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  1. ADPKD affects approximately 1:1000 of the worldwide population. It is caused by mutations in two genes, PKD1 and PKD2. Although allelic variation has some influence on disease severity, genic effects are strong, ...

    Authors: Caroline Robinson, Thomas F Hiemstra, Deborah Spencer, Sarah Waller, Laura Daboo, Fiona E Karet Frankl and Richard N Sandford
    Citation: BMC Nephrology 2012 13:79
    Content type: Research article Published on:

  2. This study tests the hypotheses that health-related quality of life (HRQOL) in prevalent dialysis patients with diabetes is lower than in dialysis patients without diabetes, and is at least as poor as diabetic...

    Authors: Tone Britt Hortemo Østhus, Nanna von der Lippe, Lis Ribu, Tone Rustøen, Torbjørn Leivestad, Toril Dammen and Ingrid Os
    Citation: BMC Nephrology 2012 13:78
    Content type: Research article Published on:

  3. The worldwide increasing trend of chronic kidney disease (CKD) is of great concern and the role of heart disease deserves longitudinal studies. This study investigated the risk of developing CKD among patients...

    Authors: Jiung-Hsiun Liu, Shih-Yi Lin, Chung-Yi Hsu, Hsin-Hung Lin, Chih-Chia Liang, Fung-Chang Sung and Chiu-Ching Huang
    Citation: BMC Nephrology 2012 13:77
    Content type: Research article Published on:

  4. Elevated serum phosphorus (P) levels have been linked to increased morbidity and mortality in dialysis patients with secondary hyperparathyroidism (SHPT) but may be difficult to control if parathyroid hormone ...

    Authors: João M Frazão, Johann Braun, Piergiorgio Messa, Bastian Dehmel, Caroline Mattin and Martin Wilkie
    Citation: BMC Nephrology 2012 13:76
    Content type: Research article Published on:

  5. The interleukin (IL)18 rs360719 CC genotype is associated with the development of antibodies to hepatitis B virus surface antigen (anti-HBs) in hemodialysis (HD) patients. IL18 shares biological properties with I...

    Authors: Alicja E Grzegorzewska, Piotr M Wobszal, Adrianna Mostowska and Paweł P Jagodziński
    Citation: BMC Nephrology 2012 13:75
    Content type: Research article Published on:

  6. Systematic reviews comparing the effectiveness of strategies to prevent, detect, and treat chronic kidney disease are needed to inform patient care. We engaged stakeholders in the chronic kidney disease commun...

    Authors: Deidra C Crews, Raquel C Greer, Jeffrey J Fadrowski, Michael J Choi, David Doggett, Jodi B Segal, Kemi A Fawole, Pammie R Crawford and L Ebony Boulware
    Citation: BMC Nephrology 2012 13:74
    Content type: Correspondence Published on:

  7. Fabry disease is an X-linked lysosomal storage disorder that results from a deficiency of the enzyme α-galactosidase A. Fabry disease is present in 4–5% of men with unexplained left ventricular hypertrophy or ...

    Authors: James O Burton, John P Dormer, Helen E Binns and Warren P Pickering
    Citation: BMC Nephrology 2012 13:73
    Content type: Case report Published on:

  8. Central venous catheters (CVCs) are associated with early mortality in dialysis patients. However, some patients progress to end stage renal disease after an acute illness, prior to reaching an estimated glome...

    Authors: Karthik K Tennankore, Steven D Soroka and Bryce A Kiberd
    Citation: BMC Nephrology 2012 13:72
    Content type: Research article Published on:

  11. Peritoneal dialysis has been proven to be a safe and effective mode of renal replacement therapy for patients with end-stage renal disease. The usage of laparoscopic catheter placement technique was increased ...

    Authors: Haiying Xie, Wei Zhang, Jun Cheng and Qiang He
    Citation: BMC Nephrology 2012 13:69
    Content type: Research article Published on:

  12. This multicenter phase II study in renal transplantation compared 3 concentration-controlled ranges of FK778 (manitimus) with mycophenolate mofetil (MMF) both given in combination with tacrolimus and corticost...

