- Research article
- Open Access
Primary care physicians’ familiarity, beliefs, and perceived barriers to practice guidelines in non-diabetic CKD: a survey study
BMC Nephrology volume 15, Article number: 64 (2014)
Most non-dialysis dependent chronic kidney disease (CKD) patients are cared for by their primary care physicians (PCPs). Studies suggest many CKD patients receive suboptimal care. Recently, CKD clinical practice guidelines were updated with additional emphasis on albuminuria.
We performed an internet-based, cross-sectional survey of active PCPs in the United States using the American Medical Association Physician Masterfile. We explored CKD guideline familiarity, self-reported practice behaviors, and attitudinal and external barriers to implementing guideline recommendations, including albuminuria testing.
Of 12,034 PCPs targeted, 848 opened a study email, 165 (19.5%) responded. Most respondents (88%) spent ≥50% of their time in clinical care. Respondents were generally in private practice (46%). Most PCPs (96%) felt that eGFR values were helpful. Approximately, 75% and 91% of PCPs reported testing for albuminuria in non-diabetic hypertensive patients with an eGFR > 60 ml/min/1.73 m2 and < 60 ml/min/1.73 m2, respectively. Barriers to albuminuria testing included a lack of effect on management, limited time, and the perceived absence of guidelines recommending testing. While PCPs expressed high levels of agreement with the definition of CKD, 30% were concerned with overdiagnosis in older adults with an eGFR in the CKD stage 3a range. Most PCPs felt that angiotensin converting enzyme inhibitor (ACEi)/ angiotensin II receptor blockers (ARBs) improved outcomes in CKD, though agreement was lower with severe vs. moderate albuminuria (78% vs. 85%, respectively, p = 0.03). Many PCPs (51%) reported being unfamiliar with CKD guidelines, but were receptive to systematic interventions to improve their CKD care.
PCPs generally agree with CKD clinical practice guidelines regarding CKD definition and albuminuria testing. However, future interventions are necessary to improve PCPs’ familiarity with CKD guidelines, overcome barriers to albuminuria testing and, assist PCPs in targeting ACEi/ARBs to the patients most likely to benefit.
Chronic kidney disease (CKD) affects millions of Americans  and estimates suggest that over 50% of adults in the United States (US) will develop CKD during their lifetime . Primary care providers (PCPs) deliver the majority of non-dialysis dependent CKD care and this trend is expected to continue due to limitations in the nephrologist workforce .
Multiple studies have documented deficiencies in PCP delivery of CKD care. These include suboptimal screening/monitoring of patients with CKD risk factors [4, 5], infrequent discussions between providers and patients regarding CKD , suboptimal albuminuria testing in CKD patients [7, 8], suboptimal blood pressure control , and suboptimal renin-angiotensin blockade in CKD patients with proteinuria [10, 11]. In light of these deficiencies, studies have also demonstrated shortcomings in PCP knowledge of CKD risk factors [12, 13] and poor awareness of Kidney Disease Outcomes Quality Initiative (KDOQI) clinical practice guidelines [14–17].
Recently, Kidney Disease Improving Global Outcomes (KDIGO) released updated CKD clinical practice guidelines . For PCPs, perhaps the most salient modification is the emphasis on albuminuria as a risk stratification marker for poor outcomes. We employed the knowledge, attitudes, and behavior framework adapted by Cabana  to study reasons for PCP non-adherence to key components of the 2012 KDIGO CKD guidelines (i.e., assessing estimated glomerular filtration rate [eGFR] and albuminuria/proteinuria, definition of CKD, and use of angiotensin converting enzyme inhibitor [ACEi] or angiotensin II receptor blockers [ARBs] in overtly albuminuric/proteinuric patients) , focusing on non-diabetic CKD. We chose to concentrate on non-diabetic CKD because several studies have noted superior PCP performance in diabetic CKD (including albuminuria quantification and ACEi/ARB use) and high rates of familiarity with the American Diabetic Association’s clinical practice guidelines [7, 12, 20]. We also assessed interventions PCPs would find most acceptable to optimize CKD care.
Study design, population, and setting
We performed a web-based, cross-sectional survey of US PCPs between April and June 2013. We identified PCPs actively practicing in the US and included in the American Medical Association’s (AMA) Physician Masterfile. We emailed a simple random sample of 12,034 PCPs for this survey.
Questionnaire design and content
The questionnaire included items assessing PCPs’ knowledge, beliefs, attitudes, self-reported behavior, and perceived barriers regarding aspects of CKD care as well as demographic and practice characteristics. Questions were developed following appraisal of the literature (KA) [6–11, 13–19, 21–30]. An internist and nephrologist with domain and survey expertise revised the questionnaire (RG, MU). We subsequently pilot-tested the questionnaire among 16 community- and hospital-based internists and family practitioners. We revised the questionnaire based on feedback. Several items (e.g., regarding cystatin C) were universally unfamiliar to PCPs and were removed from the survey. We then formatted the questionnaire for web-based administration and pilot tested the web-based questionnaire among 5 additional PCPs who had not reviewed previous versions.
