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  1. Renal kallikrein (KLK1) synthesis and urinary excretion are reportedly diminished during AKI (acute kidney injury) in animal models, and provision of kallikrein abrogates renal injury in this setting, but data...

    Authors: Sun Woo Kang, Pei-an Betty Shih, Roy O Mathew, Manjula Mahata, Nilima Biswas, Fangwen Rao, Liying Yan, Josee Bouchard, Rakesh Malhotra, Ashita Tolwani, Srikrishna Khandrika, Ravindra L Mehta and Daniel T O'Connor
    Citation: BMC Nephrology 2011 12:27
    Content type: Research article Published on:

  2. Pulmonary-renal syndrome associated with anti-glomerular basement membrane (GBM) antibodies, also known as Goodpasture's syndrome, is a rare but acute and life-threatening condition. One third of patients pres...

    Authors: Christoph Etter, Ariana Gaspert, Stephan Regenass, Rudolf P Wüthrich, Thomas Kistler, Renate Kain and Clemens D Cohen
    Citation: BMC Nephrology 2011 12:26
    Content type: Case report Published on:

  3. Primary hyperoxaluria type I (PH1) is a rare genetic disorder characterized by allelic and clinical heterogeneity. Four mutations (G170R, 33_34insC, I244T and F152I) account for more than 50% of PH1 alleles an...

    Authors: Ibtihel Benhaj Mbarek, Saoussen Abroug, Asma Omezzine, Dorsaf Zellama, Abdellatif Achour, Abdelaziz Harbi and Ali Bouslama
    Citation: BMC Nephrology 2011 12:25
    Content type: Research article Published on:

  4. Circulating 25-hydroxyvitamin D [25(OH)D] concentration is inversely associated with peripheral arterial disease and hypertension. Vascular remodeling may play a role in this association, however, data relatin...

    Authors: Haimanot Wasse, Francesca Cardarelli, Christine De Staercke, Craig Hooper, Emir Veledar and Idris Guessous
    Citation: BMC Nephrology 2011 12:24
    Content type: Research article Published on:

  5. Increased plasma levels of cellular adhesion molecules (CAMs) have been shown to be predictors of all cause mortality in individuals with chronic renal failure [1, 2] and patients with end-stage renal disease rec...

    Authors: Grainne M Connolly, Ronan Cunningham, Peter T McNamee, Ian S Young and Alexander P Maxwell
    Citation: BMC Nephrology 2011 12:23
    Content type: Research article Published on:

  6. A key goal of anemia management in dialysis patients is to maintain patients' hemoglobin (Hb) levels consistently within a target range. Our aim in this study was to assess the association of facility-level pr...

    Authors: Irfan Khan, Mahesh Krishnan, Anupam Kothawala and Akhtar Ashfaq
    Citation: BMC Nephrology 2011 12:22
    Content type: Research article Published on:

  7. Human leukocyte antigen (HLA) alleles are associated with many autoimmune diseases, including anti-glomerular basement membrane (GBM) disease. In our previous study, it was demonstrated that HLA-DRB1*1501 was ...

    Authors: Huan Luo, Min Chen, Zhao Cui, Rui Yang, Peng-Cheng Xu, Xu-Jie Zhou and Ming-Hui Zhao
    Citation: BMC Nephrology 2011 12:21
    Content type: Research article Published on:

  8. Aluminium-containing phosphate binders have long been used for treatment of hyperphosphatemia in dialysis patients. Their safety became controversial in the early 1980's after reports of aluminium related neur...

    Authors: David W Mudge, David W Johnson, Carmel M Hawley, Scott B Campbell, Nicole M Isbel, Carolyn L van Eps and James JB Petrie
    Citation: BMC Nephrology 2011 12:20
    Content type: Debate Published on:

  9. Macrocytosis occurs in chronic hemodialysis (CHD) patients; however, its significance is unknown. The purpose of this study was to establish the prevalence and distribution of macrocytosis, to identify its cli...

