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  1. Serum p-cresyl sulfate (PCS) associates with cardiovascular disease in patients with chronic kidney disease. PCS concentrations are determined by intestinal uptake of p-cresol, human metabolism to PCS and renal c...

    Authors: Ruben Poesen, Liesbeth Viaene, Kristin Verbeke, Patrick Augustijns, Bert Bammens, Kathleen Claes, Dirk Kuypers, Pieter Evenepoel and Björn Meijers
    Citation: BMC Nephrology 2014 15:87
    Content type: Research article Published on:

  2. Medication safety in patients with chronic kidney disease (CKD) is a growing concern. This is particularly relevant in older adults due to underlying CKD. Metformin use is contraindicated in patients with abno...

    Authors: Deborah L Huang, Itamar B Abrass and Bessie A Young
    Citation: BMC Nephrology 2014 15:86
    Content type: Research article Published on:

  3. After the publication of our paper Lin et al. “Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease: a cross-sectional study” BMC Nephrology 2013...

    Authors: Yen-chung Lin, Nisha Bansal, Eric Vittinghoff, Alan S Go and Chi-yuan Hsu
    Citation: BMC Nephrology 2014 15:85
    Content type: Erratum Published on:

    The original article was published in BMC Nephrology 2013 14:268

  4. AKI is common among hospital in-patients and places a huge financial burden on the UK National Health Service, causing increased length of hospital stay and use of critical care services, with increased requir...

    Authors: Rachael Challiner, James P Ritchie, Catherine Fullwood, Paul Loughnan and Alastair J Hutchison
    Citation: BMC Nephrology 2014 15:84
    Content type: Research article Published on:

  5. There is no national policy for allocation of kidneys from Donation after circulatory death (DCD) donors in the UK. Allocation is geographical and based on individual/regional centre policies. We have evaluate...

    Authors: Shanka K Benaragama, Teressa Tymkewycz, Biku J John, Andrew Davenport, Ben Lindsey, David Nicol, Jonathon Olsburgh, Martin Drage, Nizam Mamode, Francis Calder, John Taylor, Geoff Koffman, Nicos Kessaris, Mohamed Morsy, Roberto Cacciola, Carmelo Puliatti…
    Citation: BMC Nephrology 2014 15:83
    Content type: Research article Published on:

  6. Urinary (U)-complement components have been detected in patients with proteinuric renal diseases, and complement activation via the alternative pathway (AP) is believed to play a role in renal tubular damage. ...

    Authors: Seiji Nagamachi, Isao Ohsawa, Hiyori Suzuki, Nobuyuki Sato, Hiroyuki Inoshita, Atsuko Hisada, Daisuke Honda, Mamiko Shimamoto, Yoshio Shimizu, Satoshi Horikoshi and Yasuhiko Tomino
    Citation: BMC Nephrology 2014 15:82
    Content type: Research article Published on:

  7. AMG 416 is a novel peptide agonist of the calcium-sensing receptor (CaSR). This report describes the activity of AMG 416 in two different rodent models of uremia, compared in each case to cinacalcet, an approv...

    Authors: Sarah Walter, Amos Baruch, Shawn T Alexander, Julie Janes, Eiketsu Sho, Jin Dong, Qun Yin, Derek Maclean, Dirk B Mendel, Felix Karim and Randolph M Johnson
    Citation: BMC Nephrology 2014 15:81
    Content type: Research article Published on:

  8. The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), and albuminuria (A). The KNOW-CKD (KoreaN Cohort Study for Outcome...

    Authors: Kook-Hwan Oh, Sue Kyung Park, Hayne Cho Park, Ho Jun Chin, Dong Wan Chae, Kyu Hun Choi, Seung Hyeok Han, Tae Hyun Yoo, Kyubeck Lee, Yong-Soo Kim, Wookyung Chung, Young-Hwan Hwang, Soo Wan Kim, Yeong Hoon Kim, Sun Woo Kang, Byung-Joo Park…
    Citation: BMC Nephrology 2014 15:80
    Content type: Study protocol Published on:

  9. Many older patients have chronic kidney disease (CKD), and a lower dose of anti-depressants paroxetine, mirtazapine and venlafaxine is recommended in patients with CKD to prevent drug accumulation from reduced...

    Authors: Varun Dev, Stephanie N Dixon, Jamie L Fleet, Sonja Gandhi, Tara Gomes, Ziv Harel, Arsh K Jain, Salimah Z Shariff, Davy Tawadrous, Matthew A Weir and Amit X Garg
    Citation: BMC Nephrology 2014 15:79
    Content type: Research article Published on:

  10. This study investigated the impact of renal dysfunction (RD) on long-term outcomes in elderly patients with acute coronary syndrome (ACS), and evaluated prognostic factors in elderly patients with ACS and RD.

