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  1. Approximately 50% of patients with stage 3 Chronic Kidney Disease are 25-hydroxyvitamin D insufficient, and this prevalence increases with falling glomerular filtration rate. Vitamin D is now recognised as hav...

    Authors: William G Petchey, Ingrid J Hickman, Emma Duncan, Johannes B Prins, Carmel M Hawley, David W Johnson, Katherine Barraclough and Nicole M Isbel
    Citation: BMC Nephrology 2009 10:41
    Content type: Study protocol Published on:

  2. Risk factors in childhood create a life-long burden important in the development of cardiovascular (CV) disease in adulthood. Many risk factors for CV disease (e.g., hypertension) also increase the risk of ren...

    Authors: Paul Muntner, Asghar Arshad, Stephen A Morse, Dharmendrakumar A Patel, Pronabesh D Manapatra, Efrain Reisin, Erwin A Aguilar, Wei Chen, Sathanur Srinivasan and Gerald S Berenson
    Citation: BMC Nephrology 2009 10:40
    Content type: Research article Published on:

  3. Although health-related quality of life (HRQOL) is a potential independent predictor of mortality, nephrologists have shown little interest in HRQOL with respect to mortality in chronic kidney disease (CKD). T...

    Authors: Seung Seok Han, Ki Woong Kim, Ki Young Na, Dong-Wan Chae, Yon Su Kim, Suhnggwon Kim and Ho Jun Chin
    Citation: BMC Nephrology 2009 10:39
    Content type: Research article Published on:

  4. Alport syndrome (AS) is a progressive renal disease with cochlear and ocular involvement. The majority of AS cases are X-linked (XLAS) and due to mutations in the COL4A5 gene. Although the disease may appear e...

    Authors: Genevieve Pont-Kingdon, Kelli Sumner, Friederike Gedge, Chris Miller, Joyce Denison, Martin Gregory and Elaine Lyon
    Citation: BMC Nephrology 2009 10:38
    Content type: Technical advance Published on:

  5. Autosomal dominant pseudohypoaldosteronism type 1 (PHA1) is a rare inherited condition that is characterized by renal resistance to aldosterone as well as salt wasting, hyperkalemia, and metabolic acidosis. Re...

    Authors: Kyoko Kanda, Kandai Nozu, Naoki Yokoyama, Ichiro Morioka, Akihiro Miwa, Yuya Hashimura, Hiroshi Kaito, Kazumoto Iijima and Masafumi Matsuo
    Citation: BMC Nephrology 2009 10:37
    Content type: Research article Published on:

  6. Profound alterations in immune responses associated with uraemia and exacerbated by dialysis increase the risk of developing active tuberculosis (TB) in chronic haemodialysis patients (HDPs). In the current st...

    Authors: Antonios I Christopoulos, Athanasios A Diamantopoulos, Panagiotis A Dimopoulos, Demetrios S Goumenos and George A Barbalias
    Citation: BMC Nephrology 2009 10:36
    Content type: Research article Published on:

  7. The prevalence of patients with end stage renal disease (ESRD) who need dialysis and/or transplantation has more than doubled in Thailand during the past two decades. It has been suggested that therapeutic str...

    Authors: Leena Ong-ajyooth, Kriengsak Vareesangthip, Panrasri Khonputsa and Wichai Aekplakorn
    Citation: BMC Nephrology 2009 10:35
    Content type: Research article Published on:

  8. Chronic kidney disease (CKD) is increasingly being recognized as a predictor for both end-stage renal disease and cardiovascular disease. The present study, conducted on individuals from a community in Arita, ...

    Authors: Norimichi Takamatsu, Hideharu Abe, Tatsuya Tominaga, Kunihiko Nakahara, Yumi Ito, Yoko Okumoto, Jiyoong Kim, Masafumi Kitakaze and Toshio Doi
    Citation: BMC Nephrology 2009 10:34
    Content type: Research article Published on:

  9. The Italian and European Best Practice Guidelines (EBPG) recommend a target haemoglobin value greater than 11 g/dl in most patients with Chronic Kidney Diseases. However, it is still difficult to maintain thes...

