Interventions Made to Preserve Cognitive Function Trial (IMPCT) study protocol: a multi-dialysis center 2x2 factorial randomized controlled trial of intradialytic cognitive and exercise training to preserve cognitive function
BMC Nephrology volume 21, Article number: 383 (2020)
Kidney disease and dialysis significantly impact cognitive function across the age spectrum. Cognitive training (CT) and/or exercise training (ET) are promising approaches to preserve cognitive function among community-dwelling older adults, but have not been tested for cognition preservation in hemodialysis patients of all ages. In this manuscript, we summarize the protocol for the Interventions Made to Preserve Cognitive Function Trial (IMPCT).
We will perform a 2 × 2 factorial randomized controlled trial (RCT) of eligible adult (≥18 years) hemodialysis initiates (n = 200) to test whether intradialytic CT (brain games on a tablet PC), ET (foot peddlers) and combined CT + ET while undergoing hemodialysis preserves executive function compared to standard of care (SC). Participants will engage in the interventions to which they are randomized for 6 months. The primary objective is to compare, among interventions, the 3-month change in executive function measured using the Trail Making Test A (TMTA) and B (TMTB); specifically, executive function is calculated as TMTB-TMTA to account for psychomotor speed. This primary outcome was selected based on findings from our pilot study. The secondary objectives are to compare the risk of secondary cognitive outcomes, ESKD-specific clinical outcomes, and patient-centered outcomes at 3-months and 6-months. All data collection and interventions are conducted in the dialysis center.
We hypothesize that receiving intradialytic CT or ET will better preserve executive function than SC but receiving combined CT + ET, will be the most effective intervention. The current trial will be an important step in understanding how intradialytic interventions might preserve cognitive health.
Clinicaltrials.Gov (Date: 8/6/18): # NCT03616535. Protocol Version: 10 (April 2020). Funding: NIDDK R01DK114074.
Over 640,000 adults in the US suffer from end-stage kidney disease (ESKD)  and over 95% of newly diagnosed patients initiate hemodialysis. Hemodialysis is often the only long-term treatment option for ESKD patients . Hemodialysis is performed at a minimum of 3 times a week for at least 4–6 h per session and continues for the patient’s lifetime or until successful kidney transplantation. However, given the kidney transplantation waiting list of nearly 100,000 patients, a substantial amount of patient time can be spent on hemodialysis while waiting for KT . In a study of 431 patients undergoing hemodialysis, 87.9% reported watching television and 72.4% reported sleeping during the dialysis session; participating in these passive intradialytic activities was associated with worse health-related quality of life (HRQOL), particularly mental and kidney disease-specific HRQOL . Therefore, it is likely that the time spent on hemodialysis may be a missed opportunity to improve the health of patients with ESKD.
Cognitive decline and dementia [4,5,6] are well-recognized complications of ESKD and hemodialysis [7, 8]. One study suggested that only 13% of patients undergoing hemodialysis have normal cognitive function . Many patients already have partially compromised cognitive function upon initiating hemodialysis [10,11,12], and cognitive function declines at an accelerated rate  while undergoing hemodialysis . In fact, patients undergoing hemodialysis suffer from a 3-fold higher rate of cognitive impairment than age-matched controls . In the hemodialysis population, poor cognitive function is not limited to older adults but occurs across the age spectrum [16,17,18,19,20].
Among patients undergoing hemodialysis, cognitive impairment is associated with poor medication compliance, increased number of hospitalizations , increased mortality [15, 21], and decreased access to kidney transplantation [17, 19]. Severe cognitive impairment is problematic as it impedes patients’ ability to comply with their dialysis schedule, maintain complicated medication regimens for chronic conditions, retain the capacity for self-care, make informed decisions, and adhere to fluid and dietary restrictions .
In community-dwelling older adults, cognitive and exercise training, have been identified as effective non-pharmacological interventions to prevent cognitive decline [22,23,24,25,26,27,28,29,30,31,32]. Exercise training (ET) that generally targets cognitive function [22,23,24] has been found to have the greatest impact on preserving executive function specifically [25,26,27,28,29,30]. The impact of ET begins even before improvements in strength and physical functioning are observed . Additionally, cognitive training (CT) has been found to prevent declines in multiple domains of cognitive function, such as executive function, and can impact working memory, abstraction, verbal reasoning, and inhibition [34,35,36,37,38,39,40,41,42]. It is thought that CT impacts cognitive function by improving neural functions [43,44,45]. Therefore, multi-domain approaches to CT are preferred over memory training alone. This approach has been associated with broad benefits in cognitive function and provides lasting gains that extend to everyday life activities up to 10 years post-intervention , among community-dwelling older adults [40, 46, 47]. CT has also been combined with exercise training for community-dwelling older adults, and this multi-modal approach has been found to be more effective than either intervention alone [43, 48], especially for executive function [33, 39, 48, 49]. We conducted a pilot study of intradialytic ET and CT and found that these interventions preserved cognitive function compared to standard of care (SC) .
