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  1. Sixty mutations of claudin 16 coding gene have been reported in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients. Recent investigations revealed that a highly conserved glycine...

    Authors: Jingru Lu, Xiangzhong Zhao, Alessandro Paiardini, Yanhua Lang, Irene Bottillo and Leping Shao
    Citation: BMC Nephrology 2018 19:181
    Content type: Case report Published on:

  2. Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have r...

    Authors: Tamara Milagres, Fernando E. García-Arroyo, Miguel A. Lanaspa, Gabriela Garcia, Takuji Ishimoto, Ana Andres-Hernando, Masanari Kuwabara, Thomas Jensen, Yuka Sato, Jason Glaser, Laura G. Sánchez-Lozada, Richard J. Johnson and Carlos Roncal-Jimenez
    Citation: BMC Nephrology 2018 19:180
    Content type: Research article Published on:

  3. Angiotensin II (Ang II) contributes to the progression of renal diseases associated with proteinuria and glomerulosclerosis mainly by inducing podocyte apoptosis. In the present study, we investigated whether ...

    Authors: Vanessa Gerolde Cardoso, Guilherme Lopes Gonçalves, Juliana Martins Costa-Pessoa, Karina Thieme, Bruna Bezerra Lins, Fernando Augusto Malavazzi Casare, Mariana Charleaux de Ponte, Niels Olsen Saraiva Camara and Maria Oliveira-Souza
    Citation: BMC Nephrology 2018 19:179
    Content type: Research article Published on:

  4. Renal impairment (RI) is common in multiple myeloma (MM) and is associated with poor survival. This study reports the associations between renal function and disease characteristics including serum free light ...

    Authors: Punit Yadav, Paul Cockwell, Mark Cook, Jennifer Pinney, Hannah Giles, Yu Sandar Aung, David Cairns, Roger G. Owen, Faith E. Davies, Graham H. Jackson, J. Anthony Child, Gareth J. Morgan and Mark T. Drayson
    Citation: BMC Nephrology 2018 19:178
    Content type: Research article Published on:

  5. Graft survival after kidney transplantation has significantly improved within the last decades but there is a substantial number of patients with declining transplant function and graft loss. Over the past yea...

    Authors: Anna Wiegand, Alexander Ritter, Nicole Graf, Spyridon Arampatzis, Daniel Sidler, Karine Hadaya, Thomas F. Müller, Carsten A. Wagner, Rudolf P. Wüthrich and Nilufar Mohebbi
    Citation: BMC Nephrology 2018 19:177
    Content type: Study protocol Published on:

  6. Echocardiographic characteristics across the spectrum of chronic kidney disease (CKD) have not been well described. We assessed the echocardiographic characteristics of patients with preserved renal function a...

    Authors: Thomas A. Mavrakanas, Aisha Khattak, Karandeep Singh and David M. Charytan
    Citation: BMC Nephrology 2018 19:176
    Content type: Research article Published on:

  7. The management of proliferative lupus nephritis (LN) comprises timely and coordinated immunosuppressive therapy. This study aimed to evaluate and compare the effectiveness and safety profile of low dose mycoph...

    Authors: Arun Sedhain, Rajani Hada, Rajendra K. Agrawal, Gandhi R. Bhattarai and Anil Baral
    Citation: BMC Nephrology 2018 19:175
    Content type: Research article Published on:

  8. Current guidelines regarding plasma-sampling techniques for glomerular filtration rate (GFR) determination are inconsistent. Single-sample methods are commonly believed not to be precise enough to meet clinica...

    Authors: Yong Zhang, Zhun Sui, Ze Yu, Tai Feng Li, Wan Yu Feng and Li Zuo
    Citation: BMC Nephrology 2018 19:174
    Content type: Research article Published on:

  9. We present a case series of 5 patients with proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) of renal allografts to better define its natural history, presenting characteristics, patholog...

    Authors: Jiqiu Wen, Wei Wang, Feng Xu, Jinsong Chen, Mingchao Zhang, Dongrui Cheng, Xuefeng Ni, Xue Li and Zhihong Liu
    Citation: BMC Nephrology 2018 19:173
    Content type: Research article Published on:

  10. Nephrolithiasis is a risk factor for Osteopenia and osteoporosis. Receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) regulate bone remodeling and osteoclastogenesis. This stud...

