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  1. While observational studies show an association between serum lipid levels and cardiovascular disease (CVD), intervention studies that examine the preventive effects of serum lipid levels on the development of...

    Authors: Liu Miao, Yan Min, Bin Qi, Chuan-Meng Zhu, Jian-Hong Chen, Guo-Xiong Deng, Yong Wang, Jian-Fei Li and Rong-Shan Li
    Citation: BMC Nephrology 2021 22:35
    Content type: Research article Published on:

  2. IgG4-related kidney disease causes renal impairment of unknown pathogenesis that may progress to kidney failure. Although ectopic germinal centers contribute to the pathogenesis of the head and neck lesions of...

    Authors: Tatsuhito Miyanaga, Keishi Mizuguchi, Satoshi Hara, Takeshi Zoshima, Dai Inoue, Ryo Nishioka, Ichiro Mizushima, Kiyoaki Ito, Hiroshi Fuji, Kazunori Yamada, Yuki Sato, Motoko Yanagita and Mitsuhiro Kawano
    Citation: BMC Nephrology 2021 22:34
    Content type: Case report Published on:

  3. The extent to which patients with End-stage renal disease (ESRD) are at a higher risk of COVID-19-related death is still unclear. Therefore, the aim of this study was to identify the ESRD patients at increased...

    Authors: Hadith Rastad, Hanieh-Sadat Ejtahed, Gita Shafiee, Anis Safari, Ehsan Shahrestanaki, Zeinab Khodaparast, Neda Shafiabadi Hassani, Mohammad Rezaei, Morteza Nazari, Akram Zakani, Mohammad Mahdi Niksima, Mehdi Azimzadeh, Fatemeh Karimi, Ramin Tajbakhsh and Mostafa Qorbani
    Citation: BMC Nephrology 2021 22:33
    Content type: Research article Published on:

  4. Treatment with proteasome inhibitors like carfilzomib in patients with multiple myeloma (MM) can induce thrombotic microangiopathy (TMA) characterized by neurological symptoms, acute kidney injury, hemolysis a...

    Authors: Michael Rassner, Rebecca Baur, Ralph Wäsch, Mario Schiffer, Johanna Schneider, Andreas Mackensen and Monika Engelhardt
    Citation: BMC Nephrology 2021 22:32
    Content type: Case report Published on:

  5. Weight gain (mainly gain of fat mass) occurs quickly after successful kidney transplantation and is associated with metabolic complications (alterations of glycaemic control, hyperlipidaemia). Determinants of ...

    Authors: Karine Moreau, Aurélie Desseix, Christine Germain, Pierre Merville, Lionel Couzi, Rodolphe Thiébaut and Philippe Chauveau
    Citation: BMC Nephrology 2021 22:31
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:61

  6. Patients in maintenance hemodialysis (HD) need a patent vascular access for optimal treatment. The recommended first choice is a native arteriovenous fistula (AVF). Complications of AVF are frequent and includ...

    Authors: Anna Wärme, Henrik Hadimeri, Salmir Nasic and Bernd Stegmayr
    Citation: BMC Nephrology 2021 22:30
    Content type: Research article Published on:

  7. Maintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics and determinant...

    Authors: Kenan Turgutalp, Savas Ozturk, Mustafa Arici, Necmi Eren, Numan Gorgulu, Mahmut Islam, Sami Uzun, Tamer Sakaci, Zeki Aydin, Erkan Sengul, Bulent Demirelli, Yavuz Ayar, Mehmet Riza Altiparmak, Savas Sipahi, Ilay Berke Mentes, Tuba Elif Ozler…
    Citation: BMC Nephrology 2021 22:29
    Content type: Research article Published on:

  8. Roxadustat has been shown effective in treating patients with anemia due to chronic kidney disease. However, its long-term effect on clinical outcomes and socioeconomic burden and safety remains unclear.