    Authors: Silvia Soffritti, Giorgia Russo, Stefano Cantelli, Giuseppe Gilli and Luigi Catizone
    Citation: BMC Nephrology 2009 10:33
    Content type: Research article Published on:

  10. Oxidative stress is associated with increased cardiovascular morbidity and mortality particularly in patients with end stage kidney disease. Although observational data from the general population has shown di...

    Authors: Ashleigh Reed, Yeoung Jee Cho, Jeff S Coombes and Robert G Fassett
    Citation: BMC Nephrology 2009 10:32
    Content type: Study protocol Published on:

  11. Chronic heart failure (CHF) has a high morbidity and mortality. Chronic kidney disease (CKD) has consistently been found to be an independent risk factor for unfavorable cardiovascular (CV) outcomes. Early int...

    Authors: Arise GS Galil, Hélady S Pinheiro, Alfredo Chaoubah, Darcília MN Costa and Marcus G Bastos
    Citation: BMC Nephrology 2009 10:31
    Content type: Research article Published on:

  12. The Alberta Kidney Disease Network is a collaborative nephrology research organization based on a central repository of laboratory and administrative data from the Canadian province of Alberta.

    Authors: Brenda R Hemmelgarn, Fiona Clement, Braden J Manns, Scott Klarenbach, Matthew T James, Pietro Ravani, Neesh Pannu, Sofia B Ahmed, Jennifer MacRae, Nairne Scott-Douglas, Kailash Jindal, Robert Quinn, Bruce F Culleton, Natasha Wiebe, Richard Krause, Laurel Thorlacius…
    Citation: BMC Nephrology 2009 10:30
    Content type: Database Published on:

  13. Adiponectin is a major adipocyte-derived protein with insulin-sensitizing, anti-inflammatory and anti-atherogenic properties. Adiponectin levels correlate inversely with renal function and higher levels are pr...

    Authors: Mohd O Kaisar, Kirsty Armstrong, Carmel Hawley, Scott Campbell, David Mudge, David W Johnson, John B Prins and Nicole M Isbel
    Citation: BMC Nephrology 2009 10:29
    Content type: Research article Published on:

  14. Secondary hyperparathyroidism is a common feature in patients with chronic kidney disease. Its serious clinical consequences include renal osteodystrophy, calcific uremic arteriolopathy, and vascular calcifica...

    Authors: Ditte Hansen, Lisbet Brandi and Knud Rasmussen
    Citation: BMC Nephrology 2009 10:28
    Content type: Study protocol Published on:

  15. Acute kidney injury is among the most serious complications after cardiac surgery and is associated with an impaired outcome. Multiple factors may concur in the development of this disease. Moreover, severe re...

    Authors: Jose Ramon Perez-Valdivieso, Pablo Monedero, Marc Vives, Nuria Garcia-Fernandez and Maira Bes-Rastrollo
    Citation: BMC Nephrology 2009 10:27
    Content type: Research article Published on:

  16. It is unknown whether defining chronic kidney disease (CKD) based on one versus two estimated glomerular filtration rate (eGFR) assessments changes the prognostic importance of reduced eGFR in a community-base...

    Authors: Daniel E Weiner, Maria Krassilnikova, Hocine Tighiouart, Deeb N Salem, Andrew S Levey and Mark J Sarnak
    Citation: BMC Nephrology 2009 10:26
    Content type: Research article Published on:

  17. Early detection of chronic kidney disease (CKD) is sub-optimal among the general population and among high risk patients. The prevalence and impact of major CKD risk factors, diabetes (DM) and hypertension (HT...

    Authors: Idris Guessous, William McClellan, Suma Vupputuri and Haimanot Wasse
    Citation: BMC Nephrology 2009 10:25
    Content type: Research article Published on:

  18. Chronic kidney disease (CKD) is an emerging worldwide problem. The lack of attention paid to kidney disease is well known and has been described in previous publications. However, little is known about the mag...

    Authors: Giorgio Gentile, Maurizio Postorino, Raymond D Mooring, Luigi De Angelis, Valeria Maria Manfreda, Fabrizio Ruffini, Manuela Pioppo and Giuseppe Quintaliani
    Citation: BMC Nephrology 2009 10:24
    Content type: Research article Published on:

  19. Catheter-related bacteraemias (CRBs) contribute significantly to morbidity, mortality and health care costs in dialysis populations. Despite international guidelines recommending avoidance of catheters for hae...

