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  1. The role of hyperuricemia in disease progression of autosomal dominant polycystic kidney disease (ADPKD) has not been defined well. We investigated the association of serum uric acid (sUA) with renal function ...

    Authors: Miyeun Han, Hayne Cho Park, Hyunsuk Kim, Hyung Ah Jo, Hyuk Huh, Joon Young Jang, Ah-Young Kang, Seung Hyup Kim, Hae Il Cheong, Duk-Hee Kang, Jaeseok Yang, Kook-Hwan Oh, Young-Hwan Hwang and Curie Ahn
    Citation: BMC Nephrology 2014 15:63
  2. Levetiracetam is a frequently used drug in the therapy of partial onset, myoclonic and generalized tonic-clonic seizures. The main route of elimination is via the kidneys, which eliminate 66% of the unchanged ...

    Authors: Svenja K Bahte, Marcus Hiss, Ralf Lichtinghagen and Jan T Kielstein
    Citation: BMC Nephrology 2014 15:49
  3. Urinary creatinine can be quantified by Jaffe or enzymatic assays and is commonly used as denominator of urinary excretion of electrolytes or protein. Paired analysis in pediatric and adult samples documented ...

    Authors: Karel Allegaert, Pieter Vermeersch, Anne Smits, Djalila Mekahli, Elena Levtchenko and Steven Pauwels
    Citation: BMC Nephrology 2014 15:62
  4. Diabetes mellitus is the leading cause of end-stage renal disease (ESRD) globally. Diabetes and human immunodeficiency virus (HIV), both prevalent in South Africa, have not been reported as significant causes ...

    Authors: Nomandla D Madala, Gertrude P Thusi, Alain G H Assounga and Saraladevi Naicker
    Citation: BMC Nephrology 2014 15:61
  5. Carotid intima-media thickness (CIMT) and carotid atherosclerotic plaque (CAP) are well-known indicators of atherosclerosis. However, few studies have reported the value of CIMT and CAP for predicting renal ar...

    Authors: Yonggu Lee, Jeong-Hun Shin, Hwan-Cheol Park, Soon Gil Kim and Seong-il Choi
    Citation: BMC Nephrology 2014 15:60
  6. Renal transplant recipients frequently experience neurological complications. Whereas ischemic stroke, cerebral haemorrhage or hypertensive encephalopathy often result from vascular alterations prior to transp...

    Authors: Arash Haghikia, Meike Heeren, Clemens Bockmeyer, Bernd Haubitz and Wilfried Gwinner
    Citation: BMC Nephrology 2014 15:59
  7. Hypertension is a major risk factor for renal disease progression. However, the mechanisms by which hypertension aggravates the effects of diabetes on the kidney are incompletely understood. We tested the hypo...

    Authors: Stella P Hartono, Bruce E Knudsen, Lilach O Lerman, Stephen C Textor and Joseph P Grande
    Citation: BMC Nephrology 2014 15:58
  8. Dietary sodium restriction is a key management strategy in chronic kidney disease (CKD). Recent evidence has demonstrated short-term reduction in blood pressure (BP) and proteinuria with sodium restriction, ho...

    Authors: Katrina L Campbell, David W Johnson, Judith D Bauer, Carmel M Hawley, Nicole M Isbel, Michael Stowasser, Jonathan P Whitehead, Goce Dimeski and Emma McMahon
    Citation: BMC Nephrology 2014 15:57
  9. Osmotic demyelination syndrome (ODS) primarily occurs after rapid correction of severe hyponatremia. There are no proven effective therapies for ODS, but we describe the first case showing the successful treat...

    Authors: Kyung Yoon Chang, In-Hee Lee, Gi Jun Kim, Kangwon Cho, Hoon Suk Park and Hyung Wook Kim
    Citation: BMC Nephrology 2014 15:56
  10. CLIC4, a member of the CLIC family of proteins, was recently demonstrated to translocate to the nucleus in differentiating keratinocytes where it potentiates TGFβ-driven gene regulation. Since TGFβ signaling i...

