The causal relationship between COVID-19 and estimated glomerular filtration rate: a bidirectional Mendelian randomization study

Li, Qiuling; Lin, Mengjiao; Deng, Yinghui; Huang, Haozhang

doi:10.1186/s12882-023-03443-4

Table 2 Causal estimates of genetically predicted COVID‑19 on eGFR and CKD from the summary-level data-based MR from the GWAS summary statistics

From: The causal relationship between COVID-19 and estimated glomerular filtration rate: a bidirectional Mendelian randomization study

MR method	Genetically predicted exposure	Outcome	beta	Standard error	P	Outcome	beta	Standard error	P
Inverse variance weighted	Critical COVID-19 vs. general population	eGFRcrea	-0.0002	9.39E-05	0.109	CKD	-0.001	0.001	0.189
MR-Egger			-0.000225	0.0003	0.463		-0.001	0.004	0.770
Panelized weighted median			-0.0001	4.37E-05	0.999		0.000	0.001	0.950
MR-PRESSO			-0.0001	3.39E-05	0.159		-0.001	0.001	0.434
Inverse variance weighted	Severe COVID-19 with respiratory failure vs. general population	eGFRcrea	-0.0003	0.0003	0.357	CKD	0.008	0.010	0.393
MR-Egger			-0.0001	0.0008	0.896		0.014	0.023	0.567
Panelized weighted median			-0.0002	0.0003	0.538		-0.006	0.011	0.615
MR-PRESSO			-7.87E-05	0.0003	0.765		0.008	0.010	0.406
Inverse variance weighted	Severe COVID-19 vs. general population	eGFRcrea	-0.0005	0.0004	0.244	CKD	-0.008	0.013	0.526
MR-Egger			-0.0008	0.001	0.490		-0.044	0.034	0.200
Panelized Weighted median			-0.0001	0.0005	0.999		-0.010	0.016	0.516
MR-PRESSO			-0.0005	0.0003	0.172		-0.008	0.013	0.530
Inverse variance weighted	Hospitalized COVID-19 vs. non-hospitalized COVID-19	eGFRcrea	0.0002	0.0009	0.684	CKD	0.013	0.010	0.201
MR-Egger			0.0016	0.0011	0.145		0.046	0.019	0.023
Panelized Weighted median			0.00001	0.0004	0.999		0.006	0.014	0.688
MR-PRESSO			0.00018	0.000253	0.484		0.013	0.010	0.211
Inverse variance weighted	Hospitalized COVID-19 vs. general population	eGFRcrea	0.0001	0.0004	0.786	CKD	0.024	0.012	0.055
MR-Egger			-0.0002	0.0008	0.841		0.025	0.027	0.363
Panelized Weighted median			-7.91E-05	0.0005	0.876		0.022	0.017	0.196
MR-PRESSO			-9.80E-05	0.0003	0.773		0.024	0.012	0.060
Inverse variance weighted	COVID-19 vs. general population	eGFRcrea	-0.0010	0.001	0.327	CKD	0.014	0.025	0.560
MR-Egger			-0.0004	0.002	0.863		-0.006	0.056	0.916
Panelized Weighted median			-0.0001	0.001	0.999		-0.015	0.031	0.635
MR-PRESSO			0.0007	0.001	0.338		0.014	0.025	0.564

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