    Authors: Karthik K Tennankore, Steven D Soroka, Kenneth A West and Bryce A Kiberd
    Citation: BMC Nephrology 2011 12:19
    Content type: Research article Published on:

  10. Subclinical inflammation is a common phenomenon in patients on either continuous ambulatory peritoneal dialysis (CAPD) or maintenance hemodialysis (MHD). We hypothesized that vitamin C had anti-inflammation ef...

    Authors: Kunying Zhang, Li Liu, Xuyang Cheng, Jie Dong, Qiuming Geng and Li Zuo
    Citation: BMC Nephrology 2011 12:18
    Content type: Research article Published on:

  11. Previous studies of predictors of end-stage renal disease (ESRD) have limitations: (1) some focused on patients with clinically recognized chronic kidney disease (CKD); (2) others identified population-based p...

    Authors: Eric S Johnson, David H Smith, Micah L Thorp, Xiuhai Yang and Juhaeri Juhaeri
    Citation: BMC Nephrology 2011 12:17
    Content type: Research article Published on:

  13. Extracorporeal lung assist devices are increasingly used in the intensive care unit setting to improve extracorporeal gas exchange mainly in patients with acute respiratory distress syndrome. ARDS is frequentl...

    Authors: Jan T Kielstein, Soeren Tolk, Carsten Hafer, Anna Heiden, Olaf Wiesner, Christian Kühn, Johannes Hadem, Marius M Hoeper and Stefan Fischer
    Citation: BMC Nephrology 2011 12:15
    Content type: Research article Published on:

  14. A rapid decrease of serum potassium concentrations during haemodialysis produces a significant increase in blood pressure parameters at the end of the session, even if effects on intra-dialysis pressure are no...

    Authors: Luca Gabutti, Igor Salvadé, Barbara Lucchini, Davide Soldini and Michel Burnier
    Citation: BMC Nephrology 2011 12:14
    Content type: Research article Published on:

  15. Anemia is common among peritoneal dialysis (PD) patients, and most patients require erythropoiesis-stimulating agents (ESA) to maintain their hemoglobin concentrations within current guideline recommendations....

    Authors: Mariano Feriani, Johan MJ De Meester, Lawrence P McMahon, Jacques B Rottembourg, Ian Bridges, Mourad Farouk and Wolfgang Pronai
    Citation: BMC Nephrology 2011 12:13
    Content type: Research article Published on:

  16. Chronic kidney disease (CKD) is a common disorder associated with increased morbidity and mortality. Primary care physicians (PCPs) care for the majority of pre-dialysis CKD patients; however, PCPs often do no...

    Authors: Khaled Abdel-Kader, Gary S Fischer, James R Johnston, Chen Gu, Charity G Moore and Mark L Unruh
    Citation: BMC Nephrology 2011 12:12
    Content type: Research article Published on:

  17. The increasing use of erythropoietins with long half-lives and the tendency to lengthen the administration interval to monthly injections call for raising awareness on the pharmacokinetics and risks of new ery...

    Authors: Luca Gabutti, Filippo Nobile, Valentina Forni, Fabio Rigamonti, Nadir Weibel and Michel Burnier
    Citation: BMC Nephrology 2011 12:11
    Content type: Research article Published on:

  18. Many nephrology observational studies use renal registries, which have well known limitations. The Canadian Kidney Disease Cohort Study (CKDCS) is a large prospective observational study of patients commencing...

    Authors: Aminu K Bello, Ravi Thadhani, Brenda Hemmelgarn, Scott Klarenbach, John Gill, Christopher Chan, Deborah Zimmerman, Daniel Holmes, George Cembrowski, Dawn Opgenorth, Rafael Sibrian, Mohammad Karkhaneh, Sophanny Tiv, Natasha Wiebe and Marcello Tonelli
    Citation: BMC Nephrology 2011 12:10
    Content type: Study protocol Published on:

  19. Hyperphosphatemia in patients with chronic kidney disease (CKD) contributes to secondary hyperparathyroidism, soft tissue calcification, and increased mortality risk. This trial was conducted to examine the ef...

