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  1. Content type: Research article

    Anisodamine is used for the treatment of reperfusion injury in various organs. In this study, we investigated the effectiveness and mechanisms of action of anisodamine in promoting recovery from glycerol-induc...

    Authors: Yun-feng Li, Bing-yuan Xu, Ran An, Xin-fang Du, Kun Yu, Jia-hua Sun, Guo-hong Zhang, Wei Wang, Li-ping An and Guang-li Wu

    Citation: BMC Nephrology 2019 20:223

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  2. Content type: Research article

    Carbon dioxide (CO2) accumulation is a challenging issue in critically ill patients. CO2 can be eliminated by renal replacement therapy but studies are scarce and clinical relevance is unknown. We prospectively s...

    Authors: Joop Jonckheer, Herbert Spapen, Aziz Debain, Joy Demol, Marc Diltoer, Olivier Costa, Katrien Lanckmans, Taku Oshima, Patrick Honoré, Manu Malbrain and Elisabeth De Waele

    Citation: BMC Nephrology 2019 20:222

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  3. Content type: Research article

    Cilastatin (CL) is an inhibitor of dehydropeptidase-I, which is safely used in clinical practice to prevent nephrotoxicity of antibiotics. Tacrolimus (TAC) is the most important immunosuppressant in renal tran...

    Authors: Kang Luo, Sun Woo Lim, Jian Jin, Long Jin, Hyo Wook Gil, Dai Sig Im, Hyeon Seok Hwang and Chul Woo Yang

    Citation: BMC Nephrology 2019 20:221

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  4. Content type: Research article

    The ASTRAL trial showed no difference in clinical outcomes between medical therapy and revascularization for atherosclerotic renal vascular disease (ARVD). Here we report a sub-study using echocardiography to ...

    Authors: Darren Green, Diana Vassallo, Kelly Handley, Natalie Ives, Keith Wheatley, Constantina Chrysochou, Janet Hegarty, Julian Wright, Jon Moss, Rajan K. Patel, Chris Deighan, John Webster, Peter Rowe, Sue Carr, Jenny Cross, Jamie O’Driscoll…

    Citation: BMC Nephrology 2019 20:220

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  5. Content type: Case report

    Bacterial peritonitis is a serious complication of patients undergoing peritoneal dialysis (PD). Although the identification of causative organisms and use of appropriate antibiotics are essential for treatmen...

    Authors: Katsuyuki Tanabe, Shugo Okamoto, Sumie Hiramatsu Asano and Jun Wada

    Citation: BMC Nephrology 2019 20:219

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  6. Content type: Research article

    Chronic-active antibody mediated rejection (c-aABMR) is a major contributor to long-term kidney allograft loss. We conducted a retrospective analysis to establish the efficacy of treatment with intravenous imm...

    Authors: Kasia A. Sablik, Marian C. Clahsen-van Groningen, Caspar W. N. Looman, Jeffrey Damman, Madelon van Agteren and Michiel G. H. Betjes

    Citation: BMC Nephrology 2019 20:218

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  7. Content type: Research article

    Klotho is a transmembrane protein acting as a co-receptor for FGF-23 and thus exerts clinical actions on mineral metabolism. The association of secreted Klotho with outcomes in CKD patients is unclear. This st...

    Authors: Evangelos Memmos, Pantelis Sarafidis, Panagiotis Pateinakis, Apostolos Tsiantoulas, Danai Faitatzidou, Panagiotis Giamalis, Vassileios Vasilikos and Aikaterini Papagianni

    Citation: BMC Nephrology 2019 20:217

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  8. Content type: Research article

    Diuresis has been observed within a week following renal transplantation, suggesting that the procedure causes acute disturbance of renal water homeostasis. Aquaporin (AQP) 1 and AQP2, important proteins for r...

    Authors: Sayaka Oshikawa-Hori, Naoko Yokota-Ikeda, Hiroko Sonoda and Masahiro Ikeda

    Citation: BMC Nephrology 2019 20:216

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  9. Content type: Research article

    Survival analysis of patients on maintenance hemodialysis (HD) has been the subject of many studies. No study has evaluated the effect of different factors on the survival time of these patients. In this study...

    Authors: Vahid Ebrahimi, Mohammad Hossein Khademian, Seyed Jalil Masoumi, Mohammad Reza Morvaridi and Shahrokh Ezzatzadegan Jahromi

    Citation: BMC Nephrology 2019 20:215

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  10. Content type: Research article

    Many studies have evaluated the usefulness of creatinine- (eGFRcr) and cystatin C-based estimated glomerular filtration rate (eGFRcys) at specific time points in predicting renal outcome. This study compared t...

