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  1. The increased demand for nephrology care for patients with chronic kidney disease (CKD) necessitates a critical review of the need for secondary care facilities and the possibilities for referral back to prima...

    Authors: Carola van Dipten, Davy Gerda Hermina Antoin van Dam, Wilhelmus Joannes Carolus de Grauw, Marcus Antonius Gerard Jan ten Dam, Marcus Matheus Hendrik Hermans, Willem Jan Jozef Assendelft, Nynke Dorothea Scherpbier-de Haan and Jacobus Franciscus Maria Wetzels
    Citation: BMC Nephrology 2021 22:186
    Content type: Research Published on:

  2. Recent European Society of Cardiology (ESC)/European Association for the Study of Diabetes (EASD) guidelines provide recommendations for detecting and treating chronic kidney disease (CKD) in diabetic patients...

    Authors: Peter Bramlage, Stefanie Lanzinger, Sascha R. Tittel, Eva Hess, Simon Fahrner, Christoph H. J. Heyer, Mathias Friebe, Ivo Buschmann, Thomas Danne, Jochen Seufert and Reinhard W. Holl
    Citation: BMC Nephrology 2021 22:184
    Content type: Research Published on:

  3. Osteoporosis is one of the important bone abnormalities in chronic kidney disease-mineral and bone disorder (CKD-MBD) and still lacks a sensitive biomarker to diagnose. Fibroblast growth factor 21 (FGF21) can ...

    Authors: Lili Zhu, Min Li, Qianqian Zha, Min Yang, Jirong Yu, Mingming Pan, Qing Yin, Liqiong Jiang, Meixia Xia, Bi-Cheng Liu and Bin Wang
    Citation: BMC Nephrology 2021 22:183
    Content type: Research Published on:

  4. The hypertriglyceridemic waist (HTGW) phenotype has been proposed to be related to the occurrence and progression of chronic kidney disease (CKD). The ageing trend of the Chinese population continues to intens...

    Authors: Ruping Chen, Guangshan Sun, Rui Liu, Ao Sun, Yujie Cao, Xiaojie Zhou and Sha Zhang
    Citation: BMC Nephrology 2021 22:182
    Content type: Research article Published on:

  5. The purpose of this study was to evaluate the clinical value of color and power doppler sonography (CPDS) when combined it with 99mTc-dimercaptosuccinic acid scintigraphy (DMSA) in assessment of acute pyelonep...

    Authors: Min Guang Chen, Yan Yang, Qing Yang, Jie Qiu Zhuang, Xiao Hua Ye and Wen Jie Zheng
    Citation: BMC Nephrology 2021 22:181
    Content type: Research article Published on:

  6. The Identification of B cell subsets with regulatory functions might open the way to new therapeutic strategies in the field of transplantation, which aim to reduce the dose of immunosuppressive drugs and prol...

    Authors: Eman H. Ibrahim, Mostafa G. Aly, Gerhard Opelz, Christian Morath, Martin Zeier, Caner Süsal, Douaa M. Sayed, Eman Hassan, Naruemol Ekpoom and Volker Daniel
    Citation: BMC Nephrology 2021 22:180
    Content type: Research Published on:

  7. We tested whether CHA2DS2-VASc and/or HAS-BLED scores better predict ischemic stroke and major bleeding, respectively, than their individual components in maintenance hemodialysis (MHD) patients with atrial fibri...

    Authors: Anat Bel-Ange, Shani Zilberman Itskovich, Liana Avivi, Kobi Stav, Shai Efrati and Ilia Beberashvili
    Citation: BMC Nephrology 2021 22:179
    Content type: Research Published on:

  8. Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disorder that leads to end stage renal disease (ESRD). Cyst expansion in ADPKD is strongly associated with the decline ...

    Authors: Bunyong Phakdeekitcharoen, Watcharapong Treesinchai, Pornphan Wibulpolprasert, Sarinya Boongird and Pinkael Klytrayong
    Citation: BMC Nephrology 2021 22:178
    Content type: Research Published on:

  9. Sodium-glucose cotransporter 2 inhibitor (SGLT2i) should be considered for patients with type 2 diabetes (T2D) and chronic kidney disease (CKD) having estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1....

