Articles

Renal Association Clinical Practice Guideline on Haemodialysis

This guideline is written primarily for doctors and nurses working in dialysis units and related areas of medicine in the UK, and is an update of a previous version written in 2009. It aims to provide guidance...

Authors: Damien Ashby, Natalie Borman, James Burton, Richard Corbett, Andrew Davenport, Ken Farrington, Katey Flowers, James Fotheringham, R. N. Andrea Fox, Gail Franklin, Claire Gardiner, R. N. Martin Gerrish, Sharlene Greenwood, Daljit Hothi, Abdul Khares, Pelagia Koufaki…

Developing nephrology services in low income countries: a case of Tanzania

The burden of kidney diseases is reported to be higher in lower- and middle-income countries as compared to developed countries, and countries in sub-Saharan Africa are reported to be most affected. Health sys...

Authors: Francis F. Furia, Jacqueline Shoo, Paschal J. Ruggajo, Kajiru Kilonzo, Gopal Basu, Karen Yeates, Santosh Varughese, Einar Svarstad and Onesmo Kisanga

Renal injury following long-term exposure to carbon disulfide: analysis of a case series

To investigate the clinicopathological characteristics of renal damage caused by long-term exposure to carbon disulfide (CS2) in nine patients.

Authors: Yongqin Yan, Cheng Wang, Zhiyong Zheng, Lijuan Qu, Dehua Zeng and Min Li

A case report on lipofuscin deposition in a graft biopsy two years after kidney transplantation: an insignificant bystander or a pathogenic benefactor?

Lipofuscin deposition is a characteristic manifestation of aging. There is very limited literature in humans and in animals describing these deposits in native kidneys. Overall, it is thought to be non-pathoge...

Authors: Vivian W. Y. Leung, Sarah-Jeanne Pilon, Pierre O. Fiset and Shaifali Sandal

TAFRO syndrome as a cause of glomerular microangiopathy: a case report and literature review

TAFRO syndrome is a systemic inflammatory disorder that manifests as thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Renal dysfunction is frequently complicated wit...

Authors: Yoshikuni Nagayama, Mizuki Yamano, Motoka Yagame, Tomoyuki Nariyama, Mikiko Takahashi, Masashi Kawamoto and Katsuyuki Matsui

Treatment of lead and arsenic poisoning in anuric patients – a case report and narrative review of the literature

Heavy metal poisoning can cause debilitating illness if left untreated, and its management in anuric patients poses challenges. Literature with which to guide clinical practice in this area is rather scattered.

Authors: Chun-Yuan Hsiao, Chip Gresham and Mark R. Marshall

Association of medication non-adherence with short-term allograft loss after the treatment of severe acute kidney transplant rejection

Medication non-adherence is a risk factor for acute kidney transplant rejection. The association of non-adherence with short-term allograft loss in patients who develop acute rejection and are subsequently tre...

Authors: Ahmed Al-Sheyyab, Laura Binari, Mohammed Shwetar, Everly Ramos, Meghan E. Kapp, Stefanie Bala, Nikita Wilson, Rachel C. Forbes, J. Harold Helderman, Khaled Abdel-Kader and Beatrice P. Concepcion

A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat, administered three times weekly in patients with anemia on hemodialysis

Daprodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor currently being investigated as a treatment for anemia of chronic kidney disease (CKD) in both dialysis and nondialysis patients. In clini...

Authors: Christine K. Bailey, Stephen Caltabiano, Alexander R. Cobitz, Chun Huang, Kelly M. Mahar and Vickas V. Patel

Comparison between three different equations for the estimation of glomerular filtration rate in predicting mortality after coronary artery bypass

This study was undertaken to compare the accuracy of chronic kidney disease-epidemiology collaboration (eGFR_CKD-EPI) to modification of diet in renal disease (eGFR_MDRD) and the Cockcroft-Gault formulas of Creatin...