    Authors: Yaling Zhang, Song Ren, Hen Xue, Amanda Y Wang, Yang Zou, Yanrong Cai, Jingdong He, Xiaoling Yuan, Feifei Jiang, Jinxi Wei, Dongmei Yang, Dong He, Shide Hu, Min Lei, Fei Deng, Jin Chen…
    Citation: BMC Nephrology 2021 22:28
    Content type: Study protocol Published on:

  9. Diabetic nephropathy (DN) is a primary complication of diabetes mellitus (DM). The pathology of DN is still vague, and diagnostic accuracy is not enough. This study was performed to identify miRNAs and genes t...

    Authors: Yue Yu, Yuan-Yuan Jia, Meng Wang, Lin Mu and Hong-Jun Li
    Citation: BMC Nephrology 2021 22:27
    Content type: Research article Published on:

  10. Post-Transplant erythrocytosis (PTE) has not been studied in large recent cohorts. In this study, we evaluated the incidence, risk factors, and outcome of PTE with current transplant practices using the presen...

    Authors: Sami Alasfar, Isaac E. Hall, Sherry G. Mansour, Yaqi Jia, Heather R. Thiessen-Philbrook, Francis L. Weng, Pooja Singh, Bernd Schröppel, Thangamani Muthukumar, Sumit Mohan, Rubab F. Malik, Meera N. Harhay, Mona D. Doshi, Enver Akalin, Jonathan S. Bromberg, Daniel C. Brennan…
    Citation: BMC Nephrology 2021 22:26
    Content type: Research article Published on:

  11. Immunoglobulin M (IgM) mesangial deposition in pediatric minimal change disease (MCD) has been reported to be associated with steroid dependence and poor renal outcomes. However, the evidence linking the impac...

    Authors: Cheng-Wen Yang, Fan-Yu Chen, Fu-Pang Chang, Yang Ho, Bo-Sheng Wu, An-Hang Yang, Der-Cherng Tarng and Chih-Yu Yang
    Citation: BMC Nephrology 2021 22:25
    Content type: Research article Published on:

  12. Dent disease is an X-linked form of progressive renal disease. This rare disorder was characterized by hypercalciuria, low molecular weight (LMW) proteinuria and proximal tubular dysfunction, caused by pathoge...

    Authors: Nan Duan, Chenwei Huang, Lu Pang, Shiju Jiang, Wenshuang Yang and Haixia Li
    Citation: BMC Nephrology 2021 22:24
    Content type: Case report Published on:

  13. Nephropathy associated metabolic disorder induces high incidence of fragility fracture in end-stage renal disease (ESRD) patients. As the risk factors and prognosis of fragility fracture in ESRD patients are u...

    Authors: Lihua Xie, Xuantao Hu, Wenzhao Li and Zhengxiao Ouyang
    Citation: BMC Nephrology 2021 22:23
    Content type: Research article Published on:

  14. IgG4-related kidney disease (IgG4-RKD) can affect multiple organs, which was first reported as a complication or extra-organ manifestation of autoimmune pancreatitis in 2004. It is characterized by abundant Ig...

    Authors: Yili Xu, Guang Yang, Xueqiang Xu, Yaoyu Huang, Kang Liu, Tongfu Yu, Jun Qian, Xiufen Zhao, Jingfeng Zhu, Ningning Wang and Changying Xing
    Citation: BMC Nephrology 2021 22:22
    Content type: Case report Published on:

  15. Damage to the endothelial glycocalyx is an early indicator of vascular damage and a potential marker of endothelial dysfunction. This study aimed to assess the relationship between markers of glycocalyx damage...

    Authors: Hui Liew, Matthew A. Roberts, Alun Pope and Lawrence P. McMahon
    Citation: BMC Nephrology 2021 22:21
    Content type: Research article Published on:

  16. Although patients undergoing continuous renal replacement therapy (CRRT) due to acute kidney injury (AKI) frequently have instability in mean arterial pressure (MAP), no consensus exists on the target value of...