    Authors: Su Jin Jeong, Seung Eun Lee, Dong Hyun Shin, Ie Byung Park, Hui Seung Lee and Kyoung-Ah Kim
    Citation: BMC Nephrology 2021 22:177
    Content type: Research Published on:

  10. Combining tubular damage and functional biomarkers may improve prediction precision of acute kidney injury (AKI). Serum cystatin C (sCysC) represents functional damage of kidney, while urinary N-acetyl-β-D-glu...

    Authors: Jianchao Ma, Yujun Deng, Haiyan Lao, Xin Ouyang, Silin Liang, Yifan Wang, Fen Yao, Yiyu Deng and Chunbo Chen
    Citation: BMC Nephrology 2021 22:176
    Content type: Research Published on:

  11. Gemcitabine and cisplatin are chemotherapeutic agents used for treating multiple cancers, and these agents are sometimes used in combination. Drug-induced thrombotic microangiopathy (TMA) is a rare but potenti...

    Authors: Masashi Nishikubo, Yoshimitsu Shimomura, Nobuhiro Hiramoto, Naohiko Sawamura, Takako Yamaguchi, Shigeo Hara and Takayuki Ishikawa
    Citation: BMC Nephrology 2021 22:175
    Content type: Case report Published on:

  12. End-stage kidney disease (ESKD) and the required kidney replacement therapy (KRT) are significant public health challenges for low-and-middle-income countries. The South African government adopted a KRT ration...

    Authors: Thabang T Molaoa, Feziwe B Bisiwe and Kwazi CZ Ndlovu
    Citation: BMC Nephrology 2021 22:174
    Content type: Research Published on:

  13. Acute kidney injury (AKI) is a prevalent and severe complication of sepsis contributing to high morbidity and mortality among critically ill patients. In this retrospective study, we develop a novel risk-predi...

    Authors: Shanglin Yang, Tingting Su, Lina Huang, Lu-Huai Feng and Tianbao Liao
    Citation: BMC Nephrology 2021 22:173
    Content type: Research Published on:

  14. Patients with kidney disease may have concurrent hypertension and infection. Dihydropyridine calcium-channel blockers (CCB) are the most popular class of antihypertensive drugs used in clinical settings and ca...

    Authors: Xinju Zhao, Chunyan Zhang, Li Zhu, Bei Wu, Yun Han, Michael Heung and Li Zuo
    Citation: BMC Nephrology 2021 22:172
    Content type: Case report Published on:

  16. Blood Pressure (BP) control is largely unsatisfied in End Stage Kidney Disease (ESKD) principally due to sodium retention. Peritoneal Dialysis (PD) is the most common type of home dialysis, using a peritoneal ...

    Authors: Luigi Vecchi, Mario Bonomini, Roberto Palumbo, Arduino Arduini and Silvio Borrelli
    Citation: BMC Nephrology 2021 22:170
    Content type: Case report Published on:

  17. Immunosuppression in solid organ transplantation is associated with frequent infections. Renal allograft recipients are susceptible to opportunistic infections and can acquire human cytomegalovirus (HCMV) infe...

    Authors: Sahra Pajenda, Sebastian Kapps, Daniela Gerges, Gregor Hoermann, Ludwig Wagner, Nina Buchtele, Barbara Geist, Robert Strassl, Alice Schmidt and Wolfgang Winnicki
    Citation: BMC Nephrology 2021 22:169
    Content type: Research Published on:

  18. Lower low-density lipoprotein cholesterol (LDL-C) is significantly associated with improved prognosis in patients with coronary artery disease (CAD). However, LDL-C reduction does not decrease all-cause mortal...

    Authors: Bo Wang, Shiqun Chen, Jin Liu, Yan Liang, Liangguang Meng, Xiaoming Yan, Haozhang Huang, Guanzhong Chen, Zhidong Huang, Danyuan Xu, Min Li, Jingjing Liang, Shuangxin Liu, Jiyan Chen, Yong Liu and Ning Tan
    Citation: BMC Nephrology 2021 22:168
    Content type: Research Published on:

  19. Financial hardship is associated with poor health, however the association of financial hardship and incident diabetic kidney disease (DKD) is unknown. This study aimed to examine the longitudinal relationship...