Because studies indicate that PCPs are more likely to recognize, evaluate, and treat diabetic CKD [5, 7, 31], and given the added emphasis on albuminuria in the new guidelines , we focused questionnaire items on non-diabetic CKD and on the assessment, recognition, and treatment of albuminuria in non-diabetic CKD care. The final questionnaire featured both vignette-based and non-vignette based multiple choice questions with 33 items concerning CKD (see Additional file 1 for full questionnaire).
The initial items followed a vignette of a 73-year-old white man with well controlled hypertension treated with amlodipine and hydrochlorothiazide who presented for routine follow-up. The patient had a normal history and exam and an elevation in serum creatinine and decrement in eGFR that progressed over 12 months (1.3 mg/dl to 1.4 mg/dl and 55 ml/min/1.73 m2 to 50 ml/min/1.73 m2, respectively). We designed the vignette to simulate a common scenario that has raised concerns regarding CKD overdiagnosis due to age-related decline in kidney function [23, 32–36]. Subsequent questions featured a 4-point Likert scale (ranging from strongly agree to strongly disagree, with a 5th option for “Don’t Know”) to assess participants’ agreement with statements regarding the utility of eGFR, further testing with quantitative albuminuria or urinalysis, perceived limitations of urine testing due to patient burden or poor test reliability, and the presence of CKD in the described patient. Later questions more directly assessed concerns for overdiagnosis in patients with a stable eGFR between 45–59 ml/min/1.73 m2 and 30–44 ml/min/1.73 m2.
We also assessed how frequently (ranging from twice a year to never/rarely) PCPs reported testing for urine albumin/protein in non-diabetic hypertensives and potential barriers to urine testing. PCPs could select multiple barriers including patient level (e.g., cost, adherence), environmental (e.g., limited time), and attitudinal (e.g., lack of outcome expectancy) barriers.
In two items, we provided PCPs with an intersecting grid of albuminuria and eGFR values to assess their beliefs regarding (a) the presence of CKD in a 65 year-old non-diabetic patient and (b) whether ACEi/ARBs would improve outcomes in a non-diabetic patient with the specified test results (e.g., Figure 1). These grids represented abbreviated versions of the 2012 KDIGO CKD classification system  and respondents used a drop down menu in each cell to choose their response (i.e., “yes”, “no”, or “unsure”). We also assessed patient level, environmental, and attitudinal barriers to ACEi/ARB use in non-diabetics with “macroalbuminuria”.
We assessed PCPs’ familiarity and perceived helpfulness of the KDOQI/KDIGO guidelines and their potential interest in interventions to optimize CKD care. We also collected information on PCPs’ demographics and practice characteristics.
We sent broadcast emails in 2 waves. To maximize responses , we sent PCPs a personally addressed introductory email that included the investigators’ university affiliations as well as a statement regarding the importance of the topic. We sent PCPs a personally addressed email invitation several days later. The invitation included a link to the web-based questionnaire and disclosed a 1-week deadline for completion. The subject heading for the broadcast emails did not mention “survey” or “questionnaire” (e.g., “Assessing the potential impact of CKD staging changes”). Emails contained statements ensuring the confidentiality of respondents and offering a $20 electronic gift card for participation. We ascertained the opened status of emails by encoding a pixel in the messages that communicated when an email was opened. We gave survey recipients 21 days to open and/or respond to the email. The University of Pittsburgh Institutional Review Board approved this study.
We described questionnaire responses using descriptive statistics. We collapsed Likert scales into 3 categories: strongly agree/agree, strongly disagree/disagree, and don’t know. Chi-square or Fisher’s exact test was used to assess independence of categorical variables as appropriate. We employed multivariable logistic regression to quantify associations between PCP demographic/practice characteristics (independent variables) and the following dependent variables (a) reported familiarity/utility of CKD guidelines, (b) agreement with classification of stage 1–2 CKD (i.e., eGFR ≥60 ml/min/1.73 m2 and microalbuminuria) in a non-diabetic individual as representing CKD, and (c) concern regarding overdiagnosis in stage 3a CKD. In regression modeling, p ≤ 0.1 in univariable analysis was used to identify factors for inclusion in a multivariable backwards selection approach. Analyses were performed using Stata version 13.0 (College Station, TX) and P-values < 0.05 were considered significant.
