- Research article
- Open Access
- Open Peer Review
Duration of acute kidney injury and mortality in critically ill patients: a retrospective observational study
- Seung Seok Han†1,
- Sejoong Kim†1, 2,
- Shin Young Ahn1, 2,
- Jeonghwan Lee3,
- Dong Ki Kim1,
- Ho Jun Chin1, 2,
- Dong-Wan Chae1, 2 and
- Ki Young Na1, 2Email author
© Han et al.; licensee BioMed Central Ltd. 2013
- Received: 18 October 2012
- Accepted: 24 June 2013
- Published: 27 June 2013
The addition of relevant parameters to acute kidney injury (AKI) criteria might allow better prediction of patient mortality than AKI criteria alone. Here, we evaluated whether inclusion of AKI duration could address this issue.
AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines in 2,143 critically ill patients, within 15 days of patient admission. AKI cases were categorized according to tertiles of AKI duration: 1st tertile, 1–2 days; 2nd tertile, 3–5 days; and 3rd tertile, ≥6 days. The hazard ratios (HRs) for overall survival rates in three groups were calculated after adjustment for multiple covariates compared with ICU patients without AKI as the reference group. The predictive ability for mortality was assessed by calculating the area under the curve (AUC) of the receiver operating characteristic curve.
AKI increased the HRs for overall mortality, and the mortality rate increased with AKI duration: the adjusted HRs were 1.99 (1st tertile), 2.67 (2nd tertile), and 2.85 (3rd tertile) compared with the non-AKI group (all Ps < 0.001). The AUC of the ROC curve for overall mortality based on the AKI duration groups (0.716) was higher than the AUC of AKI staging using the KDIGO guidelines (0.696) (P = 0.001). When considering KDIGO stage and AKI duration together, the AUC (0.717) was also significantly higher than that using the KDIGO stage alone (P < 0.001).
AKI duration is an additional parameter for the prediction of mortality in critically ill patients. The inclusion of AKI duration could be considered as a refinement of the AKI criteria.
- Acute kidney injury
- Acute renal failure
Acute kidney injury (AKI) is an important field of study in nephrology because AKI leads to long-term kidney sequelae, such as chronic kidney disease (CKD) and end-stage kidney disease [1, 2]. Furthermore, AKI affects the fate of other organs and overall mortality [3, 4]. Although therapy for AKI has improved in recent years, AKI is still highly prevalent, especially in critically ill patients in the intensive care unit (ICU) . AKI in the ICU has high mortality rates, reaching 80% ; these rates have remained largely unchanged despite improvements in therapies . For these reasons, the diagnosis of AKI and its classification according to severity are of major importance for clinicians in managing AKI patients.
Efforts have been made to define and stage AKI cases for use in clinical practice and research. Various criteria for AKI were used in early studies; the first evidence-based consensus, the RIFLE classification, was established by the Acute Dialysis Quality Initiative (ADQI) group . The RIFLE classification defines grades of AKI according to changes in serum creatinine, glomerular filtration rate (GFR), and/or urine output. This RIFLE classification was further refined by the Acute Kidney Injury Network (AKIN) group . The most noticeable change in the AKI criteria defined by AKIN was the inclusion of a smaller change in serum creatinine (≥ 0.3 mg/dL), which may increase the sensitivity of detecting AKI. Recently, Kidney Disease: Improving Global Outcomes (KDIGO) proposed a new set of guidelines for the definition and classification of AKI based on the previous two classifications . Whereas the urine output criterion (UOCr) did not change, some changes in the serum creatinine criterion (CrCr) were made for further clarity and simplicity.
Several epidemiological studies have supported the validity of AKI criteria in predicting mortality. However, identifying only changes in serum creatinine and urine output is not sufficient to improve the reliability of the criteria, thus other factors should be considered. One of the most readily confirmable factors in clinical practice is the duration of AKI. Three previous studies evaluated the association between AKI duration and mortality [11–13], but these results were limited because critically ill patients admitted to the ICU, where the observed negative impact of AKI is the greatest, were not included and because UOCr was not considered. Here, we assessed AKI duration using CrCr and UOCr from the KDIGO guidelines in a large cohort of ICU patients. Using these data, we compared the ability to predict mortality from AKI duration, from the conventional AKI stages, and from AKI duration and stage together to evaluate whether the inclusion of AKI duration could allow better predictions of patient mortality than the conventional AKI criteria alone.
