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  1. Chronic refractory hypotension (IDH, intradialytic hypotension) is a rare but serious problem encountered in patients on hemodialysis. Patients with chronic hypotension are often disqualified by transplant tea...

    Authors: Ewa Ignacak, Dominik Cieniawski, Alina Bętkowska-Prokop, Czesław Osuch, Marek Kuźniewski and Władysław Sułowicz
    Citation: BMC Nephrology 2017 18:248
    Content type: Case report Published on:

  2. Acute kidney injury (AKI) is common in patients with multiple myeloma (MM). Whether serum free light chain (sFLC) measurements can distinguish between myeloma and other causes of AKI requires confirmation to g...

    Authors: Jennifer L. J. Heaney, John P. Campbell, Punit Yadav, Ann E. Griffin, Meena Shemar, Jennifer H. Pinney and Mark T. Drayson
    Citation: BMC Nephrology 2017 18:247
    Content type: Research article Published on:

  3. Chronic Kidney Disease (CKD) is a worldwide public health problem. There are few studies in Latin America, especially in primary care settings. Our objective was to determine the prevalence, stages, and associ...

    Authors: Percy Herrera-Añazco, Alvaro Taype-Rondan, María Lazo-Porras, E. Alberto Quintanilla, Victor Manuel Ortiz-Soriano and Adrian V. Hernandez
    Citation: BMC Nephrology 2017 18:246
    Content type: Research article Published on:

  4. The application of mycophenolate mofetil (MMF) in treating patients with immunoglobulin A nephropathy (IgAN) remains uncertain. This update meta-analysis was performed to re-evaluate the therapeutic potential ...

    Authors: Bing Du, Ye Jia, Wenhua Zhou, Xu Min, Lining Miao and Wenpeng Cui
    Citation: BMC Nephrology 2017 18:245
    Content type: Research article Published on:

  5. The epidemiology and outcomes of acute kidney injury (AKI) in prevalent non-renal solid organ transplant recipients is unknown.

    Authors: Girish N. Nadkarni, Kinsuk Chauhan, Achint Patel, Aparna Saha, Priti Poojary, Sunil Kamat, Shanti Patel, Rocco Ferrandino, Ioannis Konstantinidis, Pranav S. Garimella, Madhav C. Menon and Charuhas V. Thakar
    Citation: BMC Nephrology 2017 18:244
    Content type: Research article Published on:

  6. Hemolytic uremic syndrome (HUS) can occur as a primary process due to mutations in complement genes or secondary to another underlying disease. HUS sometimes occurs in the setting of glomerular diseases, and i...

    Authors: Joseph L. Alge, Scott E. Wenderfer, John Hicks, Mir Reza Bekheirnia, Deborah A. Schady, Jamey S. Kain and Michael C. Braun
    Citation: BMC Nephrology 2017 18:243
    Content type: Case report Published on:

  7. The Literature on rhabdomyolysis in the HIV-positive population is sparse and limited. We aimed to explore the incidence, patient characteristics, etiologies and outcomes of rhabdomyolysis in a cohort of HIV-p...

    Authors: Sahar H. Koubar, Michelle M. Estrella, Rugmini Warrier, Richard D. Moore, Gregory M. Lucas, Mohamed G. Atta and Derek M. Fine
    Citation: BMC Nephrology 2017 18:242
    Content type: Research article Published on:

  8. Prediction models in autosomal dominant polycystic kidney disease (ADPKD) are useful in clinical settings to identify patients with greater risk of a rapid disease progression in whom a treatment may have more...

    Authors: Laura Girardat-Rotar, Julia Braun, Milo A. Puhan, Alison G. Abraham and Andreas L. Serra
    Citation: BMC Nephrology 2017 18:241
    Content type: Research article Published on:

  9. Asians have among the highest prevalence of chronic kidney disease (CKD) or end-stage renal disease in the world. A risk score capable of identifying high risk individuals at the primary care level could allow...

    Authors: Krittika Saranburut, Prin Vathesatogkit, Nisakron Thongmung, Anchalee Chittamma, Somlak Vanavanan, Tuangrat Tangstheanphan, Piyamitr Sritara and Chagriya Kitiyakara
    Citation: BMC Nephrology 2017 18:240
    Content type: Research article Published on:

  10. Monoclonal immunoglobulin deposition disease (MIDD) is characterized by the non-amyloid deposition of monoclonal immunoglobulin fragments in the basement membranes. Heavy chain deposition disease (HCDD) is a t...