    Authors: Jennifer K Broom, Stacey O'Shea, Sridevi Govindarajulu, E Geoffrey Playford, Carmel M Hawley, Nicole M Isbel, Scott B Campbell, David W Mudge, Sally Carpenter, Barbara C Johnson, Neil P Underwood and David W Johnson
    Citation: BMC Nephrology 2009 10:23
    Content type: Study protocol Published on:

  20. Ideally, care prior to the initiation of dialysis should increase the likelihood that patients start electively outside of the hospital setting with a mature arteriovenous fistula (AVF) or peritoneal dialysis ...

    Authors: David C Mendelssohn, Christine Malmberg and Bassem Hamandi
    Citation: BMC Nephrology 2009 10:22
    Content type: Review Published on:

  21. The most common cause of idiopathic nephrotic syndrome in children and younger adults is the minimal change nephrotic syndrome (MCNS). In the elderly MCNS is relatively uncommon. Over the last decade some repo...

    Authors: Christian Clajus, Janine Spiegel, Verena Bröcker, Christos Chatzikyrkou and Jan T Kielstein
    Citation: BMC Nephrology 2009 10:21
    Content type: Case report Published on:

  22. The main hypothesis of this study is that oral heme iron polypeptide (HIP; Proferrin® ES) administration will more effectively augment iron stores in erythropoietic stimulatory agent (ESA)-treated peritoneal dial...

    Authors: Katherine A Barraclough, Euan Noble, Diana Leary, Fiona Brown, Carmel M Hawley, Scott B Campbell, Nicole M Isbel, David W Mudge, Carolyn L van Eps, Joanna M Sturtevant and David W Johnson
    Citation: BMC Nephrology 2009 10:20
    Content type: Study protocol Published on:

  23. There has not been a comprehensive, multi-centre study of streptococcal peritonitis in patients on peritoneal dialysis (PD) to date.

    Authors: Stacey O'Shea, Carmel M Hawley, Stephen P McDonald, Fiona G Brown, Johan B Rosman, Kathryn J Wiggins, Kym M Bannister and David W Johnson
    Citation: BMC Nephrology 2009 10:19
    Content type: Research article Published on:

  24. There is limited knowledge of Chronic Kidney Disease (CKD) among high risk populations, especially in the developing countries. We report our study of testing for CKD in at-risk subjects.

    Authors: Ernest K Sumaili, Eric P Cohen, Chantal V Zinga, Jean-Marie Krzesinski, Nestor M Pakasa and Nazaire M Nseka
    Citation: BMC Nephrology 2009 10:18
    Content type: Research article Published on:

  27. It is well know that arterial stiffness, oxidative stress and inflammation are features of chronic kidney disease. The arterial changes have a multitude of potential interconnected causes including endothelial...

    Authors: Robert G Fassett, Vincent D'Intini, Helen Healy, John Gowardman, Jay-Sen Gan, James E Sharman and Jeff S Coombes
    Citation: BMC Nephrology 2009 10:15
    Content type: Study protocol Published on:

  28. Post-transplant anaemia remains a common problem after kidney transplantation, with an incidence ranging from nearly 80% at day 0 to about 25% at 1 year. It has been associated with poor graft outcome, and rec...

    Authors: David W Mudge, Ken-Soon Tan, Rhianna Miles, David W Johnson, Scott B Campbell, Carmel M Hawley, Nicole M Isbel, Carolyn L Van Eps and David L Nicol
    Citation: BMC Nephrology 2009 10:14
    Content type: Study protocol Published on:

  29. To facilitate in the identification of gene products important in regulating renal glomerular structure and function, we have produced an annotated transcriptome database for normal human glomeruli using the S...

    Authors: Jenny Nyström, Wolfgang Fierlbeck, Anna Granqvist, Stephen C Kulak and Barbara J Ballermann
    Citation: BMC Nephrology 2009 10:13
    Content type: Database Published on:

  31. Previous studies have examined the spectrum of diseases identified with a kidney biopsy and the complications of the procedure. However, few studies have examined the utility of the test to clarify the diagnos...

