Authors: Michael Duerr, Eva V. Schrezenmeier, Lukas J. Lehner, Léon Bergfeld, Petra Glander, Stephan R. Marticorena Garcia, Christian E. Althoff, Ingolf Sack, Susanne Brakemeier, Kai-Uwe Eckardt, Klemens Budde and Fabian Halleck

    Citation: BMC Nephrology 2019 20:36

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  34. Content type: Research article

    Innovative care models such as public-private partnerships (PPPs) may help meet the challenge of providing cost-effective high-quality care for the steadily growing and complex chronic kidney disease populatio...

    Authors: L. A. Pedrini, A. C. Winter, F. Cerino, A. M. Zawada, M. Garbelli, A. Feuersenger, A. Feliciani, P. Ruggiero, S. Civardi, C. Amato, B. Canaud, S. Stuard, A. Karch and A. Gauly

    Citation: BMC Nephrology 2019 20:35

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  35. Content type: Research article

    Globally, there is increased clinical interest and uptake of hemodiafiltration (HDF) for increased removal of uremic toxins. To date, there has been no epidemiological analysis of HDF in China. We present HDF ...

    Authors: Weiming Zhang, Changlin Mei, Nan Chen, Xiaoqiang Ding, Zhaohui Ni, Chuanming Hao, Jinghong Zhang, Jinyuan Zhang, Niansong Wang, Gengru Jiang, Zhiyong Guo, Chen Yu, Yueyi Deng, Haiming Li, Qiang Yao, Mark R. Marshall…

    Citation: BMC Nephrology 2019 20:34

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  36. Content type: Research article

    An increasing amount of evidence has demonstrated an association between an increase in the level of tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) progression. We aimed...

    Authors: Hyung Ah Jo, Seung Seok Han, Sunhwa Lee, Joo Young Kim, Seung Hee Yang, Hajeong Lee, Jae Seok Yang, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Curie Ahn, Jin Suk Han and Dong Ki Kim

    Citation: BMC Nephrology 2019 20:33

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  37. Content type: Research article

    Electronic health records (EHR) detect the onset of acute kidney injury (AKI) in hospitalized patients, and may identify those at highest risk of mortality and renal replacement therapy (RRT), for earlier targ...

    Authors: Sanmay Low, Anantharaman Vathsala, Tanusya Murali Murali, Long Pang, Graeme MacLaren, Wan-Ying Ng, Sabrina Haroon, Amartya Mukhopadhyay, Shir-Lynn Lim, Bee-Hong Tan, Titus Lau and Horng-Ruey Chua

    Citation: BMC Nephrology 2019 20:32

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  38. Content type: Research article

    People with chronic kidney disease (CKD) are at an increased risk of developing hyperkalaemia due to their declining kidney function. In addition, these patients are often required to reduce or discontinue gui...

    Authors: Marc Evans, Eirini Palaka, Hans Furuland, Hayley Bennett, Cecilia Linde, Lei Qin, Phil McEwan and Ameet Bakhai

    Citation: BMC Nephrology 2019 20:31

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  39. Content type: Research article

    Only few studies of living kidney donors have included controls that were similarly healthy, including excellent kidney function.

    Authors: Ayelet Grupper, Yoel Angel, Aharon Baruch, Idit F. Schwartz, Doron Schwartz, Richard Nakache, Yaacov Goykhman, Paulina Katz, Ido Nachmany, Nir Lubezky, Talia Weinstein, Moshe Shashar, Orit Kliuk Ben-Bassat, Shlomo Berliner, Ori Rogowski, David Zeltser…

    Citation: BMC Nephrology 2019 20:30

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  40. Content type: Case report

    Anti-glomerular basement membrane (anti-GBM) disease is characterized by circulating IgG glomerular basement membrane antibodies and is clinically expressed as a rapidly progressive crescentic glomerulonephrit...

    Authors: Barbora Sporinova, Susanna A. McRae, Daniel A. Muruve, Marvin J. Fritzler, Samih H. Nasr, Alex C. Chin and Hallgrimur Benediktsson

    Citation: BMC Nephrology 2019 20:29

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  41. Content type: Research article

    Data on radial access (RA) as an independent risk factor for acute kidney injury (AKI) in myocardial infarction (MI) patients are conflicting. Our aim was to assess how RA influences the incidence of AKI in MI...

    Authors: Vojko Kanic, Gregor Kompara, David Šuran, Alojz Tapajner, Franjo Husam Naji and Andreja Sinkovic

    Citation: BMC Nephrology 2019 20:28

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  42. Content type: Case report

    Hemophagocytic lymphohistiocytosis (HLH) is characterized by excessive activation of the immune system due to infection, autoimmune diseases, or malignancy. As an aggressive and life-threatening clinical syndr...

    Authors: Bixia Gao, Xiaoyu Jia, Jicheng Lv and Jie Dong

    Citation: BMC Nephrology 2019 20:27

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  43. Content type: Research article

    Garlic can be considered as a useful natural herb in inhibition of inflammation. The aim of this study was to assess the effectiveness of garlic extract in lowering inflammatory markers in peritoneal dialysis ...

    Authors: Elham Zare, Amirhesam Alirezaei, Mahmood Bakhtiyari and Asieh Mansouri

    Citation: BMC Nephrology 2019 20:26

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  44. Content type: Case report

    Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy. We present a rare case having a combination of these two diseases, a...

    Authors: Tadasu Kojima, Go Hirose, Shuuhei Komatsu, Taito Oshima, Kentaro Sugisaki, Tomohiro Tomiyasu, Noriko Yoshikawa, Muneharu Yamada and Takashi Oda

    Citation: BMC Nephrology 2019 20:25

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  45. Content type: Research article

    Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes.

    Authors: Silvi Shah, Renganathan Lalgudi Venkatesan, Ayank Gupta, Maitrik K. Sanghavi, Jeffrey Welge, Richard Johansen, Emily B. Kean, Taranpreet Kaur, Anu Gupta, Tiffany J. Grant and Prasoon Verma

    Citation: BMC Nephrology 2019 20:24

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  46. Content type: Case report

    Understanding the uncommon association of IgG4-related disease with other disorders is essential for the accurate diagnosis and effective treatment of patients. To the best of our knowledge, there have been on...

    Authors: Shen-Ju Gou, Lu-Jia Xue and Zhang-Xue Hu

    Citation: BMC Nephrology 2019 20:23

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  47. Content type: Research article

    After two-years of follow-up of 263 apparently healthy 18- to 30-year-old men in communities affected by Mesoamerican nephropathy (MeN), we identified three distinct case groups: a subgroup with (i) establishe...

    Authors: Marvin Gonzalez-Quiroz, Evangelia-Theano Smpokou, Neil Pearce, Ben Caplin and Dorothea Nitsch

    Citation: BMC Nephrology 2019 20:21

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