    Authors: Takayuki Katsuno, Shige Mizuno, Masatsuna Mabuchi, Naotake Tsuboi, Atsushi Komatsuda and Shoichi Maruyama
    Citation: BMC Nephrology 2017 18:239
    Content type: Case report Published on:

  11. Because chronic fluid volume overload is associated with higher mortality, we tested whether blood-volume monitored regulation of ultrafiltration and dialysate conductivity (UCR) and/or regulation of ultrafilt...

    Authors: Marlies Antlanger, Peter Josten, Michael Kammer, Isabella Exner, Katharina Lorenz-Turnheim, Manfred Eigner, Gernot Paul, Renate Klauser-Braun, Gere Sunder-Plassmann, Marcus D. Säemann and Manfred Hecking
    Citation: BMC Nephrology 2017 18:238
    Content type: Research article Published on:

  12. Toxic epidermal necrolysis (TEN) is a rare life-threatening condition almost exclusively attributed to drugs. The main etiologic factors for TEN are sulphonamides, anticonvulsants, and antibiotics; however, th...

    Authors: Katsuaki Kasahara, Yoshimitsu Gotoh, Yoshiyuki Kuroyanagi and China Nagano
    Citation: BMC Nephrology 2017 18:237
    Content type: Case report Published on:

  14. Cardiovascular disease is the major cause of death in patients with end-staged kidney disease (ESRD). Most ESRD patients have systemic inflammation, and increasing the risk of cardiovascular event. Endotoxin d...

    Authors: Chien-Chin Hsu, Tsui-Shan Wei, Chien-Cheng Huang and Yi-Ming Chen
    Citation: BMC Nephrology 2017 18:235
    Content type: Research article Published on:

  15. Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been describe...

    Authors: Rhian L. Clissold, Helen C. Clarke, Olivera Spasic-Boskovic, Kim Brugger, Stephen Abbs, Coralie Bingham and Charles Shaw-Smith
    Citation: BMC Nephrology 2017 18:234
    Content type: Case report Published on:

  16. Tubular biomarkers have been regarded as emerging and promising markers for early diagnosis of diabetic kidney disease (DKD). The study was to determine the diagnostic capabilities of tubular biomarkers (urina...

    Authors: Xian-Fei Zeng, Dong-Xue Lu, Jun-Min Li, Yun Tan, Zhuo Li, Lei Zhou, Zeng-Qian Xi, Shu-Miao Zhang and Wei Duan
    Citation: BMC Nephrology 2017 18:233
    Content type: Research article Published on:

  17. Intermedin [IMD, adrenomedullin-2 (ADM-2)] attenuates renal fibrosis by inhibition of oxidative stress. However, the precise mechanisms remain unknown. Heme oxygenase-1 (HO-1), an antioxidant agent, is associa...

    Authors: Xi Qiao, Lihua Wang, Yanhong Wang, Xiaole Su, Yufeng Qiao, Yun Fan and Zhiqiang Peng
    Citation: BMC Nephrology 2017 18:232
    Content type: Research article Published on:

  18. An association between serum complement levels and poor renal prognosis in patients with immunoglobulin A nephropathy (IgAN) remains controversial.

    Authors: Min Pan, Ji Zhang, Zhanyuan Li, Lingwei Jin, Yu Zheng, Zhihong Zhou, Su Zhen and Guoyuan Lu
    Citation: BMC Nephrology 2017 18:231
    Content type: Research article Published on:

  19. Rare diseases may elude diagnosis due to unfamiliarity of the treating physicians with the specific disorder. Yet, advances in genetics have tremendously enhanced our ability to establish specific and sometime...

    Authors: Stephen Benedict Walsh, Robert Unwin, Robert Kleta, William van’t Hoff, Paul Bass, Khalid Hussain, Sian Ellard and Detlef Bockenhauer
    Citation: BMC Nephrology 2017 18:230
    Content type: Case report Published on:

  20. The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown. To investigate whether...

    Authors: Hung-Chieh Yeh, I-Wen Ting, Ching-Wei Tsai, Jenn-Yu Wu and Chin-Chi Kuo
    Citation: BMC Nephrology 2017 18:229
    Content type: Research article Published on:

  21. Physical and psychological symptoms are among main manifestations of Chronic Kidney Disease (CKD). This study aimed to assess the symptom burden and self-perceived severity of symptoms among CKD patients livin...