Of the 12,034 PCPs, 45 had nonworking email addresses, and 11,141 did not open the study emails. Of the 848 recipients who opened a study email, 165 (19.5%) responded including 14 respondents who partially completed the survey, answering between 9 and 30 questions each. Respondent characteristics are summarized in Table 1. Nearly 90% of respondents spent at least half their time in patient care activities. The majority of respondents were internists (56%) and generally practiced in an urban (38%) or suburban (46%) locale. Nearly half of respondents (46%) were part of a private practice. Compared to targeted PCPs, respondents were more likely to be internists (47% vs 56%, respectively, p = 0.03) and had graduated medical school more recently (13% vs. 30% within 10 years, 31% vs. 28% between 11 to 20 years, 29% vs. 24% between 21 to 30 years, and 27% vs. 19% over 30 years ago, respectively, p < 0.001). Respondents were similar in gender to targeted PCPs (data not shown).
eGFR and albuminuria testing
Following the clinical vignette, 96% of PCPs agreed that an eGFR was useful in assessing kidney function. In addition, 72% and 76% of respondents agreed with the utility of a urine dipstick or a quantitative albuminuria assessment, respectively. While few respondents (5%) felt that a urine dipstick would be burdensome to the patient, 20% felt that it would not be helpful due to poor reliability. In contrast, 30% of PCPs felt a quantitative albuminuria would be burdensome to the patient and 14% felt it would not be helpful due to poor reliability.
In non-diabetic hypertensive patients with an eGFR ≥ 60 ml/min/1.73 m2, 75% of PCPs reported testing for albuminuria or proteinuria; 51%, 13%, and 10% of PCPs reported performing such testing annually, every 2–3 years, and twice a year, respectively. In non-diabetic hypertensive patients with an eGFR < 60 ml/min/1.73 m2, 91% of PCPs reported testing for albuminuria or proteinuria; 55%, 12%, and 22% of PCPs reported performing such testing annually, every 2–3 years, and twice a year, respectively. Commonly endorsed barriers to urine testing are shown in Table 2.
CKD definition: agreement and concerns regarding overdiagnosis
Respondents generally agreed with current guideline-based CKD definitions (Figure 1). An area where respondents expressed less agreement was in patients with an eGFR ≥ 60 ml/min/1.73 m2 and “microalbuminuria” (i.e., moderate albuminuria). Only 55% of PCPs felt this represented CKD.
When presented as part of the clinical vignette, 92% agreed that a chronically reduced eGFR of 50 ml/min/1.73 m2 represented CKD. However, when asked about overdiagnosis, 30% of PCPs agreed that classifying older adults with stable eGFRs of 45-59 ml/min/1.73 m2 as having CKD led to overdiagnosis, while 66% disagreed, and 4% were uncertain. In contrast, only 5% agreed that classifying older adults with eGFRs of 30–44 ml/min/1.73 m2 as having CKD led to overdiagnosis.
ACEi/ARB use: outcome expectancy and barriers
The majority of respondents reported that ACEi/ARBs would improve outcomes in non-diabetics under a variety of eGFR and albuminuria categorizations (Table 3). This included 86% and 77% of PCPs when eGFR was < 60 ml/min/1.73 m2 and “microalbuminuria” or “macroalbuminuria” was present, respectively (microalbuminuria vs. macroalbuminuria, p = 0.03).
Commonly endorsed barriers to ACEi/ARB use in non-diabetics with “macroalbuminuria” were adverse effects (23%), poor adherence (8%), not recommended by guidelines (8%), will not improve outcomes (7%), and more urgent patient issues/limited time (6%).
KDOQI/KDIGO: guideline familiarity
Over half of respondents (Figure 2) reported the KDOQI/KDIGO guidelines were not helpful in managing their CKD patients due to a lack of familiarity.
Interventions to enhance CKD care
PCPs were receptive to multiple systematic interventions to improve their CKD care (Table 4). Excluding continuing medical education (CME), 75% of PCPs supported an alternative intervention to improve their CKD care.
Association of PCP demographic/practice characteristics and responses
While adjusting for practice locale in logistic regression modeling, agreement with the definition of stage 1 or 2 CKD (eGFR ≥ 60 ml/min/1.73 m2 and moderate albuminuria) was associated with training in internal medicine (vs. family medicine, odds ratio [OR] 2.8, 95% confidence interval [CI] 1.4 - 5.9). Similarly, only training in internal medicine (vs. family medicine, OR 2.3, 95% CI 1.1 - 4.7) associated with reporting that the KDOQI/KDIGO guidelines were helpful in managing patients. None of the PCP characteristics were associated with concerns regarding overdiagnosis in stage 3a CKD.
