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  1. Excess cadmium (Cd) intake poses a general risk to health and to the kidneys in particular. Among indices of renal dysfunction under Cd burden measures are the urinary N-acetyl-β-D-glucosidase (UNAG) and urina...

    Authors: Yuting Li, Hongmei Wang, Jie Yu, Qiong Yan, Honggang Hu, Lishu Zhang, Tian Tian, Xianglei Peng, Shuo Yang and Shen Ke

    Citation: BMC Nephrology 2020 21:385

    Content type: Research article

    Published on:

  2. This article describes the analysis and interpretation of data relating to the presence of cadmium, lead, mercury and fluoride in human bone samples obtained from cadavers of patients dying of Chronic Kidney D...

    Authors: Thalarabe Bulathge Ananda Jayalal, Sanath Thushara Chamakara Mahawithanage, Senanayaka Mudiyanselage Harshana Mahendra Kumara Senanayaka and Prasanna Bandara Dassanayaka

    Citation: BMC Nephrology 2020 21:384

    Content type: Research article

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  3. Kidney disease and dialysis significantly impact cognitive function across the age spectrum. Cognitive training (CT) and/or exercise training (ET) are promising approaches to preserve cognitive function among ...

    Authors: Mara A. McAdams-DeMarco, Nadia M. Chu, Malu Steckel, Sneha Kunwar, Marlís González Fernández, Michelle C. Carlson, Derek M. Fine, Lawrence J. Appel, Marie Diener-West and Dorry L. Segev

    Citation: BMC Nephrology 2020 21:383

    Content type: Study protocol

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  4. Previous studies have identified retinal microvascular features associated with renal dysfunction. Biopsies are necessary to confirm kidney microvascular damage and retinal imaging may enable evaluation of mic...

    Authors: R. A. O’Neill, A. P. Maxwell, F. Kee, I. Young, B. McGuinness, R. E. Hogg and McKay GJ

    Citation: BMC Nephrology 2020 21:382

    Content type: Research article

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  5. Acute kidney injury (AKI) often occurs in critically ill patients. AKI is associated with mortality and morbidity. Interventions focusing on the reduction of AKI are suggested by the Kidney Disease: Improving ...

    Authors: Jacqueline Koeze, Iwan C. C. van der Horst, Renske Wiersema, Frederik Keus, Willem Dieperink, Eline G. M. Cox, Jan G. Zijlstra and Matijs van Meurs

    Citation: BMC Nephrology 2020 21:381

    Content type: Research article

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  6. Despite its established association with chronic kidney disease (CKD) the role of myosin-9 (MYH9) gene variation on transplanted kidney function remains unknown. This study aimed at evaluating the effect of donor...

    Authors: Joanna Pazik, Monika Oldak, Dominika Oziębło, Dominika Dęborska Materkowska, Anna Sadowska, Jacek Malejczyk and Magdalena Durlik

    Citation: BMC Nephrology 2020 21:380

    Content type: Research article

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  7. Concentration of the urine is primarily regulated via vasopressin dependent aquaporin-2 water channels in the apical membrane of kidney principal cells. It is unclear whether urine concentration ability in ADP...

    Authors: M. H. Malmberg, F. H. Mose, E. B. Pedersen and J. N. Bech

    Citation: BMC Nephrology 2020 21:379

    Content type: Research article

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  8. Uricemia dramatically rises with the stage of chronic kidney disease (CKD) and correlates with its mortality. Hemodialysis (HD) being the most used treatment at the end stage in sub-Saharan Africa, we sought t...

    Authors: Marie Doualla, Jan René Nkeck, Marie Patrice Halle, Félicité Kamdem, Aude Ingrid Agouak, Mickael Essouma, Yonathan Batchama Lobe and Gloria Ashuntantang

    Citation: BMC Nephrology 2020 21:378

    Content type: Research article

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  9. Older haemodialysis patients accompany a high burden of functional impairment, limited life expectancy, and healthcare utilization. This meta-analysis aimed to evaluate how various risk factors influenced the ...