    Authors: Yaerim Kim, Donghwan Yun, Soie Kwon, Kyubok Jin, Seungyeup Han, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Sejoong Kim and Seung Seok Han
    Citation: BMC Nephrology 2021 22:20
    Content type: Research article Published on:

  17. Acute kidney injury (AKI) associated with severe coronavirus disease 19 (COVID-19) is common and is a significant predictor of morbidity and mortality, especially when dialysis is required. Case reports and au...

    Authors: Katarzyna Szajek, Marie-Elisabeth Kajdi, Valerie A. Luyckx, Thomas Hans Fehr, Ariana Gaspert, Alexia Cusini, Karin Hohloch and Philipp Grosse
    Citation: BMC Nephrology 2021 22:19
    Content type: Case report Published on:

  18. Albuminuria is an established risk marker for both cardiovascular and renal outcomes. In this study, we expected to use portable and inexpensive test strips to detect urine albumin level for risk stratificatio...

    Authors: Noppawit Aiumtrakul, Kitinan Phichedwanichskul, Surapong Saravutthikul, Kamonwan Ottasat, Kesinee Visuthitepkul, Thitinat Jaruthiti, Sarita Jinawong, Kwanchanok Chanthowong, Varot Pengsritong, Nattawinee Horadee, Chotip Jitudomtham, Torpathom Pruekprasert, Thakorn Tawatkiratipol, Tunjira Chokjutha, Panuwat Pongpripoom, Chirayu Wiwatwarapon…
    Citation: BMC Nephrology 2021 22:18
    Content type: Research article Published on:

  19. Valid instruments for measuring physical activity at the low end of the physical activity range and producing quantitative results are required among dialysis patients who are extremely inactive. This study ai...

    Authors: Rui Huang, Haifen Zhang, Yan Yang, Nina Fang, Qian Liu, Jun Ma, Min Wang, Ling Shi and Xingjuan Tao
    Citation: BMC Nephrology 2021 22:17
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:38

  20. Hemodialysis is considered a major therapeutic method for patients with chronic kidney disease. Pruritus is a common complaint of hemodialysis patients. The 5-D pruritus scale is amongst the most common tools ...

    Authors: Amin Kordi Yoosefinejad, Fatemeh Karjalian, Marzieh Momennasab and Shahrokh Ezzatzadegan Jahromi
    Citation: BMC Nephrology 2021 22:16
    Content type: Research article Published on:

  21. Serum and tissue-based tests using phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain containing 7A (THSD7A) are established immune biomarkers for the diagnosis of primary membranous nephropa...

    Authors: Bingileki F Lwezaula, Oluwatoyin I Ameh, Udeme E Ekrikpo, Francois CJ Botha, Ugochi S Okpechi-Samuel, Nicola Wearne, Pierre Ronco, Aminu K Bello and Ikechi G. Okpechi
    Citation: BMC Nephrology 2021 22:15
    Content type: Research article Published on:

  22. Some sea anemone toxins cause renal injuries resembling hemolytic uremic syndrome (HUS). To date, only a few cases of HUS caused by sea anemone stings have been reported. In this case report, we have described...

    Authors: A Young Kim, Kyu Hyang Cho, Seok Hui Kang, Jong Won Park, Jun Young Do and Min Kyoung Kim
    Citation: BMC Nephrology 2021 22:14
    Content type: Case report Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:255

  23. The relationship between malnutrition-inflammation-atherosclerosis syndrome (MIAS) and self-management ability has not been previously revealed even though both play an important role in the management of peri...

    Authors: Zehui Huang, Junyan Fang, Ahui Song, Yan Tong, Hai Deng, Shan Wei, Ouyang Ji, Chun Hu, Pu Li, Chunli Zhang and Yingli Liu
    Citation: BMC Nephrology 2021 22:13
    Content type: Research article Published on:

  25. AarF domain-containing kinase 4 (ADCK4)-associated glomerulopathy is a mitochondrial nephropathy caused by mutations in the ADCK4 gene, which disrupt coenzyme Q10 biosynthesis.