    Authors: Timothy R. Corwin, Mukoso N. Ozieh, Emma Garacci, Anna Palatnik and Leonard E. Egede
    Citation: BMC Nephrology 2021 22:167
    Content type: Research Published on:

  20. Measuring glomerular filtration rate (GFR) using iohexol plasma clearance has been proposed as the preferred way for GFR determination. The extended multiple-sample protocol is based on fitting the full concen...

    Authors: Hans Pottel, Elke Schaeffner, Natalie Ebert, Markus van der Giet and Pierre Delanaye
    Citation: BMC Nephrology 2021 22:166
    Content type: Research Published on:

  21. Chronic kidney disease has been linked to cardiovascular disease and specifically ischemic heart disease (IHD), but large-scale population data in patients with immunoglobulin A nephropathy (IgAN) are missing.

    Authors: Simon Jarrick, Sigrid Lundberg, Johan Sundström, Adina Symreng, Anna Warnqvist and Jonas F. Ludvigsson
    Citation: BMC Nephrology 2021 22:165
    Content type: Research Published on:

  22. Demands of dialysis regimens may pose challenges for primary care provider (PCP) engagement and timely preventive care. This is especially the case for patients initiating dialysis adjusting to new logistical ...

    Authors: Virginia Wang, Lindsay Zepel, Clarissa J. Diamantidis, Valerie A. Smith, Sarah Hudson Scholle and Matthew L. Maciejewski
    Citation: BMC Nephrology 2021 22:164
    Content type: Research Published on:

  23. This manuscript is a brief biography and reminiscence of Dr. Robert H. Heptinstall, a preeminent nephropathologist who had a major and formative impact on the field of nephropathology, and on nephrology in gen...

    Authors: Lorraine C. Racusen
    Citation: BMC Nephrology 2021 22:163
    Content type: Editorial Published on:

  24. Monosodium glutamate (MSG) is frequently consumed as a flavor enhancer or food additive. Possible damages induced by MSG effects on some organs have been stated in experimental animal models. The aim of the pr...

    Authors: Farhad Koohpeyma, Morvarid Siri, Shaghayegh Allahyari, Marzieh Mahmoodi, Forough Saki and Sanaz Dastghaib
    Citation: BMC Nephrology 2021 22:162
    Content type: Research Published on:

  25. Acute interstitial nephritis (AIN) is an important and common cause of acute renal failure. There are no generally accepted guidelines for the treatment of AIN, due to the lack of prospective randomized trials...

    Authors: Frank H. Mose, Henrik Birn, Nikolai Hoffmann-Petersen and Jesper N. Bech
    Citation: BMC Nephrology 2021 22:161
    Content type: Study protocol Published on:

  26. Omega-3 fatty acids (FAs) have been suggested as a beneficial supplement in chronic kidney disease (CKD) patients, but the results of randomized clinical trials (RCTs) are controversial. We conducted a systematic...

    Authors: Siavash Fazelian, Fatemeh Moradi, Shahram Agah, Akramsadat Hoseini, Hafez Heydari, Mojgan Morvaridzadeh, Amirhosein Omidi, Ana Beatriz Pizarro, Atie Ghafouri and Javad Heshmati
    Citation: BMC Nephrology 2021 22:160
    Content type: Research article Published on:

  27. Acquired Gitelman syndrome is a very rare disorder reported in association with autoimmune disorders, mostly Sjögren syndrome. It is characterized by the presence of hypokalaemic metabolic alkalosis, hypocalci...

    Authors: Rasika Ranaweerage, Shehan Perera and Aruna Gunapala
    Citation: BMC Nephrology 2021 22:159
    Content type: Case report Published on:

  29. Patients undergoing haemodialysis may experience troubling symptoms such as fatigue, anxiety, depression and sleep quality, which may affect their quality of life. The main objective of this study is to determ...

