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  1. Patient activation is associated with better outcomes and lower costs. Although the concept is widely investigated, little attention was given to patient activation and its predictors in patients undergoing he...

    Authors: Liesbet Van Bulck, Kathleen Claes, Katrien Dierickx, Annelies Hellemans, Sofie Jamar, Sven Smets and Gijs Van Pottelbergh
    Citation: BMC Nephrology 2018 19:126
    Content type: Research article Published on:

  2. People with chronic renal disease are insulin resistant. We hypothesized that in a healthy population, baseline renal function is associated with insulin sensitivity three years later.

    Authors: Soline Siméon, Ziad Massy, Kurt Højlund, Katarina Lalic, Francesca Porcellati, Jacqueline Dekker, John Petrie, Gemma Currie and Beverley Balkau
    Citation: BMC Nephrology 2018 19:124
    Content type: Research article Published on:

  3. Epithelioid angiomyolipoma is defined as potentially malignant mesenchymal neoplasm, characterized by proliferating epithelioid cells, whereas classic angiomyolipoma, composed of fat, smooth muscle cells and d...

    Authors: Jan Tuma, Holger Moch, Gerd Stuckmann, Walter Gysel and Andreas L. Serra
    Citation: BMC Nephrology 2018 19:123
    Content type: Case report Published on:

  4. Liddle’s syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome prese...

    Authors: Eriko Yamaguchi, Kazuhiro Yoshikawa, Izaya Nakaya, Karen Kato, Yoshikazu Miyasato, Terumasa Nakagawa, Yutaka Kakizoe, Masashi Mukoyama and Jun Soma
    Citation: BMC Nephrology 2018 19:122
    Content type: Case report Published on:

  5. Inadequate volume control may be a main contributor to poor survival and high mortality in hemodialysis patients. Bioimpedance measurement has the potential to improve fluid management, but several dialysis ce...

    Authors: Jenny Stenberg, Catrin Henriksson, Magnus Lindberg and Hans Furuland
    Citation: BMC Nephrology 2018 19:121
    Content type: Research article Published on:

  6. Podocyte phospholipase A2 receptor (PLA2R) is a major target antigen in idiopathic adult membranous nephropathy (MN). Histological PLA2R staining in the renal tissue has proven to be useful for the detection of i...

    Authors: Kenta Tominaga, Takahiro Uchida, Toshihiko Imakiire, Kenji Itoh, Hideyuki Shimazaki, Kuniaki Nakanishi, Hiroo Kumagai and Naoki Oshima
    Citation: BMC Nephrology 2018 19:120
    Content type: Case report Published on:

  7. Both peritoneal small solute transport and peritoneal protein clearance are closely linked to outcomes in peritoneal dialysis (PD) patients. However, the associated factors of these two components are not full...

    Authors: Yuanyuan Shi, Hao Yan, Jiangzi Yuan, He Zhang, Jiaying Huang, Zhaohui Ni, Jiaqi Qian and Wei Fang
    Citation: BMC Nephrology 2018 19:119
    Content type: Research article Published on:

  9. There are limited data on the associations of circulating angiogenic factors with chronic kidney disease (CKD). We investigate the associations of circulating vascular endothelial growth factor (VEGF)-A, angio...

    Authors: Christopher E. Anderson, L. Lee Hamm, Gem Batuman, Damodar R. Kumbala, Chung-Shiuan Chen, Swapna G. Kallu, Ravi Siriki, Shilpa Gadde, Myra A. Kleinpeter, N. Kevin Krane, Eric E. Simon, Jiang He and Jing Chen
    Citation: BMC Nephrology 2018 19:117
    Content type: Research article Published on:

  10. The magnitude effects of human leukocyte antigen (HLA) mismatching on post-transplant outcomes of kidney transplantation remain controversial. We aim to quantitatively assess the associations of HLA mismatchin...

    Authors: Xinmiao Shi, Jicheng Lv, Wenke Han, Xuhui Zhong, Xinfang Xie, Baige Su and Jie Ding
    Citation: BMC Nephrology 2018 19:116
    Content type: Research article Published on:

  11. Chronic kidney disease of unknown origin (CKDu) in Sri Lanka is grouped with several other epidemics of similar nature across the world as Chronic Interstitial Nephritis in Agricultural Communities (CINAC). In...

