Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study

BMC Nephrology

Table 3 Mean eGFRs and CKD prevalence with respect to cytokine polymorphism genotypes

Genotype	n	eGFR (ml/min/1.73 m²)		CKD (eGFR < 60 ml/min/1.73 m²)
		mean ± SD	P-value^†	n	(%)	P-value^‡
IL1B T-31C (rs1143627)
T T	954	74.0 ± 14.9		163	(16.6%)
C T	1,621	73.9 ± 14.6	0.576	266	(16.3%)	0.727
C C	748	74.6 ± 15.3		117	(15.6%)
IL2 T-330G (rs2069762)
T T	1,469	74.0 ± 14.8		244	(16.6%)
T G	1,480	74.2 ± 14.9	0.860	241	(16.3%)	0.938
G G	371	74.3 ± 14.5		59	(15.9%)
IL4 T-33C (rs2070874)
T T	1,452	73.4 ± 14.6		259	(17.8%)
T C	1,467	74.4 ± 15.1	0.012	241	(16.4%)	0.009
C C	403	75.8 ± 14.5		46	(11.4%)
IL6 C-572G (rs1800796)
C C	1,912	74.2 ± 14.7		312	(16.3%)
G C	1,185	73.4 ± 14.8	0.004	208	(17.6%)	0.082
G G	225	76.9 ± 15.9		26	(11.6%)
IL8 T-251A (rs4073)
T T	1,535	74.1 ± 14.4		254	(17.3%)
A T	1,439	73.9 ± 15.2	0.745	235	(16.3%)	0.917
A A	330	74.6 ± 15.4		57	(16.5%)
IL10 T-819C (rs1800871)
T T	1,427	73.6 ± 14.7		252	(17.7%)
C T	1,461	74.2 ± 14.8	0.155	239	(16.4%)	0.070
C C	425	75.2 ± 15.0		55	(12.9%)
IL13 C-1111T (rs1800925)
C C	2,217	74.0 ± 14.9		370	(16.7%)
T C	998	74.3 ± 14.7	0.734	158	(15.8%)	0.827
T T	106	74.7 ± 14.3		17	(16.0%)
TNFA C-857T (rs1799724)
C C	2,161	73.6 ± 14.7		373	(17.3%)
C T	1,042	74.9 ± 15.0	0.054	155	(14.9%)	0.212
T T	120	75.5 ± 15.4		18	(15.0%)
TNFA T-1031C (rs1799964)
T T	2,317	73.9 ± 14.6		383	(16.5%)
C T	908	74.5 ± 15.4	0.641	144	(15.9%)	0.652
C C	98	74.1 ± 14.6		19	(19.4%)
CD14 T-260C (rs2569190)
T T	929	74.5 ± 14.5		144	(15.5%)
T C	1,687	74.2 ± 14.9	0.226	275	(16.3%)	0.403
C C	707	73.3 ± 14.9		127	(18.0%)

^†P for ANOVA, ^‡P for the χ² test. eGFR = estimated glomerular filtration rate. CKD = chronic kidney disease. CKD is defined by eGFR < 60 ml/min/1.73 m². Bold style represents P < 0.05.

ISSN: 1471-2369