    Authors: John C Edwards, Jonathan Bruno, Phillip Key and Yao-Wen Cheng
    Citation: BMC Nephrology 2014 15:54
  11. Some studies but not others suggest angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) use prior to major surgery associates with a higher risk of postoperative acute kidney i...

    Authors: Mitesh Shah, Arsh K Jain, Steven M Brunelli, Steven G Coca, Philip J Devereaux, Matthew T James, Jin Luo, Amber O Molnar, Marko Mrkobrada, Neesh Pannu, Chirag R Parikh, Michael Paterson, Salimah Shariff, Ron Wald, Michael Walsh, Richard Whitlock…
    Citation: BMC Nephrology 2014 15:53
  12. Many studies have shown that clinical characteristics and outcomes differ depending on pathologic variants of focal segmental glomerulosclerosis (FSGS). However, these are not well defined in Asian populations.

    Authors: Young Eun Kwon, Seung Hyeok Han, Jeong Hae Kie, Seong Yeong An, Yung Ly Kim, Kyoung Sook Park, Ki Heon Nam, Ah Young Leem, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Ea Wha Kang, Shin-Wook Kang, Kyu Hun Choi, Beom Jin Lim, Hyeon Joo Jeong…
    Citation: BMC Nephrology 2014 15:52
  13. No consensus exists on how to define abnormally rapid deterioration in renal function (Rapid Progression, RP). We developed an operational definition of RP in HIV-positive persons with baseline estimated glome...

    Authors: David A Kamara, Lene Ryom, Michael Ross, Ole Kirk, Peter Reiss, Philippe Morlat, Olivier Moranne, Christoph A Fux, Amanda Mocroft, Caroline Sabin, Jens D Lundgren and Colette J Smith
    Citation: BMC Nephrology 2014 15:51
  14. Patients on chronic dialysis are at increased risk of vitamin D deficiency. In observational studies plasma 25-hydroxyvitamin D (p-25(OH) D) levels are inversely correlated with plasma BNP and adverse cardiova...

    Authors: Frank H Mose, Henrik Vase, Thomas Larsen, Anne SP Kancir, Renata Kosierkiewic, Bartlomiej Jonczy, Annebirthe B Hansen, Anna E Oczachowska-Kulik, Ingrid M Thomsen, Jesper N Bech and Erling B Pedersen
    Citation: BMC Nephrology 2014 15:50
  15. The appropriate exercise counseling for chronic kidney disease (CKD) patients is crucial to improve their prognosis. There have been few studies about exercise counseling by primary care physicians for CKD pat...

    Authors: Yoshiyuki Morishita, Akihiko Numata, Atushi Miki, Mari Okada, Kenichi Ishibashi, Fumi Takemoto, Yasuhiro Ando, Shigeaki Muto, Daisuke Nagata and Eiji Kusano
    Citation: BMC Nephrology 2014 15:48
  16. Previous studies have shown that treatment with ergocalciferol in patients with CKD stage 3 + 4 is not effective with less than 33% of patients achieving a 25-OH vitamin D target of >30 ng/ml. The aim of this ...

    Authors: Amay Parikh, Herbert S Chase, Linda Vernocchi and Leonard Stern
    Citation: BMC Nephrology 2014 15:47
  17. Dose selection is an important step in pharmacokinetic (PK) studies of hemodialysis patients. We propose a simulation-based dose-selection method for PK studies of hemodialysis patients using a subpharmacologi...

    Authors: Dong Ki Kim, Jay Wook Lee, Kwang-Hee Shin, Sejoong Kim, Kook-Hwan Oh, Myounghee Kim, Kyung-Sang Yu, Jung Pyo Lee, Chun-Soo Lim, Yon Su Kim and Kwon Wook Joo
    Citation: BMC Nephrology 2014 15:46
  18. Chronic kidney disease (CKD) is a progressive and usually irreversible disease. Different types of outcomes are of interest in the course of CKD such as time-to-dialysis, transplantation or decline of the glom...

