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  1. Metabolic acidosis leads to chronic kidney disease (CKD) progression. The guidelines recommend a lower limit of serum bicarbonate level, but no upper limit. For serum bicarbonate level to be clinically useful ...

    Authors: Eiichiro Kanda, Masumi Ai, Masayuki Yoshida, Renjiro Kuriyama and Tatsuo Shiigai
    Citation: BMC Nephrology 2013 14:4
    Content type: Research article Published on:

  2. Hemolytic and uremic syndrome (HUS) diagnosis involves association of non immune hemolytic anemia, thrombocytopenia, and renal failure. HUS without thrombocytopenia has been observed, we call it partial HUS. I...

    Authors: Marion Sallée, Khalil Ismail, Fadi Fakhouri, Henri Vacher-Coponat, Julie Moussi-Francés, Véronique Frémaux-Bacchi and Stéphane Burtey
    Citation: BMC Nephrology 2013 14:3
    Content type: Research article Published on:

  3. Anemia is a common condition in CKD that has been identified as a cardiovascular (CV) risk factor in end-stage renal disease, constituting a predictor of low survival. The aim of this study was to define the o...

    Authors: José Portolés, Jose Luis Gorriz, Esther Rubio, Fernando de Alvaro, Florencio García, Vicente Alvarez-Chivas, Pedro Aranda and Alberto Martinez-Castelao
    Citation: BMC Nephrology 2013 14:2
    Content type: Research article Published on:

  4. Urinary tract infection (UTI) occurs in 30%-50% of individuals with autosomal dominant polycystic kidney disease (ADPKD). However, the clinical relevance of asymptomatic pyuria in ADPKD patients remains unknown.

    Authors: Jin Ho Hwang, Hayne Cho Park, Jong Cheol Jeong, Seon ha Baek, Mi Yeun Han, Kitae Bang, Jeong Yeon Cho, Suk Hee Yu, Jaeseok Yang, Kook-Hwan Oh, Young-Hwan Hwang and Curie Ahn
    Citation: BMC Nephrology 2013 14:1
    Content type: Research article Published on:

  5. Subacute bacterial endocarditis (SBE) occasionally exhibits positive cytoplasmic anti-neutrophil cytoplasmic antibody (c-ANCA) of the anti-proteinase-3 (PR-3) type. Clinically, it mimics ANCA-associated vascul...

    Authors: Hui Peng, Wen-fang Chen, Chao Wu, Yan-ru Chen, Bo Peng, Sujay Dutta Paudel and Tan-qi Lou
    Citation: BMC Nephrology 2012 13:174
    Content type: Case report Published on:

  6. Little is known about the rate of progression to chronic kidney disease (CKD) among hypertensive patients, particularly at the primary care level. This study aims to examine risk factors associated with new on...

    Authors: Yook Chin Chia and Siew Mooi Ching
    Citation: BMC Nephrology 2012 13:173
    Content type: Research article Published on:

  9. Health Related Quality of Life (HRQOL) instruments need disease and country specific validation. In Arab countries, there is no specific validated questionnaire for assessment of HRQOL in chronic kidney diseas...

    Authors: Samar Abd ElHafeez, Sunny A Sallam, Zahira M Gad, Carmine Zoccali, Claudia Torino, Giovanni Tripepi, Hala S ElWakil and Noha M Awad
    Citation: BMC Nephrology 2012 13:170
    Content type: Research article Published on:

  10. Insulin-like growth factor I (IGF-I), which is mostly carried in blood by IGF-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a multiethnic study amo...

    Authors: Kathleen Dittmann, Henri Wallaschofski, Rainer Rettig, Sylvia Stracke, Karlhans Endlich, Henry Völzke, Matthias Nauck and Nele Friedrich
    Citation: BMC Nephrology 2012 13:169
    Content type: Research article Published on:

  11. Renal scintigraphy using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) is widely used for the assessment of renal function in humans. However, the application of this method to animal models of renal disease is cur...

    Authors: Mohammed N Tantawy, Rosie Jiang, Feng Wang, Keiko Takahashi, Todd E Peterson, Dana Zemel, Chuan-Ming Hao, Hiroki Fujita, Raymond C Harris, Christopher C Quarles and Takamune Takahashi
    Citation: BMC Nephrology 2012 13:168
    Content type: Research article Published on:

  12. Evidence is lacking to inform providers’ and patients’ decisions about many common treatment strategies for patients with end stage renal disease (ESRD).