    Authors: Yu-Huan Song, Guang-Yan Cai, Yue-Fei Xiao and Xiang-Mei Chen

    Citation: BMC Nephrology 2020 21:377

    Content type: Research article

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  10. Primary coenzyme Q10 (CoQ10) deficiency of genetic origin is one of a few treatable focal segmental glomerulosclerosis (FSGS). Renal morphologic evidence for COQ8B mutation and CoQ10 deficiencies of other gene mu...

    Authors: Yujiro Maeoka, Toshiki Doi, Masaho Aizawa, Kisho Miyasako, Shuma Hirashio, Yukinari Masuda, Yoshihito Kishita, Yasushi Okazaki, Kei Murayama, Toshiyuki Imasawa, Shigeo Hara and Takao Masaki

    Citation: BMC Nephrology 2020 21:376

    Content type: Case report

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  11. Continuous renal replacement therapy (CCRT) is a frequently used modality for the support of intensive care patients with acute kidney injury (AKI). Nevertheless, there are no objective criteria for the discon...

    Authors: Josefine Thomsen, Ulrik Sprogøe and Palle Toft

    Citation: BMC Nephrology 2020 21:375

    Content type: Research article

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  12. After kidney transplantation non-adherence and inadequate self-management undermine clinical outcomes and quality of life. Both have been demonstrated to be substantial in all age groups. However, intervention...

    Authors: Denise Karin Beck, Mirjam Tielen, Marloes Rechards, Reinier Timman, Charlotte Boonstra, Josette Versteegh, Jacqueline van de Wetering, Robert Zietse, Teun van Gelder, Willem Weimar, Jan van Saase, Jan van Busschbach and Emma Kay Massey

    Citation: BMC Nephrology 2020 21:374

    Content type: Study protocol

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  13. Acute kidney injury (AKI) remains a frequent complication in children undergoing hematopoietic stem cell transplantation (HSCT) and an independent risk factor of the patient’s survival and a prognostic factor ...

    Authors: Daishi Hirano, Daisuke Kakegawa, Saori Miwa, Chisato Umeda, Yoichi Takemasa, Ai Tokunaga, Yuhei Kawakami and Akira Ito

    Citation: BMC Nephrology 2020 21:373

    Content type: Research article

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  14. To determine the prevalence, distribution, concordance and associations of chronic kidney disease (CKD) determined by five glomerular filtration rate (GFR) formulae in urban black residents of Cape Town.

    Authors: Nasheeta Peer, Jaya George, Carl Lombard, Krisela Steyn, Naomi Levitt and Andre-Pascal Kengne

    Citation: BMC Nephrology 2020 21:372

    Content type: Research article

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  15. Apolipoprotein L1, APOL1, is a trypanosome lytic factor present in human and certain other primates. APOL1 gene variants, present in individuals of recent sub-Saharan African descent, increase risk for glomerular...

    Authors: Hidefumi Wakashin, Jurgen Heymann, Hila Roshanravan, Parnaz Daneshpajouhnejad, Avi Rosenberg, Myung Kyun Shin, Maarten Hoek and Jeffrey B. Kopp

    Citation: BMC Nephrology 2020 21:371

    Content type: Research article

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  16. Chronic kidney disease-mineral and bone disorder (CKD-MBD) management in patients with end-stage renal disease is important owing to the risk of cardiovascular diseases. In clinical practice, we manage patient...

    Authors: Masamitsu Morishita, Yukio Maruyama, Masatsugu Nakao, Nanae Matsuo, Yudo Tanno, Ichiro Ohkido, Masato Ikeda and Takashi Yokoo

    Citation: BMC Nephrology 2020 21:370

    Content type: Research article

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  17. When we encounter patients who present with both a neck mass and nephrotic syndrome, both malignancy and Kimura’s disease need to be evaluated as the therapeutic strategies differ vastly between them.