Therefore, we built upon the findings of our pilot trial of ET and CT to design a trial to test whether these interventions alone or in combination preserve cognitive function among patients initiating hemodialysis. We describe our protocol for the Interventions Made to Preserve Cognitive Function Trial (IMPCT), a randomized controlled trial (RCT) of 200 hemodialysis initiates to test whether intradialytic CT, ET, and combined CT + ET preserves executive function compared to standard of care (SC).
The primary aim of this trial is to determine if receiving intradialytic CT, ET, or CT + ET preserves executive function relative to those with SC. The secondary objectives are to compare the risk of secondary cognitive outcomes, ESKD-specific clinical outcomes, and patient-centered outcomes among those receiving CT, ET, or CT + ET relative to those in SC. We will accomplish these goals by conducting a multi-dialysis center 2 by 2 factorial RCT (n = 200).
Study setting and team
Eligible adult ESKD patients who are initiating twice or thrice weekly maintenance hemodialysis will be recruited from 13 centers in the Baltimore, Maryland area (Fig. 1); additional centers will be added if needed to achieve a sample size of 200 participants. Screening, consent, enrollment, assessments and interventions will be conducted at the dialysis center. A project manager and trained research assistants will conduct all aspects of the clinical trial. Additionally, the study will have a medical monitor who will review all unexpected adverse events and a Data, Safety, and Monitoring Board (DSMB); see below. The DSMB will be comprised of a patient advocate, an ethicist, a statistician, a nephrologist, and a research nurse.
The inclusion and exclusion criteria are listed in Table 1. We will only enroll hemodialysis patients within 3 months to 3 years of hemodialysis initiation because: 1) they will not have already experienced the cognitive decline associated with hemodialysis; 2) there is a high dementia incidence even within the first year of hemodialysis ; 3) survival bias is present when studying prevalent hemodialysis patients; and 4) we want to intervene before the hemodialysis-associated neurodegenerative process begins. At each center, all English-speaking hemodialysis patients aged ≥18 years who are within 3 months to 3 years of hemodialysis initiation will be screened for eligibility based on exclusion criteria (Table 1). Only those who are willing to participate in research, based on willingness to sign the consent form and to complete the baseline assessment, will be enrolled and then randomized. Finally, approval by the treating provider at the dialysis center is required prior to enrollment to ensure that the interventions will be safe for the participants.
We will exclude participants who are prisoners and those who are unable to participate in ET without assistance. Also, participants with the following conditions that would limit participation will be excluded: pregnancy, angina pectoris, chronic lung disease requiring oxygen, musculoskeletal conditions, lower- or upper-extremity amputation, orthopedic disorders exacerbated by physical activity, femoral AV access, legally blind, inability to recognize numbers and letters, or hepatitis B infection requiring medical isolation (Table 2). Trained research assistants will obtain written informed consent from eligible participants.
We expect to screen 340–350 participants to identify 200 eligible participants to randomize to interventions. We will prematurely terminate a study participant after randomization if they violate study procedures, become too medically unfit to continue, receive kidney transplantation, change dialysis centers to one that is not a part of the study, or request early discontinuation for any other reason.
All data collection is conducted in the dialysis center. Any assessment that may be impacted by the hemodialysis treatment is collected prior to initiation of hemodialysis. Personal information will be collected in private and not be shared to protect confidentiality.
At the baseline assessment (Table 3), participants will self-report demographics including age, sex, race/ethnicity, education, employment status, and marital status. Furthermore, trained research assistants will measure frailty using the physical frailty phenotype , functional dependence using activities of daily living  as well as instrumental activities of daily living , impairment in lower extremity function using the Short Physical Performance Battery , comorbidity using the Charlson comorbidity index for ESKD [55, 56], and self-reported HRQOL . Additional pre-hemodialysis medical factors, dialysis factors, and clinical measures will be abstracted from the dialysis medical records. At baseline, measures of primary and secondary outcomes (ascertainment described below), are obtained to be able to calculate change in outcome measures after 3 and 6 months of intervention. All participants completing the baseline assessments will be compensated $10 (funding from NIDDK R01DK114074).
Participants will be randomized after completion of the baseline assessment. Participants will be block randomized by sex, race, and dialysis center. They will be randomly assigned to one of the 4 arms using a blind and secure computer-based allocation system. To assure desired sample sizes in the 4 arms, the randomized block size will also be randomized. We will perform the randomization schema using R. Blinding of intervention groups to participants and clinical staff will not be possible; however, those collecting the primary and secondary outcomes will be blinded to the intervention group.
Participants will be asked to participate in CT and ET for a minimum of 30 min during each hemodialysis session. After 15 min on hemodialysis, the research assistant will approach the participant to initiate the intervention. When the participant is finished with their assigned intervention, the study staff will record the duration of the intervention for each session. Additionally, the blood pressure of participants will be recorded before and after each intervention. Participants in the CT, ET, or CT + ET arm will be compensated with a $5 gift card for every intervention session in which they participate so as to encourage participation. We will administer the interventions for 6 months (funding from NIDDK R01DK114074).