    Authors: Zakariya Al Naamani, Kevin Gormley, Helen Noble, Olinda Santin and Mohammed Al Maqbali
    Citation: BMC Nephrology 2021 22:157
    Content type: Research Published on:

  30. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the commonest of the hereditary kidney diseases and mostly ensues in utero with signs delayed until after several decades. This study assessed the demogr...

    Authors: Perditer Okyere, Richard K.D. Ephraim, Isaac Okyere, Joseph Attakorah, Dorcas Serwaa, Grace Essuman, Albert Abaka-Yawson and Prince Adoba
    Citation: BMC Nephrology 2021 22:156
    Content type: Research article Published on:

  31. Hospital readmission after transplantation is common in kidney transplant recipients (KTRs). In this study, we aim to compare the risk of 3-month hospital readmission after kidney transplantation with differen...

    Authors: Yiman Wang, Martin B. A. Heemskerk, Wieneke M. Michels, Aiko P. J. de Vries, Friedo W. Dekker and Yvette Meuleman
    Citation: BMC Nephrology 2021 22:155
    Content type: Research Published on:

  32. End-stage renal disease (ESRD) patients receiving haemodialysis (HD) are a vulnerable group of patients with increased mortality from COVID-19. Despite improved understanding, the duration of host immunity fol...

    Authors: Olivia Wickens, Rajkumar Chinnadurai, Fahmida Mannan, Frida Svendsen, Mirza Yasar Baig, Chukwuma Chukwu, Ibrahim Ali, Christina Summersgill, Dawn Evans, Berckley V. Antoine, Julie Oxton, Nathan Mairs, Emma Flanagan, Robert Oliver, Philip A. Kalra and Dimitrios Poulikakos
    Citation: BMC Nephrology 2021 22:154
    Content type: Research Published on:

  33. Obstructive sleep apnoea (OSA) induced chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH). Our study investigate the mechanism underlying CIH-induced renal damage and whether the can...

    Authors: Li Zhao, Tao Liu, Zhan-jun Dou, Mei-ting Wang, Zi-xuan Hu and Bei Wang
    Citation: BMC Nephrology 2021 22:153
    Content type: Research Published on:

  34. Given the age-related decline in glomerular filtration rate (GFR) in healthy individuals, we examined the association of all-cause death or cardiovascular event with the Kidney age - Chronological age Differen...

    Authors: Duncan J. Campbell, Jennifer M. Coller, Fei Fei Gong, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Simon Stewart, Alice J. Owen, Henry Krum, Christopher M. Reid and David L. Prior
    Citation: BMC Nephrology 2021 22:152
    Content type: Research article Published on:

  35. Considering that current peritoneal dialysis has its own shortcomings, In this study, the Seldinger technique was modified to explore the relationship between different catheter placement methods of peritoneal...

    Authors: Yibo Ma, Shuiqing Liu, Min Yang, Yun Zou, Dong Xue, Yanping Liu, Yufeng Wang, Xiao Xie and Hui Chen
    Citation: BMC Nephrology 2021 22:151
    Content type: Research article Published on:

  36. Renal hyperparathyroidism is a disease entity that is complex and poorly understood. Although there are guidelines regarding how to manage this patient group, evidence is scarce. Therefore, this survey-based s...

    Authors: Jaimie L. H. Zhang, Natasha M. Appelman-Dijkstra, Edouard L. Fu, Joris I. Rotmans and Abbey Schepers
    Citation: BMC Nephrology 2021 22:150
    Content type: Research Published on:

  37. Acute kidney injury (AKI) is a common and critical complication of liver transplantation (LT), which is associated with increased morbidity, mortality and health care cost. We aimed to identify modifiable risk...

    Authors: Jian Zhou, Xueying Zhang, Lin Lyu, Xiaojun Ma, Guishen Miao and Haichen Chu
    Citation: BMC Nephrology 2021 22:149
    Content type: Research Published on:

  38. Membranous nephropathy (MN) is mainly classified into idiopathic MN (iMN) and secondary MN in etiology. In recent years, a new kind of membranous nephropathy, atypical membranous nephropathy (aMN) which shows ...