    Authors: Suhyun Kim, Subin Hwang, Hye Ryoun Jang, Insuk Sohn, Hyeon Seon Ahn, Hyung-Doo Park, Wooseong Huh, Dong-Chan Jin, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh and Jung Eun Lee

    Citation: BMC Nephrology 2019 20:214

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  11. Content type: Research article

    Pneumocystis jirovecii pneumonia (PCP) remains an important cause of morbidity and mortality in kidney transplant recipients. While the acute phase toxicity in patients with PCP is well-characterized, there is a ...

    Authors: Ji Eun Kim, Ahram Han, Hajeong Lee, Jongwon Ha, Yon Su Kim and Seung Seok Han

    Citation: BMC Nephrology 2019 20:212

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  12. Content type: Research article

    High serum calcium levels should be avoided in patients on hemodialysis (HD) because they can induce cardiovascular diseases and worsen the patient’s prognosis. In contrast, low serum calcium levels worsen the...

    Authors: Mineaki Kitamura, Yohei Tateishi, Shuntaro Sato, Satoko Kitamura, Yuki Ota, Kumiko Muta, Hiroshi Yamashita, Tadashi Uramatsu, Yoko Obata, Yasushi Mochizuki, Masaharu Nishikido, Tsuyoshi Izumo, Takashi Harada, Satoshi Funakoshi, Takayuki Matsuo, Akira Tsujino…

    Citation: BMC Nephrology 2019 20:210

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  13. Content type: Research article

    Evidence of chronic low levels of exposure to heavy metals in Sri Lanka has emerged in a number of studies carried out in the recent past. The source and magnitude of such exposures have to be understood in or...

    Authors: T. B. Ananda Jayalal, T. W. M. A. Jayaruwan Bandara, Sanath T. C. Mahawithanage, M. A. Jagath Wansapala and Sapthala P. L. Galappaththi

    Citation: BMC Nephrology 2019 20:208

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  14. Content type: Case report

    Successful pregnancy outcomes after in vitro fertilization in kidney transplant recipients have been reported, but few cases of successful pregnancy after ABO-incompatible kidney transplantation have been desc...

    Authors: Akihiro Kosoku, Junji Uchida, Keiko Maeda, Yuki Yoshikawa, Akihiro Hamuro, Hisao Shimada, Kazuya Kabei, Shunji Nishide, Tomoaki Iwai, Nobuyuki Kuwabara, Toshihide Naganuma, Norihiko Kumada, Yoshiaki Takemoto and Tatsuya Nakatani

    Citation: BMC Nephrology 2019 20:206

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  15. Content type: Research article

    Methanol poisoning is a serious public health issue in developing countries, but few data are available in the literature on acute kidney injury (AKI) after methanol intoxication.

    Authors: Shu-Ting Chang, Yu-Ting Wang, Yi-Chou Hou, I-Kuan Wang, Hsiang-Hsi Hong, Cheng-Hao Weng, Wen-Hung Huang, Ching-Wei Hsu and Tzung-Hai Yen

    Citation: BMC Nephrology 2019 20:205

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  16. Content type: Research article

    Despite the interrelationships between obesity, eGFR and albuminuria, few large studies examine how obesity modifies the association between these markers of kidney function and adverse clinical outcomes.

    Authors: Marcello Tonelli, Natasha Wiebe, Csaba P. Kovesdy, Matthew T. James, Scott W. Klarenbach, Braden J. Manns and Brenda R. Hemmelgarn

    Citation: BMC Nephrology 2019 20:204

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  17. Content type: Research article

    Infection is the second most common cause of mortality for patients with end-stage renal disease (ESRD), accompanying with immune dysfunction. Endothelin (EDN) is known to be related to inflammation; however, it ...

    Authors: Chih-Chin Kao, Shih-Ying Cheng, Yu-Jia Wang, Shu-Chen Chien, Yu-Wen Hsu, Mei-Yi Wu, Hsing-Fang Lu, Sean Nam, Tao Sun, Mai-Szu Wu and Wei-Chiao Chang

    Citation: BMC Nephrology 2019 20:203

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  18. Content type: Case report

    Persistent left superior vena cava (PLSVC) is a common vena cava malformation, and drains blood into the right atrium via the dilated coronary sinus in most cases. It is usually asymptomatic and detected incid...