Participants randomized to the ET arm will be given a stationary foot peddler, which will be placed at a distance from the dialysis chair that is comfortable for the participant. The research assistant will adjust the resistance on the foot peddler for each participant.
To standardize the dose of ET, all ET will start with a 2 min warm up, then the resistance will be adjusted so that the participant is working at perceived exertion of “somewhat hard,” using the Borg scale  (~ 50 rpm). Resistance will be increased when the rating falls below “somewhat hard.” Heart rate and blood pressure are routinely monitored throughout the session. Participants will participate in ET when their blood pressure is between 110/50–200/100 mmHg and heart rate is < 80% This approach is consistent with previous intradialytic ET .
Intradialytic CT consists of playing brain games through Lumosity®, which is a web-based cognitive training program on a tablet PC for at least 30 min. Lumosity is available for research purposes and has been used for cognitive training interventions across a variety of research settings [60,61,62,63]. We chose this intervention because it will be well recognized by participants and was generally regarded as a fun activity during the pilot study. We expect that this will lead to increased participation and adherence. Lumosity has adapted scientifically developed cognitive training tasks into over 40 games. Participants will have 10 different brain games each session to play and these games will vary for each session.
The brain games used in the CT arm are not designed to teach a specific cognitive ability. Therefore, we will test whether there is a transfer of training to global cognition and executive function; see below. It is important to show that we are not just teaching the test, which can occur when the cognitive exercise is the same as the outcome.
Combined Intradialytic CT + ET
For those in the intradialytic CT + ET arm, participants will start with 30 min of CT with a 15 min break and then 30 min of ET. We chose 30 min of participation in each arm as that was the average duration from the pilot study  where participants were asked to partake in these intradialytic interventions for as long as they were able. Research assistants will record the duration of both CT and ET for the participants in this arm.
Outcomes are measured at 3 and 6 months of intervention and will be conducted at the dialysis centers. All staff who perform the baseline and follow-up assessments for the primary and secondary outcomes will be blinded to the treatment group. Participants randomized to CT, ET, or ET + CT will be compensated $10 for the completion of each follow-up assessment; those in the SC arm will be compensated $25 (funding from NIDDK R01DK114074); the compensation is higher because these participants will not receive any compensation for participating in the intervention.
Based on the findings of the pilot study , the primary endpoint chose was the 3-month change in executive function; executive function is measured using two tests, the Trail Making Test Part A (TMTA) and Trail Making Test Part B (TMTB) ; specifically, executive function is calculated as TMTB-TMTA to account for psychomotor speed. The TMTA and TMTB are validated measures of executive function (i.e. cognitive shifting, cognitive flexibility), attention, concentration, and psychomotor speed . The tests measure the time required to connect a series of sequentially numbered (TMTA) and numbered/lettered (TMTB) circles. Needing more time to complete the tests indicates worse executive function. The times are capped at 3 min for TMTA and 5 min for TMTB.
The secondary outcomes were: 1) cognitive, 2) ESKD-specific clinical outcomes, and 3) patient-centered outcomes; see below.
The secondary cognitive measures included the 6-month change in executive function. Additional tests of global cognitive function and executive function that are less prone to floor or ceiling effects will be secondary cognitive outcomes. The 3- and 6-month change in executive function will be measured using the Digit Symbol Substitution Test  and Stroop test . The Digit Symbol Substitution Test  evaluates the speed and working memory components of executive function and consists of 9 number/symbol pairs (for example: 1+, 2X, 3=, etc.). Participants are asked to write the corresponding symbol as quickly as possible (for example: 3_, 1_, 9_). The correct number of symbols within 90 s is measured. The Stroop test (reading, color-naming, and interference sub-tasks)  evaluates the inhibitory control of executive function and involves reading the name of a color printed in a different color ink: BLUE. The time ratio of color-word interference and color only tasks will be calculated. The 3- and 6-month changes in global cognitive function will be measured by the Montreal Cognitive Assessment (MoCA) , a commonly studied, clinically useful, and validated test of global cognitive function. It is an alternative to the Modified Mini-mental State (3MS) examination and measures cognitive performance across the whole continuum, with higher sensitivity for detecting mild cognitive impairment . Finally, the 3- and 6-month change in memory measured by Auditory/Verbal Learning Test (AVLT) , a screening test for memory impairment. The AVLT measures a patient’s immediate recall. A series of unrelated words are presented aloud and participants are asked to recall as many as they can.
Secondary ESKD-specific clinical outcomes include, measured lower extremity function by the Short Physical Performance Battery , the number of injurious falls, amputations, and hospitalizations, as well as return to work and mortality.
Secondary patient-centered outcomes include self-reported anxiety, depression, fatigue, pain interference, perceived physical function, sleep disturbance, ability to participate in social roles and activities as well as HRQOL. These patient-reported outcomes will each be measured by 4-items in the Patient-Reported Outcomes Measurement Information System (PROMIS)-29 short form profile from the NIH toolbox . PROMIS is a set of person-centered measures that evaluates physical mental, and social health in adults. The items were developed and validated in a way that is psychometrically sound and relevant across chronic health conditions. Each is measured by 4-items in the PROMIS-29 short form profile. We will measure HRQOL using a self-report of current health and health in the past year.