    Authors: S. B. Agampodi, G. S. Amarasinghe, P. G. C. R. Naotunna, C. S. Jayasumana and S. H. Siribaddana
    Citation: BMC Nephrology 2018 19:115
    Content type: Research article Published on:

  12. About 40–50% of patients with familial microscopic hematuria (FMH) caused by thin basement membrane nephropathy (TBMN) inherit heterozygous mutations in collagen IV genes (COL4A3, COL4A4). On long follow-up, the ...

    Authors: Konstantinos Voskarides, Gregory Papagregoriou, Despina Hadjipanagi, Ioanelli Petrou, Isavella Savva, Avraam Elia, Yiannis Athanasiou, Androulla Pastelli, Maria Kkolou, Michalis Hadjigavriel, Christoforos Stavrou, Alkis Pierides and Constantinos Deltas
    Citation: BMC Nephrology 2018 19:114
    Content type: Research article Published on:

  13. The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to as...

    Authors: Irene Ruderman, Edward R. Smith, Nigel D. Toussaint, Tim D. Hewitson and Stephen G. Holt
    Citation: BMC Nephrology 2018 19:113
    Content type: Research article Published on:

  14. Although the relationship between hyperparathyroidism and hypertension has been described for decades, the role of hyperparathyroidism in hypertension in dialysis is still unclear. Following the case of a seve...

    Authors: Andreea Corina Sofronie, Isabelle Kooij, Claude Bursot, Giulia Santagati, Jean-Philippe Coindre and Giorgina Barbara Piccoli
    Citation: BMC Nephrology 2018 19:112
    Content type: Case report Published on:

  15. Lipodystrophy syndromes are rare disorders of variable body fat loss associated with potentially serious metabolic complications. Familial partial lipodystrophy (FPLD) is mostly inherited as an autosomal domin...

    Authors: Ru-Xuan Chen, Lei Zhang, Wei Ye, Yu-Bing Wen, Nuo Si, Hang Li, Ming-Xi Li, Xue-Mei Li and Ke Zheng
    Citation: BMC Nephrology 2018 19:111
    Content type: Case report Published on:

  16. The impact of the low-protein diet on nutrition in CKD diabetics is uncertain.

    Authors: Vincenzo Bellizzi, Patrizia Calella, Julia Nava Hernández, Verónica Figueroa González, Silvia Moran Lira, Serena Torraca, Rocio Urbina Arronte, Pietro Cirillo, Roberto Minutolo and Rafael A. Montúfar Cárdenas
    Citation: BMC Nephrology 2018 19:110
    Content type: Research article Published on:

  17. This study aimed to evaluate the longitudinal changes in cardiac structure and function in incident-automated peritoneal dialysis (APD) patients.

    Authors: Jin-Bor Chen, Ben-Chung Cheng, Wen-Hao Liu, Shang-Chih Liao, Mao-Young Morgan Fu, Sin-Hua Moi and Cheng-Hong Yang
    Citation: BMC Nephrology 2018 19:109
    Content type: Research article Published on:

  18. Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway. In most cases, C3 glomerulopa...

    Authors: Shuma Hirashio, Ayaka Satoh, Takahiro Arima, Kouichi Mandai, Tadasuke Awaya, Kumi Oshima, Shigeo Hara and Takao Masaki
    Citation: BMC Nephrology 2018 19:108
    Content type: Case report Published on:

  19. African Americans have persistently poor access to living donor kidney transplants (LDKT). We conducted a small randomized trial to provide preliminary evidence of the effect of informational decision support ...

    Authors: L. Ebony Boulware, Patti L. Ephraim, Jessica Ameling, LaPricia Lewis-Boyer, Hamid Rabb, Raquel C. Greer, Deidra C. Crews, Bernard G. Jaar, Priscilla Auguste, Tanjala S. Purnell, Julio A. Lamprea-Monteleagre, Tope Olufade, Luis Gimenez, Courtney Cook, Tiffany Campbell, Ashley Woodall…
    Citation: BMC Nephrology 2018 19:107
    Content type: Research article Published on:

  20. Monoclonal gammopathy causes several kinds of renal pathology. A rare and special form is monoclonal gammopathy-induced C3 glomerulopathy (MG-C3G). Like idiopathic C3G, MG-C3G frequently leads to end-stage ren...

