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  1. Small non-coding RNA molecules (miRNAs) play a pivotal role in regulating gene expression in development. miRNAs regulate key processes at the cellular level and thereby influence organismal and tissue develop...

    Authors: Malte P Bartram, Claudia Dafinger, Sandra Habbig, Thomas Benzing, Bernhard Schermer and Roman-Ulrich Müller
    Citation: BMC Nephrology 2015 16:55
    Content type: Research article Published on:

  2. The last decade has witnessed considerable improvement in dialysis technology and changes in clinical management of patients in peritoneal dialysis (PD) with a significant impact on long term clinical outcomes...

    Authors: Gianluigi Zaza, Carlo Rugiu, Alessandra Trubian, Simona Granata, Albino Poli and Antonio Lupo
    Citation: BMC Nephrology 2015 16:53
    Content type: Research article Published on:

  3. People with kidney failure are often deficient in zinc and selenium, but little is known about the optimal way to correct such deficiency.

    Authors: Marcello Tonelli, Natasha Wiebe, Stephanie Thompson, David Kinniburgh, Scott W Klarenbach, Michael Walsh, Aminu K Bello, Labib Faruque, Catherine Field, Braden J Manns and Brenda R Hemmelgarn
    Citation: BMC Nephrology 2015 16:52
    Content type: Research article Published on:

  4. Hyperlipidemia is thought to be a major risk factor for the progression of renal diseases in diabetes. Recent studies have shown that lipid profiles are commonly abnormal early on type 2 diabetes mellitus (T2D...

    Authors: Liang He, Lili Hao, Xin Fu, Mingshu Huang and Rui Li
    Citation: BMC Nephrology 2015 16:51
    Content type: Research article Published on:

  5. In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that a...

    Authors: Renata P Assis, Juliana FA Castro, Vânia O Gutierres, Carlos A Arcaro, Renata S Brotto, Olga MMF Oliveira, Amanda M Baviera and Iguatemy L Brunetti
    Citation: BMC Nephrology 2015 16:50
    Content type: Research article Published on:

  6. Disparities in access to kidney transplantation (KT) remain inadequately understood and addressed. Detailed descriptions of patient attitudes may provide insight into mechanisms of disparity. The aims of this ...

    Authors: Megan L Salter, Komal Kumar, Andrew H Law, Natasha Gupta, Kathryn Marks, Kamna Balhara, Mara A McAdams-DeMarco, Laura A Taylor and Dorry L Segev
    Citation: BMC Nephrology 2015 16:49
    Content type: Research article Published on:

  7. Peritoneal fibrosis is a common complication in patients treated with long-term peritoneal dialysis. The aim of this study was to identify the microRNAs (miRNAs) involved in regulation of peritoneal fibrosis i...

    Authors: Fan Lin, Xu Wu, Huidi Zhang, Xiaohan You, Zhoucang Zhang, Rongrong Shao and Chaoxing Huang
    Citation: BMC Nephrology 2015 16:48
    Content type: Research article Published on:

  8. Uremic pruritus is a common and deleterious condition among hemodialysis (HD) patients. Central gating of μ/κ opiate circuitry plays an important role in mediating and countering pruritogenic sensation. The ob...

    Authors: Amale Hawi, Harry Alcorn Jr, Jolene Berg, Carey Hines, Howard Hait and Thomas Sciascia
    Citation: BMC Nephrology 2015 16:47
    Content type: Research article Published on:

  9. Urinary density (UD) has been routinely used for decades as a surrogate marker for urine osmolality (Uosm). We asked if UD can accurately estimate Uosm both in healthy subjects and in different clinical scenarios...

    Authors: Ana Carolina P Souza, Roberto Zatz, Rodrigo B de Oliveira, Mirela A R Santinho, Marcia Ribalta, João E Romão Jr and Rosilene M Elias
    Citation: BMC Nephrology 2015 16:46
    Content type: Research article Published on:

  10. We examined whether renal resistive index (RI), a simple index of renal vascular resistance, is associated with the presence and severity of anemia, and can predict the future development of anemia in patients...

    Authors: Muneyoshi Tanimura, Kaoru Dohi, Masumi Matsuda, Yuichi Sato, Emiyo Sugiura, Naoto Kumagai, Shiro Nakamori, Tomomi Yamada, Naoki Fujimoto, Takashi Tanigawa, Norikazu Yamada, Mashio Nakamura and Masaaki Ito
    Citation: BMC Nephrology 2015 16:45
    Content type: Research article Published on:

  11. Diabetic nephropathy (DN) is a major cause of Chronic Kidney Disease and End-Stage Renal Disease throughout the world; however, the reversibility of diabetic nephropathy remains controversial. Endoplasmic reti...