Patients and data collection
The institutional review board at the Seoul National University Bundang Hospital approved the study (no. B-1112-142-103). A total of 2,823 patients were admitted from June 2004 through June 2010 to the ICU at the Seoul National University Bundang Hospital, Gyeonggi-do, Korea. The patients were followed up until December 31, 2010. We excluded patients younger than 18 years old (n = 49) and patients previously diagnosed with end-stage renal disease on dialysis (n = 94). Two patients who remained in hospital at the end of the study were also excluded. Among the study subjects, 9 patients were excluded based on the unavailability of serum creatinine or urine output data. If the patients were admitted more than once to the ICU without AKI, only the first admission was counted as the single case. Consequently, 2,143 patients were reviewed retrospectively using electronic medical records. A standardized data form approved by the institutional review board was used to collect the data.
Clinical parameters, such as age, sex, weight (kg), systolic/diastolic blood pressure, primary diagnosis, underlying CKD, history of malignancy, the need for mechanical ventilation, and the use of vasoactive drugs were recorded. The primary diagnosis was categorized as cardiovascular disease, sepsis, surgical admission, and others. The Acute Physiology and Chronic Health Evaluation (APACHE) ІІ score was used to assess illness severity . Changes in serum creatinine and urine output after ICU admission were measured, and the urine output data were recorded hourly. Additionally, we gathered laboratory blood data such as white blood cell count, hemoglobin, platelet count, blood urea nitrogen, cholesterol, protein, bilirubin, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase; there was only about 1% of data missing.
Definition and classification of acute kidney injury
Definition and staging for acute kidney injury
Serum creatinine criterion
Urine output criterion
≥ 0.3 mg/dl increase within 48 hours or 1.5–1.9 times baseline
< 0.5 ml/kg/h for 6–12 hours
2.0–2.9 times baseline
< 0.5 ml/kg/h for ≥ 12 hours
≥ 3.0 times baseline or increase in serum creatinine to ≥ 4.0 mg/dl, or initiation of renl replacement therapy
< 0.3 ml/kg/h for ≥ 24 hours or anuria for ≥ 12 hours
All of the analyses and calculations were performed using SPSS (SPSS version 16.0, IBM, Armonk, NY, USA) and MedCalc software (MedCalc version 11.5.1, Mariakerke, Belgium). The data are presented as means ± standard deviation (SD) for continuous variables and as proportions for categorical variables. Variables with a non-normal distribution are expressed as median (interquartile range (IQR)). The in-hospital survival rates and the overall survival rates which were recorded after the patients had been discharged were calculated using the Kaplan-Meier method. The survival comparison among the groups based on KDIGO stage or AKI duration was performed using the log-rank test. The hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality rates were calculated using the Cox proportional hazard model after adjustment for potential confounders, including age, sex, APACHE ІІ score, primary diagnosis, underlying CKD, history of malignancy, the need for mechanical ventilation, the use of vasoactive drugs, and AKI stage. ICU patients without AKI were used as the reference group. For additional analyses, lengths of hospital stay were compared among the AKI duration groups using the Mann–Whitney U test or Kruskal-Wallis test according to the number of groups. The relationship between AKI duration and AKI recovery was evaluated using a Chi-square test. A goodness of fit test was used to evaluate the applicability of the model. The discriminative ability of the criteria to correctly predict mortality was assessed by calculating the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. A comparison of the ROC curves was performed using a method described by DeLong and colleagues . A P value of less than 0.05 was considered to be significant.
