Skip to main content

A rare complication following internal jugular vein catheterization to malposition: acute Budd Chiari syndrome

Abstract

Background

Tunneled catheters can be used as an alternative vascular access in patients with limited health expectancy,vascular access problems and several comorbidities. We aimed to present a patient with venous stenosis related- reversible acute Budd-Chiari syndrome after catheter malposition.

Case presentation

After changing of tunneled catheter insertion, 36-year old man was admitted to our hospital with sudden onset of nausea, fever, chills and worsening general condition In computed tomography (CT) imaging, a hypodense thrombus was observed in which the distal end of the catheter is at the level of drainage of the hepatic veins in the inferior vena cava and that blocked hepatic vein drainage around the catheter. The catheter was removed and a new catheter was inserted in the same session. Because patient’s general condition was good and without fever, he was discharged with advices on the 9th day of hospitalization.

Conclusion

Although catheter malposition and thrombosis are not a common complication, clinicians should be alert of these complications.

Peer Review reports

Background

The incidence of end stage renal disease (ESRD), which is one of the important health problems of worldwide, is gradually increasing and one of the treatment options is hemodialysis. Hemodialysis requires effective vascular access routes with a blood flow of at least 350 mL/min [1,2,3]. It has been suggested that the first choice for vascular access is arteriovenous fistula (AVF), but tunneled catheters can be used as an alternative to AVF in patients with limited health expectancy, comorbidities and vascular access problems according to Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines [4].

Infection, internal jugular vein (IJV) stenosis and thrombosis are also common complications of permanent intrajugular hemodialysis catheterization [5]. Despite all complications, usage of dialysis catheter is still very common in this cohort according to the annual report of the United States Renal Data System (USRDS), approximately 63% of patients used a catheter for vascular access for the first dialysis treatment in the USA [6]. Another important complication such as catheter malposition ratio was between 3.6–14% in small and medium-sized studies in the literature. However, catheter malposition is rare in right IJV catheterization [7, 8].

Additionally, all complications related to IJV (infection, hematoma, malposition) were found to have a lower rate in the literature [9,10,11].

Budd-Chiari syndrome is caused by partial/complete hepatic venous perfusion obstruction at any localization of hepatic vein, inferior vena cava or right atrium level. As a result, liver venous obstruction occurs due to increased hepatic sinusoidal pressure, which leads to portal hypertension and decreased liver perfusion. Patients can usually apply with ascites, abdominal swelling and pain. This process may eventually progress to liver fibrosis and cirrhosis [12, 13].

In this case report, we aimed to present a patient with venous stenosis related- reversible acute Budd-Chiari syndrome after catheter malposition.

Case presentation

A 36-year-old man was admitted to the emergency department of our university hospital with sudden onset of nausea, fever, chills and worsening general condition.

He had been diagnosed with familial mediterranean fever 10 years ago and renal biopsy was resulted with AA amyloidosis. After uremic symptoms, hemodialysis was started 3 days a week by transjugular catheter 5 months ago. Because of catheter malfunction, his catheter was replaced in the another medical center. Ten days after catheter malposition, his complaints started. On admission, the patient was good, conscious and orientated and his fever was: 38.5 °C, pulse: 104 beats/minute, respiratory rate: 26/min, blood pressure: 100/50 mmHg. During physical examination, distension, right flank pain and venous collateral development was observed in the patient’s abdomen. Laboratory studies revealed that blood urea nitrogen: 59 (6–20) mg/dl, creatinine: 4.4 (0.5–1.2) mg /dl, sodium: 137 (136–145) mmol /l, potassium: 3,9 (3.5–5.1) mmol/l, Total bilirubin: 1.1 (0–1.4) mg/dl, direct bilirubin: 1.0 (0–0.3) mg/dl, Total protein: 5.1 (6.4–8.3) gr/dL, albumin: 2.4 (3.5–5.2) gr/dl, alkaline phosphatase: 99 (44–130) u / L, − lactate dehydrogenase: 327 (135–250) u/L, aspartate aminotransferase: 142 (0–40) u/L, alanine aminotransferase: 453 (0–41) u /L, gamma glutamyl transferase:: 256, (10–71) u /L, C reactive protein: 174 (0–5) mg /L, procalcitonin: 100 (0–0.5) ng /dl, Hemoglobin: 9.5 (12–16) g /dl, platelet: 65000 (130–400) μ /L, white blood cell: 11 × 109 (4.8–10.7)(109)/liter, d dimer: 4220(0–500) ug/L. In the axial contrast enhanced venous phase CT image, a hypodense thrombus was observed in which the distal end of the catheter is at the level of drainage of the hepatic veins into the vena cava inferior and that blocked hepatic vein drainage around the catheter. Additionally, mosaic contrast pattern and perihepatic fluid is seen on computed tomography (CT) (optima CT 540, GE, USA) image (Fig. 1). Thrombus around the catheter was also confirmed by Doppler US (GE Logiq Pg medical System (GE, Healthcare,Chicago,IL,USA))examination.