    Authors: Zeng Si Wang, Fei Xiong, Xiao Hang Xie, Dan Chen, Jian Hua Pan and Li Cheng
    Citation: BMC Nephrology 2015 16:44
    Content type: Research article Published on:

  12. Screening for renal diseases should be performed at the time of diagnosis of human immunodeficiency virus (HIV) infection. Despite the high prevalence of HIV/AIDS in Northern Uganda, little is known about the ...

    Authors: Pancras Odongo, Ronald Wanyama, James Henry Obol, Paska Apiyo and Pauline Byakika-Kibwika
    Citation: BMC Nephrology 2015 16:43
    Content type: Research article Published on:

  13. Reducing dietary sodium has potential to benefit patients with chronic kidney disease (CKD). Little research is available defining dietary sodium knowledge gaps in patients with pre-dialysis CKD. We designed a...

    Authors: Julie A Wright Nunes, Cheryl A M Anderson, Jane H Greene, Talat Alp Ikizler and Kerri L Cavanaugh
    Citation: BMC Nephrology 2015 16:42
    Content type: Research article Published on:

  14. Cinacalcet reduces parathyroid hormone (PTH) levels in patients receiving hemodialysis, but no non-experimental studies have evaluated the association between changes in PTH levels following cinacalcet initiat...

    Authors: Wendy L St. Peter, Akeem A Yusuf, Thy Do, Kimberly A Lowe, Jiannong Liu, Kimberly M Nieman, Brian D Bradbury and Allan J Collins
    Citation: BMC Nephrology 2015 16:41
    Content type: Research article Published on:

  15. Glomerulonephritis is one of the most severe complications of lupus, a systemic disease with multi-organ involvement, with tissue damage produced mainly by complement activation. As a result of this activation...

    Authors: Pilar Nozal, Sofía Garrido, Jorge Martínez-Ara, María Luz Picazo, Laura Yébenes, Rita Álvarez-Doforno, Sheila Pinto, Santiago Rodríguez de Córdoba and Margarita López-Trascasa
    Citation: BMC Nephrology 2015 16:40
    Content type: Case report Published on:

  16. Patients with end-stage renal disease (ESRD) due to lupus nephritis (LN-ESRD) may be followed by multiple providers (nephrologists and rheumatologists) and have greater opportunities to receive recommended ESR...

    Authors: Laura C Plantinga, Rachel E Patzer, Cristina Drenkard, Stephen O Pastan, Jason Cobb, William McClellan and Sung Sam Lim
    Citation: BMC Nephrology 2015 16:39
    Content type: Research article Published on:

  17. Podocyte detachment and apoptosis are two risk factors causing podocyte loss, F-actin rearrangement is involved in detachment and apoptosis. However, the nature of events that promote detachment and apoptosis ...

    Authors: Rufeng Dai, Yi Lin, Haimei Liu, Jia Rao, Yihui Zhai, Xiliang Zha, Xiaoyan Fang and Hong Xu
    Citation: BMC Nephrology 2015 16:38
    Content type: Research article Published on:

  18. Early preparation for renal replacement therapy (RRT) is recommended for patients with advanced chronic kidney disease (CKD), yet many patients initiate RRT urgently and/or are inadequately prepared.

    Authors: Raquel C Greer, Jessica M Ameling, Kerri L Cavanaugh, Bernard G Jaar, Vanessa Grubbs, Carrie E Andrews, Patti Ephraim, Neil R Powe, Julia Lewis, Ebele Umeukeje, Luis Gimenez, Sam James and L Ebony Boulware
    Citation: BMC Nephrology 2015 16:37
    Content type: Research article Published on:

  19. Symptom burden in chronic kidney disease (CKD) is poorly understood. To date, the majority of research focuses on single symptoms and there is a lack of suitable multidimensional symptom measures. The purpose ...

    Authors: Hayfa Almutary, Ann Bonner and Clint Douglas
    Citation: BMC Nephrology 2015 16:36
    Content type: Research article Published on:

  20. Recent studies suggest a causal role for increased plasma uric acid in the progression of chronic renal insufficiency (CRI). However, uric acid also functions as an antioxidant with possible beneficial effects.

