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  1. Although aortic calcification has a significant negative impact on prognosis in patients on hemodialysis (HD), risk factors for aortic calcification progression remain unclear. The aim of this study was to inv...

    Authors: Teppei Okamoto, Shingo Hatakeyama, Hirotake Kodama, Hirotaka Horiguchi, Yuka Kubota, Koichi Kido, Masaki Momota, Shogo Hosogoe, Yoshimi Tanaka, Tooru Takashima, Fumitada Saitoh, Tadashi Suzuki and Chikara Ohyama
    Citation: BMC Nephrology 2018 19:71
    Content type: Research article Published on:

  2. Decreased residual urine volume (RUV) is associated with higher mortality in hemodialysis (HD). However, few studies have examined RUV in patients on HD in Sub-Saharan Africa. The aim of this study was to iden...

    Authors: Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, François Bompeka Lepira, Fiston Ikwa Ndol Mbutiwi, Jean Robert Rissassy Makulo, Justine Busanga Bukabau, Patrick Parmba Izeidi, Jeannine Losa Luse, Stéphane Kalambay Mukendi, Désiré Kulimba Mashinda and Nazaire Mangani Nseka
    Citation: BMC Nephrology 2018 19:68
    Content type: Research article Published on:

  3. Anemia is common in non-dialysis-dependent chronic kidney disease (NDD-CKD) patients, but detailed information on prevalence and treatment is lacking.

    Authors: Wendy L. St. Peter, Haifeng Guo, Shaum Kabadi, David T. Gilbertson, Yi Peng, Trudy Pendergraft and Suying Li
    Citation: BMC Nephrology 2018 19:67
    Content type: Research article Published on:

  4. Chronic Kidney Disease affects approximately 10% of the world’s adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidn...

    Authors: Giorgina B. Piccoli, Mona Alrukhaimi, Zhi-Hong Liu, Elena Zakharova and Adeera Levin
    Citation: BMC Nephrology 2018 19:66
    Content type: Editorial Published on:

  5. Patients with late referral and positive history of volume overload may have a poor prognosis after initiating dialysis due to insufficient and/or inadequate management of complications of renal failure and th...

    Authors: Masaki Okazaki, Daijo Inaguma, Takahiro Imaizumi, Akiko Kada, Takaaki Yaomura, Naotake Tsuboi and Shoichi Maruyama
    Citation: BMC Nephrology 2018 19:65
    Content type: Research article Published on:

  6. Both prevention and treatment of recurrent immunoglobulin A nephropathy (IgAN) in kidney transplant recipients are important since recurrent IgAN seems to affect long-term graft survival. We present here a cas...

    Authors: Haruki Katsumata, Izumi Yamamoto, Yo Komatsuzaki, Mayuko Kawabe, Yusuke Okabayashi, Takafumi Yamakawa, Ai Katsuma, Yasuyuki Nakada, Akimitsu Kobayashi, Yudo Tanno, Jun Miki, Hiroki Yamada, Ichiro Ohkido, Nobuo Tsuboi, Hiroyasu Yamamoto and Takashi Yokoo
    Citation: BMC Nephrology 2018 19:64
    Content type: Case report Published on:

  7. Accumulating evidence suggests that a decrease in brain-derived neurotrophic factor (BDNF) level induces a variety of psychiatric and neurological disorders. However, the expression and role of BDNF in the kid...

    Authors: Yuan Sheng Tao, Shang Guo Piao, Ying Shun Jin, Ji Zhe Jin, Hai Lan Zheng, Hai Yan Zhao, Sun Woo Lim, Chul Woo Yang and Can Li
    Citation: BMC Nephrology 2018 19:63
    Content type: Research article Published on:

  8. The classical approach to the analysis of kidney biopsies is based on semi-quantitative scores of the amount of sclerosis, inflammatory infiltrate, fibrosis and vascular damage. However, advanced renal lesions...

    Authors: Michelangelo Nigro, Davide Viggiano, Vincenzo Ragone, Tiziana Trabace, Annamaria di Palma, Michele Rossini, Giovambattista Capasso, Loreto Gesualdo and Giuseppe Gigliotti
    Citation: BMC Nephrology 2018 19:62
    Content type: Technical advance Published on:

  9. Necrotizing glomerular lesions are a feature of severe glomerulonephritis. Unlike apoptosis, cellular necrosis has the potential to release damage-associated proteins into the microenvironment, thereby potenti...