    Authors: Yuqi Liu, Lei Gao, Qiao Xue, Muyang Yan, Pu Chen, Yu Wang and Yang Li
    Citation: BMC Nephrology 2014 15:78
    Content type: Research article Published on:

  11. Asian patients undergoing kidney transplantation (KT) generally have better renal allograft survival and a lower burden of cardiovascular disease than those of other racial groups. The KNOW-KT aims to explore ...

    Authors: Jaeseok Yang, Joongyup Lee, Kyu Ha Huh, Jae Berm Park, Jang-Hee Cho, Sik Lee, Han Ro, Seung-Yeup Han, Young Hoon Kim, Jong Cheol Jeong, Byung-Joo Park, Duck Jong Han, Sung-Bae Park, Wookyung Chung, Sung Kwang Park, Chan-Duck Kim…
    Citation: BMC Nephrology 2014 15:77
    Content type: Study protocol Published on:

  12. Familial juvenile hyperuricaemic nephropathy is a rare inherited nephropathy with genetic heterogeneity. Categorised by genetic defect, mutations in uromodulin (UMOD), renin (REN) and hepatocyte nuclear factor-1β...

    Authors: Lucy A Plumb, Matko Marlais, Agnieszka Bierzynska, Howard Martin, Kim Brugger, Stephen Abbs and Moin A Saleem
    Citation: BMC Nephrology 2014 15:76
    Content type: Case report Published on:

  13. Many patients on renal replacement therapy (RRT) require parathyroidectomy (PTX). Trends and current rates of PTX on a national level are not known. Furthermore, it is not completely clear which factors influe...

    Authors: Shahriar Akaberi, Naomi Clyne, Gunnar Sterner, Bengt Rippe, Eva Reihnér, Philippe Wagner, Rebecca Rylance, Karl Göran Prütz and Martin Almquist
    Citation: BMC Nephrology 2014 15:75
    Content type: Research article Published on:

  14. Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results...

    Authors: Claudio Bazzi, Virginia Rizza, Daniela Casellato, Rafid Tofik, Anna-Lena Berg, Maurizio Gallieni, Giuseppe D’Amico and Omran Bakoush
    Citation: BMC Nephrology 2014 15:74
    Content type: Research article Published on:

  15. In the UK, chronic disease, including chronic kidney disease (CKD) is largely managed in primary care. We developed a tool to assess practitioner confidence and knowledge in managing CKD compared to other chro...

    Authors: Mohammad Tahir, Simon Hassan, Simon de Lusignan, Lazza Shaheen, Tom Chan and Olga Dmitrieva
    Citation: BMC Nephrology 2014 15:73
    Content type: Research article Published on:

  17. High levels of circulating fibroblast growth factor 23 (FGF23) are associated with chronic kidney disease (CKD) progression and high mortality. In the Phosphate Reduction Evaluation of FGF23 in Early CKD Treat...

    Authors: Pablo Ureña-Torres, Dominique Prié, Karim Keddad, Peter Preston, Paul Wilde, Hong Wan and J Brian Copley
    Citation: BMC Nephrology 2014 15:71
    Content type: Research article Published on:

  19. Experimental models are important to the understanding of the pathophysiology of, as well as the effects of therapy on, certain diseases. In the case of chronic kidney disease-mineral bone disorder, there are ...

    Authors: Guaraciaba O Ferrari, Juliana C Ferreira, Raquel T Cavallari, Katia R Neves, Luciene M dos Reis, Wagner V Dominguez, Elizabeth C Oliveira, Fabiana G Graciolli, Jutta Passlick-Deetjen, Vanda Jorgetti and Rosa MA Moysés
    Citation: BMC Nephrology 2014 15:69
    Content type: Research article Published on:

  20. This is the first study that has examined non-cardiac incidental findings in research cardiac computed tomography (CT) of hemodialysis patients and their relationship with patient characteristics.

    Authors: Bernard G Jaar, Lili Zhang, Svetlana V Chembrovich, Stephen M Sozio, Tariq Shafi, Julia J Scialla, Gordon F Tomaselli, Joao A C Lima, Wen Hong Linda Kao, Rulan S Parekh and Lucy A Meoni
    Citation: BMC Nephrology 2014 15:68
    Content type: Research article Published on:

  21. Geographical variation in lupus nephritis epidemiology may indicate important environmental factors contributions to the etiology of lupus nephritis. This paper first describes the epidemiology of biopsy-prove...

