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  1. Contrast-associated acute kidney injury (CA-AKI) is a common complication with poor prognosis after coronary angiography (CAG). With the prevention methods widely being implemented, the temporal trends of inci...

    Authors: Jin Liu, Qiang Li, Disheng Lai, Guoqin Chen, Bo Wang, Liwei Liu, Haozhang Huang, Zhubin Lun, Ming Ying, Guanzhong Chen, Zhidong Huang, Danyuan Xu, Liangguang Meng, Xiaoming Yan, Weiyan Qiu, Ning Tan…
    Citation: BMC Nephrology 2021 22:235
    Content type: Research Published on:

  2. Most studies of chronic kidney disease (CKD) in Sub-Saharan Africa (SSA) have been conducted in urban settings. They relied on GFR estimated from serum creatinine alone and on the inexpensive, convenient urina...

    Authors: Mannix Imani Masimango, Michel P. Hermans, Espoir Bwenge Malembaka, Pierre Wallemacq, Ernest Kiswaya Sumaili, Catherine Fillée, William D’Hoore, Cheryl A. Winkler, Sophie Limou and Michel Jadoul
    Citation: BMC Nephrology 2021 22:234
    Content type: Research Published on:

  3. Patient-reported outcome (PRO) instruments should capture the experiences of disease and treatment that patients consider most important in order to inform patient-centred care and product development. The aim...

    Authors: Jennifer E. Flythe, Niklas Karlsson, Anna Sundgren, Paul Cordero, Amanda Grandinetti, Henry Cremisi and Anna Rydén
    Citation: BMC Nephrology 2021 22:233
    Content type: Research Published on:

  4. After dialysis initiation, older adults may experience orthostatic or post-dialysis hypotension. Some orthostasis-causing antihypertensives (i.e., central alpha agonists and alpha blockers), are considered pot...

    Authors: Rasheeda K. Hall, Sarah Morton, Jonathan Wilson, Patti L. Ephraim, L. Ebony Boulware, Wendy L. St. Peter, Cathleen Colón-Emeric, Jane Pendergast and Julia J. Scialla
    Citation: BMC Nephrology 2021 22:232
    Content type: Research Published on:

  5. Common subtypes seen in Chinese patients with membranous nephropathy (MN) include idiopathic membranous nephropathy (IMN) and hepatitis B virus-related membranous nephropathy (HBV-MN). However, the morphologic...

    Authors: Tianqi Tu, Xueling Wei, Yue Yang, Nianrong Zhang, Wei Li, Xiaowen Tu and Wenge Li
    Citation: BMC Nephrology 2021 22:231
    Content type: Research article Published on:

  6. IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Although most IgAN cases are sporadic, few show a familial aggregation. However, the prevalence and prognosis of IgAN individuals...

    Authors: Yoshinori Sato, Hiroyasu Tsukaguchi, Koichiro Higasa, Naoto Kawata, Kiyoko Inui, Tran Nguyen Truc Linh, Tran Thuy Huong Quynh, Inoue Yoshihiko, Fumihiko Koiwa and Ashio Yoshimura
    Citation: BMC Nephrology 2021 22:230
    Content type: Research Published on:

  7. Worldwide, hypertensive disorders in pregnancy (HDPs) complicate between 5 and 10% of pregnancies. Sub-Saharan Africa (SSA) is disproportionately affected by a high burden of HDPs and chronic kidney disease (C...

    Authors: Salisu M. Ishaku, Timothy Olusegun Olanrewaju, Joyce L. Browne, Kerstin Klipstein-Grobusch, Gbenga A. Kayode, Arie Franx, Diederick E. Grobbee and Charlotte E. Warren
    Citation: BMC Nephrology 2021 22:229
    Content type: Research Published on:

  8. Silver nanoparticles (AgNPs) can accumulate in various organs after oral exposure. The main objective of the current study is to evaluate the renal toxicity induced by AgNPs after repeated oral exposure and to...

    Authors: Hamed Nosrati, Manijeh Hamzepoor, Maryam Sohrabi, Massoud Saidijam, Mohammad Javad Assari, Nooshin Shabab, Zahra Gholami Mahmoudian and Zohreh Alizadeh
    Citation: BMC Nephrology 2021 22:228
    Content type: Research Published on:

  9. End-stage Kidney Disease patients have a high mortality and hospitalization risk. The association of these outcomes with physical activity is described in the general population and in other chronic diseases. ...