    Authors: Hayato Fujioka, Tsutomu Koike, Teruhiko Imamura, Kota Kakeshita, Hidenori Yamazaki, Hideharu Abe, Takahiko Nakajima and Koichiro Kinugawa

    Citation: BMC Nephrology 2020 21:369

    Content type: Case report

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  18. Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by a pathogenic variant in UMOD (ADTKD-UMOD) is a rare group of diseases characterized by hyperuricaemia with decreased urinary excretion of ura...

    Authors: Ying Wang, Haibo Liu, Qingnan He, Zhuwen Yi, Yongzhen Li and Xiqiang Dang

    Citation: BMC Nephrology 2020 21:368

    Content type: Case report

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  19. Glomerular diseases, a set of debilitating and complex disease entities, are related to mortality and morbidity. To gain insight into pathophysiology and novel treatment targets of glomerular disease, various ...

    Authors: Eunjeong Kang, Yaerim Kim, Yong Chul Kim, Eunyoung Kim, Nankyoung Lee, Yeonghui Kim, Soojin Lee, Seungyeup Han, Misun Choe, Jin Ho Hwang, Sunhwa Lee, Ji In Park, Jung Tak Park, Beom Jin Lim, Jung Pyo Lee, Jung Nam An…

    Citation: BMC Nephrology 2020 21:367

    Content type: Study protocol

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  20. IgA nephropathy is the most common glomerulonephritis. Secondary IgA nephropathy complicated with systemic diseases, including psoriasis, is also often reported. Generalized pustular psoriasis is a form of pso...

    Authors: Yuka Segawa, Ryo Ishida, Fuminao Kanehisa, Kunihiro Nakai, Mari Morimoto, Masafumi Seno, Mayuka Nakayama, Tetsuro Kusaba, Norito Katoh and Keiichi Tamagaki

    Citation: BMC Nephrology 2020 21:366

    Content type: Case report

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  21. Reliable estimates of the absolute and relative risks of postoperative complications in kidney transplant recipients undergoing elective surgery are needed to inform clinical practice. This systematic review a...

    Authors: Dharmenaan Palamuthusingam, Kuhan Kunarajah, Elaine M. Pascoe, David W. Johnson, Camel M. Hawley and Magid Fahim

    Citation: BMC Nephrology 2020 21:365

    Content type: Research article

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  22. Anti-low density lipoprotein receptor-related protein 2 (LRP2) nephropathy/anti-brush border antibody (ABBA) disease is a disorder characterized by acute tubulointerstitial injury associated with circulating a...

    Authors: Xiaoye Zhu, Lingxue Tu, Shaojun Liu, Huaizhou You, Jun Xue and Chuanming Hao

    Citation: BMC Nephrology 2020 21:364

    Content type: Case report

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  23. Congenital nephrotic syndrome (CNS) and infantile nephrotic syndrome (INS) cause substantial morbidity and mortality. In Japan, there is a lack of knowledge regarding the characteristics of CNS and INS. This s...

    Authors: Yuko Hamasaki, Riku Hamada, Masaki Muramatsu, Shinsuke Matsumoto, Kunihiko Aya, Kenji Ishikura, Tetsuji Kaneko and Kazumoto Iijima

    Citation: BMC Nephrology 2020 21:363

    Content type: Research article

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  24. Mutations in the Wilms tumor 1 gene cause a spectrum of podocytopathy ranging from diffuse mesangial sclerosis to focal segmental glomerulosclerosis. In a considerable fraction of patients with Wilms tumor 1 muta...

    Authors: Daisuke Matsuoka, Shunsuke Noda, Motoko Kamiya, Yoshihiko Hidaka, Hisashi Shimojo, Yasushi Yamada, Tsutomu Miyamoto, Kandai Nozu, Kazumoto Iijima and Hiroyasu Tsukaguchi

    Citation: BMC Nephrology 2020 21:362

    Content type: Case report

    Published on:

  25. Up to one third of patients on renal replacement programmes have an unknown cause of kidney disease, and the diagnosis may only be established following renal transplantation when the disease recurs or if new ...

