Existing creatinine-based equations overestimate glomerular filtration rate in Indians

BMC Nephrology

Table 2 Characteristics and measurements in study population (n = 130)

Parameter	Total study participants (n = 130)
Age	44.62 ± 11.92
Sex (M/F)	72/58
Height (cm)	161.25 ± 10.82
Weight (kg)	63.17 ± 12.54
BMI (kg/m²)	24.62 ± 7.65
Hemoglobin (g/dL)	13.24 ± 1.97
Serum creatinine (mg/dL)	1.37 ± 0.88
Serum cystatin C (mg/dL)	1.75 ± 0.87
Blood urea nitrogen (mg/dL)	19.10 ± 11.67
Serum albumin (g/dL)	4.26 ± 0.40
Measured GFR by urinary inulin clearance (ml/min/1.73m²)	51.66 ± 31.68
Estimated GFR
CKD-EPI_Cr equation (ml/min/1.73m²)	76.58 ± 41.05^a
CKD-EPI (PK) equation (ml/min/1.73m²)	68.50 ± 38.40^a
CKD-EPI (JAP) equation (ml/min/1.73m²)	62.26 ± 33.38^a
MDRD equation (ml/min/1.73m²)	77.79 ± 43.36^a
CKD-EPI_Cys equation (ml/min/1.73m²)	55.19 ± 33.58^b

BMI body mass index, CKD-EPI Chronic Kidney Disease Epidemiology Collaboration, Cys cystatin C, GFR glomerular filtration rate, F: female, JAP Japan, M male, MDRD Modification of Diet in Renal Disease, PK Pakistan
^asignificantly different from measured GFR by urinary inulin clearance (p < 0.01 for each comparison)
^bNot significantly different from measured GFR by urinary inulin clearance (p = 0.31)
Mann-Whitney U test used for comparison between measured GFR and estimated GFR
Expressed as mean ± standard deviation except sex

ISSN: 1471-2369