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  1. Content type: Guidelines

    This report comments on the relevance and utility of the recently published (2017) KDIGO Clinical Practice Guideline Update for the diagnosis, evaluation, prevention and treatment of mineral bone disease in pa...

    Authors: James O. Burton, David J. Goldsmith, Nicki Ruddock, Rukshana Shroff and Mandy Wan

    Citation: BMC Nephrology 2018 19:240

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  2. Content type: Research article

    Few investigations have evaluated the incremental usefulness of multiple biomarkers representing varying physiological pathways for predicting risk of renal outcomes in African Americans.

    Authors: Stanford E. Mwasongwe, Bessie Young, Aurelian Bidulescu, Mario Sims, Adolfo Correa and Solomon K. Musani

    Citation: BMC Nephrology 2018 19:239

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  3. Content type: Research article

    Conversion from calcineurin inhibitor (CNI) therapy to a mammalian target of rapamycin (mTOR) inhibitor following kidney transplantation may help to preserve graft function. Data are sparse, however, concernin...

    Authors: Claudia Sommerer, Oliver Witzke, Frank Lehner, Wolfgang Arns, Petra Reinke, Ute Eisenberger, Bruno Vogt, Katharina Heller, Johannes Jacobi, Markus Guba, Rolf Stahl, Ingeborg A. Hauser, Volker Kliem, Rudolf P. Wüthrich, Anja Mühlfeld, Barbara Suwelack…

    Citation: BMC Nephrology 2018 19:237

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  4. Content type: Research article

    Metabolic syndrome (MetS) has been established as a risk for cardiovascular diseases and mortality in hemodialysis patients. Energy intake (EI) is an important nutritional therapy for preventing MetS. We exami...

    Authors: Tuyen Van Duong, Te-Chih Wong, Hsi-Hsien Chen, Tzen-Wen Chen, Tso-Hsiao Chen, Yung-Ho Hsu, Sheng-Jeng Peng, Ko-Lin Kuo, Hsiang-Chung Liu, En-Tzu Lin, Chi-Sin Wang, I-Hsin Tseng, Yi-Wei Feng, Tai-Yue Chang, Chien-Tien Su and Shwu-Huey Yang

    Citation: BMC Nephrology 2018 19:236

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  5. Content type: Research article

    Liver cirrhosis is characterized by avid sodium retention where the activation of the renin angiotensin aldosterone system (RAAS) is considered to be the hallmark of the sodium retaining mechanisms. The direct...

    Authors: A. D. Fialla, O. B. Schaffalitzky de Muckadell, P. Bie and H. C. Thiesson

    Citation: BMC Nephrology 2018 19:238

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  6. Content type: Research article

    Emergency start (ES) of dialysis has been associated with worse outcome, but remains poorly documented. This study aims to compare the profile and outcome of a large cohort of patients starting dialysis as an ...

    Authors: Alain Michel, Adelaide Pladys, Sahar Bayat, Cécile Couchoud, Thierry Hannedouche and Cécile Vigneau

    Citation: BMC Nephrology 2018 19:233

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    The Correction to this article has been published in BMC Nephrology 2018 19:266

  7. Content type: Research article

    The effect of pretransplant peritoneal dialysis (PD) or hemodialysis (HD) modality on outcomes of kidney transplantation (KT) for end-stage renal disease (ESRD) is debatable. We evaluated the outcomes these mo...

    Authors: Xiajing Che, Xiaoqian Yang, Jiayi Yan, Yanhong Yuan, Qing Ma, Liang Ying, Minfang Zhang, Qin Wang, Ming Zhang, Zhaohui Ni and Shan Mou

    Citation: BMC Nephrology 2018 19:235

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  8. Content type: Case report

    Kidney transplantation is the preferred renal replacement therapy for patients with end-stage renal disease, but the waiting list for kidneys continues to grow because of a shortage of donor organs. The reuse ...

    Authors: Wen-Hsin Tseng, Yu-Feng Tian, Alex Chien-Hwa Liao, Ming-Jenn Chen, Hsuan-Ying Ho, Jinn-Rung Kuo and Steven K. Huang

    Citation: BMC Nephrology 2018 19:234

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  9. Content type: Research article

    In low-immunological risk kidney transplant recipients (KTRs), reduced exposure to calcineurin inhibitor (CNI) appears particularly attractive for avoiding adverse events, but may increase the risk of developi...