    Authors: Asieh Mansour, Maryam Aboeerad, Mostafa Qorbani, Amir Pejman Hashemi Taheri, Mohamad Pajouhi, Abbas Ali Keshtkar, Bagher Larijani, Mohammad Reza Mohajeri-Tehrani and Mohammad Reza Ganji
    Citation: BMC Nephrology 2018 19:172
    Content type: Research article Published on:

  11. Choice of dialysis is context sensitive, explored for PD and extracorporeal dialysis, but less studied for haemodialysis (HD) and hemodiafiltration (HDF), both widely employed in Italy and France; reasons of c...

    Authors: Giorgina Barbara Piccoli, Gianfranca Cabiddu, Maria Rita Moio, Antioco Fois, Riccardo Cao, Ida Molfino, Ana Kaniassi, Francoise Lippi, Ludivine Froger, Antonello Pani and Marilisa Biolcati
    Citation: BMC Nephrology 2018 19:171
    Content type: Research article Published on:

  12. Recurrence of glomerulonephritis is an important risk factor for renal graft dysfunction. Cryoglobulinemia is known as a relatively rare cause of renal failure, and doctors are usually hesitant to perform tran...

    Authors: Tomomichi Kasagi, Hironobu Nobata, Kaori Ikeda, Shogo Banno and Yasuhiko Ito
    Citation: BMC Nephrology 2018 19:170
    Content type: Case report Published on:

  13. Chronic kidney disease (CKD) poses a substantial health burden in sub-Saharan Africa, with risk factors ranging from communicable to non-communicable diseases. Hyperuricemia has been recently identified as a f...

    Authors: Marie Doualla, Marie Patrice Halle, Jude Moutchia, Steve Tegang and Gloria Ashuntantang
    Citation: BMC Nephrology 2018 19:169
    Content type: Research article Published on:

  15. Substrate reduction therapy with analogs reduces the accumulation of substrates by inhibiting the metabolic pathways involved in their biosynthesis, providing new treatment options for patients with primary hy...

    Authors: Huan Yang, Musa Male, Yang Li, Ning Wang, Chenming Zhao, Shan Jin, Juncheng Hu, Zhiqiang Chen, Zhangqun Ye and Hua Xu
    Citation: BMC Nephrology 2018 19:167
    Content type: Research article Published on:

  16. There are conflicting reports on the impact of HIV in the era of combined antiretroviral (c-ART) on survival of patient with ESKD. We aimed to compare the one-year survival of HIV positive patients to that of ...

    Authors: Marie Patrice Halle, Anais Mfoula Edjomo, Hermine Fouda, Hilaire Djantio, Noel Essomba and Gloria Enow Ashuntantang
    Citation: BMC Nephrology 2018 19:166
    Content type: Research article Published on:

  17. Gallbladder perforation is a rare but lethal condition and its diagnosis is usually difficult and delayed. Frequently, gallbladder rupture is associated with cholecystitis, but spontaneous perforation was ever...

    Authors: Yueh-Lin Wu, Yi-Sheng Lin, Thomas Yu-Ren Hsueh, Wen-Ching Lo, Kuo-Chou Peng and Mu-Jung Kao
    Citation: BMC Nephrology 2018 19:165
    Content type: Case report Published on:

  18. Organ donation after brain death (DBD) is the standard strategy for organ transplantation; however, the concept of brain death is not universally accepted due to cultural beliefs and barriers amongst billions ...

    Authors: Qipeng Sun, Honglan Zhou, Ronghua Cao, Minzhuan Lin, Xuefeng Hua, Liangqing Hong, Zhengyu Huang, Ning Na, Ruiming Cai, Gang Wang, Fanhang Meng and Qiquan Sun
    Citation: BMC Nephrology 2018 19:164
    Content type: Research article Published on:

  19. Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder, leading to end stage renal failure and kidney transplantation in its most serious form. The severity of the di...

    Authors: Veronika Elisakova, Miroslav Merta, Jana Reiterova, Alica Baxova, Jaroslav Kotlas, Katerina Hirschfeldova, Lena Obeidova, Vladimir Tesar and Jitka Stekrova
    Citation: BMC Nephrology 2018 19:163
    Content type: Case report Published on:

  20. While the majority of adult-onset minimal change nephrotic syndrome (MCNS) is a primary or an idiopathic form of disease, it can also occur as a secondary form. Reports on the spontaneous remission of MCNS are...