Baseline characteristics and laboratory findings of the patients at the time of admission to the intensive care unit
No AKI (n = 488)
1sttertile (n = 552)
2ndtertile (n = 497)
3rdtertile (n = 437)
RRT (n = 169)
65.0 ± 16.11
66.8 ± 16.49
69.5 ± 15.40
69.7 ± 15.34
66.2 ± 14.30
Male sex (%)
Body weight (kg)
58.1 ± 11.61
59.0 ± 13.19
57.1 ± 11.94
57.8 ± 13.45
62.0 ± 11.09
History of malignancy
Need for MV
Use of vasoactive drugs
133.1 ± 31.37
132.3 ± 33.58
128.1 ± 35.15
128.4 ± 36.02
118.4 ± 32.54
71.1 ± 23.61
70.1 ± 26.18
64.8 ± 26.81
63.6 ± 28.42
56.2 ± 25.59
White blood cells (1000/mm3)*
10.9 (7.53 – 15.37)
12.8 ± 2.32
12.7 ± 2.63
12.0 ± 2.58
11.7 ± 2.74
10.8 ± 2.90
Blood urea nitrogen (mg/dL)*
170.0 ± 49.48
161.5 ± 56.57
152.4 ± 52.38
153.2 ± 59.00
138.6 ± 50.88
6.6 ± 0.99
6.5 ± 1.03
6.4 ± 1.04
6.2 ± 1.05
6.1 ± 1.07
Alkaline phosphatase (mg/dL)*
APACHE ІІ score
13.4 ± 6.51
16.7 ± 7.33
20.7 ± 7.80
20.3 ± 7.86
22.1 ± 8.51
LOS in hospital (days)*
Acute kidney injury and its duration
Hazard ratios (95% confidence intervals) for mortality according to the duration of acute kidney injury
No AKI (n = 488)
1st tertile (n = 552)
2nd tertile (n = 497)
3rd tertile (n = 437)
RRT (n = 169)
Predicting mortality based on the duration of acute kidney injury
The AUC (95% CI) of the ROC curve for overall mortality was 0.696 (0.676–0.715) when AKI was staged according to the KDIGO guidelines, and 0.716 (0.697–0.735) for the AKI duration groups (P = 0.001). When AKI duration was considered as a continuous variable (0 to 15 days), the AUC was 0.718 (0.698–0.737); the AUC was 0.711 (0.690–0.731) in the patients who did not receive RRT. The AUC for overall mortality in patients who did not receive RRT was analyzed according to duration as determined by each criterion with the following results: AKI duration using CrCr, 0.670 (0.648–0.690), and AKI duration using UOCr, 0.596 (0.574–0.618). When considering AKI staging according to the KDIGO guidelines and AKI duration together, the AUC for overall mortality (0.717 (0.697–0.736)) was significantly higher than the AUC calculated from the AKI staging (P < 0.001). The AUCs for in-hospital mortality were also higher when using AKI staging and AKI duration together (0.751 (0.732–0.769)) than the AUCs calculated using only AKI staging (0.731 (0.712–0.750)) (P < 0.001).
AKI worsens the survival of patients with a variety of presenting conditions, especially critically ill patients. Several factors in addition to those currently measured may be involved in the inverse association of AKI with survival. This study shows that AKI duration is an additional predictive parameter for mortality during and after ICU admission. In addition to revealing a strong correlation between AKI duration and mortality, the present data has several strengths. First, we adopted the KDIGO guidelines for AKI, which are the most recently revised guidelines, offering clarity and simplicity in clinical use. Furthermore, we used an hourly collected UOCr. The hourly collection of urine output is essential in staging and defining AKI, but can be difficult and thus has rarely been considered in most previous studies. Therefore, our study results may be a good reference for future studies using the KDIGO guidelines. The second strength of this study is that patients admitted to the ICU were included in our analysis. Two previous studies on AKI duration have used a cohort of patients who underwent cardiac or noncardiac surgery [12, 13]. However, those studies did not cover a heterogeneous population of critically ill patients, who are most vulnerable to AKI.
The detection and classification of AKI is important for determining patient prognosis. The RIFLE and AKIN criteria used to define AKI have been shown to be good predictors of patient prognosis [17, 18]. The KDIGO guidelines, which represent a combination of RIFLE and AKIN criteria, may also allow the prediction of morbidity and mortality, although few studies using this guideline have been conducted so far. However, the AKI criteria have not yet been fully optimized: some cases of AKI can remain undiagnosed [19, 20]; a non-gradual increase in mortality with increasing AKI stage has been shown in some studies [19–22]. These problems can be explained by shortcoming of serum creatinine as an early AKI marker , limitation in the use of UOCr , and the failure to identify other factors such as the cause of AKI . We were interested primarily in the latter point; among several other predictive factors, we focused on the effect of AKI duration, because this can be easily measured without further extensive tests.