    Authors: Huisi He, Bingyang Li, Yiyi Ma, Yuqiang Zhang, Chaoyang Ye, Changlin Mei, Shengqiang Yu, Bing Dai and Yawei Liu

    Citation: BMC Nephrology 2019 20:202

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  19. Content type: Research article

    A low FT3 level is significantly associated with a variety of kidney disease and acute myocardial infarction (AMI). However, it remains unclear whether low FT3 is associated with CI-AKI in patients who underwe...

    Authors: Kai-Yang Lin, Sun-Ying Wang, Hui Jiang, Han-Chuan Chen, Zhi-Yong Wu, Yan-Song Guo and Peng-Li Zhu

    Citation: BMC Nephrology 2019 20:201

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  20. Content type: Research article

    Chloride is speculated to have nephrotoxic properties. In healthy subjects we tested the hypothesis that acute chloride loading with 3% saline would induce kidney injury, which could be prevented with the loop...

    Authors: F. H. Mose, A. N. Jörgensen, M. H. Vrist, N. P. Ekelöf, E. B. Pedersen and J. N. Bech

    Citation: BMC Nephrology 2019 20:200

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  21. Content type: Research article

    Due to rising vascular comorbidities of patients undergoing dialysis, the prevalence of permanent hemodialysis catheters as hemodialysis access is increasing. However, infection is a major complication of thes...

    Authors: Fani Delistefani, Manuel Wallbach, Gerhard A. Müller, Michael J. Koziolek and Clemens Grupp

    Citation: BMC Nephrology 2019 20:199

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  22. Content type: Research article

    Anabolic-androgenic steroids and growth hormone are among the most commonly used supplements by sportsmen and sportswomen. The aim of this systematic review is to collect and report available data about renal ...

    Authors: Dorna Davani-Davari, Iman Karimzadeh and Hossein Khalili

    Citation: BMC Nephrology 2019 20:198

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  23. Content type: Research article

    Successful vascular access (VA) cannulation is integral to the delivery of adequate dialysis, highlighting the importance of ensuring the viability of arteriovenous access in hemodialysis (HD) patients. Missed...

    Authors: Linda L. Coventry, Jon M. Hosking, Doris T. Chan, Evelyn Coral, Wai H. Lim, Amanda Towell-Barnard, Diane E. Twigg and Claire M. Rickard

    Citation: BMC Nephrology 2019 20:197

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  24. Content type: Research article

    Gait speed (GS) and handgrip strength (HGS), both factors associated with frailty and sarcopenia, are reportedly associated with CV events in the general population. However, little is known about the impact o...

    Authors: Atsumi Kuki, Kentaro Tanaka, Akifumi Kushiyama, Yoshihide Tanaka, Shuta Motonishi, Yasuji Sugano, Toru Furuya and Takashi Ozawa

    Citation: BMC Nephrology 2019 20:196

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  25. Content type: Research article

    Acute kidney injury (AKI) is a major complication of acute myocardial infarction(AMI), which can significantly increase mortality. This study is to analyze the related risk factors and establish a prediction s...

    Authors: Feng-bo Xu, Hong Cheng, Tong Yue, Nan Ye, He-jia Zhang and Yi-pu Chen

    Citation: BMC Nephrology 2019 20:195

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  26. Content type: Research article

    Acid-base imbalance might promote the progression of chronic kidney disease (CKD), but whether nutrient-derived dietary acid load increases the risk of albuminuria or even high normoalbuminuria is unclear.

    Authors: Keiko Kabasawa, Michihiro Hosojima, Ribeka Takachi, Kazutoshi Nakamura, Yumi Ito, Akihiko Saito, Norie Sawada, Shoichiro Tsugane, Junta Tanaka and Ichiei Narita

    Citation: BMC Nephrology 2019 20:194

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  27. Content type: Study protocol

    The use of metformin in patients with type 2 diabetes mellitus has been associated with lactic acidosis. However, the information available in patients with moderate-severe chronic kidney disease is scarce.

    Authors: Consuelo Pedrós, Mónica Ávila, Ainhoa Gómez-Lumbreras, Marcela Manríquez and Rosa Morros

    Citation: BMC Nephrology 2019 20:193

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  28. Content type: Research article

    Chronic kidney disease (CKD) is a worldwide public health problem. Clinical practice guidelines (CPGs) are being developed and implemented in order to improve clinical practice related to the detection and tre...