    Authors: Pedro Martins, Elisa A. Marques, Diogo V. Leal, Aníbal Ferreira, Kenneth R Wilund and João L. Viana
    Citation: BMC Nephrology 2021 22:227
    Content type: Research Published on:

  10. Early diagnosis and treatment of Polyomavirus BK Nephropathy (PVBKN) is a challenging issue in the management of patients with kidney transplantation. Currently, histopathologic diagnosis is the gold standard ...

    Authors: Fatemeh Nili, Maliheh Mohammadhoseini, Seyed Mohammadreza Khatami, Golnar Seirafi and Majidreza Haghzare
    Citation: BMC Nephrology 2021 22:226
    Content type: Research Published on:

  11. Chronic kidney disease is highly prevalent across the globe with more than 2 million people worldwide requiring renal replacement therapy. Interdialytic weight gain is the change in body weight between two ses...

    Authors: Soraiya Manji, Jasmit Shah, Ahmed Twahir and Ahmed Sokwala
    Citation: BMC Nephrology 2021 22:225
    Content type: Research Published on:

  12. Coronavirus-19 (COVID-19) has been declared a global pandemic by the World Health Organisation. Severe disease typically presents with respiratory failure but Acute Kidney Injury (AKI) and a hypercoagulable st...

    Authors: Kathrine Parker, Patrick Hamilton, Prasanna Hanumapura, Laveena Castelino, Michelle Murphy, Rachael Challiner, Jecko Thachil and Leonard Ebah
    Citation: BMC Nephrology 2021 22:224
    Content type: Research Published on:

  13. Diabetic kidney disease (DKD) is a major long-term complication of diabetes mellitus (DM). Given the paucity of data on DKD in Jordan, we aimed to evaluate the prevalence, characteristics and correlates of DKD...

    Authors: Randa I. Farah, Mohammed Q. Al-Sabbagh, Munther S. Momani, Asma Albtoosh, Majd Arabiat, Ahmad M. Abdulraheem, Husam Aljabiri and Mohammad Abufaraj
    Citation: BMC Nephrology 2021 22:223
    Content type: Research Published on:

  14. Von Willebrand Factor (VWF) multimers are cleaved into smaller and less coagulant forms by the metalloprotease ADAMTS13. The aim of this study was to investigate the association between VWF and ADAMTS13 and mo...

    Authors: Gurbey Ocak, Mark Roest, Marianne C. Verhaar, Maarten B. Rookmaaker, Peter J. Blankestijn, Willem Jan W. Bos, Rob Fijnheer, Nathalie C. Péquériaux and Friedo W. Dekker
    Citation: BMC Nephrology 2021 22:222
    Content type: Research article Published on:

  15. Increasing the blood flow rate (BFR) is a useful method for increasing Kt/V and the clearance for low molecular solutes. Hemodialysis patients are often anemic due to hypoerythropoiesis and their chronic infla...

    Authors: Masateru Yamamoto, Tomio Matsumoto, Hiromitsu Ohmori, Masahiko Takemoto, Masanobu Ikeda, Ryo Sumimoto, Tsuyoshi Kobayashi, Akihiko Kato and Hideki Ohdan
    Citation: BMC Nephrology 2021 22:221
    Content type: Research Published on:

  16. Heparin-induced thrombocytopenia (HIT) involves platelet activation and aggregation caused by heparin or HIT antibodies associated with poor survival outcomes. We report a case of HIT that occurred after hemod...

    Authors: Yoshitaka Furuto, Mariko Kawamura, Jumpei Yamashita, Takahiro Yoshikawa, Akio Namikawa, Rei Isshiki, Hiroko Takahashi and Yuko Shibuya
    Citation: BMC Nephrology 2021 22:220
    Content type: Case report Published on:

  17. Sepsis is the most common cause of acute kidney injury (AKI) among critically ill patients. This study aimed to determine whether presepsin is a predictor of septic acute kidney injury, renal replacement thera...

    Authors: Yuichiro Shimoyama, Osamu Umegaki, Noriko Kadono and Toshiaki Minami
    Citation: BMC Nephrology 2021 22:219
    Content type: Research article Published on:

  18. Adiponectin is an adipocytokine that plays a key regulatory role in glucose and lipid metabolism in obesity. The prevalence of obesity has led to an increase in the incidence of obesity-related glomerulopathy ...