    Authors: Yan Zhang, Xiaohua Liao, Yupeng Jiang, Xin Lv, Yue Yu, Qin Dai, Liyun Ao, Lijian Tao and Zhangzhe Peng
    Citation: BMC Nephrology 2021 22:11
    Content type: Case report Published on:

  27. Older patients with end-stage kidney disease (ESKD) often live with unidentified frailty and multimorbidity. Despite guideline recommendations, geriatric assessment is not part of standard clinical care, resul...

    Authors: Carlijn G. N. Voorend, Noeleen C. Berkhout-Byrne, Yvette Meuleman, Simon P. Mooijaart, Willem Jan W. Bos and Marjolijn van Buren
    Citation: BMC Nephrology 2021 22:9
    Content type: Research article Published on:

  28. We investigated whether implementation of the end-stage renal disease prospective payment system (ESRD PPS) was associated with changes in thrombolytic therapy use and other aspects of catheter management in h...

    Authors: Nicholas S. Roetker, Haifeng Guo, Marquita R. Decker-Palmer, Yi Peng and James B. Wetmore
    Citation: BMC Nephrology 2021 22:8
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:93

  29. Vascular calcification is a prominent feature in chronic kidney disease (CKD) and diabetes mellitus. A recent report suggests that angiotensin II is protective to vascular calcification. Therefore, we investig...

    Authors: Kaori Takaori, Hirotsugu Iwatani, Masafumi Yamato and Takahito Ito
    Citation: BMC Nephrology 2021 22:7
    Content type: Research article Published on:

  30. Multiple myeloma (MM) is a plasma-cell derived hematologic malignant disease. The malignant proliferating plasma cells secrete massive monoclonal immunoglobulins which lead to various pathologic types of renal...

    Authors: Zi-hao Yong, Xiao-juan Yu, Zi-shan Lin, Fu-de Zhou, Xi-nan Cen, Su-xia Wang and Ming-hui Zhao
    Citation: BMC Nephrology 2021 22:6
    Content type: Case report Published on:

  31. Atypical hemolytic uremic syndrome (aHUS) triggered by pregnancy is a rare disease caused by dysregulation of the alternative complement pathway that occurs in approximately 1 in 25,000 pregnancies. The 311 ph...

    Authors: Anja Gäckler, Ulf Schönermarck, Vladimir Dobronravov, Gaetano La Manna, Andrew Denker, Peng Liu, Maria Vinogradova, Sung-Soo Yoon and Manuel Praga
    Citation: BMC Nephrology 2021 22:5
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:49

  32. Rehospitalization is a major problem for end stage renal disease (ESRD) populations. However, researches on 30-day unexpected rehospitalzation of incident peritoneal dialysis (PD) patients were limited. This s...

    Authors: Jianbo Li, Jing Yu, Naya Huang, Hongjian Ye, Dan Wang, Yuan Peng, Xiaobo Guo, Chunyan Yi, Xiao Yang and Xueqing Yu
    Citation: BMC Nephrology 2021 22:4
    Content type: Research article Published on:

  33. The present study aims to examine the expression of leukocyte adhesion molecules and renal metabolic factors in diabetic mouse kidneys with periodontal pathogen Pg-LPS-induced nephropathy.

    Authors: Koichiro Kajiwara, Yoshihiko Sawa, Takahiro Fujita and Sachio Tamaoki
    Citation: BMC Nephrology 2021 22:3
    Content type: Research article Published on:

  34. Inherited cystic kidney disease is a spectrum of disorders in which clusters of renal cysts develop as the result of genetic mutation. The exact methods and pipelines for defining genetic mutations of inherite...

