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Table 3 Mean (95% CI) difference between the CKD-EPI and MDRD equation estimates (defined as CKD-EPI – MDRD ), stratified by level of renal function using CKD–EPI equation as reference, age (<65 years compared to ≥65 years) and gender N (Males:%), in a randomly selected representative sample of middle and older aged Irish population

From: Prevalence of diminished kidney function in a representative sample of middle and older age adults in the Irish population

CKD-EPI eGFR≥60ml/min1
  All <65 years ≥65 years
N=968 N=716 N=252
Males: 46% Males: 42% Males: 52%
  Females: 54% Females: 58% Females: 48%
All 4.9 (4.5, 5.2) 1 6.4 (6.0, 6.8) 2 0.6 (−0.2, 1. 4) 3
Males 3.43 (2.9, 3.9) 5.1 (4.6, 5.6) -.0.3 (−1.4, 0.9)
Females 6.03 (5.5, 6.6) 7.4 (6.8, 8.0) 1.7 (0.4, 2.7)
p value 4 0.0001 0.0001 0.025
CKD-EPI eGFR<60ml/min 1
  All <65 years ≥65 years
N=130 N=31 N=99
Males: 50% Males: 35% Males: 52%
  Females: 50% Females: 65% Females: 48%
All 1.1 (0.8, 1.5) 1 3.7 (3.3, 4.1) 2 0.3 (0.03,0.6) 3
Males 0.2 (−0.2, 0.7) 3.3 (2.6, 4.0) −0.4 (−0.8, -0.1)
Females 1.7 (1.3, 2.1) 3.9 (3.4, 4.4) 1.2 (0.8, 1.5)
p value 4 0.0001 0.16 0.0001
  1. 1p values for comparisons across GFR strata for all subjects p=0.0001.
  2. 2p values for comparisons across GFR strata for all subjects <65 years: p = 0.007.
  3. 3p values for comparisons across GFR strata for all subjects >=65 years p=0.68.
  4. 4p value for comparisons across gender within GFR strata, and age groups.