    Authors: L Ebony Boulware, Navdeep Tangri, Patti L Ephraim, Julia J Scialla, Stephen M Sozio, Deidra C Crews, Tariq Shafi, Dana C Miskulin, Jiannong Liu, Wendy St Peter, Bernard G Jaar, Albert W Wu, Neil R Powe, Sankar D Navaneethan and Karen Bandeen-Roche
    Citation: BMC Nephrology 2012 13:167
    Content type: Study protocol Published on:

  13. Endothelin, via endothelin A receptors (ETA), exerts multiple pathologic effects that contribute to disease pathogenesis throughout the body. ETA antagonists ameliorate many experimental diseases and have been...

    Authors: Deborah Stuart, Sara Rees, Stephanie K Woodward, Robert Koesters, Kevin A Strait and Donald E Kohan
    Citation: BMC Nephrology 2012 13:166
    Content type: Research article Published on:

  14. Hemodialysis (HD) patients have multiple causes of immune dysfunction and poor immune response to influenza vaccination. We investigated the antibody response rate to a pandemic H1N1/2009 influenza vaccination...

    Authors: Sung Jin Moon, Sang Hun Lee, Young-Ho Byun, Gi Young Yun, Seung Kyu Kim, Baik-Lin Seong, Ah Reum Kim, Eun sun Park, Hyung-Jong Kim, Jung Eun Lee, Sung Kyu Ha, Jae Myun Lee and Hyeong-Cheon Park
    Citation: BMC Nephrology 2012 13:165
    Content type: Research article Published on:

  15. The aim of this study was to investigate the characteristics and outcomes of patients receiving renal replacement therapy for end-stage kidney disease (ESKD) secondary to haemolytic uraemic syndrome (HUS).

    Authors: Wen Tang, Janaki Mohandas, Stephen P McDonald, Carmel M Hawley, Sunil V Badve, Neil Boudville, Fiona G Brown, Philip A Clayton, Kathryn J Wiggins, Kym M Bannister, Scott B Campbell and David W Johnson
    Citation: BMC Nephrology 2012 13:164
    Content type: Research article Published on:

  16. Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans. Recently, we found that ...

    Authors: Junko Inoue, Jun Wada, Sanae Teshigawara, Kazuyuki Hida, Atsuko Nakatsuka, Yuji Takatori, Shoichirou Kojo, Shigeru Akagi, Kazushi Nakao, Nobuyuki Miyatake, John F McDonald and Hirofumi Makino
    Citation: BMC Nephrology 2012 13:163
    Content type: Research article Published on:

  17. Cardiovascular deaths account for about 40% of all deaths of patients with chronic kidney disease (CKD), particularly those on dialysis, while sudden cardiac death (SCD) might be responsible for as many as 60%...

    Authors: Beata Franczyk-Skóra, Anna Gluba, Maciej Banach, Dariusz Kozłowski, Jolanta Małyszko and Jacek Rysz
    Citation: BMC Nephrology 2012 13:162
    Content type: Review Published on:

  18. Complement activation products are present in atherosclerotic plaques. Recently, binding of complement to elastin and collagen in the aortic wall has been demonstrated, suggesting a role of complement in the d...

    Authors: Florian Knoll, Emanuel Zitt, Denis Intemann and Karl Lhotta
    Citation: BMC Nephrology 2012 13:161
    Content type: Case report Published on:

  19. Urinary Ca2+ excretion increases with dietary NaCl. NaCl-induced calciuria may be associated with hypertension, urinary stone formation and osteoporosis, but its mechanism and long-term effects are not fully unde...

    Authors: Midori Sasaki Yatabe, Junichi Yatabe, Kozue Takano, Yuta Murakami, Rina Sakuta, Sadahiko Abe, Hironobu Sanada, Junko Kimura and Tsuyoshi Watanabe
    Citation: BMC Nephrology 2012 13:160
    Content type: Research article Published on:

  20. Treatment with selective vitamin D receptor activators such as paricalcitol have been shown to exert an anti-inflammatory effect in patients on hemodialysis, in addition to their action on mineral metabolism a...

    Authors: María Jesús Izquierdo, Mónica Cavia, Pilar Muñiz, Angel LM de Francisco, Manuel Arias, Javier Santos and Pedro Abaigar
    Citation: BMC Nephrology 2012 13:159
    Content type: Research article Published on:

  21. The Oxford classification of IgA nephropathy (IgAN) provides a useful tool for prediction of renal prognosis. However, the application of this classification in children with IgAN needs validation in different...