    Authors: Hayne Cho Park, Hyunjin Ryu, Yong-Chul Kim, Curie Ahn, Kyu-Beck Lee, Yeong Hoon Kim, Yunmi Kim, Seungyeup Han, Yaerim Kim, Eun hui Bae, Seong Kwon Ma, Hee Gyung Kang, Yo Han Ahn, Eujin Park, Kyungjo Jeong, Jaewon Lee…
    Citation: BMC Nephrology 2021 22:2
    Content type: Study protocol Published on:

  35. Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare hereditary disease caused by a variety of genetic mutations. Carriers of a mutation in the responsible genes are at risk of reaching end-s...

    Authors: Tamehito Onoe, Satoshi Hara, Kazunori Yamada, Takeshi Zoshima, Ichiro Mizushima, Kiyoaki Ito, Takayasu Mori, Shoichiro Daimon, Hiroaki Muramoto, Maki Shimizu, Akira Iguchi, Akihiro Kuma, Yoshifumi Ubara, Michihiro Mitobe, Hiroaki Tsuruta, Nao Kishimoto…
    Citation: BMC Nephrology 2021 22:1
    Content type: Research article Published on:

  37. An arteriovenous fistula (AVF) is the first choice when considering access for haemodialysis (HD). When a forearm AVF fails an upper arm AVF is a frequent subsequent dialysis access option. The latter may caus...

    Authors: Michaela Wärja, Emelie Laveborn, Michael Ott, Andreas P. Jonsson and Bernd Stegmayr
    Citation: BMC Nephrology 2020 21:544
    Content type: Case report Published on:

  38. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Simon D. S. Fraser, Paul J. Roderick, Carl R. May, Natasha McIntyre, Christopher McIntyre, Richard J. Fluck, Adam Shardlow and Maarten W. Taal
    Citation: BMC Nephrology 2020 21:543
    Content type: Correction Published on:

    The original article was published in BMC Nephrology 2015 16:193

  39. Climate change is a significant threat to the health of the Ghanaian people. Evidence abounds in Ghana that temperatures in all the ecological zones are rising, whereas rainfall levels have been generally redu...

    Authors: Richard Kobina Dadzie Ephraim, Christopher Amey Asamoah, Albert Abaka-Yawson, Precious Kwablah Kwadzokpui and Samuel Adusei
    Citation: BMC Nephrology 2020 21:542
    Content type: Research article Published on:

  40. Blood pressure is an important and modifiable cardiovascular risk factor. Ambulatory blood pressure monitoring (ABPM) provides valuable prognostic information in patients with chronic kidney disease (CKD), yet...

    Authors: Ruo-wei Wen, Xiao-qiu Chen, Ye Zhu, Jian-ting Ke, Yi Du, Cheng Wang and Tan-qi Lou
    Citation: BMC Nephrology 2020 21:541
    Content type: Research article Published on:

  41. Acute kidney injury (AKI) occurs commonly in the intensive care unit (ICU). Insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2), known as [TIMP-2] x [IGFB...

    Authors: Lan Jia, Xiaohua Sheng, Anna Zamperetti, Yun Xie, Valentina Corradi, Shikha Chandel, Massimo De Cal, Diego Pomarè Montin, Carlotta Caprara and Claudio Ronco
    Citation: BMC Nephrology 2020 21:540
    Content type: Research article Published on:

  42. Intravenous iron is often used to treat iron deficiency anaemia in non-dialysis chronic kidney disease (ND-CKD), but the optimal dosing regimen remains unclear. We evaluated the impact of high- versus low-dose...

    Authors: Philip A. Kalra, Sunil Bhandari, Michael Spyridon, Rachel Davison, Sarah Lawman, Ashraf Mikhail, David Reaich, Nick Pritchard, Kieran McCafferty and Jason Moore
    Citation: BMC Nephrology 2020 21:539
    Content type: Research article Published on:

  43. Patient awareness of CKD and primary care provider (PCP) recognition of CKD are lower than for other chronic conditions. Understanding how patients may become aware of CKD is critical to their participation in...