    Authors: Tayeba Roper, Mark Harber, Gareth Jones, Robert D. S. Pitceathly and Alan D. Salama

    Citation: BMC Nephrology 2020 21:361

    Content type: Case report

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  27. Pulse wave velocity (PWV), central pulse pressure and augmentation index are arterial stiffness- related hemodynamic parameters but their associations with renal outcome are still controversial. We hereby aim ...

    Authors: Jian-Jun Liu, Sylvia Liu, Janus Lee, Resham L. Gurung, M. Yiamunaa, Keven Ang, Yi Ming Shao, Robin W. M. Choo, Subramaniam Tavintharan, Wern Ee Tang, Chee Fang Sum and Su Chi Lim

    Citation: BMC Nephrology 2020 21:359

    Content type: Research article

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  28. Acute kidney injury (AKI) is independently related to the adverse outcome of septic shock, but it lacks effective early predictors. Renal anginal index (RAI) was used to predict subsequent severe AKI (AKIs) in...

    Authors: Linlin Huang, Ting Shi, Wei Quan, Weiming Li, Lili Zhang, Xueping Liu, Saihu Huang, Ying Li and Xiaozhong Li

    Citation: BMC Nephrology 2020 21:358

    Content type: Research article

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  29. Chronic kidney disease (CKD) involves many factors that can cause frailty and oral hypofunction. We aimed to investigate the prevalence of frailty and oral hypofunction and to examine the associations among ki...

    Authors: Shiho Kosaka, Yuki Ohara, Shotaro Naito, Soichiro Iimori, Hiroshi Kado, Tsuguru Hatta, Masaaki Yanishi, Shinichi Uchida and Makoto Tanaka

    Citation: BMC Nephrology 2020 21:357

    Content type: Research article

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  30. Extracorporeal blood purification has been proposed as one of the therapeutic approaches in patients with coronavirus infection, because of its beneficial impact on elimination of inflammatory cytokines.

    Authors: Masoumeh Asgharpour, Hamed Mehdinezhad, Masoumeh Bayani, Mahmoud Sadeghi Haddad Zavareh, Seyed Hossein Hamidi, Roghayeh Akbari, Reza Ghadimi, Ali Bijani and Simin Mouodi

    Citation: BMC Nephrology 2020 21:356

    Content type: Research article

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  31. Although recipients and donors in living kidney transplantation experience psychological distress—including depression and anxiety—during the pre-operative period, very few studies have evaluated the related p...

    Authors: Yujin Lee, Hyewon Park, Hee-Jung Jee, Heon-Jeong Lee, Jun Gyo Gwon, Hyeonjin Min, Cheol Woong Jung, Myung-Gyu Kim and Chul-Hyun Cho

    Citation: BMC Nephrology 2020 21:355

    Content type: Research article

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  32. In de novo kidney transplant recipients (KTR) treatment with belatacept has been established as a comparable option as maintenance immunosuppression, preferably as a strategy to convert from calcineurin inhibi...

    Authors: Mira Choi, Friederike Bachmann, Kaiyin Wu, Nils Lachmann, Danilo Schmidt, Susanne Brakemeier, Michael Duerr, Andreas Kahl, Kai-Uwe Eckardt, Klemens Budde and Peter Nickel

    Citation: BMC Nephrology 2020 21:354

    Content type: Research article

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  33. Ankle-brachial index (ABI), the first-line diagnostic test for peripheral artery disease, can be falsely elevated when ankle arteries are incompressible, showing a J-shaped association with mortality. In this ...

