Table 2 Primary and Secondary Endpoints for the Interventions Made to Preserve Cognitive Function Trial (IMPCT)
Primary Endpoint(s) | 3-month change in executive function measured using the Trail Making Test Part A (TMTA) and Part B (TMTB). Executive function is measured as TMTB-TMTA. |
|---|---|
Secondary Endpoint(s) | 1. Secondary cognitive measures (change in) |
a. 6-month executive function (TMTB-TMTA) | |
b. 3- and 6-month executive function (additional measures) | |
c. 3- and 6-month memory | |
d. 3- and 6-month global cognitive function | |
2. ESKD-specific clinical measures | |
a. Measured physical function | |
b. Number of falls | |
c. Hospitalization | |
d. Mortality | |
e. Return to work | |
f. Amputation | |
3. Patient-centered outcomes | |
a. HRQOL | |
b. Anxiety | |
c. Depression | |
d. Fatigue | |
e. Pain interference | |
f. Perceived physical function | |
g. Sleep disturbance | |
h. Ability to participate in social roles and activities |