Urinary TIMP-2 and IGFBP7 for the prediction of acute kidney injury following cardiac surgery

BMC Nephrology

Table 3 Adjusted odds ratios and AUC for prediction of AKI

	Clinical Model Alone		Clinical Model with [TIMP-2]•[IGFBP7]
Adjusted Odds Ratio	Value (95% CI)	P	Value (95% CI)	P
Sex (Male/Female)	11.5 (1.6–107.4)	0.04	9.5 (2.6–83.6)	0.03
Hypertension	5.7 (1.7–18.0)	0.03	6.4 (3.2–35.7)	0.04
Preoperative creatinine >78 μmol/L	3.8(1.2–12.3)	0.01	4.0 (0.9–21.5)	0.04
[TIMP-2]•[IGFBP7]^a	--	--	115 (4–2156)	0.01
Model AUC^b	0.83(0.73–0.91)	<0.001	0.94 (0.83–0.98)	<0.001

AUC areas under the curves, AKI acute kidney injury, TIMP-2 urinary tissue inhibitor of metalloproteinase 2, IGFBP7 insulin-like growth factor binding protein 7
^aValues were log10 transformed
^bAUC for clinical model with [TIMP-2]•[IGFBP7] was significantly greater than the AUC for the clinical model alone, p = 0.03

ISSN: 1471-2369