Authors: Sandro Gelsomino, Massimo Bonacchi, Fabiana Lucà, Fabio Barili, Stefano Del Pace, Orlando Parise, Daniel M. Johnson and Michele Massimo Gulizia

Clinical practice guideline on undernutrition in chronic kidney disease

Authors: Mark Wright, Elizabeth Southcott, Helen MacLaughlin and Stuart Wineberg

Association between mineral and bone disorder in patients with acute kidney injury following cardiac surgery and adverse outcomes

Numerous studies have evaluated the prevalence and importance of mineral and bone disorders among patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, little is known about d...

Authors: Tianye Yang, Wenji Wang, Xiao Tang, Peng Shi, Lulu Zhang, Wenyan Yu, Yingxin Xie, Daqiao Guo and Feng Ding

Complete post-operative resolution of “temporary” end-stage kidney disease secondary to aortic dissection without static renal artery obstruction: a case study

Acute kidney injury (AKI), which may progress to end-stage kidney disease (ESKD), is a potential complication of aortic dissection. Notably, in all reported ESKD cases secondary to aortic dissection, imaging e...

Authors: Yoshihiro Mukaiyama, Akira Okada, Yutaro Kawakatsu, Satoshi Akuzawa, Kazuchika Suzuki, Naoyuki Ishigami and Tatsuo Yamamoto

Early detection of acute kidney injury in the perioperative period of liver transplant with neutrophil gelatinase-associated lipocalin

Acute kidney injury (AKI) is a common complication in patients undergoing liver transplant (LT) and is associated with high morbidity and mortality. We aim to evaluate the pattern of urine and plasma neutrophi...

Authors: Camila Lima, Luciana Bertocco de Paiva Haddad, Patrícia Donado Vaz de Melo, Luiz Marcelo Malbouisson, Lilian Pires Freitas do Carmo, Luiz Augusto Carneiro D’Albuquerque and Etienne Macedo

Ipilimumab-induced renal granulomatous arteritis: a case report

Immune Checkpoint Inhibitors (ICPIs) are promising new drugs in treatment of advanced tumours targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death protein-1 (PD1) or its ligand (PDL-1)...

Authors: Mathilde Lemoine, Baptiste Dilly, Alexandre Curie, Vivien Hébert, Charlotte Laurent, Mélanie Hanoy, Steven Grangé, Dominique Guerrot, Arnaud François and Dominique Bertrand

The EKiTE network (epidemiology in kidney transplantation - a European validated database): an initiative epidemiological and translational European collaborative research

Kidney transplantation is considered to be the treatment of choice for people with end-stage renal disease (ESRD). However, due to the shortage of available organs and the increase in the ESRD prevalence in Eu...

Authors: M. Lorent, Y. Foucher, K. Kerleau, S. Brouard, C. Baayen, S. Lebouter, M. Naesens, O. Bestard Matamoros, A. Åsberg and M. Giral

Use of intravoxel incoherent motion imaging to monitor a rat kidney chronic allograft damage model

Chronic allograft damage (CAD) is the leading cause of long-term graft dysfunction. A noninvasive method that can diagnose CAD early and monitor its development is needed.

Authors: Qiang Zhang, Zexing Yu, Song Zeng, Lu Liang, Yue Xu, Zijian Zhang, Hao Tang, Wenjiao Jiao, Wenrui Xue, Wei Wang, Xiaodong Zhang, Tao Jiang and Xiaopeng Hu

Association between the Charlson Comorbidity Index and the risk of 30-day unplanned readmission in patients receiving maintenance dialysis

Patients receiving maintenance hemodialysis (HD) and peritoneal dialysis (PD) are frequently hospitalized. Reducing unplanned 30-day hospital readmissions is a key priority for improving the quality of health ...

Authors: Yu Lin, Chao Yang, Hong Chu, Jingyi Wu, Ke Lin, Ying Shi, Haibo Wang, Guilan Kong and Luxia Zhang

Hyperphosphatemia and risks of acute kidney injury, end-stage renal disease, and mortality in hospitalized patients

Hyperphosphatemia is associated with vascular calcification and bone mineral disorders and is a major concern among patients with chronic kidney disease (CKD). However, the relationship between hyperphosphatem...