    Authors: Qingjun Pan, Yaning Li, Ling Ye, Zhenzhen Deng, Lu Li, Yongmin Feng, Weijing Liu and Huafeng Liu
    Citation: BMC Nephrology 2014 15:67
    Content type: Research article Published on:

  22. The optimal revascularization strategy for patients with impaired glomerular filtration rate (IGFR) has not been established in acute coronary syndrome (ACS). We investigated the prognosis and impact of IGFR a...

    Authors: Tsung-Hsien Lin, Ho-Tsung Hsin, Chun-Li Wang, Wen-Ter Lai, Ai-Hsien Li, Chi-Tai Kuo, Juey-Jen Hwang, Fu-Tien Chiang, Shu-Chen Chang and Chee-Jen Chang
    Citation: BMC Nephrology 2014 15:66
    Content type: Research article Published on:

  23. Left ventricular hypertrophy (LVH) is common in kidney transplant (KT) recipients. LVH is associated with a worse outcome, though m-TOR therapy may help to revert this complication. We therefore conducted a lo...

    Authors: Domingo Hernández, Pedro Ruiz-Esteban, Daniel Gaitán, Dolores Burgos, Auxiliadora Mazuecos, Rocío Collantes, Eva Briceño, Eulalia Palma, Mercedes Cabello, Miguel González-Molina and Manuel De Mora
    Citation: BMC Nephrology 2014 15:65
    Content type: Research article Published on:

  24. Most non-dialysis dependent chronic kidney disease (CKD) patients are cared for by their primary care physicians (PCPs). Studies suggest many CKD patients receive suboptimal care. Recently, CKD clinical practi...

    Authors: Khaled Abdel-Kader, Raquel C Greer, L Ebony Boulware and Mark L Unruh
    Citation: BMC Nephrology 2014 15:64
    Content type: Research article Published on:

  25. The role of hyperuricemia in disease progression of autosomal dominant polycystic kidney disease (ADPKD) has not been defined well. We investigated the association of serum uric acid (sUA) with renal function ...

    Authors: Miyeun Han, Hayne Cho Park, Hyunsuk Kim, Hyung Ah Jo, Hyuk Huh, Joon Young Jang, Ah-Young Kang, Seung Hyup Kim, Hae Il Cheong, Duk-Hee Kang, Jaeseok Yang, Kook-Hwan Oh, Young-Hwan Hwang and Curie Ahn
    Citation: BMC Nephrology 2014 15:63
    Content type: Research article Published on:

  26. Levetiracetam is a frequently used drug in the therapy of partial onset, myoclonic and generalized tonic-clonic seizures. The main route of elimination is via the kidneys, which eliminate 66% of the unchanged ...

    Authors: Svenja K Bahte, Marcus Hiss, Ralf Lichtinghagen and Jan T Kielstein
    Citation: BMC Nephrology 2014 15:49
    Content type: Case report Published on:

  27. Urinary creatinine can be quantified by Jaffe or enzymatic assays and is commonly used as denominator of urinary excretion of electrolytes or protein. Paired analysis in pediatric and adult samples documented ...

    Authors: Karel Allegaert, Pieter Vermeersch, Anne Smits, Djalila Mekahli, Elena Levtchenko and Steven Pauwels
    Citation: BMC Nephrology 2014 15:62
    Content type: Research article Published on:

  28. Diabetes mellitus is the leading cause of end-stage renal disease (ESRD) globally. Diabetes and human immunodeficiency virus (HIV), both prevalent in South Africa, have not been reported as significant causes ...

    Authors: Nomandla D Madala, Gertrude P Thusi, Alain G H Assounga and Saraladevi Naicker
    Citation: BMC Nephrology 2014 15:61
    Content type: Research article Published on:

  29. Carotid intima-media thickness (CIMT) and carotid atherosclerotic plaque (CAP) are well-known indicators of atherosclerosis. However, few studies have reported the value of CIMT and CAP for predicting renal ar...

    Authors: Yonggu Lee, Jeong-Hun Shin, Hwan-Cheol Park, Soon Gil Kim and Seong-il Choi
    Citation: BMC Nephrology 2014 15:60
    Content type: Research article Published on:

  30. Renal transplant recipients frequently experience neurological complications. Whereas ischemic stroke, cerebral haemorrhage or hypertensive encephalopathy often result from vascular alterations prior to transp...