    Authors: Philipp Moog, Philipp J. Jost and Maike Büttner-Herold
    Citation: BMC Nephrology 2018 19:106
    Content type: Case report Published on:

  21. Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple o...

    Authors: Line Aas Mortensen, Helle C. Thiesson, Birgitte Tougaard, Martin Egfjord, Anne Sophie Lind Fischer and Claus Bistrup
    Citation: BMC Nephrology 2018 19:105
    Content type: Study protocol Published on:

  22. Urinothorax is defined as the presence of urine in the pleural space and is a rather rare cause of transudate pleural effusion. The potential etiologies are urinary tract obstruction and trauma. Diagnosis requ...

    Authors: Tae Won Lee, Ha Nee Jang, Hyun Seop Cho, See Min Choi, Bong-Hoi Choi, Eunjin Bae, Se-Ho Chang and Dong Jun Park
    Citation: BMC Nephrology 2018 19:104
    Content type: Case report Published on:

  23. Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognos...

    Authors: Shihui Fu, Yi Guo, Leiming Luo and Ping Ye
    Citation: BMC Nephrology 2018 19:103
    Content type: Research article Published on:

  24. Acute kidney injury (AKI) is a common post-cardiac surgery complication and influences patient morbidity and prognosis. This study was designed to identify preoperative candidate urine biomarkers in patients u...

    Authors: Michael L. Merchant, Michael E. Brier, Mark S. Slaughter, Jon B. Klein and Kenneth R. McLeish
    Citation: BMC Nephrology 2018 19:102
    Content type: Research article Published on:

  25. We hypothesized that the use of actual body weight might lead to more frequent misdiagnosis of acute kidney injury (AKI) than when ideal body weight is used in underweight and/or obese patients. We examined wh...

    Authors: Shinshu Katayama, Kansuke Koyama, Yuya Goto, Toshitaka Koinuma, Ken Tonai, Jun Shima, Masahiko Wada and Shin Nunomiya
    Citation: BMC Nephrology 2018 19:101
    Content type: Research article Published on:

  27. Health-Related Quality of Life (HRQoL) assessment after kidney transplantation has become an important tool in evaluating outcomes. This study aims to identify the associated factors with HRQoL among a represe...

    Authors: Yosra Mouelhi, Elisabeth Jouve, Marine Alessandrini, Nathalie Pedinielli, Valérie Moal, Aurélie Meurette, Elisabeth Cassuto, Georges Mourad, Antoine Durrbach, Bertrand Dussol and Stéphanie Gentile
    Citation: BMC Nephrology 2018 19:99
    Content type: Research article Published on:

  28. The transition from pre-dialysis chronic kidney disease (CKD) to renal replacement therapy (RRT) is a stressful event. Anxiety, depression and stress are frequent conditions in this population, and might play ...

    Authors: Cicero Italo L. Bezerra, Bruno C. Silva and Rosilene M. Elias
    Citation: BMC Nephrology 2018 19:98
    Content type: Research article Published on:

  29. Following publication of the original article [1], the authors reported that one of the authors’ name is spelled incorrectly. In this Erratum the incorrect and correct author name are shown. The original publi...

    Authors: Iain C. Macdougall, Naomi V. Dahl, Kristine Bernard, Zhu Li, Alka Batycky and William E. Strauss
    Citation: BMC Nephrology 2018 19:97
    Content type: Correction Published on:

    The original article was published in BMC Nephrology 2017 18:117

  30. Research on factors associated with dialysis withdrawal is scarce. This study examined the predictors that might influence rate of dialysis withdrawal. Existing literature is summarized, analyzed and synthesiz...

    Authors: Hammad Ali Qazi, Helen Chen and Meng Zhu
    Citation: BMC Nephrology 2018 19:96
    Content type: Research article Published on:

  31. Increasing evidence has shown that albuminuria is related to serum uric acid. Little is known about whether this association may be interrelated via renal handling of uric acid. Therefore, we aim to study urin...

