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Table 1 Baseline characteristics of included patients

From: Higher serum chloride concentrations are associated with acute kidney injury in unselected critically ill patients

Variables

Total (n = 1221)

AKI (n = 357)

Non-AKI (n = 864)

P value

Age (years)

59.7 ± 19.6

62.0 ± 19.8

58.8 ± 19.5

0.011

Sex (male, %)

788 (64.5%)

233 (65.3%)

556 (64.2%)

0.117

Charlson index (median, IQR)

0 (0-2)

1 (0-2)

0 (0-2)

0.0095

Primary Classification (n, %)

   

<0.001

  Medical

340 (27.8)

111 (31.1)

229 (26.5)

0.104

  Coronary

152 (12.4)

28 (8.0)

124 (14.4)

0.002

Post-cardiac surgery

101 (8.0)

22 (6.0)

79 (9.0)

0.085

  Surgical

628 (51.4)

196 (54.9)

432 (50.0)

0.119

Fluid balance (ml)†

1061 ± 789

1245 ± 782

984 ± 780

<0.001

Saline 0.9% administration (ml)†

983 ± 678

1052 ± 768

954 ± 650

0.023

Use of diuretics (n, %)

408 (33.42)

115 (32.21)

293 (33.91)

0.567

Use of MV (n; %)

598 (49.0)

224 (62.8)

374 (43.3)

<0.001

Survivors (n; %)

967 (79.2)

260 (72.8)

707 (81.8)

<0.001

Hospital LOS (days; median, IQR)

24 (16,35)

29 (20,41)

22 (15,33)

<0.001

ICU LOS (days; median, IQR)

3 (2,7)

4 (3,9)

3 (2,6)

<0.001

Bicarbonate (mmol/l)

23.9 ± 3.0

24.0 ± 3.2

23.9 ± 2.9

0.46

Cl0 (mmol/l)

103.6 ±6.0

104.1 ± 7.3

103.4 ± 5.4

0.07

Clmean (mmol/l)

103.7 ±4.9

104.3 ±5.8

103.4 ± 4.5

0.0047

Clmin (mmol/l)

98.0 ± 5.8

97.2 ± 6.1

98.3 ± 5.6

0.002

Clmax (mmol/l)

109.1 ± 6.6

111.8 ± 8.1

107.9 ±5.4

<0.001

  1. Analysis was restricted to survivors; † data obtained on the day of the onset of acute kidney injury or on the day of the highest serum creatinine level.
  2. Abbreviations: AKI acute kidney injury, IQR interquartile range, MV mechanical ventilation, Cl 0 chloride measured on ICU entry, Cl mean mean chloride during ICU stay, Cl min minimum chloride during ICU stay, Cl max maximum chloride during ICU stay.