    Authors: Weibo Le, Cai-Hong Zeng, Zhangsuo Liu, Dong Liu, Qing Yang, Rui-Xia Lin, Zheng-Kun Xia, Zhong-Min Fan, Guanghua Zhu, Ying Wu, Hong Xu, Yihui Zhai, Ying Ding, Xiaoqing Yang, Shaoshan Liang, Hao Chen…
    Citation: BMC Nephrology 2012 13:158
    Content type: Research article Published on:

  22. An exploration of renal complications of diabetes from the patient perspective is important for developing quality care through the diabetic renal disease care pathway.

    Authors: Emma Wilkinson, Gurch Randhawa, John Feehally, Ken Farrington, Roger Greenwood, Peter Choi and Liz Lightstone
    Citation: BMC Nephrology 2012 13:157
    Content type: Research article Published on:

  23. Maintenance hemodialysis (HD) patients universally suffer from excess toxin load. Hemodiafiltration (HDF) has shown its potential in better removal of small as well as large sized toxins, but its efficacy is r...

    Authors: Vaibhav Maheshwari, Lakshminarayanan Samavedham, Gade Pandu Rangaiah, Yijun Loy, Lieng Hsi Ling, Sunil Sethi and Titus Lau Wai Leong
    Citation: BMC Nephrology 2012 13:156
    Content type: Study protocol Published on:

  24. Klotho is a single-pass transmembrane protein, which appears to be implicated in aging. The purpose of the present study was to characterize the relationship between the soluble Klotho level and renal function...

    Authors: Tetsu Akimoto, Hiromichi Yoshizawa, Yuko Watanabe, Akihiko Numata, Tomoyuki Yamazaki, Eri Takeshima, Kana Iwazu, Takanori Komada, Naoko Otani, Yoshiyuki Morishita, Chiharu Ito, Kazuhiro Shiizaki, Yasuhiro Ando, Shigeaki Muto, Makoto Kuro-o and Eiji Kusano
    Citation: BMC Nephrology 2012 13:155
    Content type: Research article Published on:

  25. There is a growing awareness in primary care of the importance of identifying patients with chronic kidney disease (CKD) so that they can receive appropriate clinical care; one method that has been widely embr...

    Authors: David H Smith, Jennifer Schneider, Micah L Thorp, Suma Vupputuri, Jessica W Weiss, Eric S Johnson, Adrianne Feldstein, Amanda F Petrik, Xuihai Yang and Susan R Snyder
    Citation: BMC Nephrology 2012 13:154
    Content type: Research article Published on:

  26. Sepsis has been identified as the most common cause of acute kidney injury (AKI) in intensive care units. Lipopolysaccharide (LPS) induces the production of several proinflammatory cytokines including tumor ne...

    Authors: Hiroyuki Miyazaki, Jun Morishita, Masaaki Ueki, Kahoru Nishina, Shunichi Shiozawa and Nobuhiro Maekawa
    Citation: BMC Nephrology 2012 13:153
    Content type: Research article Published on:

  27. Policies for allocating deceased donor kidneys have recently shifted from allocation based on Human Leucocyte Antigen (HLA) tissue matching in the UK and USA. Newer allocation algorithms incorporate waiting ti...

    Authors: Michael D Clark, Dennis Leech, Anil Gumber, Domenico Moro, Ala Szczepura, Nick West and Robert Higgins
    Citation: BMC Nephrology 2012 13:152
    Content type: Research article Published on:

  28. Chronic renal disease is a serious complication of long-term intravenous drug use (IVDU). Recent reports have postulated a changing pattern of underlying nephropathy over the last decades.

    Authors: Oliver Jung, Hans Stefan Haack, Maike Buettner, Christoph Betz, Christoph Stephan, Peter Gruetzmacher, Kerstin Amann and Markus Bickel
    Citation: BMC Nephrology 2012 13:151
    Content type: Research article Published on:

  29. Whether paricalcitol (PCT) reduces proteinuria in the presence of intensified inhibition of Renin-Angiotensin-System (RAS) is poorly studied. We evaluated the antiproteinuric effect of PCT in non-dialysis chro...