    Authors: Zbigniew Wlodarczyk, Yves Vanrenterghem, Bernhard K Krämer, Jean-Paul Squifflet and Marek Ostrowski
    Citation: BMC Nephrology 2012 13:68
    Content type: Research article Published on:

  13. Sexual dysfunction is common in patients with end stage renal disease (ESRD) and treatment options are limited. Observational studies suggest that nocturnal hemodialysis may improve sexual function. We compare...

    Authors: Adam Bass, Sofia B Ahmed, Scott Klarenbach, Bruce Culleton, Brenda R Hemmelgarn and Braden Manns
    Citation: BMC Nephrology 2012 13:67
    Content type: Research article Published on:

  14. Medullary nephrocalcinosis and distal renal tubular acidosis are closely associated and each can lead to the other. These clinical entities are rare in patients with nephrotic syndrome and polycythaemia is an ...

    Authors: Suneth Karunarathne, Yapa Udayakumara, Dumitha Govindapala and Harshini Fernando
    Citation: BMC Nephrology 2012 13:66
    Content type: Case report Published on:

  16. Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy are rare diseases with no known coherence.

    Authors: Thomas Idorn, Lone Schejbel, Casper Rydahl, James Goya Heaf, Karen Riis Jølvig, Marie Bergstrøm, Peter Garred and Anne-Lise Kamper
    Citation: BMC Nephrology 2012 13:64
    Content type: Case report Published on:

  17. Simple renal cysts usually have benign clinical features. We report a rare case of papillary renal cell carcinoma (RCC) associated with a large recurrent simple cyst following sclerotherapy.

    Authors: Yasuhiro Hashimoto, Atsushi Imai, Noriko Tokui, Atsushi Sasaki, Hisao Saitoh, Takuya Koie and Chikara Ohyama
    Citation: BMC Nephrology 2012 13:63
    Content type: Case report Published on:

  18. Living donor kidney transplantation (LDKT) is the most successful form of renal replacement therapy in terms of wait time and survival rates. However, we observed a significant inequality in the number of LDKT...

    Authors: Sohal Y Ismail, Annemarie E Luchtenburg, Willij C Zuidema, Charlotte Boonstra, Willem Weimar, Emma K Massey and Jan J Busschbach
    Citation: BMC Nephrology 2012 13:62
    Content type: Study protocol Published on:

  19. The genetic architecture responsible for chronic kidney disease (CKD) remains incompletely described. The Oligosyndactyly (Os) mouse models focal and segmental glomerulosclerosis (FSGS), which is associated with ...

    Authors: Ashraf El-Meanawy, Jeffery R Schelling, Sudha K Iyengar, Patrick Hayden, Shrinath Barathan, Katrina Goddard, Fatima Pozuelo, Essam Elashi, Viji Nair, Matthias Kretzler and John R Sedor
    Citation: BMC Nephrology 2012 13:61
    Content type: Research article Published on:

  20. Predialysis hemoglobin (Hb) may overestimate the true erithropoiesis-stimulating agents (ESA) requeriments. We tested whether predialysis Hb is a reliable predictor of the postdialysis level to better control ...

    Authors: Nieves Castillo, Patricia García-García, Antonio Rivero, Alejandro Jiménez-Sosa, Manuel Macía, María Adela Getino, María Luisa Méndez, Javier García-Pérez and Juan F Navarro-González
    Citation: BMC Nephrology 2012 13:60
    Content type: Research article Published on:

  21. Chronic kidney disease(CKD) has been proposed as a risk factor for cardiovascular disease (CVD). There is conflicting evidence among community based studies regarding the association between CKD and CVD. Furth...

    Authors: Farhad Hosseinpanah, Maryam Barzin, Hosein Aghayan Golkashani, Amir A Nassiri, Farhad Sheikholeslami and Fereidoun Azizi
    Citation: BMC Nephrology 2012 13:59
    Content type: Research article Published on:

  22. Estimated glomerular filtration rate (eGFR) levels have been shown to predict atherosclerotic vascular disease hospitalization and mortality. We sought to investigate the role of renal function in the predicti...

    Authors: Joshua R Lewis, Wai Lim, Satvinder S Dhaliwal, Kun Zhu, Ee Mun Lim, Peter L Thompson and Richard L Prince
    Citation: BMC Nephrology 2012 13:58
    Content type: Research article Published on:

  23. In addition to its canonical role in musculoskeletal health, several reports have demonstrated that serum vitamin D level may influence kidney function. However, the effect of pretransplant serum vitamin D lev...