In this study, patients with a long duration of AKI had higher mortality rates and longer hospital stays than patients with a short duration of AKI. The strong correlation between AKI duration and poor outcome can be explained as follows: the more severe and treatment-resistant an AKI case is (e.g., non-recovery case), the longer the duration of AKI become. Three previous studies investigated this issue by dividing patients into groups: transient azotemia (≤ 3 days) and acute tubular necrosis (≥ 4 days or patients with RRT) ; short (≤ 2 days), medium (3–6 days), and long (≥ 7 days or patients with RRT) [12, 13]. However, we set the patients with RRT apart because patients who received RRT may have cases of AKI that are much more severe than those of other patients and because RRT shortens the duration of AKI compared with other medical treatments . Based on the results thus far, it can be concluded that the effort to recover from AKI is an important consideration, particularly for long-term AKI cases. AKI is not merely a disease of the kidneys, as it can also affect the functioning or failure of other organs . Therefore, early detection and early treatment of AKI are essential to reduce the negative impact of AKI. However, the present study does not underestimate the importance of transient AKI, because short-duration AKI was also found to increase mortality significantly compared to no AKI, and a 1-day increase in AKI duration was associated with a 13.9% increase in overall mortality.
The ability to predict mortality was compared between AKI duration groups and conventional AKI stages (according to KDIGO) by assessing the AUC of the ROC curves. The AUCs of the ROCs indicated that AKI duration had greater ability to predict mortality than the conventional AKI stages. Furthermore, when considering AKI duration and AKI staging together, the ability to predict mortality was superior to the results based on the analysis of AKI staging alone. These results suggest that the AKI duration could be considered as an extra parameter to increase the sensitivity of the KDIGO criteria. Additionally, if AKI staging is not carried out, then AKI duration can be used as a replacement to predict mortality.
Although our results are informative, this study has some limitations. First, the ICU design of the study limits the applicability of our conclusions to other settings despite the abundance and detail of the dataset; the proportion of patients with sepsis as a cause of admission was relatively low. Second, we did not control for the use or indication of treatment for AKI because AKI duration could change depending on the treatment regimen. Further studies addressing these limitations will be necessary in the future.
In conclusion, AKI duration is a useful parameter for the prediction of mortality in critically ill patients. Comparable predictions of mortality can be made from AKI duration alone. Furthermore, the prediction of mortality can be improved when considering AKI duration in addition to the current AKI criteria. Although the current criteria for detecting and staging AKI are useful in clinical practice and research, the results of the current study should be considered in future refinements of the AKI criteria.
This work was supported by a grant from the Seoul National University Bundang Hospital Research Fund (No. 03-2012-020). We appreciate the statistical advice from the Medical Research Collaborating Center (MRCC), Seoul National University College of Medicine, and MRCC, Seoul National University Bundang Hospital.
- Finkenstaedt JT, Merrill JP: Renal function after recovery from acute renal failure. N Engl J Med. 1956, 254 (22): 1023-1026. 10.1056/NEJM195605312542203.View ArticlePubMedGoogle Scholar
- Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris BA, Collins AJ: Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol. 2009, 20 (1): 223-228. 10.1681/ASN.2007080837.View ArticlePubMedPubMed CentralGoogle Scholar
- de Mendonca A, Vincent JL, Suter PM, Moreno R, Dearden NM, Antonelli M, Takala J, Sprung C, Cantraine F: Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score. Intensive Care Med. 2000, 26 (7): 915-921. 10.1007/s001340051281.View ArticlePubMedGoogle Scholar
- Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW: Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005, 16 (11): 3365-3370. 10.1681/ASN.2004090740.View ArticlePubMedGoogle Scholar
- Clermont G, Acker CG, Angus DC, Sirio CA, Pinsky MR, Johnson JP: Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes. Kidney Int. 2002, 62 (3): 986-996. 10.1046/j.1523-1755.2002.00509.x.View ArticlePubMedGoogle Scholar