    Authors: Luca De Nicola, Giuseppe Conte, Domenico Russo, Antonio Gorini and Roberto Minutolo
    Citation: BMC Nephrology 2012 13:150
    Content type: Research article Published on:

  30. Sjögren’s syndrome is a systemic autoimmune disease in which lymphatic cells destroy the salivary and lacrimal glands. Glomerulonephritis is thought to be a rare occurrence in primary Sjögren’s syndrome. Furth...

    Authors: Chang Seong Kim, Yoo Duk Choi, Joon Seok Choi, Eun Hui Bae, Seong Kwon Ma and Soo Wan Kim
    Citation: BMC Nephrology 2012 13:149
    Content type: Case report Published on:

  31. Monocyte chemoattractant protein-1 (MCP-1) plays important roles in kidney disease susceptibility and atherogenesis in experimental models. Relationships between serum MCP-1 concentration and early nephropathy...

    Authors: Mariana Murea, Thomas C Register, Jasmin Divers, Donald W Bowden, J Jeffrey Carr, Caresse R Hightower, Jianzhao Xu, S Carrie Smith, Keith A Hruska, Carl D Langefeld and Barry I Freedman
    Citation: BMC Nephrology 2012 13:148
    Content type: Research article Published on:

  32. Bleeding severity, anatomic location, tissue characteristics, and visibility are common challenges encountered while managing intraoperative bleeding, and conventional hemostatic measures (suture, ligature, an...

    Authors: Ofer Nativ, Bababhai Patel, Jessica Shen, Jonathan Batiller, Sara Horn and James C Hart
    Citation: BMC Nephrology 2012 13:147
    Content type: Research article Published on:

  33. Tunnelled central venous dialysis catheter use is significantly limited by the occurrence of catheter-related infections. This randomised controlled trial assessed the efficacy of a 48 hour 70% ethanol lock vs...

    Authors: Jennifer K Broom, Rathika Krishnasamy, Carmel M Hawley, E Geoffrey Playford and David W Johnson
    Citation: BMC Nephrology 2012 13:146
    Content type: Research article Published on:

  34. Payments for red blood cell (RBC) transfusions are separate from US Medicare bundled payments for dialysis-related services and medications. Our objective was to examine the economic burden for payers when chr...

    Authors: Matthew Gitlin, J Andrew Lee, David M Spiegel, Jeffrey L Carson, Xue Song, Brian S Custer, Zhun Cao, Katherine A Cappell, Helen V Varker, Shaowei Wan and Akhtar Ashfaq
    Citation: BMC Nephrology 2012 13:145
    Content type: Research article Published on:

  36. Cardiovascular disease is the leading cause of mortality among peritoneal dialysis (PD) patients in Macao. Increased arterial stiffness determined by pulse wave velocity (PWV) has been established as an indepe...

    Authors: Ding-Wei Kuang, Chiu-Leong Li, Un-I Kuok, Kin Cheung, Weng-In Lio and Jing Xin
    Citation: BMC Nephrology 2012 13:143
    Content type: Research article Published on:

  37. A recent meta-analysis described a variant (p.Ile2984Val) in the cubilin gene (CUBN) that is associated with levels of albuminuria in the general population and in diabetics.

    Authors: Shay Tzur, Walter G Wasser, Saharon Rosset and Karl Skorecki
    Citation: BMC Nephrology 2012 13:142
    Content type: Research article Published on:

  38. Oxalosis is a metabolic disorder characterized by deposition of oxalate crystals in various organs including the kidney. Whereas primary forms result from genetic defects in oxalate metabolism, secondary forms...

    Authors: Marc Albersmeyer, Robert Hilge, Angelika Schröttle, Max Weiss, Thomas Sitter and Volker Vielhauer
    Citation: BMC Nephrology 2012 13:141
    Content type: Case report Published on:

  39. Secondary hyperparathyroidism (SHPT) is associated with mortality in patients with chronic kidney disease (CKD), but the economic consequences of SHPT have not been adequately studied in the European populatio...

    Authors: Silvia Chiroli, Caroline Mattin, Vasily Belozeroff, Louise Perrault, Dominic Mitchell and Ioanna Gioni
    Citation: BMC Nephrology 2012 13:140
    Content type: Research article Published on:

  40. Chronic kidney disease (CKD) is a growing public health problem and end stage renal disease (ESRD) represents a large human and economic burden. It is important to identify patients at high risk of ESRD. In or...