    Authors: N. R. Hill, H. T. Cook, C. D. Pusey and R. M. Tarzi
    Citation: BMC Nephrology 2018 19:61
    Content type: Research article Published on:

  11. Page kidney phenomenon is caused by strong renal parenchymal compression and leads to renal hypoperfusion and microvascular ischemia, resulting in renal dysfunction and hypertension. Although the development o...

    Authors: Shunta Hori, Mitsuru Tomizawa, Fumisato Maesaka, Takuya Owari, Yosuke Morizawa, Yasushi Nakai, Makito Miyake, Tatsuo Yoneda, Nobumichi Tanaka, Katsunori Yoshida and Kiyohide Fujimoto
    Citation: BMC Nephrology 2018 19:59
    Content type: Case report Published on:

  13. Membranous nephropathy (MN), the leading cause of nephrotic syndrome in adults, is characterized by the deposition of subepithelial immune deposits. Most of the cases are primary, while only approximately 25% ...

    Authors: Sanda Mrabet, Narjess Ben Aicha, Nihed Abdessayed, Moncef Mokni and Abdellatif Achour
    Citation: BMC Nephrology 2018 19:57
    Content type: Case report Published on:

  14. Renal transplant is the preferred treatment option for these patients with end-stage renal disease. Transplant renal artery stenosis (TRAS) is one of the most common and serious vascular complications after re...

    Authors: Xiaohang Li, Jialin Zhang, Yiman Meng, Lei Yang, Fengshan Wang, Baifeng Li and Xitong Zhang
    Citation: BMC Nephrology 2018 19:56
    Content type: Case report Published on:

  15. Proteinuria is well recognised as a marker of chronic kidney disease (CKD), as a risk factor for progression of CKD among those with known CKD, and as a risk factor for cardiovascular events and death among bo...

    Authors: Tracey Ying, Philip Clayton, Chetana Naresh and Steven Chadban
    Citation: BMC Nephrology 2018 19:55
    Content type: Research article Published on:

  17. It is well-recognized that injection of iodinated radiographic contrast media (CM) sometimes causes acute renal injury via multiple mechanisms, such as vasoconstriction, toxicity on glomerular endothelium and ...

    Authors: Hua Su, Chen Ye, Qian Wen, Hong-Yan Zhu, Li-Xia Yi and Chun Zhang
    Citation: BMC Nephrology 2018 19:53
    Content type: Case report Published on:

  18. Cilostazol is an antiplatelet drug that is widely prescribed for the prevention of secondary stroke. Adverse reactions to cilostazol include headaches, palpitations, and diarrhea. Little is known about the nep...

    Authors: Hisato Shima, Manabu Tashiro, Satoshi Yamada, Motokazu Matsuura, Kazuyoshi Okada, Toshio Doi, Jun Minakuchi and Shu Kawashima
    Citation: BMC Nephrology 2018 19:52
    Content type: Case report Published on:

  19. Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The prese...

    Authors: Hyo Jin Kim, Eunjeong Kang, Yun Kyu Oh, Yeong Hoon Kim, Seung Hyeok Han, Tae Hyun Yoo, Dong-Wan Chae, Joongyub Lee, Curie Ahn and Kook-Hwan Oh
    Citation: BMC Nephrology 2018 19:51
    Content type: Research article Published on:

  20. C-type natriuretic peptide (CNP) is a member of the natriuretic peptide family and have been implicated to be involved in maintaining vascular homeostasis and acting as a cardiac chronotropic agent in experime...

    Authors: Lulu Wang, Wenjin Liu, Yanting Yu, Lei Jiang and Junwei Yang
    Citation: BMC Nephrology 2018 19:50
    Content type: Research article Published on:

  21. Both diabetes and hemodialysis can seriously impair patients’ health related quality of life (HRQOL). This study seeks to obtain data which will help to address the factors associated with impaired HRQOL in he...