    Authors: Bari Scheckner, Alexandra Peyser, Jacob Rube, Freya Tarapore, Rachel Frank, Suzanne Vento, Cathy Hoffman, Elsa Valderrama, Douglas Charney, Beatrice Goilav and Howard Trachtman
    Citation: BMC Nephrology 2009 10:11
    Content type: Research article Published on:

  32. Despite the characteristic extensive tubulointerstitial fibrosis, Balkan Endemic Nephropathy (BEN) is usually considered a non-inflammatory disease.

    Authors: Wilfried Karmaus, Plamen Dimitrov, Valeri Simeonov, Svetla Tsolova and Vecihi Batuman
    Citation: BMC Nephrology 2009 10:10
    Content type: Research article Published on:

  33. Increased activation of the renin-angiotensin system (RAS) may be important in promoting coronary heart disease (CHD) and renal dysfunction, but limited data are available on associations between angiotensin t...

    Authors: Julie Lin, Frank B Hu, Lu Qi and Gary C Curhan
    Citation: BMC Nephrology 2009 10:9
    Content type: Research article Published on:

  34. Patients on peritoneal and hemodialysis have accelerated atherosclerosis associated with an increase in cardiovascular morbidity and mortality. The atherosclerosis is associated with increased arterial stiffne...

    Authors: Robert G Fassett, Ritza Driver, Helen Healy, Dwarakanathan Ranganathan, Sharad Ratanjee, Iain K Robertson, Dominic P Geraghty, James E Sharman and Jeff S Coombes
    Citation: BMC Nephrology 2009 10:8
    Content type: Study protocol Published on:

  35. A concentrate for bicarbonate haemodialysis acidified with citrate instead of acetate has been marketed in recent years. The small amount of citrate used (one-fifth of the concentration adopted in regional ant...

    Authors: Luca Gabutti, Barbara Lucchini, Claudio Marone, Lorenzo Alberio and Michel Burnier
    Citation: BMC Nephrology 2009 10:7
    Content type: Research article Published on:

  36. In patients treated by maintenance hemodialysis the relationship to survival of hemoglobin level and administered epoetin-alfa and intravenous iron is controversial. The study aim was to determine effects on p...

    Authors: Victor E Pollak, Jonathan A Lorch, Rakesh Shukla and Supriya Satwah
    Citation: BMC Nephrology 2009 10:6
    Content type: Research article Published on:

  37. Anaemia is common in patients with chronic kidney disease (CKD) and can be managed by therapy with erythropoiesis-stimulating agents (ESAs). Epoetin delta (DYNEPO®, Shire plc) is the only epoetin produced in a hu...

    Authors: Ulrich Frei, Jonathan TC Kwan and Bruce S Spinowitz
    Citation: BMC Nephrology 2009 10:5
    Content type: Research article Published on:

  38. Chronic kidney disease (CKD) is increasingly being recognized as an emerging public health problem in India. However, community based estimates of low glomerular filtration rate (GFR) and proteinuria are few. ...

    Authors: Narinder P Singh, Gopal K Ingle, Vinay K Saini, Ajita Jami, Pankaj Beniwal, Madan Lal and Gajender S Meena
    Citation: BMC Nephrology 2009 10:4
    Content type: Research article Published on:

  39. The use of peritoneal dialysis (PD) has declined in the United States over the past decade and technique failure is also reportedly higher in PD compared to hemodialysis (HD), but there are little data in the ...

    Authors: Bernard G Jaar, Laura C Plantinga, Deidra C Crews, Nancy E Fink, Nasser Hebah, Josef Coresh, Alan S Kliger and Neil R Powe
    Citation: BMC Nephrology 2009 10:3
    Content type: Research article Published on:

  40. Exercise training in hemodialysis patients improves fitness, physical function, quality of life and markers of cardiovascular disease such as arterial stiffness. The majority of trials investigating this area ...

    Authors: Kirsten P Koh, Robert G Fassett, James E Sharman, Jeff S Coombes and Andrew D Williams
    Citation: BMC Nephrology 2009 10:2
    Content type: Study protocol Published on:

  41. Haemodialysis (HD) is critically dependent on the availability of adequate access to the systemic circulation, ideally via a native arteriovenous fistula (AVF). The Primary failure rate of an AVF ranges betwee...