We found that PCPs overwhelmingly agreed that eGFR values were helpful. Most also reported testing for albuminuria in their non-diabetic hypertensives regardless of eGFR; however, frequent barriers cited included a lack of effect on management, limited time, and the perceived absence of guidelines recommending albuminuria testing. While PCPs expressed very high agreement with the definition of CKD in patients with marked decrements in eGFR (eGFR < 45 ml/min/1.73 m2) or decrements in eGFR coupled with albuminuria, agreement was less robust when eGFR was > 60 ml/min/1.73 m2 or in CKD stage 3a without albuminuria. Similarly, a substantial minority of PCPs were concerned with overdiagnosis in older adults with an eGFR of 45-59 ml/min/1.73 m2. While most PCPs felt that ACEi/ARBs improved outcomes in CKD, even in the absence of albuminuria, agreement with the potential benefits of ACEi/ARBs was surprisingly highest with moderate rather than severe albuminuria. PCPs reported a lack of familiarity with KDOQI/KDIGO guidelines; however, most were receptive to systematic interventions beyond CME to improve their CKD care.
Few have previously examined PCPs’ beliefs, attitudes, and perceived barriers to eGFR reporting, albuminuria testing, CKD definitions, and ACEi/ARB use . Since the publication of the KDOQI guidelines and the implementation of automated eGFR reporting, CKD has garnered increasing public and provider attention. Unfortunately, studies have documented limited improvements in CKD-related processes of care in recent years, including testing for proteinuria and use of ACEi/ARBs [7, 8, 38–41]. Previous surveys suggested that knowledge deficiencies [12, 13, 16, 17, 42] may contribute to continued gaps in care. In contrast to prior studies where only serum creatinine and proteinuria were used [16, 42], we found that PCPs were relatively knowledgeable in identifying CKD based on eGFR and albuminuria categories. However, PCPs were less attuned to isolated albuminuria abnormalities (Figure 1). For example, while 99% of PCPs recognized that patients with a severe reduction in eGFR to 30–44 ml/min/1.73 m2 with “normoalbuminuria” had CKD, only 84% of PCPs recognized that patients with severe albuminuria and relatively preserved eGFR had CKD (P < 0.001).
This distinction is clinically important because the renal benefits of ACEi/ARBs in non-diabetic CKD primarily accrue in severely albuminuric patients [43, 44] and the debated benefits of lower targeted blood pressure in CKD also primarily apply to albuminuric/proteinuric patients [45, 46]. The under appreciation of the significance of albuminuria may be due in part to the greater emphasis on eGFR in the 2002 KDOQI guidelines. As recent studies highlight the importance of albuminuria as a marker for poor outcomes [47–49], initiatives to disseminate this information and help PCPs understand how to use albuminuria to modify their CKD care are needed. The most frequently cited barrier to testing for albuminuria was that it would have no impact on management, perhaps because responding PCPs presumed such patients would already be receiving ACEi/ARBs. However, recent data suggests that active ACEi/ARB use is unlikely to fully explain the low rates of albuminuria/proteinuria testing [7, 38, 50]. We suspect limited time and a lack of clarity on how to integrate information regarding albuminuria in developing non-diabetic CKD care goals is also contributing to low rates of testing.
Prior studies have documented suboptimal ACEi/ARB use in CKD patients with proteinuria [10, 11]. We found that most PCPs felt that non-diabetic patients with an eGFR < 60 ml/min/1.73 m2 would benefit from an ACEi/ARB regardless of proteinuria. These patterns may be due in part to greater familiarity with recommendations from alternative guidelines  that favor ACEi/ARB use as first line treatment in patients with CKD and hypertension regardless of albuminuria. Of note, similar to prior studies [15–17], we confirmed low familiarity with KDOQI/KDIGO CKD guidelines.
Our findings support efforts to disseminate the KDIGO CKD guidelines and to provide PCPs with guidance regarding the use of albuminuria and other factors to identify patients at high risk for poor outcomes  and most likely to benefit from ACEi/ARBs. The most commonly endorsed barrier to ACEi/ARB use was adverse effects. Studies are needed to determine whether targeting high-risk CKD patients who may be more likely to achieve benefits from these medications  could reduce adverse effects and improve outcomes in older adults with multiple medications (e.g., NSAIDs, diuretics)  compared to other less nuanced recommendations [51, 54]. Such an approach could also help PCPs identify a smaller cohort of ACEi/ARB intolerant patients with a higher likelihood to benefit from the use of these medications. In the setting of severe albuminuria, these individuals may benefit from nephrologist input to determine if alternative strategies can allow for ACEi/ARB use.
Although a previous survey of PCPs noted patient non-adherence and the cost of medications as major obstacles to appropriate care and improving patient outcomes , few respondents in our survey identified these as obstacles that prevent them from ordering urine albumin tests or ACEi/ARBs. This may reflect differences in the underlying populations the responding PCPs serve and changes in the cost of medications, including the greater availability of generic ACEi/ARBs.