Participants will be followed for 1 year after the end of the intervention for the secondary outcomes.
The expected adverse events are cramping (among ET group), hypotension (among ET group), hypertension (among ET group), elevated heart rate (among ET group), or headache (among CT group). During every session, participants in all 4 arms are asked to report whether or not they have experienced any of these expected adverse events.
All unexpected adverse events are ascertained by direct observation, interviewing participants, and unsolicited reports from participants or dialysis staff. The medical monitor and PI will review each unexpected adverse event and classify it by severity (mild, moderate, severe/undesirable, potentially life threatening or death) and by grading (unrelated, possibly related, or definitely related). These adverse events will be recorded from the time of enrollment until a subject completes study participation or until 30 days after he/she withdraws.
The DSMB will meet to review interim analyses of the safety and efficacy data; meetings will occur after 10, 25, and 50% of participants, respectively, having completed 3 months of the interventions. The DSMB will review any event that potentially impacts safety at the request of the Principal Investigator, or medical monitor. Additionally, the DSMB may be called upon for ad hoc reviews of unexpected adverse events. After the initiation of the trial, the IRB will take action based on recommendations from the DSMB if there are superiority or safety concerns. A temporary halt in enrollment at all participating centers will be implemented if an ad hoc DSMB safety review is required.
We used a Monte-Carlo simulation (1000 randomly generated datasets) to estimate the power of a 2-by-2 factorial design with linear regression and Huber-White robust standard errors. We powered the RCT to detect a statistically significant difference in the CT + ET group based on a 3-month change in executive function, given the group mean change and SD in the pilot study .
So that when each arm of the study has 47 participants, we have 80% power to detect a statistically significant change of 20 s between baseline and 3 months comparing the CT + ET arm to the SC arm as well as 95% power to detect a statistically significant change of 15 s in the CT arm and > 99% to detect a statistically significant change of 18 s in the ET arm. Therefore, we would need to recruit 200 participants. Even if we were to recruit just 22 participants (rather than 47) into each arm of the study, we would still have > 80% power to observe statistically significant changes of 15 s for the main effects of CT and ET.
Data will be analyzed according to the intention-to-treat principle. We will test the main effect of CT alone and the main effect of ET alone as well as the interaction between CT + ET compared with SC. All data analyses will be conducted in Stata 14.0 (or higher) software. Statistical significance will be set at P < 0.05 for all analyses. Data will be directly entered into RedCap and weekly assessment of data completeness and range checks as well as other standard data management procedures will be used.
Descriptive statistics will include estimates of mean and standard deviations for continuous factors, percentages for categorical factors, and medians and interquartile ranges for non-normally distributed continuous factors. Skewness/kurtosis will be tested to assess the normality of all continuous data; log transformations for skewed distributions will be used. Baseline characteristics will be compared among treatment groups to test adequacy of randomization and identify possible confounders. If there are concerns about imbalances between groups with respect to important risk factors for executive function decline, we will adjust regression-based models as necessary to account for these differences. Competing events (death or transplantation) for the measurement of 3-month change in executive function will be quantified; if relevant, sensitivity analysis accounting for competing events will be performed.
Change in executive function between baseline and 3 months will be handled as a continuous outcome. Using a linear regression with the cluster option to account for the correlation of patients within centers (if needed) and any imbalance between the groups, we will analyze the primary endpoint. We will test for intervention effect measure modification by frailty, age, race, and sex for the primary endpoint as described below. Secondary endpoints will be analyzed based on the functional form of the outcome.
This trial has been approved by the Johns Hopkins IRB and reviewed by Frenova Renal Research and DaVita Clinical Research. All important protocol modifications will be reported to the Johns Hopkins IRB and reviewed by Frenova Renal Research and DaVita Clinical Research. It is registered at clinicaltrials.gov (NCT03616535): https://clinicaltrials.gov/ct2/show/NCT03616535. The trial is currently ongoing with the first patient randomized on September 7, 2018.
Cognitive decline and dementia are two major clinical and public health challenges among patients undergoing hemodialysis. Therefore, we designed a novel 2 by 2 factorial RCT of intradialytic CT and ET among patients initiating hemodialysis (n = 200); a defining feature of this study is that all visits and interventions are being conducted in the hemodialysis center.
To date, there have been only two trials that have explored exercise as an intervention with secondary outcomes of cognitive function among patients undergoing dialysis [71, 72]. The first trial was the Exercise Introduction to Enhance Performance in Dialysis (EXCITE) trial, a 6-month randomized, controlled, multicenter trial of adult patients of all ages undergoing dialysis . The goal of this trial was to test whether home-based, personalized exercise interventions improve functional status; this study additionally collected self-reported cognitive function. The EXCITE trial results suggest that exercise improves self-reported cognitive function scores as measured by the Kidney Disease QOL-SF . In a secondary analysis, this trial tested the impact and tolerance of the exercise program on older (aged ≥65 years) dialysis patients. Exercise preserved self-reported cognitive function in this older population; those randomized to the control arm experienced more declines, on average, in self-reported cognitive function .
