IgA nephropathy relapse following COVID-19 vaccination treated with corticosteroid therapy: case report
BMC Nephrology volume 23, Article number: 135 (2022)
The flare of immune-mediated disease following coronavirus disease of 2019 (COVID-19) vaccination is a rare adverse event following immunization. De novo, as well as relapsing IgA nephropathy (IgAN) cases, have been reported following either mRNA-1273 (Moderna) or BNT162b2 (Pfizer-BioNTech) vaccination. To our knowledge, the majority of IgAN relapses did not result in severe acute kidney injury (AKI) and resolved spontaneously.
This is a case of a 54-year-old female with a previous diagnosis of IgAN who developed IgAN relapse following the second dose of Moderna vaccine. Gross hematuria developed 2 days after vaccination, which was accompanied by significant AKI. Kidney biopsy showed mild tubular atrophy and IgA staining in mesangium without crescent formation. Significant improvement in serum creatinine (Cr) was observed on day 10 after initiating prednisone. Cr came back to normal within 3 months after initiating corticosteroid.
COVID-19 vaccination is associated with a flare of IgAN that may cause significant AKI. Steroid therapy is associated with recovery. IgAN flare after COVID-19 vaccination should be closely monitored to elucidate any adverse effect associated with the novel vaccine.
The flare of immune-mediated disease (IMD) following coronavirus disease of 2019 (COVID-19) vaccination is a rare adverse event following immunization. Previous studies reported flare-up of various IMDs, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), Behcet’s disease, psoriasis, vasculitis, sarcoidosis, and multiple sclerosis [1,2,3,4]. De novo, as well as relapsing IgA nephropathy (IgAN) cases, have been reported following either mRNA-1273 (Moderna) or BNT162b2 (Pfizer-BioNTech) vaccination [5,6,7,8,9,10]. The majority of relapsed IgAN in previous reports did not result in severe acute kidney injury (AKI) and resolved without intervention (Table 1). However, Plasse et al. reported an IgAN relapse following the second dose of Pfizer vaccine, which caused significant AKI and subnephrotic range proteinuria. Kidney biopsy was not reported. AKI resolved 1 month after starting steroid therapy, and proteinuria returned to baseline level within 2 months . Here we report an IgAN relapse with significant AKI after administration of Moderna vaccine, which resolved after initiating steroid therapy. Renal biopsy was performed to rule out other de-novo glomerulonephropathies.
A 54-year-old, Caucasian female with history of IgAN after strep throat infection that was diagnosed with renal biopsy in 2006. Other significant co-morbidity includes obesity (BMI 31.6), hypertension, and GERD. She had no prior documented infection with COVID-19. She was on enalapril 20 mg daily, hydrochlorothiazide 12.5 mg daily, and propranolol 120 mg daily. Her baseline creatinine level (Cr) was 1.2 (eGFR 46 mL/min/1.73m2). Urinalysis was positive for 2 + protein, 3 + blood, and red blood cell (RBC) 15 /high-power field (HPF). The total urine protein to Cr ratio was 1.03.
Two days after receiving the second Moderna vaccine, she developed gross hematuria that resolved spontaneously after 2 days. Vital sign upon examination: body temperature 36.5 °C, blood pressure 122/88 mmHg, heart rate 78 beats/minute. Physical exam was unremarkable without lower extremity edema. Follow-up Cr increased to 3.04 (eGFR 16 mL/min/1.73m2) approximately one week after vaccination. The urinalysis showed 1 + protein, 3 + blood, RBC 50/ HPF. The total urine protein to Cr ratio was 0.67. The renal ultrasound was unremarkable. Repeat kidney biopsy showed mild interstitial fibrosis and tubular atrophy without crescent formation (Fig. 1a). Immunofluorescence analysis showed weak IgA staining in mesangium (Fig. 1b). IgG staining was negative (Fig. 1c). Electron microscopy revealed some mesangial electron-dense deposits (Fig. 1d). Differential diagnosis included IgAN relapse, other de-novo glomerulonephropathies, urinary tract hemorrhage with obstruction, and urinary tract infection, among other causes of hematuria and AKI; however, given her history and kidney biopsy result, IgAN relapse was thought to be the most likely cause.
She was started on prednisone 60 mg daily. Cr level improved to 1.9 after 10 days, at which point prednisone was decreased to 40 mg daily. Thereafter prednisone was tapered down gradually over 2 months. Serum Cr recovered to 1.07 approximately 3 months after starting the steroid therapy. Patient tolerated the treatment without significant adverse effect.
Here we report a case of IgAN relapse with significant AKI following COVID-19 vaccination that resolved after initiating steroid therapy. In accord with previously reported cases, gross hematuria occurred within a week after vaccination and resolved without intervention. The natural course of AKI due to IgAN following COVID-19 vaccination is unknown, but this case took a longer period for AKI to resolve compared to the case reported by Plasse et al. . The efficacy of steroid therapy remains inconclusive; nevertheless, AKI seems to be reversible as in the cases thar are not related to COVID-19 vaccination. The previous retrospective study conducted by Kveder et al. in 2009, involving 584 adult patients, showed that all cases of AKI associated with IgAN and macroscopic hematuria resolved at a median follow-up of 15 months regardless of treatment status .