Many of the barriers we identified are potentially addressable using systematic interventions. For example, decision support within an electronic health record could alert a provider as s/he orders a serum creatinine that a patient with possible CKD does not have a documented urine albumin test and is not receiving an ACEi/ARB. The alert could also provide references to guidelines and the studies that informed those guidelines. Similarly, collaborative practice agreements or audit and feedback could target high-risk CKD patients to ensure they receive optimal, evidence-based care. Combining several of these interventions while targeting patients who are most likely to benefit from ACEi/ARBs  may prove even more impactful. Most PCPs were receptive to at least one of these approaches and studies are needed to understand whether such strategies can improve care without substantially disrupting PCP workflow .
Our findings should be interpreted in light of several limitations. First, although we employed best practices for electronic surveys , the survey response rate was low, which may limit generalizability. Responders may have substantively differed from non-responders. For example, they may have had an interest in kidney disease and been more knowledgeable than the average PCP. Respondents were more likely to be internists and had graduated medical school more recently, characteristics that may suggest greater familiarity with CKD guidelines [13, 16, 42, 56]. Indeed, self-reported guideline familiarity was modestly higher than in prior PCP survey studies [12, 15, 16], although it remained less than 50%. Second, the majority of targeted PCPs never opened a study email. While we were able to exclude individuals with non-valid emails, we could not determine whether an unopened message was due to an unmonitored email account, automated filtering into an infrequently checked folder (e.g., junk), a choice not to open the email based on the subject matter or sender, or other reasons. Including individuals with unopened emails would lower the response rate. Third, PCPs may not have accurately recalled their practice patterns or may have attempted to provide what they perceived as the correct answer. To mitigate this risk, we framed survey questions as assessing beliefs rather than knowledge. Finally, there were additional questions that would have been helpful to examine such as the perceived utility of cystatin C . Nevertheless, our findings provide novel information regarding PCPs’ beliefs and reported barriers to adoption of recent CKD practice guidelines. Future work to examine how local resources, healthcare environments, and patient characteristics influence providers’ beliefs, perceived barriers, and practice patterns is warranted.
Our survey found that PCPs value eGFR measures and are able to recognize CKD based on a decrement in eGFR. However, they were less familiar with albuminuria abnormalities and endorsed several barriers to testing for albuminuria in non-diabetics including lack of outcome expectancy, lack of guideline familiarity, and lack of time. While PCPs believed that ACEi/ARBs improve outcomes in various eGFR/albuminuria stages of CKD, future interventions will be needed to help operationalize how to identify patients at high risk for progression and who are more likely to benefit from ACEi/ARBs. Fortunately, most PCPs appear receptive to interventions to improve their CKD care.
Angiotensin converting enzyme inhibitor
American Medical Association
Angiotensin receptor blocker
Continuing medical education
Chronic kidney disease
Estimated glomerular filtration rate
Kidney Disease Improving Global Outcomes
Kidney Disease Outcomes Quality Initiative
Primary care physician
Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, Van Lente F, Levey AS: Prevalence of chronic kidney disease in the United States. JAMA. 2007, 298 (17): 2038-2047. 10.1001/jama.298.17.2038.
Grams ME, Chow EK, Segev DL, Coresh J: Lifetime incidence of CKD stages 3–5 in the United States. Am J Kidney Dis. 2013, 62 (2): 245-252. 10.1053/j.ajkd.2013.03.009.
Shahinian VB, Saran R: The role of primary care in the management of the chronic kidney disease population. Adv Chronic Kidney Dis. 2010, 17 (3): 246-253. 10.1053/j.ackd.2010.02.003.
Stevens LA, Fares G, Fleming J, Martin D, Murthy K, Qiu J, Stark PC, Uhlig K, Van Lente F, Levey AS: Low rates of testing and diagnostic codes usage in a commercial clinical laboratory: evidence for lack of physician awareness of chronic kidney disease. J Am Soc Nephrol. 2005, 16 (8): 2439-2448. 10.1681/ASN.2005020192.
Minutolo R, De Nicola L, Mazzaglia G, Postorino M, Cricelli C, Mantovani LG, Conte G, Cianciaruso B: Detection and awareness of moderate to advanced CKD by primary care practitioners: a cross-sectional study from Italy. Am J Kidney Dis. 2008, 52 (3): 444-453. 10.1053/j.ajkd.2008.03.002.
Greer RC, Cooper LA, Crews DC, Powe NR, Boulware LE: Quality of patient-physician discussions about CKD in primary care: a cross-sectional study. Am J Kidney Dis. 2011, 57 (4): 583-591. 10.1053/j.ajkd.2010.08.027.
Allen AS, Forman JP, Orav EJ, Bates DW, Denker BM, Sequist TD: Primary care management of chronic kidney disease. J Gen Intern Med. 2011, 26 (4): 386-392. 10.1007/s11606-010-1523-6.