In addition to the EXCITE trial, the second trial was a pilot randomized controlled trial studying intradialytic exercise as an intervention to preserve cognitive function . This first pilot RCT of 30 adult (aged ≥18 years) patients undergoing hemodialysis evaluated the impact of a 4-month exercise intervention of intradialytic cycling and tested whether this aerobic exercise affected cerebral blood flow and cognitive function. The results suggest that those randomized to the exercise group (N = 15) had improved cognitive function, a greater proportion of arteries with increased flow velocity, and improved basilar maximum blood flow velocity compared to the control group (N = 15).
Finally, we conducted a pilot randomized controlled trial of 20 adult (aged ≥18 years) patients undergoing hemodialysis and tested whether 3 months of intradialytic CT (tablet PC-based brain games) (N = 7), ET (foot peddlers) (N = 6), or SC (N = 7) preserved cognitive function . Cognitive function was directly measured using the 3MS,TMTA, and TMTB. While those patients randomized to the SC arm experienced decline in psychomotor speed and executive function at 3 months, those randomized to either the CT or ET arms demonstrated preserved cognitive function.
In sum, the current trial will be an important step in identifying which intradialytic interventions preserve cognitive health among patients undergoing hemodialysis. We will leverage the time spent in a dialysis center to deliver these interventions so that patients will have higher compliance with their assigned intervention and hopefully find that these activities will preserve cognitive function. We will be able to isolate the impact of intradialytic ET and CT on 1) secondary cognitive outcomes, 2) ESKD-specific clinical outcomes, and 3) patient-centered outcomes. Finally, we will test the novel hypothesis that combined intradialytic ET and CT synergistically preserve cognitive function. In light of the growing concern about cognitive decline and dementia among patients undergoing hemodialysis, we hope to provide new information about potential effective interventions to preserve cognitive function for this vulnerable population.
Availability of data and materials
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study. Access to the final trial dataset will be available to the PI (Dr. McAdams-DeMarco) by email (email@example.com). If outside investigators are interested in the randomized controlled trial data collected through the study we will consider applications for collaborative work. The PI can provide information on how to apply for permission to obtain access to the data. Results from the trial will be published in peer reviewed journals and presented at relevant scientific meetings. There are no publication restrictions.
Auditory/Verbal Learning Test
Data and Safety Monitoring Board
End-stage kidney disease
Exercise Introduction to Enhance Performance in Dialysis
Health-related quality of life
Interventions Made to Preserve Cognitive Function Trial
Modified Mini-mental State
Montreal Cognitive Assessment
Patient-Reported Outcomes Measurement Information System
Randomized controlled trial
Trail Making Test Part A
Trail Making Test Part B
United States Renal Data System. 2018 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. In: Bethesda: National Institute of Diabetes and Digestive and Kidney Diseases; 2016.
Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN / SRTR Annual Data Report. Rockville: Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation; 2012.
Warsame F, Ying H, Haugen CE, Thomas AG, Crews DC, Shafi T, Jaar B, Chu NM, Segev DL, McAdams-DeMarco MA. Intradialytic Activities and Health-Related Quality of Life Among Hemodialysis Patients. Am J Nephrol. 2018;48(3):181–9.
McAdams-DeMarco MA, Tan J, Salter ML, Gross A, Meoni LA, Jaar BG, Kao WH, Parekh RS, Segev DL, Sozio SM. Frailty and Cognitive Function in Incident Hemodialysis Patients. Clin J Am Soc Nephrol. 2015;10(12):2181–9.
McAdams-DeMarco MA, Bae S, Chu N, Gross AL, Brown CH, Oh E, Rosenberg P, Neufeld KJ, Varadhan R, Albert M, Walston J, Segev DL. Dementia and Alzheimer's Disease among Older Kidney Transplant Recipients. J Am Soc Nephrol. 2017;28(5):1575–83. https://doi.org/10.1681/ASN.2016080816.
McAdams-DeMarco MA, Daubresse M, Bae S, Gross AL, Carlson MC, Segev DL. Dementia, Alzheimer's Disease, and Mortality after Hemodialysis Initiation. Clin J Am Soc Nephrol. 2018;13(9):1339–47.
Sehgal AR, Grey SF, DeOreo PB, Whitehouse PJ. Prevalence, recognition, and implications of mental impairment among hemodialysis patients. Am J Kidney Dis. 1997;30(1):41–9.
Chu NM, McAdams-DeMarco MA. Exercise and cognitive function in patients with end-stage kidney disease. Semin Dial. 2019;32(4):283–90.
Murray AM. Cognitive impairment in the aging dialysis and chronic kidney disease populations: an occult burden. Adv Chronic Kidney Dis. 2008;15(2):123–32.
Kurella Tamura M, Wadley V, Yaffe K, McClure LA, Howard G, Go R, Allman RM, Warnock DG, McClellan W. Kidney function and cognitive impairment in US adults: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Am J Kidney Dis. 2008;52(2):227–34.