    Authors: Sameera Senanayake, Nalika Gunawardena, Paba Palihawadana, Palitha Bandara, Rashan Haniffa, R Karunarathna and Priyantha Kumara
    Citation: BMC Nephrology 2017 18:228
    Content type: Research article Published on:

  22. According to renal M type phospholipase A2 receptor (PLA2R) immunohistochemistry, idiopathic membranous nephropathy (IMN) could be categorized into PLA2R-associated and non-PLA2R-associated IMN. We conducted a re...

    Authors: Jia Wang, Qionghong Xie, Zhuxing Sun, Ningxin Xu, Yan Li, Liang Wang, Shaojun Liu, Jun Xue and Chuan-Ming Hao
    Citation: BMC Nephrology 2017 18:227
    Content type: Research article Published on:

  23. The aim of this study was to identify the optimal equation that accurately estimates the glomerular filtration rate (GFR) and the chronic kidney disease (CKD) stage in the Chinese population.

    Authors: Xiao-Hua Chi, Gui-Ping Li, Quan-Shi Wang, Yong-Shuai Qi, Kai Huang, Qian Zhang and Yao-ming Xue
    Citation: BMC Nephrology 2017 18:226
    Content type: Research article Published on:

  24. The histone deacetylase (HDAC) inhibitor, which has potential effects on epigenetic modifications, had been reported to attenuate renal fibrosis. CD4+ forkhead box P3 (FOXP3)+ T regulatory (Treg) cells may be con...

    Authors: Wen-Pyng Wu, Yi-Giien Tsai, Tze-Yi Lin, Ming-Ju Wu and Ching-Yuang Lin
    Citation: BMC Nephrology 2017 18:225
    Content type: Research article Published on:

  25. Surgical thrombectomy in the context of acute renal vein thrombosis (RVT) post-transplantation has had limited success, with considerable variation in the surgical techniques used. Unfortunately, it is usually...

    Authors: Paraish Misra, Anish Kirpalani, General Leung, Paraskevi A. Vlachou, Jason Y. Lee, Serge Jothy, Jeffrey Zaltzman and Darren A. Yuen
    Citation: BMC Nephrology 2017 18:224
    Content type: Case report Published on:

  27. Continuous renal replacement therapy (CRRT) is the recommended modality of dialysis for critically ill patients with hemodynamic instability. Yet there remains significant variability in how CRRT is prescribed...

    Authors: Michael Heung, Sean M. Bagshaw, Andrew A. House, Luis A. Juncos, Robin Piazza and Stuart L. Goldstein
    Citation: BMC Nephrology 2017 18:222
    Content type: Study protocol Published on:

  28. The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab is a low-density lipoprotein (LDL)-lowering drug with a new mechanism, which is currently available in Japan. Here, for the first ...

    Authors: Yuki Awanami, Makoto Fukuda, Yasunori Nonaka, Tsuyoshi Takashima, Keiichiro Matsumoto, Masatora Yamasaki, Motoaki Miyazono and Yuji Ikeda
    Citation: BMC Nephrology 2017 18:221
    Content type: Case report Published on:

  29. Congenital nephrotic syndrome (CNS) is a rare disorder caused by various structural and developmental defects of glomeruli. It occurs typically as an isolated kidney disorder but associates sometimes with othe...

    Authors: Jiro Kino, Hiroyasu Tsukaguchi, Takahisa Kimata, Huan Thanh Nguyen, Yorika Nakano, Noriko Miyake, Naomichi Matsumoto and Kazunari Kaneko
    Citation: BMC Nephrology 2017 18:220
    Content type: Case report Published on:

    The Erratum to this article has been published in BMC Nephrology 2017 18:271

  30. Osteoprotegerin (OPG) is a glycoprotein that plays an important regulatory role in the skeletal, vascular, and immune system. It has been shown that OPG predicts chronic kidney disease (CKD) in diabetic patien...

    Authors: Stella Bernardi, Barbara Toffoli, Fleur Bossi, Riccardo Candido, Elisabetta Stenner, Renzo Carretta, Fabio Barbone and Bruno Fabris
    Citation: BMC Nephrology 2017 18:219
    Content type: Research article Published on:

  31. Urinary biomarkers of kidney injury are presumed to reflect renal tubular damage. However, their concentrations may be influenced by other factors, such as hematuria or pyuria. We sought to examine what non-in...