Wyatt C, Konduri V, Eng J, Rohatgi R: Reporting of estimated GFR in the primary care clinic. Am J Kidney Dis. 2007, 49 (5): 634-641. 10.1053/j.ajkd.2007.02.258.
Plantinga LC, Miller ER, Stevens LA, Saran R, Messer K, Flowers N, Geiss L, Powe NR, Centers for Disease C: Blood pressure control among persons without and with chronic kidney disease: US trends and risk factors 1999–2006. Hypertension. 2009, 54 (1): 47-56. 10.1161/HYPERTENSIONAHA.109.129841.
Curtis BM, Barrett BJ, Djurdjev O, Singer J, Levin A: Evaluation and treatment of CKD patients before and at their first nephrologist encounter in Canada. Am J Kidney Dis. 2007, 50 (5): 733-742. 10.1053/j.ajkd.2007.08.004.
Philipneri MD, Rocca Rey LA, Schnitzler MA, Abbott KC, Brennan DC, Takemoto SK, Buchanan PM, Burroughs TE, Willoughby LM, Lentine KL: Delivery patterns of recommended chronic kidney disease care in clinical practice: administrative claims-based analysis and systematic literature review. Clin Exp Nephrol. 2008, 12 (1): 41-52. 10.1007/s10157-007-0016-3.
Lea JP, McClellan WM, Melcher C, Gladstone E, Hostetter T: CKD risk factors reported by primary care physicians: do guidelines make a difference?. Am J Kidney Dis. 2006, 47 (1): 72-77. 10.1053/j.ajkd.2005.09.027.
Lenz O, Fornoni A: Chronic kidney disease care delivered by US family medicine and internal medicine trainees: results from an online survey. BMC Med. 2006, 4: 30-10.1186/1741-7015-4-30.
National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002, 39 (2 Suppl 1): S1-S266.
Greer RC, Powe NR, Jaar BG, Troll MU, Boulware LE: Effect of primary care physicians’ use of estimated glomerular filtration rate on the timing of their subspecialty referral decisions. BMC Nephrol. 2011, 12: 1-10.1186/1471-2369-12-1.
Boulware LE, Troll MU, Jaar BG, Myers DI, Powe NR: Identification and referral of patients with progressive CKD: a national study. Am J Kidney Dis. 2006, 48 (2): 192-204. 10.1053/j.ajkd.2006.04.073.
Agrawal V, Ghosh AK, Barnes MA, McCullough PA: Awareness and knowledge of clinical practice guidelines for CKD among internal medicine residents: a national online survey. Am J Kidney Dis. 2008, 52 (6): 1061-1069. 10.1053/j.ajkd.2008.06.022.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group: KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013, 3: 1-150.
Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA, Rubin HR: Why don’t physicians follow clinical practice guidelines? A framework for improvement. JAMA. 1999, 282 (15): 1458-1465. 10.1001/jama.282.15.1458.
U.S. Renal Data System: USRDS 2013 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United State. 2013, Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
Agrawal V, Agarwal M, Ghosh AK, Barnes MA, McCullough PA: Identification and management of chronic kidney disease complications by internal medicine residents: a national survey. Am J Ther. 2011, 18 (3): e40-e47. 10.1097/MJT.0b013e3181bbf6fc.
Fox CH, Brooks A, Zayas LE, McClellan W, Murray B: Primary care physicians’ knowledge and practice patterns in the treatment of chronic kidney disease: an Upstate New York Practice-based Research Network (UNYNET) study. J Am Board Fam Med. 2006, 19 (1): 54-61. 10.3122/jabfm.19.1.54.
Glassock RJ, Winearls C: Screening for CKD with eGFR: doubts and dangers. Clin J Am Soc Nephrol. 2008, 3 (5): 1563-1568. 10.2215/CJN.00960208.
Glassock RJ, Winearls CG: Routine reporting of estimated glomerular filtration rate: not ready for prime time. Nat Clin Pract Nephrol. 2008, 4 (8): 422-423.
Patwardhan MB, Kawamoto K, Lobach D, Patel UD, Matchar DB: Recommendations for a clinical decision support for the management of individuals with chronic kidney disease. Clin J Am Soc Nephrol. 2009, 4 (2): 273-283. 10.2215/CJN.02590508.
Tuot DS, Plantinga LC, Hsu CY, Powe NR: Is awareness of chronic kidney disease associated with evidence-based guideline-concordant outcomes?. Am J Nephrol. 2012, 35 (2): 191-197. 10.1159/000335935.
Greer RC, Crews DC, Boulware LE: Challenges perceived by primary care providers to educating patients about chronic kidney disease. J Ren Care. 2012, 38 (4): 174-181. 10.1111/j.1755-6686.2012.00323.x.