The sagittal reformat, in which the distal tip of the catheter was inferior to the vena cava, was also observed in the CT image (Fig. 2) The patient’s diagnosis was accepted Acute Budd Chiari syndrome developed as a result of catheter malposition. Heparin and broad-spectrum antibiotic therapy (Vankomycin/meropenem) were administered for the patient immediately. The catheter was removed and a new catheter was inserted in the same session. A few days after this procedure, symptoms of liver failure regressed (Table 1). Because patient’s general condition was good and without fever, he was discharged with advices on the 9th day of hospitalization.

Fig. 1
figure1

a and b In axial contrast venous phase CT section (a), the distal end of the dialysis catheter is located at the level of drainage of the hepatic veins in the inferior vena cava (black arrow) and the hypodense thrombus (black arrow) around the catheter that prevents hepatic vein drainage. In the sagittal reformat CT image, the distal of the catheter located vena cava inferior is also observed (white arrow, b)

Table 1 Biochemical parameters of patient before and after catheter revision
Fig. 2
figure2

In axial venous phase contrast CT section; Mosaic pattern compatible with Budd-Chiari Syndrome is observed in the liver parenchyma. No contrast agent filling is observed in the hepatic veins (black arrows). In addition, acid is observed in the perihepatic area (white arrow)

Discussion and conclusion

Tunneled dialysis catheter is still very common in patients with ESRD according to the annual report of the USRDS, it has been reported that it is still most widely used vascular access for the dialysis treatment in the USA [6].

Catheter malposition generally may be related to methodological insufficiency, anatomical variation and operator experience. As a result of these reasons, catheter thrombosis, vascular injury and vascular perforation may ocur in patients [14,15,16,17,18,19].

Compared to other catheter localizations, all complications associated with the IJV (infection, hematoma, malposition) have 2–5 times less complication rate [10, 11]. Traumatic complications associated with IJV catheter insertion have been well described in the literature, such as Horner’s syndrome (a decreased pupil size, a drooping eyelid and decreased sweating on the affected side of your face with miosis, ptosis and enophthalmos), venous perforation, pneumothorax, and cardiac tamponade [20,21,22,23].

Generally, catheter related complications are divided into two as acute and chronic. In one study, hematoma, hemothorax and the lowest rate of catheter malposition were observed among acute complications [10].

After catheter malposition, development of stenosis may occur and the central veins and subsequent obstructive symptoms begin. Diagnosis is usually revealed by imaging such as X-ray, Doppler ultrasonography, CT and angiography. In a 1613 series study by Pickver et al., the malposition rate was found to be 3.3%. In another study, catheter malposition rate was found to be 8.79% of all catheterizations. In a study in which 3213 patients were studied by Napalkov et al., the rate of catheter thrombosis was found to be 0.80% [9, 24].

Budd-Chiari syndrome refers to hepatomegaly that develops as a result of venous thrombotic events, ascites, abdominal swelling and pain. This syndrome is also caused by partial or complete hepatic venous outlet obstruction at either hepatic vein, inferior vena cava (IVC) or right atrium level. In any imaging, enlargement of the caudate lobe, irregularities of the liver contour, intrahepatic collaterals and hypervascular nodules are observed in this syndrome. Etiopathological factors for Budd-Chiari syndrome include various systemic thrombotic and non-thrombotic conditions that can cause venous outflow obstruction in hepatic veins and/or IVC Typically, hypoattenuation echogenicity increases in the central region of the liver due to vascular thrombosis, decrease in periphery [13]. Its main treatment is removal of obstruction, anticoagulant therapy, elimination of the underlying condition and liver transplantation may be required in severe cases [25].