    Authors: Fengqin Li, Hui Guo, Jianan Zou, Weijun Chen, Yijun Lu, Xiaoli Zhang, Chensheng Fu, Jing Xiao and Zhibin Ye
    Citation: BMC Nephrology 2018 19:95
    Content type: Research article Published on:

  32. Cryptococcosis is an important opportunistic infection of organ transplant recipients. It is the third most common fungal infection of transplant patients and occurs especially in kidney recipients. Cryptococcus ...

    Authors: Albert Z. Muranda, Ludolf Greeff, Mike M. Sathekge, Thabo Lengano and Victor O. L. Karusseit
    Citation: BMC Nephrology 2018 19:94
    Content type: Case report Published on:

  33. Analyzing the relationships between biomarkers representing distinct pathophysiologic pathways and microalbuminuria (MA) can strengthen the identifying ability for renal damage and illuminate previously unreco...

    Authors: Shihui Fu, Yi Guo, Zhao Zhang, Leiming Luo and Ping Ye
    Citation: BMC Nephrology 2018 19:93
    Content type: Research article Published on:

  34. Gabriel Richet, one of the fathers of the French and international Nephrology, was a man remarkable for his courage, vision and empathy. He was proud and brave, and he presented himself proud of being brave. H...

    Authors: Pierre Ronco
    Citation: BMC Nephrology 2018 19:92
    Content type: Editorial Published on:

  35. Acute kidney injury (AKI), as defined by peak increase in serum creatinine, is independently associated with increased risk of mortality and length of stay. Studies have suggested that the duration of AKI may ...

    Authors: Swati Mehta, Kinsuk Chauhan, Achint Patel, Shanti Patel, Rachel Pinotti, Girish N. Nadkarni, Chirag R. Parikh and Steven G. Coca
    Citation: BMC Nephrology 2018 19:91
    Content type: Research article Published on:

  37. Removal of uraemic toxins is inadequate using current dialysis strategies. A new class of dialysis membranes have been developed that allow clearance of larger middle molecules. The REMOVAL-HD study (a tRial E...

    Authors: R. Krishnasamy, C. M. Hawley, M. J. Jardine, M. A. Roberts, Y. J. Cho, M. G. Wong, A. Heath, C. L. Nelson, S. Sen, P. F. Mount, E. M. Pascoe, D. Darssan, L. A. Vergara, P. A. Paul-Brent, N. D. Toussaint, D. W. Johnson…
    Citation: BMC Nephrology 2018 19:89
    Content type: Study protocol Published on:

  38. Genome wide association studies of patients with European descent have identified common variants associated with risk of reduced estimated glomerular filtration rate (eGFR). A panel of eight variants were sel...

    Authors: Cyril Cyrus, Samir Al-Mueilo, Chittibabu Vatte, Shahanas Chathoth, Yun R. Li, Hatem Qutub, Rudaynah Al Ali, Fahad Al-Muhanna, Matthew B. Lanktree, Khaled Riyad Alkharsah, Abdullah Al-Rubaish, Brian Kim-Mozeleski, Brendan Keating and Amein Al Ali
    Citation: BMC Nephrology 2018 19:88
    Content type: Research article Published on:

  39. Beta Trace Protein (BTP) is a promising marker of glomerular filtration rate (GFR). Equations to estimate GFR using BTP have been proposed. Very little is known about BTP’s production and metabolism. It has be...

    Authors: Debarati Chakraborty, Ayub Akbari, Greg A. Knoll, Jennifer A. Flemming, Catherine Lowe, Shareef Akbari and Christine A. White
    Citation: BMC Nephrology 2018 19:87
    Content type: Research article Published on:

  40. Donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) can be preformed or de novo (dn). Strategies to manage preformed DSA are well described, but data on the management and outcomes of dnDSA are lac...

    Authors: Yassine Bouatou, Olivia Seyde, Solange Moll, Pierre-Yves Martin, Jean Villard, Sylvie Ferrari-Lacraz and Karine Hadaya
    Citation: BMC Nephrology 2018 19:86
    Content type: Research article Published on:

  41. Accurately identifying cases of chronic kidney disease (CKD) from primary care data facilitates the management of patients, and is vital for surveillance and research purposes. Ontologies provide a systematic ...