Diamantidis CJ, Powe NR, Jaar BG, Greer RC, Troll MU, Boulware LE: Primary care-specialist collaboration in the care of patients with chronic kidney disease. Clin J Am Soc Nephrol. 2011, 6 (2): 334-343. 10.2215/CJN.06240710.
Plantinga LC, Boulware LE, Coresh J, Stevens LA, Miller ER, Saran R, Messer KL, Levey AS, Powe NR: Patient awareness of chronic kidney disease: trends and predictors. Arch Intern Med. 2008, 168 (20): 2268-2275. 10.1001/archinte.168.20.2268.
Crinson I, Gallagher H, Thomas N, de Lusignan S: How ready is general practice to improve quality in chronic kidney disease? A diagnostic analysis. Br J Gen Pract. 2010, 60 (575): 403-409. 10.3399/bjgp10X502100.
Nissenson AR, Collins AJ, Hurley J, Petersen H, Pereira BJ, Steinberg EP: Opportunities for improving the care of patients with chronic renal insufficiency: current practice patterns. J Am Soc Nephrol. 2001, 12 (8): 1713-1720.
Glassock RJ, Winearls C: An epidemic of chronic kidney disease: fact or fiction?. Nephrol Dial Transplant. 2008, 23 (4): 1117-1121.
Glassock RJ, Winearls C: The global burden of chronic kidney disease: how valid are the estimates?. Nephron Clin Pract. 2008, 110 (1): c39-c46. 10.1159/000151244. discussion c47
Glassock RJ, Winearls C: Ageing and the glomerular filtration rate: truths and consequences. Trans Am Clin Climatol Assoc. 2009, 120: 419-428.
Winearls CG, Glassock RJ: Dissecting and refining the staging of chronic kidney disease. Kidney Int. 2009, 75 (10): 1009-1014. 10.1038/ki.2009.49.
Wetzels JF, Kiemeney LA, Swinkels DW, Willems HL, den Heijer M: Age- and gender-specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical Study. Kidney Int. 2007, 72 (5): 632-637. 10.1038/sj.ki.5002374.
Edwards P, Roberts I, Clarke M, DiGuiseppi C, Wentz R, Kwan I, Cooper R, Felix L, Pratap S: Methods to increase response to postal and electronic questionnaires (Review). Cochrane Database Syst Rev. 2009, 3: 1-12.
Abdel-Kader K, Fischer GS, Johnston JR, Gu C, Moore CG, Unruh ML: Characterizing pre-dialysis care in the era of eGFR reporting: a cohort study. BMC Nephrol. 2011, 12: 12-10.1186/1471-2369-12-12.
Hemmelgarn BR, Zhang J, Manns BJ, James MT, Quinn RR, Ravani P, Klarenbach SW, Culleton BF, Krause R, Thorlacius L, Jain AK, Tonelli M, Alberta Kidney Disease N: Nephrology visits and health care resource use before and after reporting estimated glomerular filtration rate. JAMA. 2010, 303 (12): 1151-1158. 10.1001/jama.2010.303.
Jain AK, Cuerden MS, McLeod I, Hemmelgarn B, Akbari A, Tonelli M, Quinn RR, Oliver MJ, Garg AX: Reporting of the estimated glomerular filtration rate was associated with increased use of angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers in CKD. Kidney Int. 2012, 81 (12): 1248-1253. 10.1038/ki.2012.18.
Kagoma YK, Weir MA, Iansavichus AV, Hemmelgarn BR, Akbari A, Patel UD, Garg AX, Jain AK: Impact of estimated GFR reporting on patients, clinicians, and health-care systems: a systematic review. Am J Kidney Dis. 2011, 57 (4): 592-601. 10.1053/j.ajkd.2010.08.029.
Israni RK, Shea JA, Joffe MM, Feldman HI: Physician characteristics and knowledge of CKD management. Am J Kidney Dis. 2009, 54 (2): 238-247. 10.1053/j.ajkd.2009.01.258.
Jafar TH, Schmid CH, Landa M, Giatras I, Toto R, Remuzzi G, Maschio G, Brenner BM, Kamper A, Zucchelli P, Becker G, Himmelmann A, Bannister K, Landais P, Shahinfar S, de Jong PE, de Zeeuw D, Lau J, Levey AS: Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level data. Ann Intern Med. 2001, 135 (2): 73-87. 10.7326/0003-4819-135-2-200107170-00007.
Kent DM, Jafar TH, Hayward RA, Tighiouart H, Landa M, de Jong P, de Zeeuw D, Remuzzi G, Kamper AL, Levey AS: Progression risk, urinary protein excretion, and treatment effects of angiotensin-converting enzyme inhibitors in nondiabetic kidney disease. J Am Soc Nephrol. 2007, 18 (6): 1959-1965. 10.1681/ASN.2006101081.