    Authors: Arash Haghikia, Meike Heeren, Clemens Bockmeyer, Bernd Haubitz and Wilfried Gwinner
    Citation: BMC Nephrology 2014 15:59
    Content type: Case report Published on:

  31. Hypertension is a major risk factor for renal disease progression. However, the mechanisms by which hypertension aggravates the effects of diabetes on the kidney are incompletely understood. We tested the hypo...

    Authors: Stella P Hartono, Bruce E Knudsen, Lilach O Lerman, Stephen C Textor and Joseph P Grande
    Citation: BMC Nephrology 2014 15:58
    Content type: Research article Published on:

  32. Dietary sodium restriction is a key management strategy in chronic kidney disease (CKD). Recent evidence has demonstrated short-term reduction in blood pressure (BP) and proteinuria with sodium restriction, ho...

    Authors: Katrina L Campbell, David W Johnson, Judith D Bauer, Carmel M Hawley, Nicole M Isbel, Michael Stowasser, Jonathan P Whitehead, Goce Dimeski and Emma McMahon
    Citation: BMC Nephrology 2014 15:57
    Content type: Research article Published on:

  33. Osmotic demyelination syndrome (ODS) primarily occurs after rapid correction of severe hyponatremia. There are no proven effective therapies for ODS, but we describe the first case showing the successful treat...

    Authors: Kyung Yoon Chang, In-Hee Lee, Gi Jun Kim, Kangwon Cho, Hoon Suk Park and Hyung Wook Kim
    Citation: BMC Nephrology 2014 15:56
    Content type: Case report Published on:

  35. CLIC4, a member of the CLIC family of proteins, was recently demonstrated to translocate to the nucleus in differentiating keratinocytes where it potentiates TGFβ-driven gene regulation. Since TGFβ signaling i...

    Authors: John C Edwards, Jonathan Bruno, Phillip Key and Yao-Wen Cheng
    Citation: BMC Nephrology 2014 15:54
    Content type: Research article Published on:

  36. Some studies but not others suggest angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) use prior to major surgery associates with a higher risk of postoperative acute kidney i...

    Authors: Mitesh Shah, Arsh K Jain, Steven M Brunelli, Steven G Coca, Philip J Devereaux, Matthew T James, Jin Luo, Amber O Molnar, Marko Mrkobrada, Neesh Pannu, Chirag R Parikh, Michael Paterson, Salimah Shariff, Ron Wald, Michael Walsh, Richard Whitlock…
    Citation: BMC Nephrology 2014 15:53
    Content type: Research article Published on:

  37. Many studies have shown that clinical characteristics and outcomes differ depending on pathologic variants of focal segmental glomerulosclerosis (FSGS). However, these are not well defined in Asian populations.

    Authors: Young Eun Kwon, Seung Hyeok Han, Jeong Hae Kie, Seong Yeong An, Yung Ly Kim, Kyoung Sook Park, Ki Heon Nam, Ah Young Leem, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Ea Wha Kang, Shin-Wook Kang, Kyu Hun Choi, Beom Jin Lim, Hyeon Joo Jeong…
    Citation: BMC Nephrology 2014 15:52
    Content type: Research article Published on:

  38. No consensus exists on how to define abnormally rapid deterioration in renal function (Rapid Progression, RP). We developed an operational definition of RP in HIV-positive persons with baseline estimated glome...

    Authors: David A Kamara, Lene Ryom, Michael Ross, Ole Kirk, Peter Reiss, Philippe Morlat, Olivier Moranne, Christoph A Fux, Amanda Mocroft, Caroline Sabin, Jens D Lundgren and Colette J Smith
    Citation: BMC Nephrology 2014 15:51
    Content type: Research article Published on:

  39. Patients on chronic dialysis are at increased risk of vitamin D deficiency. In observational studies plasma 25-hydroxyvitamin D (p-25(OH) D) levels are inversely correlated with plasma BNP and adverse cardiova...

    Authors: Frank H Mose, Henrik Vase, Thomas Larsen, Anne SP Kancir, Renata Kosierkiewic, Bartlomiej Jonczy, Annebirthe B Hansen, Anna E Oczachowska-Kulik, Ingrid M Thomsen, Jesper N Bech and Erling B Pedersen
    Citation: BMC Nephrology 2014 15:50
    Content type: Research article Published on:

  40. The appropriate exercise counseling for chronic kidney disease (CKD) patients is crucial to improve their prognosis. There have been few studies about exercise counseling by primary care physicians for CKD pat...