    Authors: Xiaohong Xu, Xiaolin Huang, Liexiang Zhang, Xiaoli Huang, Zihan Qin and Fei Hua
    Citation: BMC Nephrology 2021 22:218
    Content type: Research Published on:

  20. Multicentric Castleman’s disease is a life-threatening disorder involving a systemic inflammatory response and multiple organ failure caused by the overproduction of interleukin-6. Although renal complications...

    Authors: Ryosuke Saiki, Kan Katayama, Yosuke Hirabayashi, Keiko Oda, Mika Fujimoto, Tomohiro Murata, Ayako Nakajima and Kaoru Dohi
    Citation: BMC Nephrology 2021 22:216
    Content type: Case report Published on:

  21. Pregnancy-related acute kidney injury (Pr-AKI) is associated with maternal and fetal morbidity and mortality. There are few studies focusing on Pr-AKI at high altitude in the literature.

    Authors: Xin Li, Xiaojing Wu, Muyin Zhang, Lili Xu, Guohui Li, Yumei Wen and Weiming Wang
    Citation: BMC Nephrology 2021 22:215
    Content type: Research article Published on:

  22. Malnutrition is a usually observed condition among patients on hemodialysis and is considered one of sturdiest indicators of mortality and morbidity.

    Authors: Manal Badrasawi, Souzan Zidan, Israa Sharif, Juliana Qaisiyha, Sanabel Ewaida, Tala Jaradat and Yasmeen Samamra
    Citation: BMC Nephrology 2021 22:214
    Content type: Research Published on:

  23. The incidence of cerebral stroke, including ischemic infarction and intracranial hemorrhage (ICH), increases in patients with nephrotic syndrome (NS). However, the clinical characteristics of patients with NS ...

    Authors: Wen-Yi Huang, Chun-Wei Chang, Chiung-Mei Chen, Kuan-Hsing Chen, Chien-Hung Chang, Hsiu-Chuan Wu and Kuo-Hsuan Chang
    Citation: BMC Nephrology 2021 22:213
    Content type: Research Published on:

  24. Interleukin-10 (IL-10), a kind of anti-inflammation cytokine, has a key role in the development of acute kidney injury (AKI). Recently, several studies addressed the link between the risk of AKI and the IL-10 ...

    Authors: Haiyan Mu, Qingqing Zheng and Lihai Hao
    Citation: BMC Nephrology 2021 22:212
    Content type: Research Published on:

  25. Matrix metalloproteinases-9 (MMP-9) can regulate extracellular matrix deposition in diabetic glomerular injury. However, it remains unknown whether MMP-9 is involved in the renal tubular injury. Meanwhile, neu...

    Authors: Huayu Yang, Haiping Chen, Fenghua Liu and Qing Ma
    Citation: BMC Nephrology 2021 22:211
    Content type: Research Published on:

  26. Health related quality of life (HRQOL) is an important indicator of medical treatment and is a strong predictor of disability and mortality. The literature has shown mixed evidence about whether kidney transpl...

    Authors: Adnan Lutfi Sarhan, Raya H. Jarareh and Mujahed Shraim
    Citation: BMC Nephrology 2021 22:210
    Content type: Research article Published on:

  27. IgA nephropathy(IgAN)) is the common pathological type of glomerular diseases. The role of gut microbiota in mediating “gut-IgA nephropathy” has not received sufficient attention in the previous studies. The p...

    Authors: Lingxiong Chai, Qun Luo, Kedan Cai, Kaiyue Wang and Binbin Xu
    Citation: BMC Nephrology 2021 22:209
    Content type: Research Published on:

  28. In 2019, more than 30 % of all newly transplanted kidney transplant recipients in The Netherlands were above 65 years of age. Elderly patients are less prone to rejection, and death censored graft loss is less...

    Authors: S. E. de Boer, J. S.F. Sanders, F. J. Bemelman, M. G.H. Betjes, J. G.M. Burgerhof, L. Hilbrands, D. Kuypers, B. C. van Munster, S. A. Nurmohamed, A. P.J. de Vries, A. D. van Zuilen, D. A. Hesselink and S. P. Berger
    Citation: BMC Nephrology 2021 22:208
    Content type: Study protocol Published on:

  29. Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymor...

    Authors: Kosuke Honda, Satoru Kuriyama, Kimiyoshi Ichida, Tomoko Nakano, Naoki Sugano and Takashi Yokoo
    Citation: BMC Nephrology 2021 22:207
    Content type: Research Published on:

  30. Diabetes mellitus is an independent risk factor for Contrast-induced nephropathy (CIN) in patients undergoing Coronary arteriography (CAG)/percutaneous coronary intervention (PCI). Glycosylated hemoglobin (HbA...