Authors: Hongran Moon, Ho Jun Chin, Ki Young Na, Kwon Wook Joo, Yon Su Kim, Sejoong Kim and Seung Seok Han

Dutch nOcturnal and hoME dialysis Study To Improve Clinical Outcomes (DOMESTICO): rationale and design

More than 6200 End Stage Renal Disease patients in the Netherlands are dependent on dialysis, either performed at home or in a dialysis centre. Visiting a dialysis centre three times a week is considered a lar...

Authors: A. van Eck van der Sluijs, A. A. Bonenkamp, F. W. Dekker, A. C. Abrahams and B. C. van Jaarsveld

Serum anti-phospholipase A2 receptor (PLA2R) antibody detected at diagnosis as a predictor for clinical remission in patients with primary membranous nephropathy: a meta-analysis

The diagnostic value of serum M-type phospholipase A2 receptor antibody (sPLA2R-ab) expression in patients with primary membranous nephropathy (PMN) has been established. However, the association between sPLA2...

Authors: Yufeng Liang, Jianxin Wan, Yongping Chen and Yangbin Pan

In search of potential predictors of erythropoiesis-stimulating agents (ESAs) hyporesponsiveness: a population-based study

Evidences show that around 20% of biosimilar or originator erythropoiesis-stimulating agents (ESAs) users are hyporesponsive. Controversial post-marketing data exist on the predictors of ESA hyporesponsiveness...

Authors: Ingrasciotta Ylenia, Lacava Viviana, Marcianò Ilaria, Giorgianni Francesco, Tripepi Giovanni, D’ Arrigo Graziella, Chinellato Alessandro, Tari Daniele Ugo, Santoro Domenico and Trifirò Gianluca

Molecular mechanisms of hydrogen sulfide against uremic accelerated atherosclerosis through cPKCβII/Akt signal pathway

Cardiovascular disease is the most common complication and leading cause of death in maintenance hemodialysis patients. The protection mechanism of hydrogen sulfide (H₂S) and the specific role of conventional pro...

Authors: Ruifang Xiong, Xiangxue Lu, Jinghong Song, Han Li and Shixiang Wang

Lab-based and diagnosis-based chronic kidney disease recognition and staging concordance

Chronic kidney disease (CKD) is often under-recognized and poorly documented via diagnoses, but the extent of under-recognition is not well understood among Medicare beneficiaries. The current study used claim...

Authors: Clarissa J. Diamantidis, Sarah L. Hale, Virginia Wang, Valerie A. Smith, Sarah Hudson Scholle and Matthew L. Maciejewski

Measuring the palpable pulsatility length as a physical examination test in defining the severity of inflow stenosis for hemodialysis fistulas

Pulsatility is an important property of hemodialysis arteriovenous fistulas (AVF) and can be perceived by the fingers as a gradual decrease in strength downstream from the anastomosis along the main trunk of t...

Authors: Matt Chiung-Yu Chen, Mei-Jui Weng, Misoso Yi-Wen Wu, Yi-Chun Liu and Wen-Che Chi

TRPP2 dysfunction decreases ATP-evoked calcium, induces cell aggregation and stimulates proliferation in T lymphocytes

Autosomal dominant polycystic kidney disease (ADPKD) is mainly characterised by the development and enlargement of renal cysts that lead to end-stage renal disease (ESRD) in adult patients. Other clinical mani...

Authors: Riccardo Magistroni, Alessandra Mangolini, Sonia Guzzo, Francesca Testa, Mario R. Rapanà, Renzo Mignani, Giorgia Russo, Francesco di Virgilio and Gianluca Aguiari

Possible beneficial association between renin-angiotensin-aldosterone-system blockade usage and graft prognosis in allograft IgA nephropathy: a retrospective cohort study

Although immunoglobulin A nephropathy (IgAN) is associated with an increased risk of renal allograft failure, evidences for its treatment, including renin-angiotensin-aldosterone system blockade (RAASB) usage,...