    Authors: S. Girerd, J. Schikowski, N. Girerd, K. Duarte, H. Busby, N. Gambier, M. Ladrière, M. Kessler, L. Frimat and A. Aarnink

    Citation: BMC Nephrology 2018 19:232

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  10. Content type: Research article

    End-stage renal disease (ESRD) although rare among infants presents many management challenges. We sought to evaluate factors associated with PD catheter failure among infants initiated on chronic PD.

    Authors: Peace D. Imani, Jennifer L. Carpenter, Cynthia S. Bell, Mary L. Brandt, Michael C. Braun and Sarah J. Swartz

    Citation: BMC Nephrology 2018 19:231

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  11. Content type: Study protocol

    Long-term outcomes in kidney transplantation (KT) have not significantly improved during the past twenty years. Despite being a leading cause of graft failure, glomerular disease (GD) recurrence remains poorly...

    Authors: Audrey Uffing, Maria José Pérez-Sáez, Gaetano La Manna, Giorgia Comai, Clara Fischman, Samira Farouk, Roberto Ceratti Manfro, Andrea Carla Bauer, Bruno Lichtenfels, Juliana B. Mansur, Hélio Tedesco-Silva, Gianna M. Kirsztajn, Anna Manonelles, Oriol Bestard, Miguel Carlos Riella, Silvia Regina Hokazono…

    Citation: BMC Nephrology 2018 19:229

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  12. Content type: Study protocol

    Patients on dialysis are physically inactive, with most reporting activity levels below the fifth percentile of healthy age-matched groups. Several small studies have reported efficacy of diverse exercise inte...

    Authors: Ram Jagannathan, Susan Lynn Ziolkowski, Mary Beth Weber, Jason Cobb, Nhat Pham, Jin Long, Shuchi Anand and Felipe Lobelo

    Citation: BMC Nephrology 2018 19:230

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  13. Content type: Research article

    Iron deficiency is highly prevalent in chronic kidney disease (CKD) patients. In clinical practice, iron deficiency is defined based on a combination of two commonly used markers, ferritin and transferrin satu...

    Authors: Michele F. Eisenga, Ilja M. Nolte, Peter van der Meer, Stephan J. L. Bakker and Carlo A. J. M. Gaillard

    Citation: BMC Nephrology 2018 19:225

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  14. Content type: Debate

    The present increase in life span has been accompanied by an even higher increase in the burden of comorbidity. The challenges to healthcare systems are enormous and performance measures have been introduced t...

    Authors: Jean Philippe Coindre, Romain Crochette, Conrad Breuer and Giorgina Barbara Piccoli

    Citation: BMC Nephrology 2018 19:227

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  15. Content type: Case report

    Anti-glomerular basement membrane (GBM) antibodies are highly specific for Goodpasture’s or anti-GBM disease, in which they are generally directed against the non-collagenous (NC1) domain of the alpha 3 chain ...

    Authors: Omid Sadeghi-Alavijeh, Scott Henderson, Paul Bass, Terence Cook, Kirsten DeGroot and Alan David Salama

    Citation: BMC Nephrology 2018 19:228

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  16. Content type: Study protocol

    Eighty percent of children with steroid-sensitive nephrotic syndrome (SSNS) relapse within 2 years and 40–50% patients show frequently-relapsing nephrotic syndrome (FRNS). Patients showing a relapse within 6 m...

    Authors: Taketsugu Hama, Koichi Nakanishi, Kenji Ishikura, Shuichi Ito, Hidefumi Nakamura, Mayumi Sako, Mari Saito-Oba, Kandai Nozu, Yuko Shima, Kazumoto Iijima and Norishige Yoshikawa

    Citation: BMC Nephrology 2018 19:223

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  17. Content type: Case report

    Paraneoplastic glomerulonephritis is rare in haematological malignancies and tends to manifest as minimal change disease, membranous glomerulonephritis or membranoproliferative glomerulonephritis. We present t...

    Authors: Monica Suet Ying Ng, Leo Francis, Elango Pillai and Andrew John Mallett

    Citation: BMC Nephrology 2018 19:224

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  18. Content type: Research article

    Corticosteroids are widely used to reduce the urine protein levels of patients with immunoglobulin A nephropathy (IgAN). However, their potential preventive effects on end-stage kidney disease (ESKD) are unclear.

    Authors: Ryoya Tsunoda, Joichi Usui, Junichi Hoshino, Takayuki Fujii, Satoshi Suzuki, Kenmei Takaichi, Yoshifumi Ubara and Kunihiro Yamagata

    Citation: BMC Nephrology 2018 19:222

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  19. Content type: Technical advance

    Transcriptome analysis is emerging as emerging as a promising tool to enhance precision of diagnosis and monitoring in solid organ transplantation. Clinical progress has however been hampered by the current re...