    Authors: Julie Boucquemont, Georg Heinze, Kitty J Jager, Rainer Oberbauer and Karen Leffondre
    Citation: BMC Nephrology 2014 15:45
  19. Increasing evidence suggests that aldosterone promotes renal damage. Since data on the association between aldosterone and renal function in the general population are sparse, we chose to address this issue. W...

    Authors: Anke Hannemann, Rainer Rettig, Kathleen Dittmann, Henry Völzke, Karlhans Endlich, Matthias Nauck and Henri Wallaschofski
    Citation: BMC Nephrology 2014 15:44
  20. Monitoring of volatile organic compounds (VOCs) in exhaled breath shows great potential as a non-invasive method for assessing hemodialysis efficiency. In this work we aim at identifying and quantifying of a w...

    Authors: Paweł Mochalski, Julian King, Matthias Haas, Karl Unterkofler, Anton Amann and Gert Mayer
    Citation: BMC Nephrology 2014 15:43
  21. Hypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India.

    Authors: Youssef MK Farag, Bharati V Mittal, Sai Ram Keithi-Reddy, Vidya N Acharya, Alan F Almeida, Anil C, Ballal HS, Gaccione P, Issacs R, Sanjiv Jasuja, Kirpalani AL, Kher V, Modi GK, Georgy Nainan, Jai Prakash, Mohan M Rajapurkar…
    Citation: BMC Nephrology 2014 15:42
  22. Schimke immuno-osseous dysplasia (SIOD, OMIM #242900) is an autosomal-recessive pleiotropic disorder characterized by spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. SIOD is caused...

    Authors: Luisa Santangelo, Maddalena Gigante, Giuseppe Stefano Netti, Sterpeta Diella, Flora Puteo, Vincenza Carbone, Giuseppe Grandaliano, Mario Giordano and Loreto Gesualdo
    Citation: BMC Nephrology 2014 15:41
  23. Residing remotely from health care resources appears to impact quality of care delivery. It remains unclear if there are differences in vascular access based on distance of one’s residence to dialysis centre a...

    Authors: Lisa M Miller, Lavern M Vercaigne, Louise Moist, Charmaine E Lok, Navdeep Tangri, Paul Komenda, Claudio Rigatto, Julie Mojica and Manish M Sood
    Citation: BMC Nephrology 2014 15:40
  24. An analysis of intracranial hemorrhage (ICH) in a national sample of autosomal dominant polycystic kidney disease (ADPKD) patients receiving long-term dialysis has not been reported. It is often assumed that p...

    Authors: David J Yoo, Lawrence Agodoa, Christina M Yuan, Kevin C Abbott and Robert Nee
    Citation: BMC Nephrology 2014 15:39
  25. Home-based dialysis, including peritoneal dialysis (PD) and home hemodialysis (HHD), is associated with improved health related quality of life and reduced health resource costs. It is uncertain to what extent...

    Authors: Patrick T Keating, Michael Walsh, Christine M Ribic and Kenneth Scott Brimble
    Citation: BMC Nephrology 2014 15:38
  26. About 1% of patients admitted to the Emergency Department (ED) have hypernatremia, a condition associated with a mortality rate of 20 to 60%. Management recommendations originate from intensive care unit studi...

    Authors: Stanislas Bataille, Camille Baralla, Dominique Torro, Christophe Buffat, Yvon Berland, Marc Alazia, Anderson Loundou, Pierre Michelet and Henri Vacher-Coponat
    Citation: BMC Nephrology 2014 15:37
  27. The prevalence of chronic kidney disease (CKD) and metabolic diseases has increased at different rates in different regions in China. The aim of our study was to estimate the prevalence of CKD and to analyze a...

    Authors: Bo Lin, Lina Shao, Qun Luo, Lingxia Ou-yang, Fangfang Zhou, Biao Du, Qiang He, Jianyong Wu, Nan Xu and Jianghua Chen
    Citation: BMC Nephrology 2014 15:36
  28. Peritoneal dialysis (PD) therapy is known to induce morphological and functional changes in the peritoneal membrane. Long-term exposure to conventional bio-incompatible dialysate and peritonitis is the main et...