Sarnak MJ, Greene T, Wang X, Beck G, Kusek JW, Collins AJ, Levey AS: The effect of a lower target blood pressure on the progression of kidney disease: long-term follow-up of the modification of diet in renal disease study. Ann Intern Med. 2005, 142 (5): 342-351. 10.7326/0003-4819-142-5-200503010-00009.
Appel LJ, Wright JT, Greene T, Agodoa LY, Astor BC, Bakris GL, Cleveland WH, Charleston J, Contreras G, Faulkner ML, Gabbai FB, Gassman JJ, Hebert LA, Jamerson KA, Kopple JD, Kusek JW, Lash JP, Lea JP, Lewis JB, Lipkowitz MS, Massry SG, Miller ER, Norris K, Phillips RA, Pogue VA, Randall OS, Rostand SG, Smogorzewski MJ, Toto RD, Wang X: Intensive blood-pressure control in hypertensive chronic kidney disease. N Engl J Med. 2010, 363 (10): 918-929. 10.1056/NEJMoa0910975.
Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT, Chronic Kidney Disease Prognosis C: Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010, 375 (9731): 2073-2081.
Tonelli M, Muntner P, Lloyd A, Manns BJ, James MT, Klarenbach S, Quinn RR, Wiebe N, Hemmelgarn BR, Alberta Kidney Disease N: Using proteinuria and estimated glomerular filtration rate to classify risk in patients with chronic kidney disease: a cohort study. Ann Intern Med. 2011, 154 (1): 12-21. 10.7326/0003-4819-154-1-201101040-00003.
Tangri N, Stevens LA, Griffith J, Tighiouart H, Djurdjev O, Naimark D, Levin A, Levey AS: A predictive model for progression of chronic kidney disease to kidney failure. JAMA. 2011, 305 (15): 1553-1559. 10.1001/jama.2011.451.
Abdel-Kader K, Fischer GS, Li J, Moore CG, Hess R, Unruh ML: Automated clinical reminders for primary care providers in the care of CKD: a small cluster-randomized controlled trial. Am J Kidney Dis. 2011, 58 (6): 894-902. 10.1053/j.ajkd.2011.08.028.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella EJ, National Heart L, Blood Institute Joint National Committee on Prevention DE, Treatment of High Blood P, National High Blood Pressure Education Program Coordinating C: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. [see comment][erratum appears in JAMA. 2003 Jul 9;290(2):197. JAMA. 2003, 289 (19): 2560-2572. 10.1001/jama.289.19.2560.
O’Hare AM, Hotchkiss JR, Kurella Tamura M, Larson EB, Hemmelgarn BR, Batten A, Do TP, Covinsky KE: Interpreting treatment effects from clinical trials in the context of real-world risk information: end-stage renal disease prevention in older adults. JAMA Intern Med. 2014, 174 (3): 391-397. 10.1001/jamainternmed.2013.13328.
Lapi F, Azoulay L, Yin H, Nessim SJ, Suissa S: Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case–control study. BMJ. 2013, 346: e8525-10.1136/bmj.e8525.
Qaseem A, Hopkins RH, Sweet DE, Starkey M, Shekelle P, Clinical Guidelines Committee of the American College of P: Screening, monitoring, and treatment of stage 1 to 3 chronic kidney disease: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2013, 159 (12): 835-847.
Fox CH, Vest BM, Kahn LS, Dickinson LM, Fang H, Pace W, Kimminau K, Vassalotti J, Loskutova N, Peterson K: Improving evidence-based primary care for chronic kidney disease: study protocol for a cluster randomized control trial for translating evidence into practice (TRANSLATE CKD). Implement Sci. 2013, 8: 88-10.1186/1748-5908-8-88.
Charles RF, Powe NR, Jaar BG, Troll MU, Parekh RS, Boulware LE: Clinical testing patterns and cost implications of variation in the evaluation of CKD among US physicians. Am J Kidney Dis. 2009, 54 (2): 227-237. 10.1053/j.ajkd.2008.12.044.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2369/15/64/prepub
This work was supported by National Institutes of Health grants K23DK090304 (Abdel-Kader) and K23DK094975 (Greer). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
The authors declare they have no competing interests.
KA, RG, MU conceptualized the study. KA obtained funding. KA, RG, MU acquired the data. KA analyzed the data. KA, RG, LEB, MU contributed to interpretation and manuscript preparation. All authors read and approved the final manuscript.
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Abdel-Kader, K., Greer, R.C., Boulware, L.E. et al. Primary care physicians’ familiarity, beliefs, and perceived barriers to practice guidelines in non-diabetic CKD: a survey study. BMC Nephrol 15, 64 (2014). https://doi.org/10.1186/1471-2369-15-64
- Chronic kidney disease
- Primary care physicians
- Estimate glomerular filtration rate
- Angiotensin converting enzyme inhibitors
- Angiotensin II receptor blockers