    Authors: Øystein Eikrem, Tedd C. Walther, Arnar Flatberg, Vidar Beisvag, Philipp Strauss, Magnus Farstad, Christian Beisland, Even Koch, Thomas F. Mueller and Hans-Peter Marti

    Citation: BMC Nephrology 2018 19:221

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  20. Content type: Research article

    Nephrotoxicity is a major hazard complicating the use of platinum based drugs (PBD), which can hinder using higher doses protocols to maximize the therapeutic gain. Shortage of serum creatinine level as an acc...

    Authors: Mostafa Abdelsalam, Ekramy Elmorsy, Hassan Abdelwahab, Osman Algohary, Mahmoud Naguib, Ahmed Abd El Wahab, Ahmed Eldeeb, Ehab Eltoraby, Adel Abdelsalam, Alaa Sabry, Mohamed El-Metwally, Mohamed Akl, Nahla Anber, Maysaa El Sayed Zaki, Fahad Almutairi and Tamer Mansour

    Citation: BMC Nephrology 2018 19:219

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  21. Content type: Research article

    Previous studies have reported a wide range of prevalence of post-donation anxiety, depression, and regret in living kidney donors (LKDs). It is also unclear what risk factors are associated with these outcomes.

    Authors: Courtenay M. Holscher, Joseph Leanza, Alvin G. Thomas, Madeleine M. Waldram, Christine E. Haugen, Kyle R. Jackson, Sunjae Bae, Allan B. Massie and Dorry L. Segev

    Citation: BMC Nephrology 2018 19:218

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  22. Content type: Correction

    Following publication of the original article [1], an error in one of the author names was reported. In this Correction the incorrect and correct author names are listed.

    Authors: Eunjeong Kang, Joongyub Lee, Hyo Jin Kim, Miyeun Han, Soo Wan Kim, Kyu-Beck Lee, Suah Sung, Tae-Hyun Yoo, Wookyung Chung, Curie Ahn and Kook-Hwan Oh

    Citation: BMC Nephrology 2018 19:217

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    The original article was published in BMC Nephrology 2018 19:203

  23. Content type: Research article

    The risk of infective endocarditis (IE) is markedly increased in patients receiving chronic hemodialysis compared with the general population, but outcome data are sparse. The present study investigated causes...

    Authors: Mavish S. Chaudry, Gunnar H. Gislason, Anne-Lise Kamper, Marianne Rix, Anders Dahl, Lauge Østergaard, Emil L. Fosbøl, Trine K. Lauridsen, Louise B. Oestergaard, Christian Hassager, Christian Torp-Pedersen and Niels E. Bruun

    Citation: BMC Nephrology 2018 19:216

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  24. Content type: Research article

    The clinical outcome varies considerably in primary membranous nephropathy (pMN). Risk factors for kidney prognosis include ageing, male gender, persistent heavy proteinuria, decreased eGFR at presentation, pe...

    Authors: Xiao-dan Zhang, Zhao Cui, Mu-fan Zhang, Jia Wang, Yi-miao Zhang, Zhen Qu, Xin Wang, Jing Huang, Fang Wang, Li-qiang Meng, Xu-yang Cheng, Su-xia Wang, Gang Liu and Ming-hui Zhao

    Citation: BMC Nephrology 2018 19:215

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  25. Content type: Research article

    To address a current paucity of European data, this study developed equations to predict risks of mortality, major adverse cardiac events (MACE) and renin angiotensin-aldosterone system inhibitor (RAASi) disco...

    Authors: Hans Furuland, Phil McEwan, Marc Evans, Cecilia Linde, Daniel Ayoubkhani, Ameet Bakhai, Eirini Palaka, Hayley Bennett and Lei Qin

    Citation: BMC Nephrology 2018 19:211

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  26. Content type: Research article

    Intradialytic hypotension is a common complication of hemodialysis. The Hemocontrol biofeedback system, improving intradialytic hemodynamic stability, is associated with an initial transient increase in plasma...

    Authors: Esmée M. Ettema, Johanna Kuipers, Martijn van Faassen, Henk Groen, Arie M. van Roon, Joop D. Lefrandt, Ralf Westerhuis, Ido P. Kema, Harry van Goor, Ron T. Gansevoort, Carlo A. J. M. Gaillard and Casper F. M. Franssen

    Citation: BMC Nephrology 2018 19:214

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  27. Content type: Research article

    With advancement of hemodialysis (HD) technique, late fistula failure (LFF) remains a problem significantly affecting life quality of patients. We attempt to identify factors affecting LFF in patients on chron...