    Authors: Ashley Irish, Gursharan Dogra, Trevor Mori, Elaine Beller, Stephane Heritier, Carmel Hawley, Peter Kerr, Amanda Robertson, Johan Rosman, Peta-Anne Paul-Brent, Melissa Starfield, Kevan Polkinghorne and Alan Cass
    Citation: BMC Nephrology 2009 10:1
    Content type: Study protocol Published on:

  42. The objective was to investigate the association between renal structural parameters and renal function. The structural parameters were renal cortical volume, total renal volume, number of glomeruli, and total...

    Authors: Anders B Lødrup, Kristian Karstoft, Thomas H Dissing, Jens R Nyengaard and Michael Pedersen
    Citation: BMC Nephrology 2008 9:18
    Content type: Research article Published on:

  43. There is evidence that renal transplant recipients have accelerated atherosclerosis manifest by increased cardiovascular morbidity and mortality. The high incidence of atherosclerosis is, in part, related to i...

    Authors: Robert G Fassett, Helen Healy, Ritza Driver, Iain K Robertson, Dominic P Geraghty, James E Sharman and Jeff S Coombes
    Citation: BMC Nephrology 2008 9:17
    Content type: Study protocol Published on:

  44. Guidelines for the management of anaemia in patients with chronic kidney disease (CKD) recommend a minimal haemoglobin (Hb) target of 11 g/dL. Recent surveys indicate that this requirement is not met in many p...

    Authors: Claudine M Mathieu, Daniel Teta, Nathalie Lötscher, Dela Golshayan, Luca Gabutti, Denes Kiss, Pierre-Yves Martin and Michel Burnier
    Citation: BMC Nephrology 2008 9:16
    Content type: Research article Published on:

  45. In hemodialysis, extracorporeal blood flow (Qb) recommendation is 300–500 mL/min. To achieve the best Qb, we based our prescription on dynamic arterial line pressure (DALP).

    Authors: Franklin G Mora-Bravo, Alfonso Mariscal, Juan P Herrera–Felix, Salvador Magaña, Guadalupe De-La-Cruz, Nelly Flores, Laura Rosales, Martha Franco and Héctor Pérez-Grovas
    Citation: BMC Nephrology 2008 9:15
    Content type: Research article Published on:

  46. The study examines differences regarding quality of life (QoL), mental health and illness beliefs between in-centre haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD/PD) patients. Differen...

    Authors: M Ginieri-Coccossis, P Theofilou, C Synodinou, V Tomaras and C Soldatos
    Citation: BMC Nephrology 2008 9:14
    Content type: Research article Published on:

  47. Focal and segmental glomerulosclerosis (FSGS) is the most common histologic pattern of renal injury seen in adults with idiopathic proteinuria. Homozygous or compound heterozygous mutations in the podocin gene NP...

    Authors: Stephen J Tonna, Alexander Needham, Krishna Polu, Andrea Uscinski, Gerald B Appel, Ronald J Falk, Avi Katz, Salah Al-Waheeb, Bernard S Kaplan, George Jerums, Judy Savige, Jennifer Harmon, Kang Zhang, Gary C Curhan and Martin R Pollak
    Citation: BMC Nephrology 2008 9:13
    Content type: Research article Published on:

  48. Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive disorder of renal calcium and magnesium wasting frequently complicated by progressive chronic renal failure i...

    Authors: Geeta Hampson, Martin A Konrad and John Scoble
    Citation: BMC Nephrology 2008 9:12
    Content type: Research article Published on:

  49. Monoclonal free light chains (FLCs) frequently cause rapidly progressive renal failure in patients with multiple myeloma. Immunoassays which provide quantitative measurement of FLCs in serum, have now been ado...

    Authors: Colin A Hutchison, Tim Plant, Mark Drayson, Paul Cockwell, Melpomeni Kountouri, Kolitha Basnayake, Stephen Harding, Arthur R Bradwell and Graham Mead
    Citation: BMC Nephrology 2008 9:11
    Content type: Research article Published on:

  50. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in genes

    Authors: Kyriacos N Felekkis, Panayiota Koupepidou, Evdokia Kastanos, Ralph Witzgall, Chang-Xi Bai, Li Li, Leonidas Tsiokas, Norbert Gretz and Constantinos Deltas
    Citation: BMC Nephrology 2008 9:10
    Content type: Research article Published on:
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BMC Nephrology

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