    Authors: Sohaib T. Khatib, Mohammad K. Hemadneh, Samer A. Hasan, Emad Khazneh and Sa’ed H. Zyoud
    Citation: BMC Nephrology 2018 19:49
    Content type: Research article Published on:

  22. Acute tubulointerstitial nephritis (ATIN) has been increasingly recognized as an important manifestation of kidney injury associated with the use of immune checkpoint inhibitors (anti-PD-1 and anti-CTLA-4). Wh...

    Authors: Ryo Koda, Hirofumi Watanabe, Masafumi Tsuchida, Noriaki Iino, Kazuo Suzuki, Go Hasegawa, Naofumi Imai and Ichiei Narita
    Citation: BMC Nephrology 2018 19:48
    Content type: Case report Published on:

  23. Rural areas in the state of New Mexico have been the “ground-zero” for the epidemic of diabetic Chronic Kidney Disease (CKD) in the United States. However, there is limited research about risk factors of diabe...

    Authors: Antonin Jaros, Hafiz A. Sroya, Venita K. Wolfe, Vikas Ghai, Maria-Eleni Roumelioti, Kamran Shaffi, Kai Wang, Vernon Shane Pankratz, Mark L. Unruh and Christos Argyropoulos
    Citation: BMC Nephrology 2018 19:47
    Content type: Study protocol Published on:

  24. Significant attention has been directed toward the high incidence of malignant tumours that occur post-transplantation. However, there are few reports of myeloid sarcomas (MSs) following renal transplantation.

    Authors: Liang Ying, Lei Tian, Yuanyuan Xie, Qin Wang, Xiajing Che, Jiayi Yan, Lijing Shen, Honghui Huang, Fangyuan Chen, Ming Zhang, Zhaohui Ni and Shan Mou
    Citation: BMC Nephrology 2018 19:46
    Content type: Case report Published on:

  25. Accelerated muscle atrophy is associated with a three-fold increase in mortality in chronic kidney disease (CKD) patients. It is suggested that hyperphosphatemia might contribute to muscle wasting, but the und...

    Authors: Yue-yue Zhang, Man Yang, Jin-fang Bao, Li-jie Gu, Hong-lei Yu and Wei-jie Yuan
    Citation: BMC Nephrology 2018 19:45
    Content type: Research article Published on:

  26. Acute kidney injury (AKI) is often observed in critically ill patients and is associated with high morbidity and mortality. Non-recovery from AKI has a negative impact on the prognosis of affected patients and...

    Authors: Fabienne Aregger, Dominik E. Uehlinger, Gerhard Fusch, Aldin Bahonjic, Rene Pschowski, Michael Walter and Joerg C. Schefold
    Citation: BMC Nephrology 2018 19:44
    Content type: Research article Published on:

  27. Chronic kidney disease (CKD) is considered a serious public health problem, both in Brazil and worldwide, with an increasing number of cases observed inrecent years. Especially, CKD has been reported to be hig...

    Authors: Natalino Salgado-Filho, Joyce Santos Lages, Dyego José Brito, João Victor Salgado, Gyl Eanes Silva, Alcione Miranda Santos, Francisco Chagas Monteiro-Júnior, Elisangela Milhomen Santos, Antônio Augusto Silva, Denizar Vianna Araújo and Ricardo Castro Sesso
    Citation: BMC Nephrology 2018 19:43
    Content type: Study protocol Published on:

  28. The risk of chronic kidney disease (CKD) is known to be elevated in patients with diabetes mellitus but the risk of young adults aged 18 to 40 years with impaired glucose tolerance/impaired fasting glucose (IG...

    Authors: Ferozkhan Jadhakhan, Tom Marshall, Ronan Ryan and Paramjit Gill
    Citation: BMC Nephrology 2018 19:42
    Content type: Research article Published on:

  29. Non-adherence to immunosuppressive therapy is a prevalent risk factor for poor clinical and after kidney transplantation (KT), and has contributed to the lack of improvement in long-term graft survival over th...