    Authors: Naïke Bigé, Pierre Patrick Lévy, Patrice Callard, Jean-Manuel Faintuch, Valérie Chigot, Virginie Jousselin, Pierre Ronco and Jean-Jacques Boffa
    Citation: BMC Nephrology 2012 13:139
    Content type: Research article Published on:

  41. Many countries have started screening and prevention programs for chronic kidney disease (CKD). However, one of the main concerns of health authorities is whether management strategies for diagnosed CKD patien...

    Authors: Mitra Mahdavi-Mazdeh, Zinat Nadia Hatmi and Sara Shahpari-Niri
    Citation: BMC Nephrology 2012 13:138
    Content type: Research article Published on:

  42. Despite evidence implicating dietary sodium in the pathogenesis of cardiovascular disease (CVD) in chronic kidney disease (CKD), quality intervention trials in CKD patients are lacking. This study aims to inve...

    Authors: Emma J McMahon, Judith D Bauer, Carmel M Hawley, Nicole M Isbel, Michael Stowasser, David W Johnson, Rachael E Hale and Katrina L Campbell
    Citation: BMC Nephrology 2012 13:137
    Content type: Study protocol Published on:

  43. Tissue injury due to hypoxia and/or free radicals is common in a variety of disease processes. This cross-sectional study aimed to investigate effect of chronic kidney diseases (CKD) and hemodialysis (HD) on h...

    Authors: Enas A Hamed, Taghrid B El-Abaseri, Amany O Mohamed, Ahmed R Ahmed and Tarek H El-Metwally
    Citation: BMC Nephrology 2012 13:136
    Content type: Research article Published on:

  44. Living related kidney transplantation (LRT) is underutilized, particularly among African Americans. The effectiveness of informational and financial interventions to enhance informed decision-making among Afri...

    Authors: Patti L Ephraim, Neil R Powe, Hamid Rabb, Jessica Ameling, Priscilla Auguste, LaPricia Lewis-Boyer, Raquel C Greer, Deidra C Crews, Tanjala S Purnell, Bernard G Jaar, Nicole DePasquale and L Ebony Boulware
    Citation: BMC Nephrology 2012 13:135
    Content type: Study protocol Published on:

  45. Pro-inflammatory cytokines play a key role in bone remodeling. Inflammation is highly prevalent in CKD-5D patients, but the relationship between pro-inflammatory cytokines and fractures in CKD-5D patients is u...

    Authors: Vincenzo Panuccio, Giuseppe Enia, Rocco Tripepi, Roberta Aliotta, Francesca Mallamaci, Giovanni Tripepi and Carmine Zoccali
    Citation: BMC Nephrology 2012 13:134
    Content type: Research article Published on:

  46. Non-equivalence in serum creatinine (SCr) measurements across Dutch laboratories and the consequences hereof on chronic kidney disease (CKD) staging were examined.

    Authors: Iefke Drion, Christa Cobbaert, Klaas H Groenier, Cas Weykamp, Henk JG Bilo, Jack FM Wetzels and Nanne Kleefstra
    Citation: BMC Nephrology 2012 13:133
    Content type: Research article Published on:

  47. Experimentally, erythropoietin (EPO) has nephroprotective as well as immunomodulatory properties when administered after ischemic renal injury. We tested the hypothesis that different doses of recombinant huma...

    Authors: Sophie de Seigneux, Belen Ponte, Lucien Weiss, Jérôme Pugin, Jacques André Romand, Pierre-Yves Martin and Patrick Saudan
    Citation: BMC Nephrology 2012 13:132
    Content type: Research article Published on:

  49. Diabetes is the most common risk factor for end-stage renal disease (ESRD) and has been associated with increased risk of death. In order to better understand the influence of diabetes on outcomes in hemodialy...

    Authors: Abdus Sattar, Christos Argyropoulos, Lisa Weissfeld, Nizar Younas, Linda Fried, John A Kellum and Mark Unruh
    Citation: BMC Nephrology 2012 13:130
    Content type: Research article Published on:

  50. Chronic kidney disease (CKD) is more prevalent in Taiwan than in most countries. This population-based cohort study evaluated the dementia risk associated with CKD.

    Authors: Kao-Chi Cheng, Yu-Lung Chen, Shih-Wei Lai, Chih-Hsin Mou, Pang-Yao Tsai and Fung-Chang Sung
    Citation: BMC Nephrology 2012 13:129
    Content type: Research article Published on:
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BMC Nephrology

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