    Authors: Girish N. Nadkarni, Steven G. Coca, Allison Meisner, Shanti Patel, Kathleen F. Kerr, Uptal D. Patel, Jay L. Koyner, Amit X. Garg, Heather Thiessen Philbrook, Charles L. Edelstein, Michael Shlipak, Joe El-Khoury and Chirag R. Parikh
    Citation: BMC Nephrology 2017 18:218
    Content type: Research article Published on:

  32. Physical, cognitive and psychosocial functioning are frequently impaired in dialysis patients and impairment in these domains relates to poor outcome. The aim of this analysis was to compare the prevalence of ...

    Authors: I. N. van Loon, M. L. Bots, F. T. J. Boereboom, M. P. C. Grooteman, P. J. Blankestijn, M. A. van den Dorpel, M. J. Nubé, P. M. Ter Wee, M. C. Verhaar and M. E. Hamaker
    Citation: BMC Nephrology 2017 18:217
    Content type: Research article Published on:

  33. Patients starting dialysis often have substantial residual kidney function. Incremental hemodialysis provides a hemodialysis prescription that supplements patients’ residual kidney function while maintaining t...

    Authors: Stephanie M. Toth-Manikowski, Surekha Mullangi, Seungyoung Hwang and Tariq Shafi
    Citation: BMC Nephrology 2017 18:216
    Content type: Case report Published on:

  35. Autosomal dominant polycystic kidney disease (PKD) is the most common genetic renal disease and the fourth leading cause of end-stage renal disease in the United States. Although there is no cure for PKD, seve...

    Authors: Wen-Ching Tran, David Huynh, Tea Chan, Catherine A. Chesla and Meyeon Park
    Citation: BMC Nephrology 2017 18:214
    Content type: Research article Published on:

  36. Patients treated with dialysis have high rates of brain infarcts, brain atrophy, and white matter disease. There are limited data regarding the presence of more subtle damage to brain white matter.

    Authors: David A. Drew, Bang-Bon Koo, Rafeeque Bhadelia, Daniel E. Weiner, Sarah Duncan, Maria Mendoza-De la Garza, Aditi Gupta, Hocine Tighiouart, Tammy Scott and Mark J. Sarnak
    Citation: BMC Nephrology 2017 18:213
    Content type: Research article Published on:

  37. Kidney Diseases contribute a significant proportion to the global burden of non-communicable diseases. Haemodialysis services as the main modality of renal replacement therapy in most resource limited countrie...

    Authors: Alfred J. Meremo, David P. Ngilangwa, Masumbuko Y. Mwashambwa, Matobogolo B. Masalu, Janet Kapinga, Rehema Tagalile and Issa Sabi
    Citation: BMC Nephrology 2017 18:212
    Content type: Research article Published on:

  38. The prognostic values of baseline, longitudinal high-sensitivity C-reactive protein (hs-CRP) and its change over time on mortality in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) remain...

    Authors: Wei Li, Liping Xiong, Li Fan, Yating Wang, Xuan Peng, Rong Rong, Yagui Qiu, Jiani Shen, Jianxiong Lin, Xueqing Yu and Haiping Mao
    Citation: BMC Nephrology 2017 18:211
    Content type: Research article Published on:

  39. Nephropathic cystinosis is a rare inherited metabolic disorder leading to progressive renal failure and extra-renal comorbidity. The prognosis relies on early adherence to cysteamine treatment and symptomatic ...

    Authors: Aurélia Bertholet-Thomas, Julien Berthiller, Velibor Tasic, Behrouz Kassai, Hasan Otukesh, Marcella Greco, Jochen Ehrich, Rejane de Paula Bernardes, Georges Deschênes, Sally-Ann Hulton, Michel Fischbach, Kenza Soulami, Bassam Saeed, Ehsan Valavi, Carlos Jose Cobenas, Bülent Hacihamdioglu…
    Citation: BMC Nephrology 2017 18:210
    Content type: Research article Published on:

  40. Although TGF-ß and the transcription factor Egr-1 play an important role in both kidney fibrosis and in response to acute changes of renal medullary osmolarity, their role under sustained hypo- or hyperosmolar...