Buchman AS, Tanne D, Boyle PA, Shah RC, Leurgans SE, Bennett DA. Kidney function is associated with the rate of cognitive decline in the elderly. Neurology. 2009;73(12):920–7.
Elias MF, Elias PK, Seliger SL, Narsipur SS, Dore GA, Robbins MA. Chronic kidney disease, creatinine and cognitive functioning. Nephrol Dial Transplant. 2009;24(8):2446–52.
Altmann P, Barnett ME, Finn WF, Group SPDLCS. Cognitive function in Stage 5 chronic kidney disease patients on hemodialysis: no adverse effects of lanthanum carbonate compared with standard phosphate-binder therapy. Kidney Int. 2007;71(3):252–9.
Harciarek M, Williamson JB, Biedunkiewicz B, Lichodziejewska-Niemierko M, Debska-Slizien A, Rutkowski B. Risk factors for selective cognitive decline in dialyzed patients with end-stage renal disease: evidence from verbal fluency analysis. J Int Neuropsychol Soc. 2012;18(1):162–7.
Murray AM, Tupper DE, Knopman DS, Gilbertson DT, Pederson SL, Li S, Smith GE, Hochhalter AK, Collins AJ, Kane RL. Cognitive impairment in hemodialysis patients is common. Neurology. 2006;67(2):216–23.
Chu NM, Gross A, Xue QL, Bandeen-Roche K, Sharrett AR, Carlson M, Segev D, McAdams DeMarco M. Frailty and Cognitive Change Among Kidney Transplant Recipients. J Am Soc Nephrol. 2019;30(2):336–45.
Chu NM, Shi Z, Haugen CE, Norman SP, Gross AL, Brennan DC, Carlson MC, Segev DL, MA MA-DM. Cognitive Function, Access to Kidney Transplantation, and Waitlist Mortality Among Kidney Transplant Candidates With or Without Diabetes. Am J Kidney Dis. 2020.
Drew DA, Weiner DE, Tighiouart H, Duncan S, Gupta A, Scott T, Sarnak MJ. Cognitive Decline and Its Risk Factors in Prevalent Hemodialysis Patients. Am J Kidney Dis. 2017;69(6):780–7.
Gupta A, Montgomery RN, Bedros V, Lesko J, Mahnken JD, Chakraborty S, Drew D, Klein JA, Thomas TS, Ilahe A, et al. Subclinical Cognitive Impairment and Listing for Kidney Transplantation. Clin J Am Soc Nephrol. 2019;14(4):567–75.
Thomas AG, Ruck J, Shaffer A, Haugen C, Ying H, Warsame F, Chu N, Carlson M, Gross A, Norman SP, et al. Cognitive Impairment and Graft Loss in Kidney Transplant Recipients. Am J Transplant. 2018;18(Supplement 2):39–40.
Griva K, Stygall J, Hankins M, Davenport A, Harrison M, Newman SP. Cognitive impairment and 7-year mortality in dialysis patients. Am J Kidney Dis. 2010;56(4):693–703.
Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao J, Greenop KR, Almeida OP. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA. 2008;300(9):1027–37.
Chapman SB, Aslan S, Spence JS, Keebler MW, DeFina LF, Didehbani N, Perez AM, Lu H, D'Esposito M. Distinct Brain and Behavioral Benefits from Cognitive vs. Physical Training: A Randomized Trial in Aging Adults. Front Hum Neurosci. 2016;10:338.
Jonasson LS, Nyberg L, Kramer AF, Lundquist A, Riklund K, Boraxbekk CJ. Aerobic Exercise Intervention, Cognitive Performance, and Brain Structure: Results from the Physical Influences on Brain in Aging (PHIBRA) Study. Front Aging Neurosci. 2016;8:336.
Anderson-Hanley C, Nimon JP, Westen SC. Cognitive health benefits of strengthening exercise for community-dwelling older adults. J Clin Exp Neuropsychol. 2010;32(9):996–1001.
Best JR, Nagamatsu LS, Liu-Ambrose T. Improvements to executive function during exercise training predict maintenance of physical activity over the following year. Front Hum Neurosci. 2014;8:353.
Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14(2):125–30.
Etnier JL, Chang YK. The effect of physical activity on executive function: a brief commentary on definitions, measurement issues, and the current state of the literature. J Sport Exerc Psychol. 2009;31(4):469–83.
Hillman CH, Belopolsky AV, Snook EM, Kramer AF, McAuley E. Physical activity and executive control: implications for increased cognitive health during older adulthood. Res Q Exerc Sport. 2004;75(2):176–85.
Erickson KI, Kramer AF. Aerobic exercise effects on cognitive and neural plasticity in older adults. Br J Sports Med. 2009;43(1):22–4.
Gregory SM, Parker B, Thompson PD. Physical activity, cognitive function, and brain health: what is the role of exercise training in the prevention of dementia? Brain sciences. 2012;2(4):684–708.
Ballesteros S, Prieto A, Mayas J, Toril P, Pita C. Ponce de León L, Reales JM, Waterworth J: Brain training with non-action video games enhances aspects of cognition in older adults: a randomized controlled trial. Front Aging Neurosci. 2014;6:277.