    Authors: Wajeh Qunibi, Wolfgang C Winkelmayer, Richard Solomon, Moustafa Moustafa, Paul Kessler, Chiang-Hong Ho, Jonathan Greenberg and Jose A Diaz-Buxo
    Citation: BMC Nephrology 2011 12:9
    Content type: Research article Published on:

  20. The lack of adequate randomized clinical trials (RCT) has hindered identification of new therapies that are safe and effective for patients with primary focal segmental glomerulosclerosis (FSGS), especially in...

    Authors: Howard Trachtman, Suzanne Vento, Debbie Gipson, Larysa Wickman, Jennifer Gassman, Melanie Joy, Virginia Savin, Michael Somers, Maury Pinsk and Tom Greene
    Citation: BMC Nephrology 2011 12:8
    Content type: Study protocol Published on:

  21. In patients with Stage 5 Chronic Kidney Disease who require renal replacement therapy a major decision concerns modality choice. However, many patients defer the decision about modality choice or they have an ...

    Authors: Mary Ann Murray, Alison Thomas, Ron Wald, Rosa Marticorena, Sandra Donnelly and Lianne Jeffs
    Citation: BMC Nephrology 2011 12:7
    Content type: Study protocol Published on:

  24. Poor adherence to treatment is common in patients on hemodialysis which may increase risk for poor clinical outcomes and mortality. Self management interventions have been shown to be effective in improving co...

    Authors: Konstadina Griva, Nandakumar Mooppil, Penny Seet, Deby Sarojiuy Pala Krishnan, Hayley James and Stanton P Newman
    Citation: BMC Nephrology 2011 12:4
    Content type: Study protocol Published on:

  25. Defined as estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2, chronic kidney disease (CKD) is strongly and independently associated with cardiovascular and overall mortality. We hypothesized that...

    Authors: Ruth Dubin, Mary Cushman, Aaron R Folsom, Linda F Fried, Walter Palmas, Carmen A Peralta, Christina Wassel and Michael G Shlipak
    Citation: BMC Nephrology 2011 12:3
    Content type: Research article Published on:

  26. A common variant of the UMOD gene was linked with prevalent chronic kidney disease (CKD) in large, genomics consortia. One community-based study found that urine concentrations of the uromodulin protein foreca...

    Authors: Michael G Shlipak, Yongmei Li, Caroline Fox, Josef Coresh, Carl Grunfeld and Mary Whooley
    Citation: BMC Nephrology 2011 12:2
    Content type: Research article Published on:

  27. Primary care providers' suboptimal recognition of the severity of chronic kidney disease (CKD) may contribute to untimely referrals of patients with CKD to subspecialty care. It is unknown whether U.S. primary...

    Authors: Raquel C Greer, Neil R Powe, Bernard G Jaar, Misty U Troll and L Ebony Boulware
    Citation: BMC Nephrology 2011 12:1
    Content type: Research article Published on:

  28. In Singapore, the prevalence of end-stage renal disease (ESRD) and the number of people on dialysis is increasing. The impact of ESRD on patient quality of life has been recognized as an important outcome meas...

    Authors: Veena D Joshi, Nandakumar Mooppil and Jeremy FY Lim
    Citation: BMC Nephrology 2010 11:36
    Content type: Research article Published on:

  29. Compared to healthy people, patients with chronic kidney disease (CKD) participate less in paid jobs and social activities. The aim of the study was to examine a) the perceived autonomy, self-esteem and labor ...

    Authors: Daphne L Jansen, Diana C Grootendorst, Mieke Rijken, Monique Heijmans, Ad A Kaptein, Elisabeth W Boeschoten and Friedo W Dekker
    Citation: BMC Nephrology 2010 11:35
    Content type: Research article Published on:

  30. The complement system is vital for innate immunity and is implicated in the pathogenesis of inflammatory diseases and the mechanism of host defense. Complement deficiencies occasionally cause life-threatening ...

    Authors: Hiroyuki Inoshita, Isao Ohsawa, Gaku Kusaba, Masaya Ishii, Kisara Onda, Satoshi Horikoshi, Hiroyuki Ohi and Yasuhiko Tomino
    Citation: BMC Nephrology 2010 11:34
    Content type: Research article Published on:

  31. Low molecular weight (LMW) heparins are used for anticoagulation during hemodialysis (HD). Studies in animals have shown that LMW-heparins release lipoprotein lipase (LPL) as efficiently as unfractionated (UF)...