    Authors: Yoshiyuki Morishita, Akihiko Numata, Atushi Miki, Mari Okada, Kenichi Ishibashi, Fumi Takemoto, Yasuhiro Ando, Shigeaki Muto, Daisuke Nagata and Eiji Kusano
    Citation: BMC Nephrology 2014 15:48
    Content type: Research article Published on:

  41. Previous studies have shown that treatment with ergocalciferol in patients with CKD stage 3 + 4 is not effective with less than 33% of patients achieving a 25-OH vitamin D target of >30 ng/ml. The aim of this ...

    Authors: Amay Parikh, Herbert S Chase, Linda Vernocchi and Leonard Stern
    Citation: BMC Nephrology 2014 15:47
    Content type: Research article Published on:

  42. Dose selection is an important step in pharmacokinetic (PK) studies of hemodialysis patients. We propose a simulation-based dose-selection method for PK studies of hemodialysis patients using a subpharmacologi...

    Authors: Dong Ki Kim, Jay Wook Lee, Kwang-Hee Shin, Sejoong Kim, Kook-Hwan Oh, Myounghee Kim, Kyung-Sang Yu, Jung Pyo Lee, Chun-Soo Lim, Yon Su Kim and Kwon Wook Joo
    Citation: BMC Nephrology 2014 15:46
    Content type: Research article Published on:

  43. Chronic kidney disease (CKD) is a progressive and usually irreversible disease. Different types of outcomes are of interest in the course of CKD such as time-to-dialysis, transplantation or decline of the glom...

    Authors: Julie Boucquemont, Georg Heinze, Kitty J Jager, Rainer Oberbauer and Karen Leffondre
    Citation: BMC Nephrology 2014 15:45
    Content type: Research article Published on:

  44. Increasing evidence suggests that aldosterone promotes renal damage. Since data on the association between aldosterone and renal function in the general population are sparse, we chose to address this issue. W...

    Authors: Anke Hannemann, Rainer Rettig, Kathleen Dittmann, Henry Völzke, Karlhans Endlich, Matthias Nauck and Henri Wallaschofski
    Citation: BMC Nephrology 2014 15:44
    Content type: Research article Published on:

  45. Monitoring of volatile organic compounds (VOCs) in exhaled breath shows great potential as a non-invasive method for assessing hemodialysis efficiency. In this work we aim at identifying and quantifying of a w...

    Authors: Paweł Mochalski, Julian King, Matthias Haas, Karl Unterkofler, Anton Amann and Gert Mayer
    Citation: BMC Nephrology 2014 15:43
    Content type: Research article Published on:

  46. Hypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India.

    Authors: Youssef MK Farag, Bharati V Mittal, Sai Ram Keithi-Reddy, Vidya N Acharya, Alan F Almeida, Anil C, Ballal HS, Gaccione P, Issacs R, Sanjiv Jasuja, Kirpalani AL, Kher V, Modi GK, Georgy Nainan, Jai Prakash, Mohan M Rajapurkar…
    Citation: BMC Nephrology 2014 15:42
    Content type: Research article Published on:

  47. Schimke immuno-osseous dysplasia (SIOD, OMIM #242900) is an autosomal-recessive pleiotropic disorder characterized by spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. SIOD is caused...

    Authors: Luisa Santangelo, Maddalena Gigante, Giuseppe Stefano Netti, Sterpeta Diella, Flora Puteo, Vincenza Carbone, Giuseppe Grandaliano, Mario Giordano and Loreto Gesualdo
    Citation: BMC Nephrology 2014 15:41
    Content type: Case report Published on:

  48. Residing remotely from health care resources appears to impact quality of care delivery. It remains unclear if there are differences in vascular access based on distance of one’s residence to dialysis centre a...

    Authors: Lisa M Miller, Lavern M Vercaigne, Louise Moist, Charmaine E Lok, Navdeep Tangri, Paul Komenda, Claudio Rigatto, Julie Mojica and Manish M Sood
    Citation: BMC Nephrology 2014 15:40
    Content type: Research article Published on:

  49. An analysis of intracranial hemorrhage (ICH) in a national sample of autosomal dominant polycystic kidney disease (ADPKD) patients receiving long-term dialysis has not been reported. It is often assumed that p...

    Authors: David J Yoo, Lawrence Agodoa, Christina M Yuan, Kevin C Abbott and Robert Nee
    Citation: BMC Nephrology 2014 15:39
    Content type: Research article Published on:

  50. Home-based dialysis, including peritoneal dialysis (PD) and home hemodialysis (HHD), is associated with improved health related quality of life and reduced health resource costs. It is uncertain to what extent...

    Authors: Patrick T Keating, Michael Walsh, Christine M Ribic and Kenneth Scott Brimble
    Citation: BMC Nephrology 2014 15:38
    Content type: Research article Published on:
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