    Authors: H. Zhang, H. Fu, X. Fu, J. Zhang, P. Zhang, S. Yang, Z. Zeng, N. Fu and Z. Guo
    Citation: BMC Nephrology 2021 22:206
    Content type: Research article Published on:

  32. Previous studies have demonstrated that excretion of urinary extracellular vesicles (EVs) from different nephron segments differs between kidney stone formers and non-stone formers (NSFs), and could reflect pa...

    Authors: Jiqing Zhang, Sanjay Kumar, Muthuvel Jayachandran, Loren P. Herrera Hernandez, Stanley Wang, Elena M. Wilson and John C. Lieske
    Citation: BMC Nephrology 2021 22:204
    Content type: Research article Published on:

  33. The number of patients with end stage kidney disease (ESKD) are increasing world-side. While interstitial fibrosis (IF) is a common step for the progression to ESKD, therapeutic options for IF is still limited...

    Authors: Yasunori Iwata, Norihiko Sakai, Yuki Nakajima, Megumi Oshima, Shiori Nakagawa-Yoneda, Hisayuki Ogura, Koichi Sato, Taichiro Minami, Shinji Kitajima, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Miho Shimizu, Kengo Furuichi and Takashi Wada
    Citation: BMC Nephrology 2021 22:203
    Content type: Research Published on:

  34. Acute kidney injury (AKI) is a complication of coronavirus disease 2019 (COVID-19). The reported incidence of AKI, however, varies among studies. We aimed to evaluate the incidence of AKI and its association w...

    Authors: Jameela Abdulaziz Kari, Mohamed A Shalaby, Amr S Albanna, Turki S Alahmadi, Adi Alherbish and Khalid A Alhasan
    Citation: BMC Nephrology 2021 22:202
    Content type: Research article Published on:

  35. Iron overload is inevitably related to chronic kidney disease (CKD) treatment. Haemochromatosis leads to multiorgan damage and is associated with increased mortality. Primary haemochromatosis is the most commo...

    Authors: Izabela Zakrocka, Iwona Baranowicz-Gąszczyk and Wojciech Załuska
    Citation: BMC Nephrology 2021 22:201
    Content type: Case report Published on:

  36. Acute kidney injury (AKI) and obesity are independent risk factors for chronic kidney disease (CKD). This study aimed to determine if obesity modifies risk for CKD outcomes after AKI.

    Authors: Helen L. MacLaughlin, Mindy Pike, Nicholas M. Selby, Edward Siew, Vernon M. Chinchilli, Andrew Guide, Thomas G. Stewart, Jonathan Himmelfarb, Alan S. Go, Chirag R. Parikh, Nasrollah Ghahramani, James Kaufman, T. Alp Ikizler and Cassianne Robinson-Cohen
    Citation: BMC Nephrology 2021 22:200
    Content type: Research Published on:

  37. Patients receiving dialysis face a high risk of cardiovascular disease, arrhythmia and sudden cardiac death. Few patients, however, are aware of this risk. Implantable cardiac monitors are currently available ...

    Authors: Eric J. Xu, LaPricia Lewis Boyer, Bernard G. Jaar, Patti L. Ephraim, Luis Gimenez, Alan Cheng, Jonathan Chrispin, Matthew R. Weir, Dominic Raj, Eliseo Guallar and Tariq Shafi
    Citation: BMC Nephrology 2021 22:199
    Content type: Commentary Published on:

  38. Individuals with end-stage kidney disease (ESKD) on dialysis are vulnerable to contracting COVID-19 infection, with mortality as high as 31 % in this group. Population demographics in the UAE are dissimilar to...

    Authors: Wasim Ahmed, Ali Abdul Kareem Al Obaidli, Princy Joseph, Edward R. Smith, Ayaz Ahmad Khan, Siddiq Anwar, Thangavelu Chandrasekar, Ayman Kamal Al Madani, Hormazdiar Dara Dastoor, Imran Zahid, Freddie Agbayani Costales, Yousef Abdul Rahim Boobes, Fatima Al Kindi, Salah Eldin Khalil Issa, Mohamed H. Hassan, Abraham George…
    Citation: BMC Nephrology 2021 22:198
    Content type: Research Published on:

  42. The Kidney Failure Risk Equation (KFRE) predicts the 2- and 5-year risk of end-stage renal disease (ESRD) in patients with chronic kidney disease (CKD) stages 3a-5. Its predictive performance in advanced CKD a...