    Authors: Venla Kurra, Tuija Vehmas, Arttu Eräranta, Jarkko Jokihaara, Päivi Pirttiniemi, Heikki Ruskoaho, Heikki Tokola, Onni Niemelä, Jukka Mustonen and Ilkka Pörsti
    Citation: BMC Nephrology 2015 16:35
    Content type: Research article Published on:

  21. It is unknown whether variability of estimated Glomerular Filtration Rate (eGFR) is a risk factor for dialysis or death in patients with chronic kidney disease (CKD). This study aimed to evaluate variability o...

    Authors: Chin-Lin Tseng, Jean-Philippe Lafrance, Shou-En Lu, Orysya Soroka, Donald R Miller, Miriam Maney and Leonard M Pogach
    Citation: BMC Nephrology 2015 16:34
    Content type: Research article Published on:

  22. Socioeconomic characteristics may affect the outcomes of patients treated with peritoneal dialysis (PD). There are two major medical insurances in China: the New Cooperative Medical Scheme (NCMS), mainly for r...

    Authors: Zengsi Wang, Yanmin Zhang, Fei Xiong, Hongbo Li, Yanqiong Ding, Yihua Gao, Li Zhao and Sheng Wan
    Citation: BMC Nephrology 2015 16:33
    Content type: Research article Published on:

  23. The usage of nursing home (NH) services is a marker of frailty among older adults. Although the Centers for Medicare & Medicaid Services (CMS) revised the Medical Evidence Report Form CMS-2728 in 2005 to inclu...

    Authors: C Barrett Bowling, Rebecca Zhang, Harold Franch, Yijian Huang, Anna Mirk, William M McClellan, Theodore M Johnson II and Nancy G Kutner
    Citation: BMC Nephrology 2015 16:32
    Content type: Research article Published on:

  24. Patient registries have great potential for providing data that describe disease burden, treatments, and outcomes; which can be used to improve patient care. Many renal registries exist, but a central reposito...

    Authors: Frank Xiaoqing Liu, Peter Rutherford, Karen Smoyer-Tomic, Sarah Prichard and Suzanne Laplante
    Citation: BMC Nephrology 2015 16:31
    Content type: Research article Published on:

  25. Acute kidney injury (AKI) is common among intensive care unit (ICU) patients and is associated with high mortality. Type of ICU, category of admission diagnosis, and socioeconomic characteristics of the region...

    Authors: Paulo Roberto Santos and Diego Levi Silveira Monteiro
    Citation: BMC Nephrology 2015 16:30
    Content type: Research article Published on:

  26. Understanding the regulation of mineral homeostasis and function of the skeleton as buffer for Calcium and Phosphate has regained new interest with introduction of the syndrome “Chronic Kidney Disease-Mineral ...

    Authors: Anders Nordholm, Maria L Mace, Eva Gravesen, Klaus Olgaard and Ewa Lewin
    Citation: BMC Nephrology 2015 16:29
    Content type: Research article Published on:

  27. Women with chronic kidney disease have an increased risk of maternal and fetal complications in pregnancy. Pre-pregnancy counselling is recommended but the format of the counselling process and the experience ...

    Authors: Kate S Wiles, Kate Bramham, Alina Vais, Kate R Harding, Paramit Chowdhury, Cath J Taylor and Catherine Nelson-Piercy
    Citation: BMC Nephrology 2015 16:28
    Content type: Research article Published on:

  28. The TNF-like weak inducer of apoptosis (TWEAK) contributes to kidney inflammation producing secretion by renal cells. The present study examined whether the level of TWEAK is associated with histologic finding...

    Authors: Yohei Sasaki, Yoshio Shimizu, Yusuke Suzuki, Satoshi Horikoshi and Yasuhiko Tomino
    Citation: BMC Nephrology 2015 16:27
    Content type: Research article Published on:

  29. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common form of Polycystic Kidney Disease (PKD) and occurs at a frequency of 1/800 to 1/1000 affecting all ethnic groups worldwide. ADPKD shows s...

    Authors: Hamad Ali, Naser Hussain, Medhat Naim, Mohamed Zayed, Fahd Al-Mulla, Elijah O Kehinde, Lauren M Seaburg, Jamie L Sundsbak and Peter C Harris
    Citation: BMC Nephrology 2015 16:26
    Content type: Research article Published on:

  30. Cool dialysate is often recommended for prevention of intra-dialytic hypotensive episodes in maintenance hemodialysis (HD) patients. However, its effect on toxin removal is not studied. It is known that inter-...

    Authors: Vaibhav Maheshwari, Titus Lau, Lakshminarayanan Samavedham and Gade P Rangaiah
    Citation: BMC Nephrology 2015 16:25
    Content type: Study protocol Published on:

  31. Acute kidney injury (AKI) is associated with poor outcome in critically ill children. While data extracted from retrospective study of pediatric populations demonstrate a high incidence of AKI, the literature ...