    Authors: Yi-Che Lee, Yau-Sheng Tsai, Shih-Yuan Hung, Tsun-Mei Lin, Sheng-Hsiang Lin, Hung-Hsiang Liou, Hsiang-Chun Liu, Min-Yu Chang, Hsi-Hao Wang, Li-Chun Ho, Yi-Ting Chen, Hsin-Pao Chen, Hong-Arh Fan, Kuang-Wen Liu, Yung-Tang Kung, Hao-Kuang Wang…
    Citation: BMC Nephrology 2014 15:35
  29. There is a lack of online, evidence-based information and resources to support home-based care of childhood CKD stages 3-5.

    Authors: Veronica M Swallow, Andrew G Hall, Ian Carolan, Sheila Santacroce, Nicholas JA Webb, Trish Smith and Noreen Hanif
    Citation: BMC Nephrology 2014 15:34
  30. Home-based renal replacement therapy (RRT) [peritoneal dialysis (PD) and home hemodialysis (HHD)] offers independent quality of life and clinical advantages compared to conventional in-center hemodialysis. How...

    Authors: Michael E Schachter, Joanne M Bargman, Michael Copland, Michelle Hladunewich, Karthik K Tennankore, Adeera Levin, Matthew Oliver, Robert P Pauly, Jeffrey Perl, Deborah Zimmerman and Christopher T Chan
    Citation: BMC Nephrology 2014 15:33
  31. Podocytic infolding glomerulopathy (PIG) is a recently described condition causing rare pathological changes to the glomeruli, and has attracted considerable attention. PIG is characterized by specific changes...

    Authors: Makoto Harada, Yuji Kamijo, Takashi Ehara, Hisashi Shimojo, Hidekazu Shigematsu and Makoto Higuchi
    Citation: BMC Nephrology 2014 15:32
  32. The major challenge in ABO-incompatible transplantation is to minimize antibody-mediated rejection. Effective reduction of the anti-ABO blood group antibodies at the time of transplantation has made ABO-incomp...

    Authors: Annelies de Weerd, Alieke Vonk, Hans van der Hoek, Marian van Groningen, Willem Weimar, Michiel Betjes and Madelon van Agteren
    Citation: BMC Nephrology 2014 15:31
  33. The choice of vascular access type is an important aspect of care for incident hemodialysis patients. However, data from the Centers for Medicare & Medicaid Services (CMS) Medical Evidence Report (form CMS-272...

    Authors: Craig A Solid, Allan J Collins, James P Ebben, Shu-Cheng Chen, Arman Faravardeh, Robert N Foley and Areef Ishani
    Citation: BMC Nephrology 2014 15:30
  34. Many patients on maintenance dialysis experience significant sleepiness and fatigue. However, the influence of the hemodialysis (HD) day and circadian rhythms on patients’ symptoms have not been well character...

    Authors: Khaled Abdel-Kader, Manisha Jhamb, Lee Anne Mandich, Jonathan Yabes, Robert M Keene, Scott Beach, Daniel J Buysse and Mark L Unruh
    Citation: BMC Nephrology 2014 15:29
  35. We report a case of progressive Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) with life-threatening complications of both the underlying disease and induction immunosuppressive therapy. Here, for...

    Authors: Elena Ernst, Matthias Girndt and Rainer U Pliquett
    Citation: BMC Nephrology 2014 15:28
  36. Activated vitamin D is the mainstay of treatment for secondary hyperparathyroidism (SHPT) in chronic hemodialysis patients. However, the optimal route of administration is still debated. The aim of our study w...

    Authors: Myriam Lessard, Denis Ouimet, Martine Leblanc, Annie-Claire Nadeau-Fredette, Robert Bell, Jean-Philippe Lafrance, Vincent Pichette and Michel Vallée
    Citation: BMC Nephrology 2014 15:27
  37. While fluid overload (FO) and alterations in the autonomic nervous system (ANS) such as hypersympathetic activity, are known risk factors for cardiovascular morbidity and mortality in patients on chronic hemod...