Barcelos N, Shah N, Cohen K, Hogan MJ, Mulkerrin E, Arciero PJ, Cohen BD, Kramer AF, Anderson-Hanley C. Aerobic and Cognitive Exercise (ACE) Pilot Study for Older Adults: Executive Function Improves with Cognitive Challenge While Exergaming. J Int Neuropsychol Soc. 2015;21(10):768–79.
Anand R, Chapman SB, Rackley A, Keebler M, Zientz J, Hart J Jr. Gist reasoning training in cognitively normal seniors. Int J Geriatr Psychiatr. 2011;26(9):961–8.
Levine B, Stuss DT, Winocur G, Binns MA, Fahy L, Mandic M, Bridges K, Robertson IH. Cognitive rehabilitation in the elderly: effects on strategic behavior in relation to goal management. J Int Neuropsychol Soc. 2007;13(1):143–52.
Karbach J, Kray J. How useful is executive control training? Age differences in near and far transfer of task-switching training. Dev Sci. 2009;12(6):978–90.
Rebok GW, Ball K, Guey LT, Jones RN, Kim HY, King JW, Marsiske M, Morris JN, Tennstedt SL, Unverzagt FW, et al. Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults. J Am Geriatr Soc. 2014;62(1):16–24.
Mahncke HW, Connor BB, Appelman J, Ahsanuddin ON, Hardy JL, Wood RA, Joyce NM, Boniske T, Atkins SM, Merzenich MM. Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study. Proc Natl Acad Sci U S A. 2006;103(33):12523–8.
Shatil E. Does combined cognitive training and physical activity training enhance cognitive abilities more than either alone? A four-condition randomized controlled trial among healthy older adults. Front Aging Neurosci. 2013;5:8.
Strenziok M, Parasuraman R, Clarke E, Cisler DS, Thompson JC, Greenwood PM. Neurocognitive enhancement in older adults: comparison of three cognitive training tasks to test a hypothesis of training transfer in brain connectivity. Neuroimage. 2014;85(Pt 3):1027–39.
Tagliabue CF, Guzzetti S, Gualco G, Boccolieri G, Boccolieri A, Smith S, Daini R. A group study on the effects of a short multi-domain cognitive training in healthy elderly Italian people. BMC Geriatr. 2018;18(1):321.
Wolinsky FD, Unverzagt FW, Smith DM, Jones R, Stoddard A, Tennstedt SL. The ACTIVE cognitive training trial and health-related quality of life: protection that lasts for 5 years. J Gerontol A Biol Sci Med Sci. 2006;61(12):1324–9.
Fabre C, Chamari K, Mucci P, Masse-Biron J, Prefaut C. Improvement of cognitive function by mental and/or individualized aerobic training in healthy elderly subjects. Int J Sports Med. 2002;23(6):415–21.
Maclin EL, Mathewson KE, Low KA, Boot WR, Kramer AF, Fabiani M, Gratton G. Learning to multitask: effects of video game practice on electrophysiological indices of attention and resource allocation. Psychophysiology. 2011;48(9):1173–83.
Mathewson KE, Basak C, Maclin EL, Low KA, Boot WR, Kramer AF, Fabiani M, Gratton G. Different slopes for different folks: alpha and delta EEG power predict subsequent video game learning rate and improvements in cognitive control tasks. Psychophysiology. 2012;49(12):1558–70.
Chapman SB, Mudar RA. Enhancement of cognitive and neural functions through complex reasoning training: evidence from normal and clinical populations. Front Syst Neurosci. 2014;8:69.
McDaniel MA, Binder EF, Bugg JM, Waldum ER, Dufault C, Meyer A, Johanning J, Zheng J, Schechtman KB, Kudelka C. Effects of cognitive training with and without aerobic exercise on cognitively demanding everyday activities. Psychol Aging. 2014;29(3):717–30.
Anderson-Hanley C, Arciero PJ, Brickman AM, Nimon JP, Okuma N, Westen SC, Merz ME, Pence BD, Woods JA, Kramer AF, et al. Exergaming and older adult cognition: a cluster randomized clinical trial. Am J Prev Med. 2012;42(2):109–19.
Maillot P, Perrot A, Hartley A. Effects of interactive physical-activity video-game training on physical and cognitive function in older adults. Psychol Aging. 2012;27(3):589–600.
McAdams-DeMarco MA, Konel J, Warsame F, Ying H, Gonzalez Fernandez M, Carlson MC, Fine DM, Appel LJ, Segev DL. Intradialytic Cognitive and Exercise Training May Preserve Cognitive Function. Kidney Int Rep. 2018;3(1):81–8.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, et al. Frailty in older adults evidence for a phenotype. J Gerontol Ser A Biol Med Sci. 2001;56(3):M146–57.
Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of Illness in the Aged. The Index of ADL: A Standardized Measure of Biological and Psychosocial Function. Jama. 1963;185:914–9.
Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3_Part_1):179–86.
Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49(2):M85–94.
Charlson M, Szatrowski TP, Peterson J, Gold J. Validation of a combined comorbidity index. J Clin Epidemiol. 1994;47(11):1245–51.