    Authors: Cheng-Chieh Yen, Ching-Fang Tsai, Yueh-Yun Luo, Hsin-Yi Yang, Mei-Yin Liu, Peir-Haur Hung and Yueh-Han Hsu

    Citation: BMC Nephrology 2018 19:213

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  28. Content type: Research article

    Cardiovascular complications are common in kidney transplant patients and calcification propensity of blood, measured as T50, is associated with cardiovascular outcomes. Paricalcitol supplementation affects calci...

    Authors: Amin Ussif, Hege Pihlstrøm, Andreas Pasch, Hallvard Holdaas, Anders Hartmann, Knut Smerud and Anders Åsberg

    Citation: BMC Nephrology 2018 19:212

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  29. Content type: Case report

    The management of malignancy post kidney transplantation includes reduction in immunosuppression and referral to an oncologist management of their malignancy. Recent advances in oncology have resulted in the a...

    Authors: Jonathan W. Goldman, Basmah Abdalla, Melody A. Mendenhall, Anthony Sisk, Jaime Hunt, Gabriel M. Danovitch and Erik L. Lum

    Citation: BMC Nephrology 2018 19:210

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  30. Content type: Research article

    Obesity emerged as the leading global health concern in 2017. Although higher body mass index (BMI) is a health risk in the general population, its implications for chronic kidney disease (CKD) are not entirel...

    Authors: Samuel Chan, Anne Cameron, Zaimin Wang, Sree K. Venuthurupalli, Ken S. Tan, Helen G. Healy and Wendy E. Hoy

    Citation: BMC Nephrology 2018 19:209

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  31. Content type: Research article

    Henoch-Schönlein purpura nephritis (HSPN) is a form of small vessel vasculitis associated with purpura and IgA deposition in the glomeruli. The International Study of Kidney Disease in Children (ISKDC) classif...

    Authors: Koji Inagaki, Ahmad Baseer Kaihan, Asaka Hachiya, Takaya Ozeki, Masahiko Ando, Sawako Kato, Yoshinari Yasuda and Shoichi Maruyama

    Citation: BMC Nephrology 2018 19:208

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  32. Content type: Research article

    Left ventricular hypertrophy (LVH) is one of the risk factors for cardiovascular (CV) disease and mortality. However, the relationship between socioeconomic status (SES) and LVH in chronic kidney disease remai...

    Authors: Eunjeong Kang, Joongyub Lee, Hyo Jin Kim, Miyeun Han, Soo Wan Kim, Kyu-Beck Lee, Suah Sung, Tae-Hyun Yoo, Wookyung Chung, Curie Ahn and Kook-Hwan Oh

    Citation: BMC Nephrology 2018 19:203

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    The Correction to this article has been published in BMC Nephrology 2018 19:217

  33. Content type: Research article

    Conservative care is argued to be a reasonable treatment alternative for dialysis in older patients with advanced chronic kidney disease (CKD). However, comparisons are scarce and generally focus on survival o...

    Authors: Wouter R. Verberne, Janneke Dijkers, Johannes C. Kelder, Anthonius B. M. Geers, Wilbert T. Jellema, Hieronymus H. Vincent, Johannes J. M. van Delden and Willem Jan W. Bos

    Citation: BMC Nephrology 2018 19:205

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  34. Content type: Research article

    Volume overload poses a major risk in hemodialysis patients but simple detection methods are lacking. We propose a novel marker, the Interdialytic Creatinine Rise (IDCR), readily calculated as the change in se...

    Authors: Ljubomir M. Ilic, Roger B. Davis, Robert S. Brown and Stewart H. Lecker

    Citation: BMC Nephrology 2018 19:202

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  35. Content type: Research article

    Minimal change disease (MCD) is a common cause of the nephrotic syndrome in adults with limited evidence on its treatment and prognosis. We examined the presenting characteristics, treatments, and outcomes of ...

    Authors: Anthony Fenton, Stuart W. Smith and Peter Hewins

    Citation: BMC Nephrology 2018 19:207

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  36. Content type: Research article

    Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We a...

    Authors: Chaomin Zhou, Hongying Peng, Jing Yuan, Xin Lin, Yan Zha and Hui Chen

    Citation: BMC Nephrology 2018 19:206

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  37. Content type: Research article

    Few post-marketing surveillance studies have examined the safety and efficacy of Rapamune® (Sirolimus) in Asian countries. This study aimed to better understand safety and efficacy of Rapamune for kidney trans...