    Authors: Hyunwook Kim, Shin-Wook Kang, Tae-Hyun Yoo, Myoung Soo Kim, Soon Il Kim, Yu Seun Kim and Kyu Hun Choi
    Citation: BMC Nephrology 2012 13:22
    Content type: Research article Published on:

  24. Indigenous peoples worldwide are experiencing elevated rates of type 2 diabetes and its complications. To better understand the disproportionate burden of diabetic end stage renal disease (ESRD) among Canadian...

    Authors: Roland F Dyck, Mariam Naqshbandi Hayward and Stewart B Harris
    Citation: BMC Nephrology 2012 13:57
    Content type: Research article Published on:

  25. Patients with chronic HCV infection have increased liver iron. Recently identified protein hepcidin synthesized in the liver, is thought to be a key regulator for iron homeostasis and is induced by infection a...

    Authors: Yasar Caliskan, Berna Yelken, Abdullah Ozkok, Numan Gorgulu, Halil Yazici, Aysegul Telci and Alaattin Yildiz
    Citation: BMC Nephrology 2012 13:56
    Content type: Research article Published on:

  26. Low 25-hydroxy vitamin D (25(OH)D) levels have been associated with an increased risk of albuminuria, however an association with glomerular filtration rate (GFR) is not clear. We explored the relationship bet...

    Authors: Matthew J Damasiewicz, Dianna J Magliano, Robin M Daly, Claudia Gagnon, Zhong X Lu, Peter R Ebeling, Steven J Chadban, Robert C Atkins, Peter G Kerr, Jonathan E Shaw and Kevan R Polkinghorne
    Citation: BMC Nephrology 2012 13:55
    Content type: Research article Published on:

  27. Kidney disease is the 9th leading cause of death in Singapore. While preventive effects have focused on early detection and education, little is known about the knowledge level of chronic kidney disease (CKD) ...

    Authors: Wai Leng Chow, Veena D Joshi, Aung Soe Tin, Saskia van der Erf, Jeremy Fung Yen Lim, Teck Sin Swah, Stephanie Swee Hong Teo, Paul Soo Chye Goh, Gilbert Choon Seng Tan, Crystal Lim and Terence Yi-shern Kee
    Citation: BMC Nephrology 2012 13:54
    Content type: Research article Published on:

  28. Tacrolimus (FK506) is associated with renal fibrosis in long-term use. Mycophenolatemofetil (MMF) can also inhibit or attenuate the progression of renal fibrosis. This study aimed to determine the different ef...

    Authors: Lei Luo, Zhaolin Sun, Weidong Wu and Guangheng Luo
    Citation: BMC Nephrology 2012 13:53
    Content type: Research article Published on:

  29. Long term longitudinal data are scarce on epidemiological characteristics and patient outcomes in patients on maintenance dialysis, especially in Switzerland. We examined changes in epidemiology of patients un...

    Authors: Petra Rhyn Lehmann, Manon Ambühl, Domenica Corleto, Richard Klaghofer and Patrice M Ambühl
    Citation: BMC Nephrology 2012 13:52
    Content type: Research article Published on:

  30. Acute worsening of renal function, an independent risk factor for adverse outcomes in acute decompensated heart failure (ADHF), occurs as a consequence of new onset kidney injury (AKI) or acute deterioration o...

    Authors: Qiugen Zhou, Chunmei Zhao, Di Xie, Dingli Xu, Jianping Bin, Pingyan Chen, Min Liang, Xun Zhang and Fanfan Hou
    Citation: BMC Nephrology 2012 13:51
    Content type: Research article Published on:

  31. Adequate anticoagulation is prerequisite for effective hemodialysis to prevent clotting in the extracorporeal circuit. We aimed providing first data on the efficacy and safety of the low-molecular-weight hepar...

    Authors: Oliver Dorsch, Detlef H Krieter, Horst-Dieter Lemke, Stefan Fischer, Nima Melzer, Christian Sieder, Peter Bramlage and Job Harenberg
    Citation: BMC Nephrology 2012 13:50
    Content type: Research article Published on:

  32. Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that is secreted from bone and serum level increases as renal function declines. Higher levels of FGF23 are associated with increased mortality in ...