    Authors: Ayumi Haruki, Eiji Ishikawa, Kan Katayama, Takayasu Ito, Takuya Hiramoto, Mika Fujimoto, Tomohiro Murata and Masaaki Ito
    Citation: BMC Nephrology 2018 19:162
    Content type: Case report Published on:

  21. Acute kidney injury (AKI) following cardiac surgery is a frequent complication and several risk factors increasing its incidence have already been characterized. This study evaluates the influence of preoperat...

    Authors: T. Kaufeld, K. A. Foerster, T. Schilling, J. T. Kielstein, J. Kaufeld, M. Shrestha, H. G. Haller, A. Haverich and B. M. W. Schmidt
    Citation: BMC Nephrology 2018 19:161
    Content type: Research article Published on:

  22. Hypokalemia is one of the most common clinical electrolyte imbalance problems, and thyrotoxic periodic paralysis (TPP) is a leading cause of presentation to the emergency department. Low renal potassium secret...

    Authors: Mei-Lan Tu, Yu-Wei Fang, Jyh-Gang Leu and Ming-Hsien Tsai
    Citation: BMC Nephrology 2018 19:160
    Content type: Case report Published on:

  23. Left ventricular hypertrophy (LVH) increases the risk of death in chronic kidney disease (CKD). The transcription factor Kruppel-like factor 15 (KLF15) is expressed in the heart and regulates cardiac remodelli...

    Authors: Sheila K. Patel, Elena Velkoska, Daniel Gayed, Jay Ramchand, Jessica Lesmana and Louise M. Burrell
    Citation: BMC Nephrology 2018 19:159
    Content type: Research article Published on:

  24. According to the literature the three stone diseases, sialolithiasis (SL), urolithiasis (UL) and cholelithiasis (CL) share comorbidities. We assess familial and spouse risks between these stone disease and com...

    Authors: Kari Hemminki, Otto Hemminki, Anni I. M. Koskinen, Asta Försti, Kristina Sundquist, Jan Sundquist and Xinjun Li
    Citation: BMC Nephrology 2018 19:158
    Content type: Research article Published on:

  25. Currently, the vasopressin V2 receptor antagonist tolvaptan is the only available treatment for autosomal dominant polycystic kidney disease (ADPKD), but there are tolerability issues due to aquaretic side-eff...

    Authors: Bart J. Kramers, Maatje D. A. van Gastel, Esther Meijer and Ron T. Gansevoort
    Citation: BMC Nephrology 2018 19:157
    Content type: Case report Published on:

  27. Although fatigue is common in dialysis patients, polypharmacy is seldom listed among its causes. In this report, we describe a dialysis patient who developed severe fatigue due to pharmacological interaction b...

    Authors: Emanuela Cataldo, Valeria Columbano, Louise Nielsen, Lurlynis Gendrot, Bianca Covella and Giorgina Barbara Piccoli
    Citation: BMC Nephrology 2018 19:155
    Content type: Case report Published on:

  28. Conversion from calcineurin inhibitor (CNI) therapy to everolimus within 6 months after kidney transplantation improves long-term graft function but can increase the risk of mild biopsy-proven acute cellular r...

    Authors: Ute Eisenberger, Klemens Budde, Frank Lehner, Claudia Sommerer, Petra Reinke, Oliver Witzke, Rudolf P. Wüthrich, Rolf Stahl, Katharina Heller, Barbara Suwelack, Anja Mühlfeld, Ingeborg A. Hauser, Silvio Nadalin, Martina Porstner and Wolfgang Arns
    Citation: BMC Nephrology 2018 19:154
    Content type: Research article Published on:

  29. Peritonitis secondary to bowel perforation is a rare and potentially fatal complication in peritoneal dialysis (PD) patients. However, the early diagnosis of bowel perforation is difficult in PD patients becau...

    Authors: Kentaro Fujii, Naoki Washida, Eri Arai, Masashi Tsuruta, Shu Wakino and Hiroshi Itoh
    Citation: BMC Nephrology 2018 19:153
    Content type: Case report Published on:

  31. For patients with end-stage renal failure (ESFR), thrice-weekly hemodialysis is a standard care. Once-weekly hemodialysis combined with low-protein and low-salt dietary treatment (OWHD-DT) have been rarely stu...