    Authors: Manuela Ferrario, Ulrich Moissl, Francesco Garzotto, Dinna N Cruz, Anna Clementi, Alessandra Brendolan, Ciro Tetta, Emanuele Gatti, Maria G Signorini, Sergio Cerutti and Claudio Ronco
    Citation: BMC Nephrology 2014 15:26
  38. Children and adolescents with end-stage renal disease (ESRD) in sub-Saharan Africa may have the worst outcomes globally. Barriers to management include late presentation, poor socioeconomic conditions, absence...

    Authors: Adanze O Asinobi, Adebowale D Ademola, Oluwatoyin O Ogunkunle and Susan A Mott
    Citation: BMC Nephrology 2014 15:25
  39. The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane a...

    Authors: Kenton P Arkill, Klaus Qvortrup, Tobias Starborg, Judith M Mantell, Carlo Knupp, C Charles Michel, Steve J Harper, Andy HJ Salmon, John M Squire, Dave O Bates and Chris R Neal
    Citation: BMC Nephrology 2014 15:24
  40. Measurement of renal perfusion is a crucial part of measuring kidney function. Arterial spin labelling magnetic resonance imaging (ASL MRI) is a non-invasive method of measuring renal perfusion using magnetise...

    Authors: Keith A Gillis, Christie McComb, John E Foster, Alison HM Taylor, Rajan K Patel, Scott TW Morris, Alan G Jardine, Markus P Schneider, Giles H Roditi, Christian Delles and Patrick B Mark
    Citation: BMC Nephrology 2014 15:23
  41. The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cyt...

    Authors: Clare M Turner, Nishkantha Arulkumaran, Mervyn Singer, Robert J Unwin and Frederick WK Tam
    Citation: BMC Nephrology 2014 15:21
  42. The natural history of patients commencing dialysis in East Yorkshire is not well characterised and there is little convincing evidence which has studied the impact of potential factors prior to commencement o...

    Authors: Oliver T Browne, Victoria Allgar and Sunil Bhandari
    Citation: BMC Nephrology 2014 15:20
  43. During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (...

    Authors: Louise Schilder, S Azam Nurmohamed, Pieter M ter Wee, Nanne J Paauw, Armand RJ Girbes, Albertus Beishuizen, Robert HJ Beelen and AB Johan Groeneveld
    Citation: BMC Nephrology 2014 15:19
  44. Many markers have been proposed for CVD risk assessment in dialysis population. Apelin is a peptide that has roles in cardiovascular functions and volume regulation namely vasodilation, decreased blood pressur...

    Authors: Serhat Karadag, Savas Ozturk, Meltem Gursu, Ahmet Gurdal, Filiz Basinoglu, Servet Yigit, Zeki Aydin, Sami Uzun, Abdullah Sumnu, Huseyin Oflaz and Rumeyza Kazancioglu
    Citation: BMC Nephrology 2014 15:18
  45. Malnutrition is associated with an increased risk of cardiovascular death and may cause protein-energy wasting in individuals with chronic kidney disease. A previous study demonstrated that blood cadmium level...

    Authors: Ching-Wei Hsu, Ja-Liang Lin, Dan-Tzu Lin-Tan, Wen-Hung Huang, Kuan-Hsing Chen and Tzung-Hai Yen
    Citation: BMC Nephrology 2014 15:17
  46. Structured comparison of pharmacoeconomic analyses for ACEIs and ARBs in patients with type 2 diabetic nephropathy is still lacking. This review aims to systematically review the cost-effectiveness of both ACE...

    Authors: Yunyu Huang, Qiyun Zhou, Flora M Haaijer-Ruskamp and Maarten J Postma
    Citation: BMC Nephrology 2014 15:15
  47. Recent studies in animal models have shown that statins can protect against renal failure independent of their lipid-lowering actions, and there is also an association between statin use and improved renal fun...

    Authors: Kefei Wu, Wenjing Lei, Jianwei Tian and Hongyan Li
    Citation: BMC Nephrology 2014 15:14

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