    Authors: Manabu Hishida, Takahiro Imaizumi, Steven Menez, Masaki Okazaki, Shin’ichi Akiyama, Hirotake Kasuga, Junichi Ishigami, Shoichi Maruyama and Kunihiro Matsushita

    Citation: BMC Nephrology 2020 21:353

    Content type: Research article

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  34. Exercise has various positive effects on hemodialysis patients. However, there is no clear evidence which type of exercise yields better results. This study aimed to determine the effects of guided functional ...

    Authors: Špela Bogataj, Jernej Pajek, Jadranka Buturović Ponikvar and Maja Pajek

    Citation: BMC Nephrology 2020 21:352

    Content type: Research article

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  35. Hypocomplementemic urticarial vasculitis syndrome is an infrequent condition characterized by ocular, renal, gastrointestinal and pulmonary involvement with low serum complement levels and autoantibodies. Rena...

    Authors: Kalliopi Vallianou, Chrysanthi Skalioti, George Liapis, John N. Boletis and Smaragdi Marinaki

    Citation: BMC Nephrology 2020 21:351

    Content type: Case report

    Published on:

  36. Acute kidney injury (AKI) is a common complication of cardiac surgery. However, the incidence rate of AKI in patients with congenital heart disease (CHD) greatly varies between reports owing to the different d...

    Authors: Dandan Li, Zhaozhuo Niu, Qiang Huang, Wei Sheng and Tianyi Wang

    Citation: BMC Nephrology 2020 21:350

    Content type: Research article

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  37. Plasma fibrinogen is significantly associated with cardiovascular (CV) events and mortality in the general population. However, the association between plasma fibrinogen and mortality in patients undergoing pe...

    Authors: Jing Yu, Tong Lin, Naya Huang, Xi Xia, Jianbo Li, Yagui Qiu, Xiao Yang, Haiping Mao and Fengxian Huang

    Citation: BMC Nephrology 2020 21:349

    Content type: Research article

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  38. Combined peritoneal dialysis (PD) and hemodialysis (HD) therapy (combined therapy) has numerous clinical benefits and should be emphasized for PD patients encountering technique failure.

    Authors: Mu-Chi Chung, Tung-Min Yu, Ming-Ju Wu, Ya-Wen Chuang, Chih-Hsin Muo, Cheng-Hsu Chen, Chao-Hsiang Chang, Jeng-Jer Shieh, Peir-Haur Hung, Jein-Wen Chen and Chi-Jung Chung

    Citation: BMC Nephrology 2020 21:348

    Content type: Research article

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  39. There is a high prevalence of rare genetic disorders in the Middle East, and their study provides unique clinical and genetic insights. Autosomal recessive polycystic kidney disease (ARPKD) is one of the leadi...

    Authors: Intisar Al Alawi, Elisa Molinari, Issa Al Salmi, Fatma Al Rahbi, Adhra Al Mawali and John A. Sayer

    Citation: BMC Nephrology 2020 21:347

    Content type: Research article

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  40. Nephrotic syndrome (NS) is associated with a hypercatabolic state expressed as an exacerbated degradation of muscle mass. However, the clinical significance of this phenomenon has not yet been investigated.

    Authors: Anna Matyjek, Slawomir Literacki, Stanislaw Niemczyk and Aleksandra Rymarz

    Citation: BMC Nephrology 2020 21:346

    Content type: Research article

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  41. Risk factors predictive of rapid linear chronic kidney disease (CKD) progression and its associations with end-stage renal disease (ESRD) and mortality requires further exploration, particularly as patients wi...

    Authors: Ibrahim Ali, Rajkumar Chinnadurai, Sara T. Ibrahim, Darren Green and Philip A. Kalra

    Citation: BMC Nephrology 2020 21:345

    Content type: Research article

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  42. The prevalence of chronic kidney disease (CKD) in Malaysia was 9.07% in 2011. We aim to determine the current CKD prevalence in Malaysia and its associated risk factors.