    Authors: Zhenbin Jiang, Meishun Cai, Bao Dong, Yu Yan, Yina Wang, Xin Li, Chunying Shao and Li Zuo
    Citation: BMC Nephrology 2021 22:148
    Content type: Research Published on:

  39. Those living with kidney disease (KD) report extensive symptom burden. However, research into how symptoms change across stages is limited. The aims of this study were to 1) describe symptom burden across dise...

    Authors: Thomas J. Wilkinson, Daniel G. D. Nixon, Jared Palmer, Courtney J. Lightfoot and Alice C. Smith
    Citation: BMC Nephrology 2021 22:147
    Content type: Research Published on:

  40. Inflammatory bowel diseases are characterized by chronic inflammation of the gastrointestinal tract. In particular, Crohn disease and ulcerative colitis represent the two most common types of clinical manifest...

    Authors: A. Angeletti, S. Arrigo, A. Madeo, M. Molteni, E. Vietti, L. Arcuri, M. C. Coccia, P. Gandullia and G. M. Ghiggeri
    Citation: BMC Nephrology 2021 22:146
    Content type: Case report Published on:

  41. The alteration of the gut microbiome in the gut-kidney axis has been associated with a pro-inflammatory state and chronic kidney disease (CKD). A small-scaled Italian study has shown an association between the...

    Authors: Agni Nhirmal Kumar Sugurmar, Rozita Mohd, Shamsul Azhar Shah, Hui-min Neoh and Rizna Abdul Cader
    Citation: BMC Nephrology 2021 22:145
    Content type: Research article Published on:

  42. SARS-CoV-2 (COVID-19) is a novel coronavirus associated with high mortality rates. The use of Continuous Positive Airway Pressure (CPAP) has been recognised as a management option for severe COVID-19 (NHS, Spe...

    Authors: Lauren Floyd, Madelena Stauss, Joshua Storrar, Parthvi Vanalia, Anna France and Ajay Dhaygude
    Citation: BMC Nephrology 2021 22:144
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:171

  44. ESRD is considered an irreversible loss of renal function, yet some patients will recover kidney function sufficiently to come off dialysis. Potentially modifiable predictors of kidney recovery, such as dialys...

    Authors: Maria Santos, Huiying Yin, Diane Steffick, Rajiv Saran and Michael Heung
    Citation: BMC Nephrology 2021 22:142
    Content type: Research Published on:

  46. Atypical haemolytic uraemic syndrome (aHUS) is a rare systemic syndrome characterized by non-immune haemolytic anaemia, thrombocytopenia, and kidney injury. In most cases, alternative complement pathway dysreg...

    Authors: Muneera Alabdulqader and Khalid Alfakeeh
    Citation: BMC Nephrology 2021 22:140
    Content type: Case report Published on:

  48. Although IgG4 deposit against phospholipase A2 receptor (anti-PLA2R) is predominantly presented in the renal biopsy of patients with primary membranous nephropathy (MN), its diagnostic value of this immune com...

    Authors: Maryam Arghiani, Boshra Hasan Zamani, Fatemeh Nazemian, Sara Samadi, Malihe Saber Afsharian, Mahmoud Habibzadeh, Saeid Eslami and Mahin Ghorban Sabbagh
    Citation: BMC Nephrology 2021 22:138
    Content type: Research Published on:

  49. IgA nephropathy (IgAN) is a kidney disease recognized by the presence of IgA antibody depositions in kidneys. The underlying mechanisms of this complicated disease are remained to be explored and still, there ...

    Authors: Alieh Gholaminejad, Yousof Gheisari, Sedigheh Jalali and Amir Roointan
    Citation: BMC Nephrology 2021 22:137
    Content type: Research Published on:

  50. End stage kidney disease (ESKD) is associated with many losses, subsequently impacting mental wellbeing. Few studies have investigated the efficacy of psychosocial interventions for people with ESKD and none e...

    Authors: Kylie M. Dingwall, Michelle Sweet, Alan Cass, Jaquelyne T. Hughes, David Kavanagh, Kirsten Howard, Federica Barzi, Sarah Brown, Cherian Sajiv, Sandawana W. Majoni and Tricia Nagel
    Citation: BMC Nephrology 2021 22:136
    Content type: Research Published on:
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BMC Nephrology

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