The pathogenesis of IgAN flare-up after COVID-19 vaccination is yet to be elucidated. The RNA vaccine has been shown to elicit antigen-specific, CD4+ and CD8+ T-cell responses producing multiple cytokines, including Interferon-ɣ, Tumor necrosis factor-α, and Interleukin-2 in animal studies . A previous study showed early serum IgA rise after COVID-19 vaccination . Hyperresponsiveness of IgA1 antibody was documented among those who developed IgAN flare following flu vaccine . Similarly, COVID-19 vaccination may induce IgAN flare via IgA1 hyperresponsiveness to systemic cytokine.
IgAN relapse with significant AKI is associated with COVID-19 vaccination, and systemic steroid therapy is associated with recovery. IgAN exacerbation after COVID-19 vaccination should be closely monitored to elucidate any adverse effect related to the novel vaccine.
Availability of data and materials
Serum chemistry and urine study data used in this case report are available in the supplementary material.
Acute kidney injury
Coronavirus disease of 2019
Estimated glomerular filtration rate
Red blood cell
Systemic lupus erythematous
Watad A, De Marco G, Mahajna H, Druyan A, Eltity M, Hijazi N, et al. Immune-mediated disease flares or new-onset disease in 27 subjects following mrna/dna sars-cov-2 vaccination. Vaccines. 2021;9:1–23.
Lavery MJ, Nawimana S, Parslew R, Stewart L. A flare of pre-existing erythema multiforme following BNT162b2 (Pfizer–BioNTech) COVID-19 vaccine. Clin Exp Dermatol. 2021;46:0–2.
Toom S, Wolf B, Avula A, Peeke S, Becker K. Familial thrombocytopenia flare-up following the first dose of mRNA-1273 Covid-19 vaccine. Am J Hematol. 2021;96:E134–5.
Cohen SR, Prussick L, Kahn JS, Gao DX, Radfar A, Rosmarin D. Leukocytoclastic vasculitis flare following the COVID-19 vaccine. Int J Dermatol. 2021;60:1032–3.
Negrea L, Rovin BH. Gross hematuria following vaccination for severe acute respiratory syndrome coronavirus 2 in 2 patients with IgA nephropathy. Kidney Int. 2021;99:1487. https://doi.org/10.1016/j.kint.2021.03.002.
Kudose S, Friedmann P, Albajrami O, D’Agati VD. Histologic correlates of gross hematuria following Moderna COVID-19 vaccine in patients with IgA nephropathy. Kidney Int. 2021;100:468–9. https://doi.org/10.1016/j.kint.2021.06.011.
Perrin P, Bassand X, Benotmane I, Bouvier N. Gross hematuria following SARS-CoV-2 vaccination in patients with IgA nephropathy. Kidney Int. 2021;100:466–8. https://doi.org/10.1016/j.kint.2021.05.022.
Bomback AS, Kudose S, D’Agati VD. De novo and relapsing glomerular diseases after COVID-19 vaccination: what do we know so far? Am J Kidney Dis. 2021. https://doi.org/10.1053/j.ajkd.2021.06.004.
Anderegg MA, Liu M, Saganas C, Montani M, Vogt B, Huynh-Do U, et al. De novo vasculitis after mRNA-1273 (Moderna) vaccination. Kidney Int. 2021;100:474–6.
Tan HZ, Tan RY, Choo JCJ, Lim CC, Tan CS, Loh AHL, et al. Is COVID-19 vaccination unmasking glomerulonephritis? Kidney Int. 2021;100:469–71. https://doi.org/10.1016/j.kint.2021.05.009.
Plasse R, Nee R, Gao S, Olson S. Acute kidney injury with gross hematuria and IgA nephropathy after COVID-19 vaccination. Kidney Int. 2021;100:944–5.
Kveder R, Lindič J, Aleš A, Kovač D, Vizjak A, Ferluga D. Acute kidney injury in immunoglobulin a nephropathy: Potential role of macroscopic hematuria and acute tubulointerstitial injury. Ther Apher Dial. 2009;13:273–7.
Pardi N, Hogan MJ, Naradikian MS, Parkhouse K, Cain DW, Jones L, et al. Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses. J Exp Med. 2018;215:1571–88.
Wisnewski AV, Luna JC, Redlich CA. Human IgG and IgA responses to COVID-19 mRNA vaccines. PLoS One. 2021;16(6):e0249499.
Van Den Wall Bake AWL, Beyer WEP, Evers-Schouten JH, Hermans J, Daha MR, Masurel N, et al. Humoral immune response to influenza vaccination in patients with primary immunoglobulin A nephropathy. An analysis of isotype distribution and size of the influenza-specific antibodies. J Clin Invest. 1989;84:1070–5.
The part of this manuscript has been presented as a poster presentation during Kidney Week 2021 organized by American Society of Nephrology.
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Watanabe, S., Zheng, S. & Rashidi, A. IgA nephropathy relapse following COVID-19 vaccination treated with corticosteroid therapy: case report. BMC Nephrol 23, 135 (2022). https://doi.org/10.1186/s12882-022-02769-9
- COVID-19 vaccine
- IgA nephropathy
- Kidney biopsy