    Authors: Toshiyuki Nakao, Yoshie Kanazawa and Toshimasa Takahashi
    Citation: BMC Nephrology 2018 19:151
    Content type: Research article Published on:

  32. Hematuria is associated with chronic kidney disease (CKD), but has rarely been examined as a risk factor for CKD progression. We explored whether individuals with hematuria had worse outcomes compared to those...

    Authors: Paula F. Orlandi, Naohiko Fujii, Jason Roy, Hsiang-Yu Chen, L. Lee Hamm, James H. Sondheimer, Jiang He, Michael J. Fischer, Hernan Rincon-Choles, Geetha Krishnan, Raymond Townsend, Tariq Shafi, Chi-yuan Hsu, John W. Kusek, John T. Daugirdas and Harold I. Feldman
    Citation: BMC Nephrology 2018 19:150
    Content type: Research article Published on:

  33. The Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury (AKI) guidelines assign the same stage of AKI to patients whether they fulfil urine output criteria, serum creatinine criteria or both ...

    Authors: Samuel H. Howitt, Stuart W. Grant, Camila Caiado, Eric Carlson, Dowan Kwon, Ioannis Dimarakis, Ignacio Malagon and Charles McCollum
    Citation: BMC Nephrology 2018 19:149
    Content type: Research article Published on:

  34. It has been suggested that C3 glomerulonephritis (C3GN) and atypical hemolytic-uremic syndrome (a stereotypical phenotype of thrombotic microangiopathy), two rare entities caused by complement alternative path...

    Authors: Jiqiu Wen, Wei Wang, Feng Xu, Jun Sun, Jinsong Chen and Xuefeng Ni
    Citation: BMC Nephrology 2018 19:148
    Content type: Case report Published on:

  35. There are no guidelines for transitioning patients from chronic kidney disease stage 5 to hemodialysis. We conducted this study to determine if there are uniform patterns in how nephrologists transition patien...

    Authors: Mary C. Mallappallil, Steven Fishbane, Rimda Wanchoo, Edgar Lerma, Andrea Roche-Recinos and Moro Salifu
    Citation: BMC Nephrology 2018 19:147
    Content type: Research article Published on:

  36. Chronic kidney disease (CKD) is highly prevalent but identification of patients at high risk for fast CKD progression before reaching end-stage renal disease in the short-term has been challenging. Whether fac...

    Authors: Alan S. Go, Jingrong Yang, Thida C. Tan, Claudia S. Cabrera, Bergur V. Stefansson, Peter J. Greasley and Juan D. Ordonez
    Citation: BMC Nephrology 2018 19:146
    Content type: Research article Published on:

  37. Neutrophil extracellular traps (NETs) are web-like DNA decorated with antimicrobial proteins, such as myeloperoxidase (MPO), which are extruded from activated neutrophils. Although NETs are essential in innate...

    Authors: Haruki Shida, Nobuhiro Hashimoto, Yoshihiro Kusunoki, Fumihiko Hattanda, Yayoi Ogawa, Terumasa Hayashi, Daigo Nakazawa, Sakiko Masuda, Utano Tomaru and Akihiro Ishizu
    Citation: BMC Nephrology 2018 19:145
    Content type: Case report Published on:

  38. Arthrogryposis-Renal dysfunction-Cholestasis syndrome (ARC, MIM#208085) is a rare multisystem disease due to mutations in the VPS33B and VIPAR genes, both involved in maintaining apical-basolateral cell polarity....

    Authors: Alejandra Rosales, Maissa Mhibik, Paul Gissen, Oscar Segarra, Susana Redecillas and Gema Ariceta
    Citation: BMC Nephrology 2018 19:144
    Content type: Case report Published on:

  39. Immunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by microtubular deposits. Immunofluorescence findings are necessary to differentiate ITG from other proliferative glomerular diseas...

    Authors: Shuma Hirashio, Takahiro Arima, Ayaka Satoh, Kouichi Mandai, Shigeo Hara and Takao Masaki
    Citation: BMC Nephrology 2018 19:143
    Content type: Case report Published on:

  40. The patients with secondary hyperparathyroidism (SHPT) usually had reduced bone mineral density, which might lead to a substantial increase in osteoporosis, fracture and mortality. Although surgical interventi...