    Authors: Ibrahim Ali, Rosemary L. Donne and Philip A. Kalra
    Citation: BMC Nephrology 2021 22:194
    Content type: Research Published on:

  43. Kidney biopsy registries all over the world benefit research, teaching and health policy. Comparison, aggregation and exchange of data is however greatly dependent on how registration and coding of kidney biop...

    Authors: Amélie Dendooven, Han Peetermans, Mark Helbert, Tri Q. Nguyen, Niels Marcussen, Michio Nagata, Loreto Gesualdo, Agnieszka Perkowska-Ptasinska, Cristina Capusa, Juan M. López-Gómez, Colin Geddes, Myrurgia A. Abdul-Hamid, Mårten Segelmark, Rosnawati Yahya, Mariela Garau, Russell Villanueva…
    Citation: BMC Nephrology 2021 22:193
    Content type: Research Published on:

  44. Quantification of proteinuria in kidney transplant recipients is important for diagnostic and prognostic purposes. Apart from correlation tests, there have been few evaluations of spot urine protein measuremen...

    Authors: Maja Mrevlje, Manca Oblak, Gregor Mlinšek, Jelka Lindič, Jadranka-Buturović-Ponikvar and Miha Arnol
    Citation: BMC Nephrology 2021 22:192
    Content type: Research Published on:

  45. Accidental fall risk is high in patients undergoing maintenance hemodialysis. Falls are associated with fatal injury, comorbidities, and mortality. Risk assessment should be a primary component of fall prevent...

    Authors: Asuka Sai, Kentaro Tanaka, Yasushi Ohashi, Akifumi Kushiyama, Yoshihide Tanaka, Shuta Motonishi, Ken Sakai, Shigeko Hara and Takashi Ozawa
    Citation: BMC Nephrology 2021 22:191
    Content type: Research article Published on:

  46. Interest in nephrology has been declining among internal medicine residents but the reasons behind this observation are not well characterized. Our objective was to evaluate factors influencing residents’ choi...

    Authors: Georges N. Nakhoul, Ali Mehdi, Jonathan J. Taliercio, Susana Arrigain, Jesse D. Schold, Abby Spencer, Jessica Greenfield, Amit Diwakar, Grace Snyder, John O’Toole, Joseph V. Nally, John R. Sedor, Patricia F. Kao and S. Beth Bierer
    Citation: BMC Nephrology 2021 22:190
    Content type: Research Published on:

  47. Urinary liver-type fatty acid-binding protein (L-FABP) is a well-known marker of proximal tubular impairment. We evaluated the relationship between cardiovascular disease (CVD) risk factors and levels of L-FAB...

    Authors: Yoshimi Kubota, Aya Higashiyama, Mikio Marumo, Masami Konishi, Yoshiko Yamashita, Tomonori Okamura, Yoshihiro Miyamoto and Ichiro Wakabayashi
    Citation: BMC Nephrology 2021 22:189
    Content type: Research article Published on:

  48. Decisions around planned ultrafiltration volumes are the only part of the haemodialysis prescription decided upon at every session. Removing too much fluid or too little is associated with both acute symptoms ...

    Authors: David Keane, Megan Glyde, Indranil Dasgupta, Claire Gardiner, Elizabeth Lindley, Sandip Mitra, Nicholas Palmer, Louise Dye, Mark Wright and Ed Sutherland
    Citation: BMC Nephrology 2021 22:188
    Content type: Research Published on:

  49. Fibromuscular dysplasia (FMD) often causes renal artery stenosis with renovascular hypertension. Recent clinical outcomes encourage percutaneous transluminal renal angioplasty (PTRA) to treat FMD; however, the...

    Authors: Shuntaro Oribe, Takafumi Toyohara, Eikan Mishima, Takehiro Suzuki, Koichi Kikuchi, Shun Watanabe, Yoshiaki Morita, Hideki Ota, Kazumasa Seiji, Mariko Miyazaki, Kei Takase and Takaaki Abe
    Citation: BMC Nephrology 2021 22:187
    Content type: Case report Published on:

  50. Management of chronic kidney disease (CKD) requires the management of risk factors, such as hypertension and albuminuria, that affect CKD progression. Identification of additional modifiable risk factors is ne...

    Authors: Navdeep Tangri, Nancy L. Reaven, Susan E. Funk, Thomas W. Ferguson, David Collister and Vandana Mathur
    Citation: BMC Nephrology 2021 22:185
    Content type: Research Published on:
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BMC Nephrology

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