- Turney JH: Acute renal failure–a dangerous condition. JAMA. 1996, 275 (19): 1516-1517. 10.1001/jama.1996.03530430060041.View ArticlePubMedGoogle Scholar
- Ympa YP, Sakr Y, Reinhart K, Vincent JL: Has mortality from acute renal failure decreased? A systematic review of the literature. Am J Med. 2005, 118 (8): 827-832. 10.1016/j.amjmed.2005.01.069.View ArticlePubMedGoogle Scholar
- Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P: Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004, 8 (4): R204-R212. 10.1186/cc2872.View ArticlePubMedPubMed CentralGoogle Scholar
- Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007, 11 (2): R31-10.1186/cc5713.View ArticlePubMedPubMed CentralGoogle Scholar
- Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group: KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Inter Suppl. 2012, 2 (1): 1-138.View ArticleGoogle Scholar
- Uchino S, Bellomo R, Bagshaw SM, Goldsmith D: Transient azotaemia is associated with a high risk of death in hospitalized patients. Nephrol Dial Transplant. 2010, 25 (6): 1833-1839. 10.1093/ndt/gfp624.View ArticlePubMedGoogle Scholar
- Brown JR, Kramer RS, Coca SG, Parikh CR: Duration of acute kidney injury impacts long-term survival after cardiac surgery. Ann Thorac Surg. 2010, 90 (4): 1142-1148. 10.1016/j.athoracsur.2010.04.039.View ArticlePubMedGoogle Scholar
- Coca SG, King JT, Rosenthal RA, Perkal MF, Parikh CR: The duration of postoperative acute kidney injury is an additional parameter predicting long-term survival in diabetic veterans. Kidney Int. 2010, 78 (9): 926-933. 10.1038/ki.2010.259.View ArticlePubMedPubMed CentralGoogle Scholar
- Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: a severity of disease classification system. Crit Care Med. 1985, 13 (10): 818-829. 10.1097/00003246-198510000-00009.View ArticlePubMedGoogle Scholar
- Seabra VF, Balk EM, Liangos O, Sosa MA, Cendoroglo M, Jaber BL: Timing of renal replacement therapy initiation in acute renal failure: a meta-analysis. Am J Kidney Dis. 2008, 52 (2): 272-284. 10.1053/j.ajkd.2008.02.371.View ArticlePubMedGoogle Scholar
- DeLong ER, DeLong DM, Clarke-Pearson DL: Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988, 44 (3): 837-845. 10.2307/2531595.View ArticlePubMedGoogle Scholar
- Ricci Z, Cruz D, Ronco C: The RIFLE criteria and mortality in acute kidney injury: A systematic review. Kidney Int. 2008, 73 (5): 538-546. 10.1038/sj.ki.5002743.View ArticlePubMedGoogle Scholar
- Thakar CV, Christianson A, Freyberg R, Almenoff P, Render ML: Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study. Crit Care Med. 2009, 37 (9): 2552-2558. 10.1097/CCM.0b013e3181a5906f.View ArticlePubMedGoogle Scholar
- Joannidis M, Metnitz B, Bauer P, Schusterschitz N, Moreno R, Druml W, Metnitz PG: Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database. Intensive Care Med. 2009, 35 (10): 1692-1702. 10.1007/s00134-009-1530-4.View ArticlePubMedGoogle Scholar
- Lopes JA, Fernandes P, Jorge S, Goncalves S, Alvarez A, Costa e Silva Z, Franca C, Prata MM: Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications. Crit Care. 2008, 12 (4): R110-10.1186/cc6997.View ArticlePubMedPubMed CentralGoogle Scholar
- Haase M, Bellomo R, Matalanis G, Calzavacca P, Dragun D, Haase-Fielitz A: A comparison of the RIFLE and Acute Kidney Injury Network classifications for cardiac surgery-associated acute kidney injury: a prospective cohort study. J Thorac Cardiovasc Surg. 2009, 138 (6): 1370-1376. 10.1016/j.jtcvs.2009.07.007.View ArticlePubMedGoogle Scholar
- Kwon SH, Noh H, Jeon JS, Kim Y, Han DC: An assessment of AKIN criteria for hospital-acquired acute kidney injury: a prospective observational cohort study. Nephron Clin Pract. 2010, 116 (3): c217-c223. 10.1159/000317202.View ArticlePubMedGoogle Scholar
- Waikar SS, Betensky RA, Bonventre JV: Creatinine as the gold standard for kidney injury biomarker studies?. Nephrol Dial Transplant. 2009, 24 (11): 3263-3265. 10.1093/ndt/gfp428.View ArticlePubMedGoogle Scholar
- Han SS, Kang KJ, Kwon SJ, Wang SJ, Shin SH, Oh SW, Na KY, Chae DW, Kim S, Chin HJ: Additional role of urine output criterion in defining acute kidney injury. Nephrol Dial Transplant. 2012, 27 (1): 161-165. 10.1093/ndt/gfr312.View ArticlePubMedGoogle Scholar
- Cruz DN, Bolgan I, Perazella MA, Bonello M, de Cal M, Corradi V, Polanco N, Ocampo C, Nalesso F, Piccinni P, et al: North East Italian Prospective Hospital Renal Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI): targeting the problem with the RIFLE Criteria. Clin J Am Soc Nephrol. 2007, 2 (3): 418-425. 10.2215/CJN.03361006.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2369/14/133/prepub
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