    Authors: Jorge Coronado Daza, Robin W. M. Vernooij, Karla Salas, Dimelza Osorio and Gerard Urrútia Cuchí

    Citation: BMC Nephrology 2019 20:192

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  29. Content type: Research article

    Thrombophilia due to protein C (PC) and protein S (PS) deficiencies is highly prevalent among patients with stage 5 chronic kidney disease and is reported to arise due to extracorporeal circulation during hemo...

    Authors: Mayuri Ichinose, Naru Sasagawa, Tetsuo Chiba, Katsuhide Toyama, Yuzo Kayamori and Dongchon Kang

    Citation: BMC Nephrology 2019 20:191

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  30. Content type: Research article

    Kidney transplant (KT) patients presenting with cardiovascular (CVD) events are being managed increasingly in non-transplant facilities. We aimed to identify drivers of mortality and costs, including transplan...

    Authors: Amit K. Mathur, Yu-Hui Chang, D. Eric Steidley, Raymond L. Heilman, Nabil Wasif, David Etzioni, Kunam S. Reddy and Adyr A. Moss

    Citation: BMC Nephrology 2019 20:190

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  31. Content type: Research article

    To evaluate renal expression of C4d, a complement component in the classical/mannose binding lectin (MBL) pathway, in patients with primary Sjögren’s syndrome (pSS)-associated renal impairments.

    Authors: Wenli Xia, Bixia Gao, Lin Duan, Yan Li, Yubing Wen, Limeng Chen, Xuemei Li, Falei Zheng and Mingxi Li

    Citation: BMC Nephrology 2019 20:189

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  32. Content type: Research article

    Patients with advanced chronic kidney disease (CKD) exhibit higher prevalence of coronary artery calcification (CaC) than general population. CaC has been proposed as a risk factor for mortality in end-stage C...

    Authors: Marta Cano-Megías, Pablo Guisado-Vasco, Hanane Bouarich, Gabriel de Arriba-de la Fuente, Patricia de Sequera-Ortiz, Concepción Álvarez-Sanz and Diego Rodríguez-Puyol

    Citation: BMC Nephrology 2019 20:188

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  33. Content type: Research article

    Vitamin D deficiency is an important health concern because it is related to several comorbidities and mortality. However, its relationship with the risk of hematuria remains undetermined in the general popula...

    Authors: Hyunjin Ryu, Hyunjeong Cho, Yun Kyu Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn and Seung Seok Han

    Citation: BMC Nephrology 2019 20:187

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  34. Content type: Research article

    The performance of urinary N-acetyl-β-D-glucosaminidase (uNAG) for the detection of acute kidney injury (AKI) was controversial. uNAG is positively correlated with blood glucose levels. Hyperglycemia is common...

    Authors: Lin Wang, Yujun Deng, Yiling Zhai, Feng Xu, Jinghua Li, Danqing Zhang, Lu Gao, Yating Hou, Xin OuYang, Linhui Hu, Jie Yuan, Heng Ye, Ruibin Chi and Chunbo Chen

    Citation: BMC Nephrology 2019 20:186

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  35. Content type: Research article

    Angiopoietin-like-3 (Angptl3) knockout is known for its protective effects on podocyte injury and proteinuria in the early stage of adriamycin (ADR) nephropathy. The current study re-evaluated the renoprotecti...

    Authors: Rufeng Dai, Haimei Liu, Xinli Han, Junchao Liu, Yihui Zhai, Jia Rao, Qian Shen and Hong Xu

    Citation: BMC Nephrology 2019 20:185

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  36. Content type: Research article

    Cardiovascular morbidity and mortality are highly prevalent in patients with end-stage renal disease, and osteoprotegerin (OPG) may be an important link between bone loss and vascular calcification. This study...

    Authors: Jia-Sian Hou, Yu-Li Lin, Chih-Hsien Wang, Yu-Hsien Lai, Chiu-Huang Kuo, Yi-Maun Subeq and Bang-Gee Hsu

    Citation: BMC Nephrology 2019 20:184

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  37. Content type: Research article

    Accurate prediction of reference ranges of renal lengths facilitates clinical decision making. Currently a single renal-length-reference chart is used for both kidneys, which is solely based on the age of the ...

    Authors: W. D. Duminda, K. G. Pathirana, M. U. J. Fernando, R. A. N. K. K. Samarasinghe, W. D. H. A. Ananda, K. S. P. Silva, C. K. Dissanayake and P. K. B. Mahesh

    Citation: BMC Nephrology 2019 20:183

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  38. Content type: Research article

    Acute kidney injury (AKI) is common after heart surgery. Neutrophil gelatinase-associated lipocalin (NGAL) is produced in injured kidney. NGAL has been used as an early plasma biomarker for AKI in patients und...

