Summary of the main results
The aim of our analysis was to estimate and compare actual consultation rate and recommended referral rates to specialist nephrology services as well as corresponding costs, based on different guideline recommendations. The proportion of subjects meeting referral criteria and associated cost differed between guidelines. DEGAM criteria yielded an overall referral rate of 4.9%, while applying DGfN/DGIM criteria resulted in a referral rate of 8.3%. In subjects older than 60 years, differences were even more pronounced, and rates ranged from 9.7% (DEGAM) to 16.5% (DGfN/DGIM). The observed actual nephrology consultation rate (2.9%) was lower and there was mismatch between eligible and referred subjects (Fig. 2). The estimated population level total costs for implementing referral criteria in the state Mecklenburg-Vorpommern, Germany, varied between € 1,432,440 (DEGAM) and € 2,386,186 (DGfN/DGIM) based upon a population of almost 1.2 million, but only considering a single specialist nephrology consultation.
Meaning of the results and comparison with literature
CKD is one of the fastest growing chronic diseases due to demographic changes [1, 3]. Moreover, the prevalence of obesity, diabetes and hypertension is increasing worldwide, which will potentially increase CKD prevalence even further [1]. Since age related decline in GFR is assumed to be an important driver of the increase in prevalence, a call for an age-adapted definition of CKD has been made [19]. This aspect has been taken into consideration by the DEGAM guideline which made a good clinical practice point for individual assessment of the benefits of nephrology referrals in older patients with concurrent morbidity. However, the available data did not allow to make such judgements. We assume we overestimate the number of patients for whom a referral would be of clinical benefit. This might also explain the lower proportion of observed actual nephrology consultations.
Measurements of albumin-to-creatinine ratio (ACR) are not frequently performed in ambulatory are [20]. In our sample we identified subjects with proteinuria according to ACR measurement within the frame of the cohort study. We can therefore assume that the degree or proteinuria was unknown to the treating physicians. This explains on the one hand the higher proportion of referrals according to recommendations and on the other hand the mismatch between consulting and referred patients.
In Germany, the prevalence of CKD in the adult population under 80 years is estimated to range between 2.3% based on GFR and 11.5% based on proteinuria, resulting in more than 10 million of the general population and more than 50% of nursing home residents meeting the criteria for CKD [6, 21]. Due to the high prevalence of CKD in combination with ultimately limited resources in the healthcare system in terms of specialist care services and cost, referral criteria for CKD have important implications for health care resource allocation [14].
Late referral to specialist nephrology services has been reported and associated with worse outcomes [22]. It has to be considered that emergency dialysis or progression to ESRD is not always preventable. This is on the one hand due to no prior medical contact, rapid and unpredictable decline in renal function or acute health conditions [23, 24]. On the other hand, progression to ESRD occurs in some patients despite medical care. It is assumed, that early referral defined as 6 or 12 months prior to renal replacement therapy or referral at GFR < 60 ml/min (CKD stage 3a) could potentially contribute to delay progression and improve prognosis in patients with CKD [7, 25]. These assumptions were based on retrospective data of patients with end stage renal disease and dialysis, where early referral was found to be associated with better preparation and placement of dialysis access, while improved care was defined according to frequency of blood pressure measurements and management of diabetes [25]. Although these are important factors in CKD management, retrospective analyses of this kind based on the small fraction of CKD patients who will reach ESRD, cannot be used to draw conclusions about the wider population of predominantly older patients with stable CKD [26]. In fact, the challenge is to distinguish between the large number of CKD patients with stable or slowly declining kidney function and low lifetime ESRD risk and patients who require specialist care because of likely progression to ESRD or treatment of uremic complications such as CKD-MBD, renal anaemia or metabolic acidosis.
Since the majority of studies regarding CKD have been conducted in clinical settings and with high risk patients, formulating referral criteria for primary care and other low risk settings is challenging [13]. Recent guidelines have tried to formulate referral criteria aimed at distinguishing between patients with low versus high risk for ESRD [4, 8,9,10,11]. Analyses of estimated implications of KDIGO referral criteria for the US indicate, that referral criteria do not effectively distinguish between high and low risk patients, when applied to primary care or population based cohorts [27]. It was estimated, that implementing KDIGO referral criteria in a primary care population would result in a 38% increase in total nephrology patient volume and a 67% increase in new referrals, leading to a supply–demand mismatch of available workforce and resources [27, 28]. This is in line with the results of our analysis, where implementing KDIGO criteria would lead to more than double increase in referral rate compared to actual referral (7.7% vs. 3%).