    Authors: Helady Sanders-Pinheiro, Fernando Antonio Basile Colugnati, Elisa Oliveira Marsicano, Sabina De Geest and José Osmar Pestana Medina
    Citation: BMC Nephrology 2018 19:41
    Content type: Study protocol Published on:

  30. The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat in...

    Authors: Ying Dong, Zengwu Wang, Zuo Chen, Xin Wang, Linfeng Zhang, Jingyu Nie, Congyi Zheng, Jiali Wang, Lan Shao, Ye Tian and Runlin Gao
    Citation: BMC Nephrology 2018 19:40
    Content type: Research article Published on:

  31. Renal angiomyolipomas (AMLs) are a major clinical feature in patients with tuberous sclerosis complex (TSC). Spontaneous bleeding can be life threatening, and appropriate information and proper surveillance an...

    Authors: I. Cockerell, M. Guenin, K. Heimdal, M. Bjørnvold, K. K. Selmer and O. Rouvière
    Citation: BMC Nephrology 2018 19:39
    Content type: Research article Published on:

  32. Surveys using traditional measures of nutritional status indicate that muscle wasting is common among persons with end-stage kidney disease (ESKD). Up to 75% of adults undergoing maintenance dialysis show some...

    Authors: Joanne Reid, Helen R. Noble, Gary Adamson, Andrew Davenport, Ken Farrington, Denis Fouque, Kamyar Kalantar-Zadeh, John Mallett, C. McKeaveney, S. Porter, David S. Seres, Joanne Shields, Adrian Slee, Miles D. Witham and Alexander P. Maxwell
    Citation: BMC Nephrology 2018 19:38
    Content type: Study protocol Published on:

  33. Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients. Th...

    Authors: Phil McEwan, Hayley Bennett Wilton, Albert C. M. Ong, Bjarne Ørskov, Richard Sandford, Francesco Scolari, Maria-Cristina V. Cabrera, Gerd Walz, Karl O’Reilly and Paul Robinson
    Citation: BMC Nephrology 2018 19:37
    Content type: Research article Published on:

  34. Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are pivotal indicators of kidney decline. Yet, it is uncertain if these and emerging biomarkers such as uric acid repr...

    Authors: Keith C. Norris, Karen E. Smoyer, Catherine Rolland, Jan Van der Vaart and Eliza Beth Grubb
    Citation: BMC Nephrology 2018 19:36
    Content type: Research article Published on:

  35. Anemia is highly prevalent in chronic kidney disease (CKD). Elevated hepcidin concentrations are an important mediator of disordered iron metabolism, a key mechanism underlying anemia of CKD. Vitamin D was rec...

    Authors: Bhupesh Panwar, Diane McCann, Gordana Olbina, Mark Westerman and Orlando M. Gutiérrez
    Citation: BMC Nephrology 2018 19:35
    Content type: Research article Published on:

  36. The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Recent studies suggest that the COMT rs4680 polymorphism is associated with the response to endogenous and exogen...

    Authors: Mehmet Oezkur, Attila Magyar, Phillip Thomas, Andreas Reif, Stefan Störk, Peter U. Heuschmann, Rainer G. Leyh and Martin Wagner
    Citation: BMC Nephrology 2018 19:34
    Content type: Research article Published on:

  37. Precise renal histopathological diagnosis will guide therapy strategy in patients with lupus nephritis. Blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) has been applicable noninvasive tech...

    Authors: Huilan Shi, Junya Jia, Dong Li, Li Wei, Wenya Shang and Zhenfeng Zheng
    Citation: BMC Nephrology 2018 19:33
    Content type: Technical advance Published on:

  38. Association between high body mass index (BMI) and survival benefit is confounded by comorbid conditions such as nutritional status and inflammation. Patients with acute kidney injury (AKI), particularly those...

    Authors: Hyoungnae Kim, Hyunwook Kim, Misol Lee, Min-Uk Cha, Ki Heon Nam, Seong Yeong An, Su-Young Jung, Jong Hyun Jhee, Seohyun Park, Hae-Ryong Yun, Youn Kyung Kee, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Shin-Wook Kang…
    Citation: BMC Nephrology 2018 19:32
    Content type: Research article Published on:

  39. The prognostic effect of gender on immunoglobulin A nephropathy (IgAN) is not clear. We explored gender-related differences in clinicopathological features and renal outcomes in IgAN.