FMF is an autoinflammatory disease and may cause vascular endothelial damage. It has been shown that FMF may predispose to thrombosis with different mechanisms in the literature [26, 27]. In our case, FMF may have contributed catheter induced-thrombosis.

In conclusion, although catheter malposition and thrombosis are not a common complication, it is also important to use imaging methods after the catheterization procedure since they cause serious morbidity and mortality. Therefore, imaging methods should be used during the catheterization process and it should be checked whether it is in appropriate localization after the procedure.

Availability of data and materials

Data sharing is not applicable.

Abbreviations

AVF:

Arteriovenous fistula

ESRD:

End stage renal disease

IVC:

Inferior vena cava

IJV:

Internal jugular vein

USRDS:

United States Renal Data System

References

  1. 1.

    Wilkin TD, Kraus MA, Lane KA, Trerotola SO. Internal jugular vein thrombosis associated with hemodialysis catheters. Radiology. 2003;228:697–700.

    Article  Google Scholar 

  2. 2.

    Ezri T, Szmuk P, Cohen Y, et al. Carotid artery-internal jugular vein fistula: a complication of internal jugular vein catheterization. J Cardiothorac Vasc Anesth. 2001;15:231–2.

    CAS  Article  Google Scholar 

  3. 3.

    Stevens PE, Levin A. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158:825–30.

    Article  Google Scholar 

  4. 4.

    Lok CE, Huber TS, Lee T, et al. KDOQI vascular access guideline work group. KDOQI clinical practice guideline for vascular access: 2019 update. Am J Kidney Dis. 2020;75(suppl 2):S1–S164.

    Article  Google Scholar 

  5. 5.

    Wilson B, Harwood L, Oudshoorn A, Thompson B. The culture of vascular access cannulation among nurses in a chronic hemodialysis unit. Can J Theol. 2010;20:35–42.

    Google Scholar 

  6. 6.

    Foley RN, Collins AJ. The USRDS: what you need to know about what it can and can't tell us about ESRD. Clin J Am Soc Nephrol. 2013;8:845–51.

    Article  Google Scholar 

  7. 7.

    Sitzmann JV, Townsend TR, Siler MC, Bartlett JG. Septic and technical complications of central venous catheterization. A prospective study of 200 consecutive patients. Ann Surg. 1985;202:766–70.

    CAS  Article  Google Scholar 

  8. 8.

    Mansfield PF, Hohn DC, Fornage BD, Gregurich MA, Ota DM. Complications and failures of subclavian-vein catheterization. N Engl J Med. 1994;331:1735–8.

    CAS  Article  Google Scholar 

  9. 9.

    Wang K, Wang P, Liang X, Lu X, Liu Z. Epidemiology of haemodialysis catheter complications: a survey of 865 dialysis patients from 14 haemodialysis centres in Henan province in China. BMJ Open. 2015;5:e007136.

    Article  Google Scholar 

  10. 10.

    Hyder SMS, Iqbal J, Lutfi IA, Shazlee MK, Hamid K, Rashid S. Complications associated with permanent internal jugular hemodialysis catheter: a retrospective study. Cureus. 2019;11:e4521.

    PubMed  PubMed Central  Google Scholar 

  11. 11.

    Pikwer A, Bååth L, Davidson B, Perstoft I, Akeson J. The incidence and risk of central venous catheter malpositioning: a prospective cohort study in 1619 patients. Anaesth Intensive Care. 2008;36:30–7.

    CAS  Article  Google Scholar 

  12. 12.

    Katkar AS, Kuo AH, Calle S, Gangadhar K, Chintapalli K. Budd-Chiari syndrome caused by TIPS malposition: a case report. Case Rep Med. 2014;2014:267913.

    CAS  Article  Google Scholar 

  13. 13.

    Cura M, Haskal Z, Lopera J. Diagnostic and interventional radiology for Budd-Chiari syndrome. Radiographics. 2009;29:669–81.

    Article  Google Scholar 

  14. 14.

    Bahcebasi S, Kocyigit I, Akyol L, et al. Carotid-jugular arteriovenous fistula and cerebrovascular infarct: a case report of an iatrogenic complication following internal jugular vein catheterization. Hemodial Int. 2011;15:284–7.