KDIGO, DGfN/DGIM and NICE (2014) criteria aim to identify high risk subgroups by proposing additional criteria for CKD patients with reduced GFR, including haematuria, albuminuria and refractory hypertension. The differences between the referral rates of the different criteria are small. We assume that criteria do not succeed in distinguishing high-risk subgroups in older patients, resulting in excessive referral rates of 16.5% (DGfN/DGIM) and 10.6% (NICE 2014) in persons aged ≥ 60 years. Implementing DEGAM criteria, resulted in the lowest overall referral rate of 5% at the population level, but even the strict application of these criteria resulted in a 9.7% referral rate in patients aged ≥ 60 years. This has implications if referral criteria are used for quality measurements. In our analysis, only a minority of participants referred, fulfilled the stipulated referral criteria (Fig. 2). The participants actually referred had a higher eGFR and were younger than those who were not referred but were eligible for referral. Our results show that the DGfN/DGIM criteria are not used in clinical practice.
Although our data set exceeds data usually available, in which ACR is often not included [20], the data do not allow to fully assess the appropriateness of selection of patients who are most likely to benefit from specific nephrology services. The KFRE identified the lowest proportion of participants eligible for nephrology referral, but only 3 out of 15 (20%) actually received a referral. This should be interpreted cautiously since other relevant comorbidities or individual arrangements cannot be excluded. It is conceivable that the risk of ESRD was underestimated in some participants, where treating physicians were not aware of the amount of proteinuria. One should keep in mind that NICE 2021 suggests additionally other criteria like decrease eGFR > 25% in 12 months, suspected genetic disease and suspected renal artery stenosis [12].
Ambulatory physicians should measure ACR more frequently to make referral decisions. This has implications for monitoring quality of medical services based on current referral recommendations. If risk estimation with the KFRE, as proposed by the updated NICE guideline, increased measurements of ACR in primary care can be expected.
There are limited specific treatment options requiring specialist care for most patients, improving CKD prognosis [29, 30], apart from hypertension and diabetes management, which are recommended regardless of kidney function, and despite recent progress with Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors. Therefore, there is no rationale for mandatory early referral of patients with uncomplicated or early CKD stages or with stable GFR considering patients age. Management of these patients can be provided by general practitioners and clinical practice guidelines on blood pressure and diabetes management are available. This approach would yield a potential cost reduction while preserving quality of care and should be complemented by conservative referral criteria, accounting for age, comorbidity and risk of ESRD. At the same time, general practitioners describe a need for informal shortcuts for specialist advice when faced with older, multimorbid patients with conflicting health care needs and low lifetime risk of ESRD [24, 31].
Recommendations for research and future guideline development
Due to the strong association of kidney function with age (age dependent decline), there is a need of an age-dependent approach to management and referral, incorporating CKD prognosis and comorbidities. Proposed age-adjusted CKD criteria were postulated by Delanaye et al. (2019), based on a meta-analysis of mortality risk in different eGFR stages [19]. Applying these criteria might be an additional factor in identifying patients with high ESRD risk from those with age related kidney function decline. Prospective population based analyses on the natural history of CKD, mortality and clinically relevant endpoints in a low-risk or primary care setting are scarce [32]. Recently, the Kidney Failure Risk Equation (KFRE) for predicting the 2 and 5 year probability of ESRD was successfully validated in a British primary care setting and a large Canadian study population [32,33,34]. Based on this equation, tools to recommend referral to a nephrologist were developed and could be used to optimise referral recommendations [35]. This has already led to a change in the updated NICE Guideline 2021 which recommends the use of the KFRE instead of an eGFR on its own for referral recommendation [12]. Further research, ideally based on large, prospective, primary care-based cohorts, would be needed to further validate evidence-based referral criteria and existing prediction tools. Future guidelines should emphasize risk for ESRD and life expectancy in referral recommendations rather than fixed eGFR values [30]. Research has shown, that treatment burden is significant in patients with CKD. Future research should address the role of specialist referral on burden of disease and quality of life in CKD patients in the German healthcare setting [36, 37].
Strengths and limitations
This is the first study to our knowledge simulating the implications of applying different referral criteria for CKD in a German population. Our analysis is based on population-based data, which allowed to consider ACR, which is not routinely measured. However, it is limited due to the attrition bias (loss-to-follow up). We might underestimate the number of referred patients, since we cannot exclude that some patients received a referral but did not actually consult. We assume that true costs are much higher than calculated, because billing codes did not reflect all cost associated with referral (laboratory tests, ultrasound) and in reality, multiple follow up visits are common. Since this limitation affects all calculated guideline referral rates, our conclusions from the comparison between guidelines are not affected. We conducted a complete case analysis. Billing data was only available for subjects with statutory health insurance and for subjects who gave consent to use their claims data (Fig. 1). Nevertheless, study results are based on 1927 study participants. GFR progression was not available on a yearly basis. Therefore, we used the 5-year progression of > 5 ml/min or ≥ 15 ml/ min or ≥ 25% corresponding to the guideline criteria. Our simulation does not allow to assess over- or underutilization of nephrology services or harm to the participants due to the different referral criteria. We have no long-time follow up data regarding renal outcome.