Impact of chronic kidney disease on the prevalence of cardiovascular disease in patients with type 2 diabetes in Spain: PERCEDIME2 study

Table 4 Multivariate analysis of chronic kidney disease impact on the prevalence of cardiovascular disease

	Unadjusted model (OR; CI95%)	Model 1 (OR; CI95%)	Model 2 (OR; CI95%)	Model 3 (OR; CI95%)
Glomerular filtration rate (eGFR)
eGFR ≥ 60 mL/min/1.73 m²	1	1	1	1
eGFR 45–59 mL/min/1.73 m²	2.07 (1.5-2.8)	1.2 (0.9-1.7)	1.2 (0.9-1.8)	1.2 (0.9-1.8)
eGFR 30–44 mL/min/1.73 m²	4.6 (2.9-7.3)	2.5 (1.5-4.1)	2.3 (1.4-3.8)	2.3 (1.4-3.9)
eGFR < 30 mL/min/1.73 m²	8.4 (3.6-19.9)	4.3 (1.7-10.7)	4.1 (1.6-10.2)	4.1 (1.6-10.2)
For each unit below 60 mL/min/1.73 m²	1.072 (1.06-1.09)	1.045 (1.03-1.06)	1.042 (1.02-1.06)	1.043 (1.02-1.06)
UACR
Normoalbuminuria	1	1	1	1
Microlbuminuria (30–299 mg/gr)	1.9 (1.4-2.7)	1.8 (1.2-2.6)	1.8 (1.3-2.7)	1.6 (1.1-2.4)
Macroalbuminuria (≥300 mg/gr)	5.0 (2.3-11.1)	4.6 (1.9-10.9)	4.2 (1.8-10.2)	3.9 (1.6 -9.5)
For each unit above 29 mg/gr	1.001 (0.99-1.01)	1.001 (0.99-1.01)	1.001 (0.99-1.01)	1.001 (0.99-1.01)
UACR (normal) + GFR (normal)	1	1	1	1
UACR ↑ and eGFR ↓	3.3 (1.5-7.3)	2.3 (1.0-5.3)	2.4 (1.0-5.4)	2.2 (0.9-5.2)

GFR: estimated glomerular filtration rate. eGFR (normal): ≥ 60 mL/min/1,73 m2. eGFR↓: < 60 mL/min/1,73 m2.
UACR: Urine albumin/creatinine ratio . UACR (normal) < 30 mg/g. UACR ↑: ≥ 30 mg/g.
Normoalbuminuria: UACR < 30 mg/g. Microalbuminuria: UACR = 30–299 mg/g . Macroalbuminuria: UACR >300 mg/g.
Model 1 Adjusted for age and sex.
Model 2 Adjusted for age, sex, hypertension, dislipidaemia, tobacco and Body Mass Index.
Model 3 Adjusted for age, sex, hypertension, dislipidaemia , tobacco, Body Mass Index , HbA1c and T2DM duration.

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