    Authors: Dana Mahmood, Maria Grubbström, Lennart DI Lundberg, Gunilla Olivecrona, Thomas Olivecrona and Bernd G Stegmayr
    Citation: BMC Nephrology 2010 11:33
    Content type: Research article Published on:

  32. Minimization of hemodynamic instability during renal replacement therapy (RRT) in patients with acute kidney injury (AKI) is often challenging. We examined the relative hemodynamic tolerability of sustained lo...

    Authors: Heather E Fieghen, Jan O Friedrich, Karen E Burns, Rosane Nisenbaum, Neill K Adhikari, Michelle A Hladunewich, Stephen E Lapinsky, Robert M Richardson and Ron Wald
    Citation: BMC Nephrology 2010 11:32
    Content type: Research article Published on:

  33. Bone Morphogenetic Protein (BMP)-7 is protective in different animal models of acute and chronic kidney disease. Its role in human kidneys, and in particular hypertensive nephrosclerosis, has thus far not been...

    Authors: Carsten P Bramlage, Björn Tampe, Michael Koziolek, Imad Maatouk, Jelena Bevanda, Peter Bramlage, Katharina Ahrens, Katharina Lange, Holger Schmid, Clemens D Cohen, Matthias Kretzler and Gerhard A Müller
    Citation: BMC Nephrology 2010 11:31
    Content type: Research article Published on:

  34. Acute kidney injury (AKI) occurs commonly in the setting of orthotopic liver transplantation (OLT). To date, the correlation between AKI post-OLT and pre-operative changes in renal function has not been rigoro...

    Authors: Jose I Iglesias, John A DePalma and Jerrold S Levine
    Citation: BMC Nephrology 2010 11:30
    Content type: Research article Published on:

  35. Previously the angiotensin II receptor blocker Irbesartan has been demonstrated to reduce the risk for progression from microalbuminuria to macroalbuminuria in type 2 diabetic patients. The purpose of this stu...

    Authors: Sten Andersen, Harald Mischak, Petra Zürbig, Hans-Henrik Parving and Peter Rossing
    Citation: BMC Nephrology 2010 11:29
    Content type: Research article Published on:

  36. Treatment with prostaglandin inhibitors can reduce renal function and impair renal water and sodium excretion. We tested the hypotheses that a reduction in prostaglandin synthesis by ibuprofen treatment during...

    Authors: Thomas G Lauridsen, Henrik Vase, Jørn Starklint, Carolina C Graffe, Jesper N Bech, Søren Nielsen and Erling B Pedersen
    Citation: BMC Nephrology 2010 11:28
    Content type: Research article Published on:

  37. Chronic kidney disease (CKD) is associated to a higher stroke risk. Anemia is a common consequence of CKD, and is also a possible risk factor for cerebrovascular diseases. The purpose of this study was to exam...

    Authors: Patrizia Del Fabbro, Jean-Christophe Luthi, Emmanuel Carrera, Patrik Michel, Michel Burnier and Bernard Burnand
    Citation: BMC Nephrology 2010 11:27
    Content type: Research article Published on:

  38. The kidneys ability to concentrate and dilute urine is deteriorated during progressive renal insufficiency. We wanted to test the hypothesis that these phenomena could be attributed to an abnormal function of ...

    Authors: Erling B Pedersen, Ingrid M Thomsen and Thomas G Lauridsen
    Citation: BMC Nephrology 2010 11:26
    Content type: Research article Published on:

  39. The main hypothesis of this study is that neutral pH, low glucose degradation product (GDP) peritoneal dialysis (PD) fluid better preserves residual renal function in PD patients over time compared with conven...

    Authors: David W Johnson, Margaret Clarke, Vanessa Wilson, Feidhlim Woods and Fiona G Brown
    Citation: BMC Nephrology 2010 11:25
    Content type: Study protocol Published on:

  40. Patients undergoing liver transplantation with preexisting renal dysfunction are prone to further renal impairment with the early postoperative use of Calcineurin-inhibitors. However, there is only little scie...