    Authors: Inger H Bleskestad, Harald Bergrem, Anders Hartmann, Kristin Godang and Lasse G Gøransson
    Citation: BMC Nephrology 2012 13:49
    Content type: Research article Published on:

  33. We investigated 1) the frequency of hypertension in patients with type 2 diabetes graded by the new classification of chronic kidney disease (CKD) reported by the Kidney Disease: Improving Global Outcomes (KDI...

    Authors: Hiroyuki Ito, Mizuo Mifune, Mariko Abe, Koshiro Oshikiri, Shinichi Antoku, Yuichiro Takeuchi, Michiko Togane, Shigenori Ando and Emiko Tsugami
    Citation: BMC Nephrology 2012 13:48
    Content type: Research article Published on:

  34. Scleroderma renal crisis is an important complication of scleroderma (systemic sclerosis) that is associated with significant morbidity and mortality. On the other hand, hyponatremia has never been reported in...

    Authors: Hirotaka Fukasawa, Ryuichi Furuya, Sayaka Ishigaki, Naoko Kinoshita, Shinsuke Isobe and Yoshihide Fujigaki
    Citation: BMC Nephrology 2012 13:47
    Content type: Case report Published on:

  35. Neutrophil gelatinase associated lipocalin (NGAL) is a highly predictive biomarker of acute kidney injury. To understand the role of NGAL in renal injury during sepsis, we investigated the temporal changes and...

    Authors: Mei Han, Ying Li, Maodong Liu, Yingmin Li and Bin Cong
    Citation: BMC Nephrology 2012 13:25
    Content type: Research article Published on:

  36. Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia without a known predisposing cause.

    Authors: Kenji Tsuji, Haruhito Adam Uchida, Tetsuichirou Ono, Tatsuyuki Inoue, Katsuji Shinagawa, Shinji Kitamura, Yohei Maeshima, Hitoshi Sugiyama and Hirofumi Makino
    Citation: BMC Nephrology 2012 13:46
    Content type: Case report Published on:

  37. The main hypothesis of this study is that patients having regular conventional haemodialysis (HD) will have a smaller decline in cardiac systolic function by using cooler dialysate. Cooler dialysate may also b...

    Authors: Aghogho Odudu, Mohamed Tarek Eldehni, Apostolos Fakis and Christopher William McIntyre
    Citation: BMC Nephrology 2012 13:45
    Content type: Study protocol Published on:

  38. Renal evaluation studies are rare in American Cutaneous Leishmaniasis (ACL). The aim of this study is to investigate whether specific treatment reverts ACL-associated renal dysfunction.

    Authors: Rodrigo A Oliveira, Cláudio G Lima, Rosa Ms Mota, Alice Mc Martins, Talita R Sanches, Antônio C Seguro, Lúcia C Andrade, Geraldo B Silva Junior, Alexandre B Libório and Elizabeth F Daher
    Citation: BMC Nephrology 2012 13:44
    Content type: Research article Published on:

  39. Patients with end-stage renal disease (ESRD) are at a higher risk for chronic hepatitis, liver cirrhosis (LC) and mortality than the general population. Optimal modalities of renal replacement therapy for ESRD...

    Authors: Chih-Chiang Chien, Jhi-Joung Wang, Yih-Min Sun, Ding-Ping Sun, Ming-Jen Sheu, Shih-Feng Weng, Chin-Chen Chu, Hung-An Chen, Chung-Ching Chio, Jyh-Chang Hwang, Yi-Hua Lu, Hsien-Yi Wang and Wei-Chih Kan
    Citation: BMC Nephrology 2012 13:43
    Content type: Research article Published on:

  40. The Chronic Kidney Disease Epidemiology Collaboration equation for estimation of glomerular filtration rate (eGFRCKD-EPI) improves GFR estimation compared with the Modification of Diet in Renal Disease Study equa...

    Authors: Tariq Shafi, Kunihiro Matsushita, Elizabeth Selvin, Yingying Sang, Brad C Astor, Lesley A Inker and Josef Coresh
    Citation: BMC Nephrology 2012 13:42
    Content type: Research article Published on:

  41. The aim of the study was to determine whether distance between residence and peritoneal dialysis (PD) unit influenced peritonitis occurrence, microbiology, treatment and outcomes.