Authors: Sehoon Park, Chung Hee Baek, Heounjeong Go, Young Hoon Kim, Sang–il Min, Jongwon Ha, Yong Chul Kim, Jung Pyo Lee, Yon Su Kim, Kyung Chul Moon, Su-Kil Park and Hajeong Lee

Case report: extreme coronary calcifications and hypomagnesemia in a patient with a 17q12 deletion involving HNF1B

17q12 deletion syndrome encompasses a broad constellation of clinical phenotypes, including renal magnesium wasting, maturity-onset diabetes of the young (MODY), renal cysts, genitourinary malformations, and n...

Authors: Howard J. Li, Catherine Groden, Melanie P. Hoenig, Evan C. Ray, Carlos R. Ferreira, Willam Gahl and Danica Novacic

Mycophenolate mofetil and tacrolimus versus tacrolimus alone for the treatment of idiopathic membranous glomerulonephritis: a randomised controlled trial

Tacrolimus (TAC) is effective in treating membranous nephropathy (MN); however relapses are frequent after treatment cessation. We conducted a randomised controlled trial to examine whether the addition of myc...

Authors: Aikaterini Nikolopoulou, Marie Condon, Tabitha Turner-Stokes, H. Terence Cook, Neill Duncan, Jack W. Galliford, Jeremy B. Levy, Liz Lightstone, Charles D. Pusey, Candice Roufosse, Thomas D. Cairns and Megan E. Griffith

Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model

Spironolactone can improve endothelial dysfunction in the setting of heart failure and diabetes models. However, its beneficial effect in the cardiovascular system is not clear in the setting of non-diabetic r...

Authors: Chun-Cheng Wang, An-Sheng Lee, Shu-Hui Liu, Kuan-Cheng Chang, Ming-Yi Shen and Chiz-Tzung Chang

Vasoactive intestinal peptide ameliorates renal injury in a pristane-induced lupus mouse model by modulating Th17/Treg balance

Lupus nephritis (LN) is an inflammation of the kidneys and is a major cause of mortality in systemic lupus erythaematosus (SLE) patients. In addition, Th17/Treg balance is one of the most important factors tha...

Authors: Dongdong Fu, Soulixay Senouthai, Junjie Wang and Yanwu You

A case report of a young girl with recurrent hematuria: a missed diagnosis - renal nutcracker syndrome

Nutcracker syndrome is an easily missed cause of hematuria in children. It is characterized by left renal vein entrapment between the abdominal aorta and the superior mesenteric artery causing renal venous hyp...

Authors: Haifa Ali Bin Dahman and Ali Omer Aljabry

Blood pressure management in hypertensive people with non-dialysis chronic kidney disease in Queensland, Australia

High blood pressure is the most significant risk factor for the development and progression of chronic kidney disease (CKD). Lowering blood pressure is a goal to prevent CKD progression. This study of adults w...

Authors: Jianzhen Zhang, Helen G. Healy, Sree Krishna Venuthurupalli, Ken-Soon Tan, Zaimin Wang, Anne Cameron and Wendy E. Hoy

Non-invasive hemodynamic profiling of patients undergoing hemodialysis - a multicenter observational cohort study

Intradialytic blood pressure (BP) measurement is currently the main parameter used for monitoring hemodynamics during hemodialysis (HD). Since BP is dependent on cardiac output and total peripheral resistance,...

Authors: Keren Doenyas-Barak, Marcia H. F. G. de Abreu, Lucas E. Borges, Helcio A. Tavares Filho, Feng Yunlin, Zou Yurong, Nathan W. Levin, Allen M. Kaufman, Shay Efrati, David Pereg, Ilya Litovchik, Shmuel Fuchs and Sa’ar Minha

Next generation sequencing based assessment of the alloreactive T cell receptor repertoire in kidney transplant patients during rejection: a prospective cohort study

Kidney transplantation is the optimal treatment in end stage renal disease but the allograft survival is still hampered by immune reactions against the allograft. This process is driven by the recognition of a...