    Authors: Alexis F. Velazquez, Alexandra Velasquez and Delphine S. Tuot
    Citation: BMC Nephrology 2020 21:538
    Content type: Research article Published on:

  44. Illness perceptions have been shown to predict a range of psychosocial and clinical outcomes in kidney disease; including quality of life, distress, treatment adherence and even survival in end-stage renal dis...

    Authors: Priscilla Muscat, John Weinman, Emanuel Farrugia, Liberato Camilleri and Joseph Chilcot
    Citation: BMC Nephrology 2020 21:537
    Content type: Research article Published on:

  45. Heart rhythm complexity, a measure of heart rate dynamics and a risk predictor in various clinical diseases, has not been systematically studied in patients with end-stage renal disease. The aim of this study ...

    Authors: Hongyun Liu, Ping Zhan, Jinlong Shi, Minlu Hu, Guojing Wang and Weidong Wang
    Citation: BMC Nephrology 2020 21:536
    Content type: Research article Published on:

  46. An increase of the frequency of uric acid urinary stones compared to calcium-containing ones has been recently described. This study was aimed at assessing the frequency of different types of urinary stones in...

    Authors: Alberto Trinchieri, Alessandro Maletta, Giovanni Simonelli, Luca Boeri, Elisa De Lorenzis and Emanuele Montanari
    Citation: BMC Nephrology 2020 21:535
    Content type: Research article Published on:

  47. Patients with chronic kidney disease (CKD) and arterial calcification are considered at increased risk of adverse cardiovascular outcomes. However, the optimal site for measurement of arterial calcification ha...

    Authors: Ida Maria Hjelm Sørensen, Sasha Asbøll Kepler Saurbrey, Henrik Øder Hjortkjær, Philip Brainin, Nicholas Carlson, Ellen Linnea Freese Ballegaard, Anne-Lise Kamper, Christina Christoffersen, Bo Feldt-Rasmussen, Klaus Fuglsang Kofoed and Susanne Bro
    Citation: BMC Nephrology 2020 21:534
    Content type: Research article Published on:

  48. Cardiovascular disease (CVD) is the most common cause of mortality in pediatric chronic kidney disease (CKD) patients. Left ventricular (LV) hypertrophy (LVH) is associated with LV diastolic dysfunction (LVDD)...

    Authors: Jeong Yeon Kim, Yeonhee Lee, Hee Gyung Kang, Il-Soo Ha, Hae Il Cheong, Hyun Jin Choi, Kyoung Hee Han, Seong Heon Kim, Min Hyun Cho, Jae Il Shin, Joo Hoon Lee, Young Seo Park and Heeyeon Cho
    Citation: BMC Nephrology 2020 21:533
    Content type: Research article Published on:

  49. The prevalence of chronic kidney disease is on the rise globally and in sub-Saharan Africa. Due to its “silent” nature, many patients often present with advanced disease. At this point options for care are oft...

    Authors: Peace Bagasha, Mhoira Leng, Elly Katabira and Mila Petrova
    Citation: BMC Nephrology 2020 21:531
    Content type: Study protocol Published on:

  50. Dialysis recovery time (DRT) surveys capture the perceived time after HD to return to performing regular activities. Prior studies suggest the majority of HD patients report a DRT > 2 h. However, the profiles ...

    Authors: Murilo Guedes, Roberto Pecoits-Filho, Juliana El Ghoz Leme, Yue Jiao, Jochen G. Raimann, Yuedong Wang, Peter Kotanko, Thyago Proença de Moraes, Ravi Thadhani, Franklin W. Maddux, Len A. Usvyat and John W. Larkin
    Citation: BMC Nephrology 2020 21:529
    Content type: Research article Published on:
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BMC Nephrology

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