    Authors: Nicholas I. Cole, Harshana Liyanage, Rebecca J. Suckling, Pauline A. Swift, Hugh Gallagher, Rachel Byford, John Williams, Shankar Kumar and Simon de Lusignan
    Citation: BMC Nephrology 2018 19:85
    Content type: Research article Published on:

  42. The poorly differentiated renal cell carcinoma (RCC) with rhabdomyosarcomatous sarcomatoid differentiation shows a severely aggressive biological behavior characterized by rapid disease progression. Preoperati...

    Authors: Xiang Liang, Yupin Liu, Pengcheng Ran, Meili Tang, Changlei Xu and Yazhen Zhu
    Citation: BMC Nephrology 2018 19:84
    Content type: Case report Published on:

  43. Over the last years, living kidney donation (LKD) has been established for patients with endstage renal failure as an alternative to post mortem donation, which is limited by organ scarcity and long lasting wa...

    Authors: Barbara Suwelack, Viktoriya Wörmann, Klaus Berger, Joachim Gerß, Heiner Wolters, Frank Vitinius and Markus Burgmer
    Citation: BMC Nephrology 2018 19:83
    Content type: Study protocol Published on:

  44. C1q nephropathy (C1qN) was first described as glomerular disease characterized by predominant meangial C1q deposits in patients with proteinuria and no evidence of systemic lupus erythematosus. Several studies...

    Authors: Takahiro Kanai, Yuko Akioka, Kenichiro Miura, Masataka Hisano, Junki Koike, Yutaka Yamaguchi and Motoshi Hattori
    Citation: BMC Nephrology 2018 19:82
    Content type: Research article Published on:

  45. Nephrotic syndrome (NS) is characterized by dyslipidemia which is a well-known risk factor for atherogenesis. Atherosclerosis in childhood is mostly subclinical and endothelial dysfunction is known to precede ...

    Authors: S. K. Patnaik, P. Kumar, M. Bamal, S. Patel, M. P. Yadav, V. Kumar, A. Sinha, A. Bagga and M. Kanitkar
    Citation: BMC Nephrology 2018 19:81
    Content type: Study protocol Published on:

  46. Aortic stenosis (AS) is common in patients on dialysis as well as in the general population. AS leads to difficulty with dialysis therapy because of unstable conditions such as intradialytic hypotension due to...

    Authors: Daijo Inaguma, Yuji Sasakawa, Noriko Suzuki, Eri Ito, Kazuo Takahashi, Hiroki Hayashi, Shigehisa Koide, Midori Hasegawa and Yukio Yuzawa
    Citation: BMC Nephrology 2018 19:80
    Content type: Study protocol Published on:

  47. The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficie...

    Authors: Ming Wen, Claudius Küchle, Dominik Steubl, Robin Satanovskji, Uwe Heemann, Yana Suttmann, Susanne Angermann, Stephan Kemmner, Lisa Rehbehn, Monika Huber, Christine Hauser, Christoph Schmaderer, Anna-Lena Reichelt, Bernhard Haller and Lutz Renders
    Citation: BMC Nephrology 2018 19:79
    Content type: Research article Published on:

  48. Chronic kidney disease (CKD) is characterized by sustained tissue damage and ongoing tubulo-interstitial inflammation and fibrosis. Pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and...

    Authors: Ingrid Stroo, Diba Emal, Loes M. Butter, Gwen J. Teske, Nike Claessen, Mark C. Dessing, Stephen E. Girardin, Sandrine Florquin and Jaklien C. Leemans
    Citation: BMC Nephrology 2018 19:78
    Content type: Research article Published on:

  49. Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides. However, the best treatment strategy remains a matter of debate. In the last 14 years, we observed a significant i...

    Authors: Andrea Angioi, Gianfranca Cabiddu, Maura Conti, Gianfranco Pili, Alice Atzeni, Valeria Matta, Riccardo Cao, Matteo Floris, Marco Songini, Maria Franca Mulas, Mitchell Rosner and Antonello Pani
    Citation: BMC Nephrology 2018 19:77
    Content type: Research article Published on:

  50. Insufficient vigilance for renal insufficiency is associated with late referral, increased morbidity and mortality. The present study examines whether increased vigilance for chronic kidney disease (CKD) leads...

    Authors: M. De Wilde, M. Speeckaert and W. Van Biesen
    Citation: BMC Nephrology 2018 19:74
    Content type: Research article Published on:
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