Authors: Constantin Aschauer, Kira Jelencsics, Karin Hu, Andreas Heinzel, Julia Vetter, Thomas Fraunhofer, Susanne Schaller, Stephan Winkler, Lisabeth Pimenov, Guido A. Gualdoni, Michael Eder, Alexander Kainz, Heinz Regele, Roman Reindl-Schwaighofer and Rainer Oberbauer

Evaluation of the association of Wnt signaling with coronary artery calcification in patients on dialysis with severe secondary hyperparathyroidism

Patients with end-stage renal disease have a higher risk of death from cardiovascular events, which can be mainly attributed to coronary artery calcification (CAC). Wnt signaling is involved in vascular develo...

Authors: Tzung-Yo Ho, Nai-Ching Chen, Chih-Yang Hsu, Chien-Wei Huang, Po-Tsang Lee, Kang-Ju Chou, Hua-Chang Fang and Chien-Liang Chen

Patient-reported outcome measures: selection of a valid questionnaire for routine symptom assessment in patients with advanced chronic kidney disease – a four-phase mixed methods study

Patient-reported outcome measures (PROMs) are becoming increasingly important in healthcare. In nephrology, there is no agreement on which chronic kidney disease (CKD) symptom questionnaire to use. Therefore, ...

Authors: Esmee M. van der Willik, Yvette Meuleman, Karen Prantl, Giel van Rijn, Willem Jan W. Bos, Frans J. van Ittersum, Hans A. J. Bart, Marc H. Hemmelder and Friedo W. Dekker

The association of neighborhood racial mix and ED visit count in a cohort of patients on hemodialysis

Neighborhood racial mix is associated with dialysis facility performance metrics and mortality outcomes in patients on hemodialysis. We explored the association of neighborhood racial mix with emergency depart...

Authors: Ladan Golestaneh, Atessa Farzami, Chikeluba Madu, Tanya Johns, Michal L. Melamed and Keith C. Norris

The relation between dialysis-requiring acute kidney injury and recovery from end-stage renal disease: a national study

Approximately 4–6% of incident end stage renal disease (ESRD) patients in the U.S. recover enough kidney function to discontinue dialysis but there is considerable geographic variation. We undertook this study...

Authors: Zijin Chen, Benjamin J. Lee, Charles E. McCulloch, Nilka Ríos Burrows, Michael Heung, Raymond K. Hsu, Meda E. Pavkov, Neil R. Powe, Rajiv Saran, Vahakn Shahinian and Chi-yuan Hsu

Prevalence of kidney damage in Chinese elderly: a large-scale population-based study

In China, both population aging and kidney damage has become emerging public health challenges. Despite the number of elders is huge, data on kidney damage in this population are scarce. The present study aime...

Authors: Honglan Wei, Yaqiong Yan, Jie Gong and Junwu Dong

Retrospective genetic analysis illustrates the spectrum of autosomal Alport syndrome in a case of living-related donor kidney transplantation

Kidney transplantation is the treatment of choice in end-stage renal disease due to Alport syndrome (AS). However, the chances of finding an adequate living-related donor in AS are much worse compared to non-h...

Authors: Friederike Petzold, Anette Bachmann, Carsten Bergmann, Udo Helmchen and Jan Halbritter

Clinical characteristics and outcomes in microscopic polyangiitis patients with renal involvement: a study of 124 Chinese patients

Microscopic polyangiitis (MPA) is a systemic autoimmune disease, and renal involvement is frequently present in MPA. MPA patients with renal involvement may have a worse prognosis. In this study, we aimed to e...

Authors: Jia Shi, Qing Shen, Xue-Mei Chen and Xiao-Gang Du

Effect of bioelectrical impedance analysis-guided dry weight adjustment, in comparison to standard clinical-guided, on the sleep quality of chronic haemodialysis patients (BEDTIME study): a randomised controlled trial

Sleep disturbance is common among chronic haemodialysis patients, which leads to poor quality of life, in addition to increased instances of morbidity and mortality. Hypervolemia has been linked to sleep probl...