Hemmelgarn BR, Manns BJ, Quan H, Ghali WA. Adapting the Charlson Comorbidity Index for use in patients with ESRD. Am J Kidney Dis. 2003;42(1):125–32.
Hays RD, Kallich JD, Mapes DL, Coons SJ, Carter WB. Development of the kidney disease quality of life (KDQOL) instrument. Qual Life Res. 1994;3(5):329–38.
Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377–81.
DePaul V, Moreland J, Eager T, Clase CM. The effectiveness of aerobic and muscle strength training in patients receiving hemodialysis and EPO: a randomized controlled trial. Am J Kidney Dis. 2002;40(6):1219–29.
Zickefoose S, Hux K, Brown J, Wulf K. Let the games begin: a preliminary study using attention process training-3 and Lumosity brain games to remediate attention deficits following traumatic brain injury. Brain Inj. 2013;27(6):707–16.
Sternberg DA, Ballard K, Hardy JL, Katz B, Doraiswamy PM, Scanlon M. The largest human cognitive performance dataset reveals insights into the effects of lifestyle factors and aging. Front Hum Neurosci. 2013;7:292.
Mayas J, Parmentier FB, Andres P, Ballesteros S. Plasticity of attentional functions in older adults after non-action video game training: a randomized controlled trial. PLoS One. 2014;9(3):e92269.
Ballesteros S, Prieto A, Mayas J, Toril P, Pita C, Ponce de Leon L, Reales JM, Waterworth J. Brain training with non-action video games enhances aspects of cognition in older adults: a randomized controlled trial. Front Aging Neurosci. 2014;6:277.
Tombaugh TN. Trail Making Test A and B: normative data stratified by age and education. Archiv Clin Neuropsychol. 2004;19(2):203–14.
Spreen O, Spreen E: A compendium of neuropsychological tests: Administration, norms and commentary, 2nd edn. New York: Oxford University Press; 1998.
Wechsler D. Wechsler Memory Scale, revised. San Antonio: Psychological Corporation; 1987.
MacLeod CM. Half a century of research on the Stroop effect: an integrative review. Psychol Bull. 1991;109(2):163–203.
Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–9.
Loring DW, Bowden SC, Staikova E, Bishop JA, Drane DL, Goldstein FC. NIH Toolbox Picture Sequence Memory Test for Assessing Clinical Memory Function: Diagnostic Relationship to the Rey Auditory Verbal Learning Test. Archiv Clin Neuropsychol. 2019;34(2):268–76.
Hays RD, Spritzer KL, Schalet BD, Cella D. PROMIS((R))-29 v2.0 profile physical and mental health summary scores. Qual Life Res. 2018;27(7):1885–91.
Stringuetta Belik F, Oliveira ESVR, Braga GP, Bazan R, Perez Vogt B, Costa Teixeira Caramori J, Barretti P, de Souza Goncalves R, Fortes Villas Boas PJ, Hueb JC, et al. Influence of Intradialytic Aerobic Training in Cerebral Blood Flow and Cognitive Function in Patients with Chronic Kidney Disease: A Pilot Randomized Controlled Trial. Nephron. 2018;140(1):9–17.
Manfredini F, Mallamaci F, D'Arrigo G, Baggetta R, Bolignano D, Torino C, Lamberti N, Bertoli S, Ciurlino D, Rocca-Rey L, et al. Exercise in Patients on Dialysis: A Multicenter, Randomized Clinical Trial. J Am Soc Nephrol. 2017;28(4):1259–68.
Baggetta R, D'Arrigo G, Torino C, ElHafeez SA, Manfredini F, Mallamaci F, Zoccali C. Tripepi G, group EW: Effect of a home based, low intensity, physical exercise program in older adults dialysis patients: a secondary analysis of the EXCITE trial. BMC Geriatr. 2018;18(1):248.
The authors would like to thank the trial participants for their contribution to the study.
Lumosity® provided the brain games for the intervention arm through the Human Cognition Project but did not participate in the study design, conduct of the study, statistical analysis, or drafting of the manuscript.
Funding for this study was provided by the National Institute of Diabetes and Digestive and Kidney Disease: R01DK114074 (PI: McAdams-DeMarco), and K24DK101828 (PI: Segev). The funders had no role in the study design, collection, management, analysis, and interpretation of data; writing of the report; and the decision to submit the report for publication. The principal investigator has no other financial or competing interests.
Ethics approval and consent to participate
All study participants will provide written informed consent. This trial has been approved by the Johns Hopkins IRB (IRB00152858) as well as the Frenova Renal Research and DaVita Clinical Research. It is registered at clinicaltrials.gov (NCT03616535).
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
McAdams-DeMarco, M.A., Chu, N.M., Steckel, M. et al. Interventions Made to Preserve Cognitive Function Trial (IMPCT) study protocol: a multi-dialysis center 2x2 factorial randomized controlled trial of intradialytic cognitive and exercise training to preserve cognitive function. BMC Nephrol 21, 383 (2020). https://doi.org/10.1186/s12882-020-02041-y