    Authors: Andreas A Schnitzbauer, Marcus N Scherer, Justine Rochon, Johannes Sothmann, Stefan A Farkas, Martin Loss, Edward K Geissler, Aiman Obed and Hans J Schlitt
    Citation: BMC Nephrology 2010 11:24
    Content type: Study protocol Published on:

  41. Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been ma...

    Authors: Panayiota Koupepidou, Kyriacos N Felekkis, Bettina Kränzlin, Carsten Sticht, Norbert Gretz and Constantinos Deltas
    Citation: BMC Nephrology 2010 11:23
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Nephrology 2011 12:6

  42. The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitati...

    Authors: Alan S Go, Chirag R Parikh, T Alp Ikizler, Steven Coca, Edward D Siew, Vernon M Chinchilli, Chi-yuan Hsu, Amit X Garg, Michael Zappitelli, Kathleen D Liu, W Brian Reeves, Nasrollah Ghahramani, Prasad Devarajan, Georgia Brown Faulkner, Thida C Tan, Paul L Kimmel…
    Citation: BMC Nephrology 2010 11:22
    Content type: Study protocol Published on:

  43. Performing clinical research among pediatric end-stage renal disease patients is challenging. Barriers to successful initiation and completion of clinical research projects include small sample sizes and resul...

    Authors: Susan M Samuel, Marcello A Tonelli, Bethany J Foster, Alberto Nettel-Aguirre, Yingbo Na, Robert Williams, Andrea Soo and Brenda R Hemmelgarn
    Citation: BMC Nephrology 2010 11:21
    Content type: Database Published on:

  44. Since men with chronic kidney disease (CKD) progress faster than women, an accurate assessment of CKD progression rates should be based on gender differences in age-related decline of glomerular filtration rat...

    Authors: Rong Xu, Lu-Xia Zhang, Pu-Hong Zhang, Fang Wang, Li Zuo and Hai-Yan Wang
    Citation: BMC Nephrology 2010 11:20
    Content type: Research article Published on:

  45. Acute interstitial nephritis (AIN) is an important cause of reversible acute kidney injury. At least 70% of AIN is caused by various drugs, mainly penicillines and non-steroidal anti-inflammatory drugs. Quinol...

    Authors: Christos Chatzikyrkou, Iyas Hamwi, Christian Clajus, Jan Becker, Carsten Hafer and Jan T Kielstein
    Citation: BMC Nephrology 2010 11:19
    Content type: Case report Published on:

  46. The apoE-/-/LDL-/- double knockout mice are bearing considerable structural homology to human atherosclerosis. We hypothesized, that advanced lesion formation in the renal artery is associated with kidney alterat...

    Authors: Alexander C Langheinrich, Marian Kampschulte, Franziska Scheiter, Christian Dierkes, Philip Stieger, Rainer M Bohle and Wolfgang Weidner
    Citation: BMC Nephrology 2010 11:18
    Content type: Research article Published on:

  47. Chronic kidney disease (CKD) is associated with an increased risk of fracture. Decreased bone mass and disruption of microarchitecture occur early in the course of CKD and worsens with the progressive decline ...

    Authors: Sarah L West, Charmaine E Lok and Sophie A Jamal
    Citation: BMC Nephrology 2010 11:17
    Content type: Study protocol Published on:

  48. Infections in hemodialysis (HD) patients lead to high morbidity and mortality rates and are associated with early cardiovascular mortality, possibly related to chronic inflammation. Intravenous (IV) iron is wi...

    Authors: Ajay Gupta, Jiaying Zhuo, Junli Zha, Srinivasa Reddy, Jonathan Olp and Amy Pai
    Citation: BMC Nephrology 2010 11:16
    Content type: Research article Published on:

  50. Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Cardiovascular risk assessment in this population is hampered by the failure of tradi...

    Authors: Mireia Junyent, Montserrat Martínez, Mercè Borràs, Blai Coll, Jose Manuel Valdivielso, Teresa Vidal, Felipe Sarró, Jordi Roig, Lourdes Craver and Elvira Fernández
    Citation: BMC Nephrology 2010 11:14
    Content type: Study protocol Published on:
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BMC Nephrology

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