Authors: Sethanant Sethakarun, Sutachard Bijaphala, Chagriya Kitiyakara, Sarinya Boongird, Pariya Phanachet, Sirimon Reutrakul, Kwanchai Pirojsakul and Arkom Nongnuch

The incidence, prevalence and trends of Chronic Kidney Disease and Chronic Kidney Disease of uncertain aetiology (CKDu) in the North Central Province of Sri Lanka: an analysis of 30,566 patients

Chronic Kidney Disease (CKD) of uncertain origin (CKDu) has affected North Central Province (Anuradhapura and Polonnaruwa districts) of Sri Lanka. The cause is still unknown. The objective of this study was to...

Authors: Asanga Venura Ranasinghe, Gardiye Weligamage Gamini Priyantha Kumara, Ranamuka Henayage Karunarathna, Ambepitiyawaduge Pubudu De Silva, Korale Gedara Dilini Sachintani, Jayaprakara Mudiyanselage Chathurika Nayani Gunawardena, Sembu Kuttige Champika Ruwan Kumari, Mohamed Shali Fathima Sarjana, Janaka Sri Chandraguptha and Mannikawadumesthri Vipula Chandu De Silva

PKD1-associated autosomal dominant polycystic kidney disease with glomerular cysts presenting with nephrotic syndrome caused by focal segmental glomerulosclerosis

Autosomal dominant polycystic kidney disease (ADPKD) may manifest non-nephrotic range proteinuria, but is rarely complicated with nephrotic syndrome. Limited number of reports describe the histology of ADPKD w...

Authors: Yasuhiro Oda, Naoki Sawa, Eiko Hasegawa, Hiroki Mizuno, Masahiro Kawada, Akinari Sekine, Rikako Hiramatsu, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Kenmei Takaichi, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii and Yoshifumi Ubara

Intrarenal microRNA signature related to the fibrosis process in chronic kidney disease: identification and functional validation of key miRNAs

Though the roles of microRNAs (miRNAs) in renal diseases have been extensively investigated, a thorough screening and comparison of miRNAs among different types of chronic kidney disease (CKD) has never been p...

Authors: Jianwen Yu, Chaolun Yu, Boya Feng, Xiaojiang Zhan, Ning Luo, Xueqing Yu and Qin Zhou

A case report of immunoglobulin M nephropathy manifesting as crescentic glomerulonephritis and nephrotic syndrome in an adult

The nature of immunoglobulin M (IgM) nephropathy has been controversial for a long time, but it is now considered an independent disease like immunoglobulin A nephropathy. IgM nephropathy has been known to hav...

Authors: Kyoung Sook Park, Ea Wha Kang and Jeong Hae Kie

Clinico-pathological considerations in a 48-years-old female with acute kidney injury: is it lupus nephritis, ANCA-associated vasculitis or something else?

The value of ANCA positivity in the setting of systemic lupus erythematous and their pathogenicity remains uncertain.

Authors: Marie Lemerle, Anne-Sophie Garnier, Anne Croue, Alain Chevailler, Jean-Paul Saint-André, Jean-François Subra, Jean-François Augusto and Julien Demiselle

Efficacy and safety of immunosuppressive treatment in IgA nephropathy: a meta-analysis of randomized controlled trials

Immunosuppressive agents have been widely used in the treatment of IgA nephropathy (IgAN), but the efficacy and safety remain controversial. The recent STOP-IgAN and TESTING studies have again focused attentio...

Authors: Zheng Zhang, Yue Yang, Shi-min Jiang and Wen-ge Li

Expression of THSD7A in neoplasm tissues and its relationship with proteinuria

Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies....

Authors: Li Xian, Dandan Dong, Jiamei Luo, Ling Zhuo, Ke Li, Ping Zhang, Wei Wang, Ying Xu, Gang Xu, Li Wang and Guisen Li

Intravenous iron supplementation does not increase infectious disease risk in hemodialysis patients: a nationwide cohort-based case-crossover study

Studies have reported conflicting findings on the infection risk posed by intravenous iron supplementation among hemodialysis (HD) patients. We used a novel study design to assess associations between intraven...

Authors: Chieh-Li Yen, Yu-Sheng Lin, Yueh-An Lu, Hsin-Fu Lee, Cheng-Chia Lee, Ying-Chang Tung, George Kuo, Lung-Sheng Wu, Ya-Chung Tian and Pao-Hsien Chu