    Authors: Rajit K Basu, Ahmad Kaddourah, Tara Terrell, Theresa Mottes, Patricia Arnold, Judd Jacobs, Jennifer Andringa and Stuart L Goldstein
    Citation: BMC Nephrology 2015 16:24
    Content type: Study protocol Published on:

  32. The outcome of kidney allograft transplantation is associated with numerous donor-dependent and recipient-dependent immunological and non-immunological factors. Studies on genetic factors affecting the non-imm...

    Authors: Leszek Domański, Karolina Kłoda, Ewa Kwiatkowska, Ewa Borowiecka, Krzysztof Safranow, Arleta Drozd, Andrzej Ciechanowicz and Kazimierz Ciechanowski
    Citation: BMC Nephrology 2015 16:23
    Content type: Research article Published on:

  33. Autosomal recessive polycystic kidney disease (ARPKD) is a rare but frequently severe disorder that is typically characterized by cystic kidneys and congenital hepatic fibrosis but displays pronounced phenotyp...

    Authors: Kathrin Ebner, Markus Feldkoetter, Gema Ariceta, Carsten Bergmann, Reinhard Buettner, Anke Doyon, Ali Duzova, Heike Goebel, Dieter Haffner, Barbara Hero, Bernd Hoppe, Thomas Illig, Augustina Jankauskiene, Norman Klopp, Jens König, Mieczyslaw Litwin…
    Citation: BMC Nephrology 2015 16:22
    Content type: Study protocol Published on:

  34. The first aim of the study was to investigate the accuracy and intra-laboratory variation of serum creatinine measurements in clinical laboratories in Flanders. The second purpose was to check the effect of th...

    Authors: Liesbeth Hoste, Kathleen Deiteren, Hans Pottel, Nico Callewaert and Frank Martens
    Citation: BMC Nephrology 2015 16:21
    Content type: Research article Published on:

  35. Increasing dialysate flow rates (Qd) from 500 to 800 ml/min has been recommended to increase dialysis efficiency. A few publications show that increasing Qd no longer led to an increase in mass transfer area c...

    Authors: Marta Albalate, Rafael Pérez-García, Patricia de Sequera, Elena Corchete, Roberto Alcazar, Mayra Ortega and Marta Puerta
    Citation: BMC Nephrology 2015 16:20
    Content type: Research article Published on:

  36. Kidney injury molecule-1 (KIM-1) is expressed in tubular epithelial cells after injury and may have a role in the development of renal graft fibrosis. In this study we evaluated the molecular and protein expre...

    Authors: Aline Lima Nogare, Francisco Veríssimo Veronese, Virna Nowotny Carpio, Rosangela Munhoz Montenegro, José Alberto Pedroso, Karla Laís Pegas, Luiz Felipe Gonçalves and Roberto Ceratti Manfro
    Citation: BMC Nephrology 2015 16:19
    Content type: Research article Published on:

  37. The role of neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic marker for acute kidney injury (AKI) in sepsis is still debated. We hypothesized that in sepsis, the performance of serum(s) and ur...

    Authors: Jill Vanmassenhove, Griet Glorieux, Norbert Lameire, Eric Hoste, Annemieke Dhondt, Raymond Vanholder and Wim Van Biesen
    Citation: BMC Nephrology 2015 16:18
    Content type: Research article Published on:

  38. Recent studies have reported an association between periodontal disease and mortality among dialysis patients. Therefore, preventive dental care should be considered very important for this population. In Japa...

    Authors: Masami Yoshioka, Yasuhiko Shirayama, Issei Imoto, Daisuke Hinode, Shizuko Yanagisawa and Yuko Takeuchi
    Citation: BMC Nephrology 2015 16:17
    Content type: Research article Published on:

  39. Irisin, an exercise induced myokine, has broad implications for metabolism and energy homeostasis. Available evidence about the association of serum irisin with chronic kidney disease (CKD) is limited.

    Authors: Shuyu Yang, Fangsen Xiao, Lingling Pan, Huijie Zhang, Zhimin Ma, Suhuan Liu, Yongwen Liu, Wei Zhang, Xin Zeng, Changqin Liu, Xiaoying Li, Xuejun Li and Zhibin Li
    Citation: BMC Nephrology 2015 16:16
    Content type: Research article Published on:

  40. Nephrotoxicity due to drugs especially beta lactams and cephalosporins has been well recognised. Cefepime is a fourth-generation cephalosporin that is widely prescribed with few severe adverse reactions report...