    Article  Google Scholar 

  15. 15.

    Thomas CS Jr, Carter JW, Lowder SC. Pericardial tamponade from central venous catheters. Arch Surg. 1969;98:217–8.

    Article  Google Scholar 

  16. 16.

    Petersen J, Delaney JH, Brakstad MT, Rk R, Bagley CM Jr. Silicone venous access devices positioned with their tips high in the superior vena cava are more likely to malfunction. Am J Surg. 1999;178:38–41.

    CAS  Article  Google Scholar 

  17. 17.

    Gk N, Bjarnason H, Dietz CA Jr, Bernadas CA, Dw H. Changes in tunneled catheter tip position when a patient is upright. J Vasc Interv Radiol. 1997;8:437–41.

    Article  Google Scholar 

  18. 18.

    Kowalski CM, Kaufman JA, Rivitz SM, Geller SC, Waltman AC. Migration of central venous catheters: implications for initial catheter tip positioning. J Vasc Interv Radiol. 1997;8:443447.

    Article  Google Scholar 

  19. 19.

    Aslamy Z, Dewald CL, Heffner JE. MRI of central venous anatomy: implications for central venous catheter insertion. Chest. 1998;114:820–6.

    CAS  Article  Google Scholar 

  20. 20.

    Parikh RK. Horner’s syndrome: a complication of percutaneous catheterization of internal jugular vein. Anaesthesia. 1972;27:327–9.

    CAS  Article  Google Scholar 

  21. 21.

    Galbert MW, Kay JE. Perforation of the right innominate vein by central venous polyethylene catheter. Br J Anaesth. 1971;43:713–4.

    CAS  Article  Google Scholar 

  22. 22.

    Arnold S, Feathers RS, Gibbs E. Bilateral pneumothoraces and subcutaneous emphysema: a complication of internal jugular venepuncture. BMJ. 1973;1:211–2.

    CAS  Article  Google Scholar 

  23. 23.

    Merrill RH, Raab SO. Dialysis catheter-induced pericardial tamponade. Arch Intern Med. 1982;142:1751–3.

    CAS  Article  Google Scholar 

  24. 24.

    Napalkov P, Felici DM, Chu LK, et al. Incidence of catheter-related complications in patients with central venous or hemodialysis catheters: a health care claims database analysis. BMC Cardiovasc Disord. 2013;13:86.

    Article  Google Scholar 

  25. 25.

    Brancatelli G, Vilgrain V, Federle MP, et al. Budd-Chiari syndrome: spectrum of imaging findings. Am J Roentgenol. 2007;188:W168–76.

    Article  Google Scholar 

  26. 26.

    Ertenli I, Kiraz S, Ozturk MA, Haznedaroglu IC, Celik I, Kirazlı S, Calguneri M. Plasma fibronectin- and thrombospondin adhesive molecules during acute attacks and attack-free periods of familial Mediterranean fever. Rheumatol Int. 2001;20:217–20.

    CAS  Article  Google Scholar 

  27. 27.

    Esmon CT. Inflammation and thrombosis. J Thromb Haemost. 2003;1:1343–8.

    CAS  Article  Google Scholar 

Download references

Acknowledgements

Not applicable.

Funding

None.

Author information

Affiliations

Authors

Contributions

SK, IK, NH, CU, OO and MS are responsible for the clinical management of the patient, GK, BT for the interpretation of imaging studies. All authors have read and approved the manuscript.

Authors’ information

None.

Corresponding author

Correspondence to Sumeyra Koyuncu.

Ethics declarations

Ethics approval and consent to participate

The research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki. Patient has given their written informed consent to publish the case (including publication of images). All information revealing patient’s identity has been avoided.

Consent for publication

Written informed consent was optained from the patient for publication of the case report including images.

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Koyuncu, S., Herdem, N., Uysal, C. et al. A rare complication following internal jugular vein catheterization to malposition: acute Budd Chiari syndrome. BMC Nephrol 21, 525 (2020). https://doi.org/10.1186/s12882-020-02182-0

Download citation

Keywords

  • Budd Chiari
  • Catheter
  • Hemodialysis
  • Malposition