    Authors: Thamil Arasu Saminathan, Lai Seong Hooi, Muhammad Fadhli Mohd Yusoff, Loke Meng Ong, Sunita Bavanandan, Wan Shakira Rodzlan Hasani, Esther Zhao Zhi Tan, Irene Wong, Halizah Mat Rifin, Tania Gayle Robert, Hasimah Ismail, Norazizah Ibrahim Wong, Ghazali Ahmad, Rashidah Ambak, Fatimah Othman, Hamizatul Akmal Abd Hamid…

    Citation: BMC Nephrology 2020 21:344

    Content type: Research article

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  43. In the general population, metabolic syndrome (MetS) is predictive of major adverse cardiovascular events (MACE). Waist circumference (WC), a component of the MetS criteria, is linked to visceral obesity, whic...

    Authors: Arnaud Delautre, François Chantrel, Yves Dimitrov, Alexandre Klein, Olivier Imhoff, Clotilde Muller, Nicole Schauder, Thierry Hannedouche and Thierry Krummel

    Citation: BMC Nephrology 2020 21:343

    Content type: Research article

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  44. Preclinical studies have identified both NAD+ and sirtuin augmentation as potential strategies for the prevention and treatment of AKI. Nicotinamide riboside (NR) is a NAD+ precursor vitamin and pterostilbene (PT...

    Authors: Petra Simic, Xavier Fernando Vela Parada, Samir M. Parikh, Ryan Dellinger, Leonard P. Guarente and Eugene P. Rhee

    Citation: BMC Nephrology 2020 21:342

    Content type: Research article

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  45. Genetic changes in the LIM homeobox transcription factor 1 beta (LMX1B) have been associated with focal segmental glomerulosclerosis (FSGS) without the extra-renal or ultrastructural manifestations of Nail-patell...

    Authors: Filippo Pinto e Vairo, Pavel N. Pichurin, Fernando C. Fervenza, Samih H. Nasr, Kevin Mills, Christopher T. Schmitz, Eric W. Klee and Sandra M. Herrmann

    Citation: BMC Nephrology 2020 21:341

    Content type: Case report

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  46. MIRAGE syndrome is a recently discovered rare genetic disease characterized by myelodysplasia (M), infection (I), growth restriction (R), adrenal hypoplasia (A), genital phenotypes (G), and enteropathy (E), ca...

    Authors: Sho Ishiwa, Koichi Kamei, Kanako Tanase-Nakao, Shinsuke Shibata, Kunihiro Matsunami, Ichiro Takeuchi, Mai Sato, Kenji Ishikura and Satoshi Narumi

    Citation: BMC Nephrology 2020 21:340

    Content type: Case report

    Published on:

  47. The nucleotide reverse transcriptase inhibitor Tenofovir Alafenamide (TAF) is a novel pro-drug of tenofovir (TFV) and possesses a superior renal safety profile compared with tenofovir disoproxil fumerate (TDF)...

    Authors: Jack E. Heron, Mark Bloch, Vinay Vanguru, John Saunders and David M. Gracey

    Citation: BMC Nephrology 2020 21:339

    Content type: Case report

    Published on:

  49. Percutaneous renal biopsy (PRB) is the primary biopsy technique and it was used by 16G needles or 18G needles in China, but there is controversy about the effect and safety of the two different diameters. The ...

    Authors: Weiji Xie, Jing Xu, Yi Xie, Zhijun Lin, Xiaochang Xu, Xialan Zhang and Yimin Zhang

    Citation: BMC Nephrology 2020 21:337

    Content type: Research article

    Published on:

  50. Renal artery aneurysms (RAAs) are rare and usually asymptomatic, and some RAAs can be associated with calcifications, which may lead to misdiagnoses as renal calculi, which are then mistakenly treated.

    Authors: Chao Chen, Xuliang Wang, Fang Xin, Lugeng He, Kang Jiang, Jia Shao and Liping Xie

    Citation: BMC Nephrology 2020 21:335

    Content type: Case report

    Published on:

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