    Authors: Kathy Mac, Ruchir Chavada, Sharon Paull, Kenneth Howlin and Jeffrey Wong
    Citation: BMC Nephrology 2015 16:15
    Content type: Case report Published on:

  41. The degree to which genetic or environmental factors are associated with early kidney damage among African Americans (AAs) is unknown.

    Authors: Ruth Tamrat, Carmen A Peralta, Salman M Tajuddin, Michele K Evans, Alan B Zonderman and Deidra C Crews
    Citation: BMC Nephrology 2015 16:14
    Content type: Research article Published on:

  42. Polycystic kidney disease (PKD), a genetic disorder characterized by multiple cysts and renal failure at an early age. In children, kidney disease is often accompanied by disordered mineral metabolism, failure...

    Authors: Kaitlin H Maditz, Brenda J Smith, Matthew Miller, Chris Oldaker and Janet C Tou
    Citation: BMC Nephrology 2015 16:13
    Content type: Research article Published on:

  43. Haemodialysis patients are at increased risk of exposure to blood borne viruses. To reduce transmission in the UK, all haemodialysis patients are regularly screened, and if susceptible to Hepatitis B virus (HB...

    Authors: Luciana Sowole, Wendy Labbett, Mauli Patel, Aisling O’Riordan, Jennifer Cross, Andrew Davenport and Tanzina Haque
    Citation: BMC Nephrology 2015 16:12
    Content type: Research article Published on:

  44. Mortality rate among patients with stage five chronic kidney disease (CKD) maintained on hemodialysis (HD) is high. Although evidence suggests that use of Vitamin D Receptor Activators (VDRA) in CKD patients i...

    Authors: Piergiorgio Messa, Mario Cozzolino, Diego Brancaccio, Giuseppe Cannella, Fabio Malberti, Anna Maria Costanzo, Umberto di Luzio Paparatti, Vincenzo Festa, Giuliana Gualberti and Sandro Mazzaferro
    Citation: BMC Nephrology 2015 16:11
    Content type: Research article Published on:

  45. Kimura's disease (KD) is a slowly progressing rare, benign inflammatory disorder of the soft tissues. It typically presents as subcutaneous tumor-like nodules, located most frequently in the head and neck regi...

    Authors: Sheng-lang Zhu, Peng-fei Wei, Jie-hui Chen, Zhen-fu Zhao, Qian-na Xu and Ling Ye
    Citation: BMC Nephrology 2015 16:10
    Content type: Case report Published on:

  46. Variants in CUBN, the gene encoding cubilin, a proximal tubular transport protein, have been associated with albuminuria and vitamin B12 (B12) deficiency. We hypothesized that low levels of B12 would be associate...

    Authors: Gearoid M McMahon, Shih-Jen Hwang, Rikki M Tanner, Paul F Jacques, Jacob Selhub, Paul Muntner and Caroline S Fox
    Citation: BMC Nephrology 2015 16:7
    Content type: Research article Published on:

  47. Numerous well-established clinical parameters are taken into consideration for the follow-up adaptation of kidney transplant recipients, but there are important disparities between countries, centres and clini...

    Authors: Yohann Foucher, Aurélie Meurette, Pascal Daguin, Angélique Bonnaud-Antignac, Jean-Benoît Hardouin, Sabrina Chailan, Karine Neau, Emmanuelle Papuchon, Sandra Gaboriau, Christophe Legendre, Emmanuel Morélon, Philippe Tessier and Magali Giral
    Citation: BMC Nephrology 2015 16:6
    Content type: Study protocol Published on:

  48. Urinary albumin can be measured in 24 h or spot samples. The 24 h urinary albumin excretion rate is considered the gold standard, but is cumbersome to collect. Instead, often an overnight sample is collected, ...

    Authors: Peter Fagerstrom, Gerd Sallsten, Magnus Akerstrom, Borje Haraldsson and Lars Barregard
    Citation: BMC Nephrology 2015 16:8
    Content type: Research article Published on:

  50. Phosphorus retention plays a pivotal role in the onset of mineral and bone disorders (MBD) in chronic kidney disease (CKD). Phosphorus retention commonly occurs as a result of net intestinal absorption exceedi...

    Authors: Claudia D’Alessandro, Giorgina B Piccoli and Adamasco Cupisti
    Citation: BMC Nephrology 2015 16:9
    Content type: Correspondence Published on:
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BMC Nephrology

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