    Authors: Miklós M. Mózes, Petra Szoleczky, László Rosivall and Gábor Kökény
    Citation: BMC Nephrology 2017 18:209
    Content type: Research article Published on:

  41. Critically ill patients requiring renal replacement therapy (RRT) are at risk of disease-related bleeding. Systemic heparinization should be avoided. AN69ST, a polyethyleneimine-treated polyacrylonitrile (AN69...

    Authors: Tao Su, Qizhuang Jin and Zhongyuan Liu
    Citation: BMC Nephrology 2017 18:208
    Content type: Research article Published on:

  42. End-Stage renal disease (ESRD) causes considerable morbidity and mortality, and significantly alters patients’ quality of life. There are very few published data on this problem in the French Overseas territor...

    Authors: Dévi Rita Rochemont, Mohamed Meddeb, Raoul Roura, Cécile Couchoud, Mathieu Nacher and Célia Basurko
    Citation: BMC Nephrology 2017 18:207
    Content type: Research article Published on:

  43. The role of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) reducing risk of cardiovascular events (CVEs) and preserving kidney function in patients with chronic kidne...

    Authors: Youxia Liu, Xinxin Ma, Jie Zheng, Junya Jia and Tiekun Yan
    Citation: BMC Nephrology 2017 18:206
    Content type: Research article Published on:

  44. Chronic kidney disease (CKD) is a major contributor to mortality in the general population. Understanding the factors that drive this process will help delay progression of CKD. The study aimed to estimate the...

    Authors: Phisitt Vejakama, Atiporn Ingsathit, Mark McEvoy, John Attia and Ammarin Thakkinstian
    Citation: BMC Nephrology 2017 18:205
    Content type: Research article Published on:

  45. High levels of fibroblast growth factor-23 (FGF23) are associated with mortality. In chronic kidney disease (CKD), FGF23 levels rise as renal function declines. We analyzed the contribution of laboratory value...

    Authors: Daisy Liu, Ana Catalina Alvarez-Elías, Brooke Wile, Vladimir Belostotsky and Guido Filler
    Citation: BMC Nephrology 2017 18:204
    Content type: Research article Published on:

  46. Acute kidney injury (AKI) places a heavy burden on the healthcare system in China and is usually misdiagnosed. However, there are limited studies that have described the epidemiology and diagnosis of AKI in Ch...

    Authors: Xiaoyan Cheng, Buyun Wu, Yun Liu, Huijuan Mao and Changying Xing
    Citation: BMC Nephrology 2017 18:203
    Content type: Research article Published on:

  47. Patients with acute myocardial infarction are at high risk for acute kidney injury. Novel biomarkers that can predict acute kidney injury in AMI may allow timely interventions. C-terminal fragment of agrin (CA...

    Authors: Spyridon Arampatzis, Georgios Chalikias, Vasilios Devetzis, Stavros Konstantinides, Uyen Huynh-Do and Dimitrios Tziakas
    Citation: BMC Nephrology 2017 18:202
    Content type: Research article Published on:

  48. Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. MN is a clinically heterogeneous disease and it is difficult to accurately predict outcomes (including end stage renal failure)...

    Authors: Sanjana Gupta, John Connolly, Ruth J Pepper, Stephen B Walsh, Magdi M Yaqoob, Robert Kleta and Neil Ashman
    Citation: BMC Nephrology 2017 18:201
    Content type: Research article Published on:

  49. Dialysis initiation rates among older adults, aged 75 years or greater, are increasing at a faster rate than for younger age groups. Older adults with advanced CKD (eGFR < 30 ml/min/1.73 m2) typically lose renal ...

    Authors: Steven J. Rosansky, Jane Schell, Joseph Shega, Jennifer Scherer, Laurie Jacobs, Cecile Couchoud, Deidra Crews and Matthew McNabney
    Citation: BMC Nephrology 2017 18:200
    Content type: Review Published on:

  50. The use of dipstick proteinuria to screen Chronic Kidney Disease of uncertain aetiology (CKDu) in Sri Lanka is a recently debated matter of dispute. The aim of this study was to assess the suitability of bioma...

    Authors: Samantha Ratnayake, Zeid Badurdeen, Nishantha Nanayakkara, Tilak Abeysekara, Neelakanthi Ratnatunga and Ranjith Kumarasiri
    Citation: BMC Nephrology 2017 18:199
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Nephrology 2017 18:236

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