    Authors: Wei Deng, Xiaojun Tan, Qian Zhou, Zhen Ai, Wenting Liu, Wei Chen, Xueqing Yu and Qiongqiong Yang
    Citation: BMC Nephrology 2018 19:31
    Content type: Research article Published on:

  40. It remains unclear whether genetic factors may explain the reported variation in the levels of biochemical markers of chronic kidney disease mineral and bone disorders (CKD- MBD) across ethnic groups. Therefor...

    Authors: Bala Waziri, Therese Dix-Peek, Caroline Dickens, Raquel Duarte and Saraladevi Naicker
    Citation: BMC Nephrology 2018 19:30
    Content type: Research article Published on:

  41. The MAPK-organizer 1 (MORG1) play a scaffold function in the MAPK and/or the PHD3 signalling paths. Recently, we reported that MORG1+/− mice are protected from renal injury induced by systemic hypoxia and acute r...

    Authors: Tzvetanka Bondeva, Claudia Schindler, Katrin Schindler and Gunter Wolf
    Citation: BMC Nephrology 2018 19:29
    Content type: Research article Published on:

  42. Chronic kidney disease (CKD) is increasing worldwide and early education to improve adherence to self-management is a key strategy to slow CKD progression. The use of the internet and mobile phone technologies...

    Authors: Ann Bonner, Kerri Gillespie, Katrina L. Campbell, Katina Corones-Watkins, Bronwyn Hayes, Barbara Harvie, Jaimon T. Kelly and Kathryn Havas
    Citation: BMC Nephrology 2018 19:28
    Content type: Research article Published on:

  43. The association of increased cancer risk with glomerulonephritis (GN) is well known, but controversy exists concerning which types of GN are involved, and the size of the association. A national registry surve...

    Authors: James Goya Heaf, Alastair Hansen and Gunnar Hellmund Laier
    Citation: BMC Nephrology 2018 19:27
    Content type: Research article Published on:

  44. It has been reported that mutations in arginine vasopressin type 2 receptor (AVPR2) cause congenital X-linked nephrogenic diabetes insipidus (NDI). However, only a few cases of AVPR2 deletion have been documented...

    Authors: Ying Bai, Yibing Chen and Xiangdong Kong
    Citation: BMC Nephrology 2018 19:26
    Content type: Research article Published on:

  45. Obstetric-related acute kidney injury (AKI) is thought to be a key contributor to the overall burden of AKI in low resource settings, causing significant and preventable morbidity and mortality. However, epide...

    Authors: William R. Cooke, Ulla K. Hemmilä, Alison L. Craik, Chimwemwe J. Mandula, Priscilla Mvula, Ausbert Msusa, Gavin Dreyer and Rhys Evans
    Citation: BMC Nephrology 2018 19:25
    Content type: Research article Published on:

  46. Changes in mineral metabolism and bone structure develop early in the course of chronic kidney disease and at end-stage are associated with increased risk of fragility fractures. The disruption of phosphorus h...

    Authors: Nikita M. Bajwa, Cheryl P. Sanchez, Richard C. Lindsey, Heather Watt and Subburaman Mohan
    Citation: BMC Nephrology 2018 19:24
    Content type: Research article Published on:

  47. Leigh syndrome (LS) is a rare neurodegenerative mitochondrial disorder which typically presents in childhood but has a varied clinical course. Renal involvement such as proximal tubulopathy in patients with mi...

    Authors: Kathryn Ducharlet, Dominic Thyagarajan, Francesco Ierino, Lawrence P. McMahon and Darren Lee
    Citation: BMC Nephrology 2018 19:23
    Content type: Case report Published on:

  48. Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correct...

    Authors: Vivek Kumar, Ashok Kumar Yadav, Yoshinari Yasuda, Masaru Horio, Vinod Kumar, Nancy Sahni, Krishan L. Gupta, Seiichi Matsuo, Harbir Singh Kohli and Vivekanand Jha
    Citation: BMC Nephrology 2018 19:22
    Content type: Research article Published on:

  50. Leptospirosis is a rare infectious disease especially in Western Countries. Renal involvement is a recognised complication of leptospirosis but leptospirosis-associated haemolytic uraemic syndrome is extremely...

    Authors: Vasantha Muthu Muthuppalaniappan, Ravindra Rajakariar and Mark John Blunden
    Citation: BMC Nephrology 2018 19:20
    Content type: Case report Published on:
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BMC Nephrology

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