    Authors: Li Fang, Jining Wu, Jing Luo, Ping Wen, Mingxia Xiong, Jinlong Cao, Xiaolan Chen and Junwei Yang
    Citation: BMC Nephrology 2018 19:142
    Content type: Research article Published on:

  41. This study describes the time trend of renal replacement therapy for end-stage renal disease (ESRD) in the Provence-Alpes Côte d’Azur region (PACA) between 2004 and 2015, and forecasts up to 2030.

    Authors: Anne-Claire Durand, Elisabeth Jouve, Jean-Christophe Delarozière, Mohamed Boucekine, Ghizlane Izaaryene, Adeline Crémades, Franck Mazoué, Bénédicte Devictor, Asmatullah Kakar, Roland Sambuc, Philippe Brunet and Stéphanie Gentile
    Citation: BMC Nephrology 2018 19:141
    Content type: Research article Published on:

  42. The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)...

    Authors: Han Xu, Na Guan, Ya-Li Ren, Qi-Jiao Wei, Ying-Hong Tao, Guo-Sheng Yang, Xiao-Ya Liu, Ding-Fang Bu, Ying Zhang and Sai-Nan Zhu
    Citation: BMC Nephrology 2018 19:140
    Content type: Research article Published on:

  43. Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20–25% of patients with chronic kidney disease and can lead...

    Authors: Lydia Namuyimbwa, Collins Atuheire, Joel Okullo and Robert Kalyesubula
    Citation: BMC Nephrology 2018 19:139
    Content type: Research article Published on:

  44. Severe infections are common complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal involvement. We investigated the clinical charact...

    Authors: Liu Yang, Honglang Xie, Zhengzhao Liu, Yinghua Chen, Jinquan Wang, Haitao Zhang, Yongchun Ge and Weixin Hu
    Citation: BMC Nephrology 2018 19:138
    Content type: Research article Published on:

  45. Thermometers that measure core (internal) body temperature are the gold standard for monitoring temperature. Despite that most modern hemodialysis machines are equipped with an internal blood monitor that meas...

    Authors: Meaghan Lunney, Bronwyn Tonelli, Rachel Lewis, Natasha Wiebe, Chandra Thomas, Jennifer MacRae and Marcello Tonelli
    Citation: BMC Nephrology 2018 19:137
    Content type: Research article Published on:

  46. Renal replacement therapy (RRT) with regional citrate anticoagulation (RCA) is an important therapeutic approach for refractory hypercalcemia complicated with renal failure. However, RCA has the potential to i...

    Authors: Buyun Wu, Jing Wang, Guang Yang, Changying Xing and Huijuan Mao
    Citation: BMC Nephrology 2018 19:136
    Content type: Case report Published on:

  47. A combination of safety concerns and labeling changes impacted use of erythropoiesis-stimulating agents (ESAs) in renal anemia. Data regarding contemporary utilization in pre-dialysis chronic kidney disease (C...

    Authors: Heide A. Stirnadel-Farrant, Jiacong Luo, Lata Kler, Borut Cizman, Delyth Jones, Steven M. Brunelli and Alexander R. Cobitz
    Citation: BMC Nephrology 2018 19:135
    Content type: Research article Published on:

  48. The high mortality and cardiovascular disease (CVD) burden in patients with end-stage renal disease (ESRD) is well-documented. Recent literature suggests that acute kidney injury is also associated with CVD. I...

    Authors: Benjamin J. Lee, Chi-yuan Hsu, Rishi V. Parikh, Thomas K. Leong, Thida C. Tan, Sophia Walia, Kathleen D. Liu, Raymond K. Hsu and Alan S. Go
    Citation: BMC Nephrology 2018 19:134
    Content type: Research article Published on:

  49. Catastrophic antiphospholipid syndrome (CAPS) is a rare, life-threatening form of antiphospholipid syndrome (APS) involving many organs and leading to their insufficiency. The pathogenesis of CAPS is associate...

    Authors: Aleksandra Rymarz and Stanisław Niemczyk
    Citation: BMC Nephrology 2018 19:132
    Content type: Case report Published on:

  50. Female sex has been included as a risk factor in models developed to predict the risk of acute kidney injury (AKI) associated with cardiac surgery, aminoglycoside nephrotoxicity and contrast-induced nephropath...

    Authors: Joel Neugarten, Ladan Golestaneh and Nitin V. Kolhe
    Citation: BMC Nephrology 2018 19:131
    Content type: Research article Published on:
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BMC Nephrology

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