    Authors: Arie Passov, Liisa Petäjä, Marjut Pihlajoki, Ulla-Stina Salminen, Raili Suojaranta, Antti Vento, Sture Andersson, Ville Pettilä, Alexey Schramko and Eero Pesonen

    Citation: BMC Nephrology 2019 20:182

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  39. Content type: Research article

    Glucose is a primary osmotic agent in peritoneal dialysis (PD) solutions, but its long-term use causes structural alteration of the peritoneal membrane (PM). Hyperbranched polyglycerol (HPG) is a promising alt...

    Authors: Bin Liu, Shijian Feng, Ghida Dairi, Qiunong Guan, Irina Chafeeva, Hao Wang, Richard Liggins, Gerald da Roza, Jayachandran N. Kizhakkedathu and Caigan Du

    Citation: BMC Nephrology 2019 20:181

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  40. Content type: Case report

    Peritonitis is a common cause of catheter removal and mortality in the patient undergoing peritoneal dialysis (PD). Various pathogenic organisms have been identified as the etiology of PD-related peritonitis, ...

    Authors: Panai Song, Jun Deng, Tao Hou, Xiao Fu, Lei Zhang, Lin Sun and Yinghong Liu

    Citation: BMC Nephrology 2019 20:180

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  41. Content type: Research article

    Reports on vitamin C in HD patients have shown effects of vitamin C deficiency in association with scurvy symptoms. Dialyzability of water soluble vitamins is high, and substantial losses in those who are dial...

    Authors: Jochen G. Raimann, Samer R. Abbas, Li Liu, Brett Larive, Gerald Beck, Peter Kotanko, Nathan W. Levin and Garry Handelman

    Citation: BMC Nephrology 2019 20:179

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  42. Content type: Research article

    Adherence to phosphate binder treatment is important to prevent high serum phosphate level in chronic dialysis patients. We therefore wanted to investigate patient knowledge, beliefs about and adherence to pho...

    Authors: Bodil Jahren Hjemås, Katrine Bøvre, Liv Mathiesen, Jonas Christoffer Lindstrøm and Kathrin Bjerknes

    Citation: BMC Nephrology 2019 20:178

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  43. Content type: Research article

    A classification tree model (CT-PIRP) was developed in 2013 to predict the annual renal function decline of patients with chronic kidney disease (CKD) participating in the PIRP (Progetto Insufficienza Renale P...

    Authors: Dino Gibertoni, Paola Rucci, Marcora Mandreoli, Mattia Corradini, Davide Martelli, Giorgia Russo, Elena Mancini and Antonio Santoro

    Citation: BMC Nephrology 2019 20:177

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  44. Content type: Research article

    Inflammation is more common among African Americans (AAs), and it is associated with frailty, poor physical performance, and mortality in community-dwelling older adults. Given the elevated inflammation levels...

    Authors: Prakriti Shrestha, Christine E. Haugen, Nadia M. Chu, Ashton Shaffer, Jacqueline Garonzik-Wang, Silas P. Norman, Jeremy D. Walston, Dorry L. Segev and Mara A. McAdams-DeMarco

    Citation: BMC Nephrology 2019 20:176

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  45. Content type: Technical advance

    Increased morbidity and mortality are well documented in Status 7(inactive list) patients. Delays in transplantation secondary to prolonged periods on inactive status also negatively impacts transplant outcome...

    Authors: Ashish Kataria, Madan Gowda, Brian Paul Lamphron, Kabir Jalal, Rocco C. Venuto and Aijaz A. Gundroo

    Citation: BMC Nephrology 2019 20:174

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  46. Content type: Case report

    Nephronophthisis (NPHP) is an autosomal recessive hereditary disease with highly variable clinical characteristics for which 20 genes (NPHP1–20) have been identified. NPHP1 is the major subtype leading to pediatr...

    Authors: Yiting Wang, Feng Chen, Jiali Wang, Yingwang Zhao and Fang Liu

    Citation: BMC Nephrology 2019 20:173

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  47. Content type: Research article

    Physicians are faced with a growing number of patients after renal transplantation undergoing graft-unrelated surgery. So far, little is known about the postoperative restitution of graft function and the risk...

    Authors: Ann-Kathrin Lederer, Dominic Haffa, Philipp Felgendreff, Frank Makowiec, Stefan Fichtner-Feigl, Roman Huber and Lampros Kousoulas

    Citation: BMC Nephrology 2019 20:170

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