    Authors: Yeoungjee Cho, Sunil V Badve, Carmel M Hawley, Stephen P McDonald, Fiona G Brown, Neil Boudville M, Kathryn J Wiggins, Kym M Bannister, Philip Clayton and David W Johnson
    Citation: BMC Nephrology 2012 13:41
    Content type: Research article Published on:

  42. Anaemia of chronic kidney disease increases the risk of death and adverse events, but can be managed using erythropoiesis stimulating agents (ESAs). However, recent evidence suggests that targeting a higher ha...

    Authors: Lawrence P McMahon, Michael X Cai, Sanjeev Baweja, Stephen G Holt, Annette B Kent, Vlado Perkovic, Murray J Leikis and Gavin J Becker
    Citation: BMC Nephrology 2012 13:40
    Content type: Research article Published on:

  43. It is well known that the quality of life of patients with chronic kidney disease can be improved by dialysis. While previous studies have used retrospective designs and adhered to a standard target prescribed...

    Authors: Jin-Bor Chen, King-Kwan Lam, Yu-Jen Su, Wen-Chin Lee, Ben-Chung Cheng, Chien-Chun Kuo, Chien-Hsing Wu, Eton Lin, Yi-Chun Wang, Te-Chuan Chen and Shang-Chih Liao
    Citation: BMC Nephrology 2012 13:39
    Content type: Research article Published on:

  44. Conditions associated with high intraglomerular filtration pressure can cause secondary focal segmental glomerulosclerosis (FSGS). Unilateral renal artery stenosis (RAS) or its occlusion results in FSGS-like c...

    Authors: Daiki Iwami, Hiroshi Harada, Hiroaki Usubuchi, Kiyohiko Hotta, Toshimori Seki, Masaki Togashi and Yuichiro Fukasawa
    Citation: BMC Nephrology 2012 13:38
    Content type: Case report Published on:

  45. Moderate to severe renal insufficiency and albuminuria have been shown to be independent risk factors for atherosclerosis. However, little is known about the direct association between subclinical atherosclero...

    Authors: XiangLei Kong, XiaoYan Jia, Yong Wei, MeiYu Cui, ZunSong Wang, LiJun Tang, WenBin Li, ZhuXian Zhu, Ping Chen and DongMei Xu
    Citation: BMC Nephrology 2012 13:37
    Content type: Research article Published on:

  46. High salt intake in patients with chronic kidney disease (CKD) may cause high blood pressure and increased albuminuria. Although, the estimation of salt intake is essential, there are no easy methods to estima...

    Authors: Makoto Ogura, Ai Kimura, Koki Takane, Masatsugu Nakao, Akihiko Hamaguchi, Hiroyuki Terawaki and Tatsuo Hosoya
    Citation: BMC Nephrology 2012 13:36
    Content type: Research article Published on:

  47. Peritoneal dialysis-associated peritonitis (PD-peritonitis) due to Mycobacterium spp is uncommon. Non-tuberculous Mycobacterium (NTB) PD-peritonitis can present in a similar fashion to more common causes of bacte...

    Authors: Simon H Jiang, Darren M Roberts, Andrew H Dawson and Meg Jardine
    Citation: BMC Nephrology 2012 13:35
    Content type: Case report Published on:

  48. Interventional diagnostic procedures are established for several diseases in medicine. Despite the KDOQI guideline recommendation for histological diagnosis of kidney disease to enable risk stratification, its...

    Authors: Dominik G Haider, Alexander Friedl, Slobodan Peric, Günther F Wiesinger, Michael Wolzt, Julian Prosenz, Henrik Fischer, Walter H Hörl, Afschin Soleiman and Valentin Fuhrmann
    Citation: BMC Nephrology 2012 13:34
    Content type: Research article Published on:

  50. Antineutrophil cytoplasmic antibody (ANCA)-associated crescentic glomerulonephritis (CGN) is a major cause of rapidly progressive glomerulonephritis (RPGN). ANCA-associated CGN is generally classified into pau...

    Authors: Ryuji Morizane, Konosuke Konishi, Akinori Hashiguchi, Hirobumi Tokuyama, Shu Wakino, Hiroshi Kawabe, Matsuhiko Hayashi, Koichi Hayashi and Hiroshi Itoh
    Citation: BMC Nephrology 2012 13:32
    Content type: Case report Published on:
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BMC Nephrology

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