    Authors: Hee Jung Jeon, Hahn-Ey Lee and Jaeseok Yang

    Citation: BMC Nephrology 2018 19:201

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  38. Content type: Research article

    Microalbuminuria signifies the onset of diabetic nephropathy, but normoalbuminuric patients with diabetes who have a low Glomerular Filtration Rate (GFR) are not uncommon. The purpose of the study was to estim...

    Authors: Polwatta Liyanage Gayani Chandima Liyanage, Sarath Lekamwasam, Thilak Priyantha Weerarathna and Dodanduwa Waduge Shyamal Yashodara Srikantha

    Citation: BMC Nephrology 2018 19:200

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  39. Content type: Study protocol

    Cardiovascular disease is prevalent in children on dialysis and accounts for almost 30% of all deaths. Randomised trials in adults suggest that haemodiafiltration (HDF) with high convection volumes is associat...

    Authors: Rukshana Shroff, Aysun Bayazit, Constantinos J. Stefanidis, Varvara Askiti, Karolis Azukaitis, Nur Canpolat, Ayse Agbas, Ali Anarat, Bilal Aoun, Sevcan Bakkaloglu, Devina Bhowruth, Dagmara Borzych-Dużałka, Ipek Kaplan Bulut, Rainer Büscher, Claire Dempster, Ali Duzova…

    Citation: BMC Nephrology 2018 19:199

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  40. Content type: Research article

    Chronic kidney disease (CKD) is often asymptomatic in its early stages but is indicated and is diagnosed with an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2. Certain sociodemographic groups are...

    Authors: Irene Ma, Maggie Guo, Daniel Muruve, Hallgrimur Benediktsson and Christopher Naugler

    Citation: BMC Nephrology 2018 19:198

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  41. Content type: Research article

    Dialysis is often initiated in the hospital during episodes of acute kidney injury and critical illness. Little is known about how patients or their surrogate decision makers feel about dialysis initiation in ...

    Authors: Amar D. Bansal, Nina R. O’Connor and David J. Casarett

    Citation: BMC Nephrology 2018 19:197

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  42. Content type: Research article

    Exercise improves functional outcomes and quality of life of older patients with end-stage renal disease undergoing hemodialysis. Yet exercise is not promoted as part of routine care. Health care providers and...

    Authors: Pia Kontos, Alisa Grigorovich, Romeo Colobong, Karen-Lee Miller, Gihad E. Nesrallah, Malcolm A. Binns, Shabbir M. H. Alibhai, Trisha Parsons, Sarbjit Vanita Jassal, Alison Thomas and Gary Naglie

    Citation: BMC Nephrology 2018 19:195

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  43. Content type: Research article

    While there is a great deal of research updating methods for estimating renal function, many of these methods are being developed in either adults with CKD or younger children. Currently, there is limited unde...

    Authors: Michael Webster-Clark, Byron Jaeger, Yi Zhong, Guido Filler, Ana Alvarez-Elias, Nora Franceschini and Maria E. Díaz-González de Ferris

    Citation: BMC Nephrology 2018 19:194

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  44. Content type: Research article

    Genitourinary tuberculosis (GUTB) is a type of extrapulmonary TB that exerts a deleterious effect on renal function by promoting renal calcification and ureteric stricture. Therefore, we investigated the risk ...

    Authors: Eun Jin Kim, Woonji Lee, Woo Yong Jeong, Hen Choi, In Young Jung, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Young Hwa Choi, Young Goo Song and June Myung Kim

    Citation: BMC Nephrology 2018 19:193

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  45. Content type: Research article

    Increased plasma level of lipoprotein(a) (Lpa) is a risk factor of cardiovascular diseases. This study aimed to explore the role of Lpa in the progression of atherosclerosis in patients with end-stage renal di...

    Authors: Kun Ling Ma, Tie Kai Gong, Ze Bo Hu, Yang Zhang, Gui Hua Wang, Liang Liu, Pei Pei Chen, Jian Lu, Chen Chen Lu and Bi Cheng Liu

    Citation: BMC Nephrology 2018 19:192

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  46. Content type: Research article

    Soluble urokinase-type plasminogen activator receptor (suPAR) has emerged as a new sepsis biomarker. It is not known whether suPAR has a role in critically ill patients with severe acute kidney injury (AKI).

    Authors: Anna Hall, Siobhan Crichton, Matt Varrier, Danielle E. Bear and Marlies Ostermann

    Citation: BMC Nephrology 2018 19:191

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