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  1. Previous study showed that purinergic P2X7 receptors (P2X7R) reach the highest expression in the first week after unilateral ureteral obstruction (UUO) in mice, and are involved in the process of inflammation,...

    Authors: José Monteiro Sad Pereira, André Luis Barreira, Conrado Rodrigues Gomes, Felipe Mateus Ornellas, Débora Santos Ornellas, Luiz Carlos Miranda, Lucio Ronaldo Cardoso, Robson Coutinho-Silva, Alberto Schanaider, Marcelo M. Morales, Maurilo Leite Jr and Christina Maeda Takiya

    Citation: BMC Nephrology 2020 21:206

    Content type: Research article

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  2. Peritoneal dialysis (PD) is a home-based therapy performed by patients or their relatives in numerous cases, and the role of patients’ educational practices in the risk of peritonitis is not well assessed. Our...

    Authors: Hélène Bonnal, Clémence Bechade, Annabel Boyer, Thierry Lobbedez, Sonia Guillouët, Christian Verger, Maxence Ficheux and Antoine Lanot

    Citation: BMC Nephrology 2020 21:205

    Content type: Research article

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  3. Thrombotic microangiopathies (TMAs) occurring in the postpartum period may be difficult to manage. They present as the combination of mechanical hemolytic anemia and consumption thrombocytopenia due to endothe...

    Authors: Cyril Mousseaux, Bérangère S. Joly, Inna Mohamadou, Romain Arrestier, Alexandre Hertig and Cédric Rafat

    Citation: BMC Nephrology 2020 21:204

    Content type: Case report

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  4. Patients with chronic kidney disease (CKD) reportedly have a high prevalence of aortic valve calcification (AVC). In population-based studies, AVC is considered a manifestation of systemic atherosclerosis. The...

    Authors: Yui Arita, Masaru Nakayama, Yuta Matsukuma, Ryota Yoshitomi, Makiko Seki, Akiko Fukui, Susumu Tsuda, Yuri Sonoda, Rina Imazu, Kimika Arakawa, Mitsuhiro Tominaga, Toshiaki Nakano, Kazuhiko Tsuruya and Takanari Kitazono

    Citation: BMC Nephrology 2020 21:203

    Content type: Research article

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  5. Urological malignancy (UM) in patients with chronic kidney disease (CKD) is an added burden to their overall morbidity and mortality. UM is itself a common cause of CKD. Understanding the associations of UM wi...

    Authors: Rajkumar Chinnadurai, Noel W. Clarke and Philip A. Kalra

    Citation: BMC Nephrology 2020 21:202

    Content type: Research article

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  6. Abdominal aortic aneurysms (AAA) primarily affect men over 65 years old who often have many other diseases, with similar risk factors and pathobiological mechanisms to AAA. The aim of this study was to assess ...

    Authors: Milena Miszczuk, Verena Müller, Christian E. Althoff, Andrea Stroux, Daniela Widhalm, Andy Dobberstein, Andreas Greiner, Helena Kuivaniemi and Irene Hinterseher

    Citation: BMC Nephrology 2020 21:201

    Content type: Research article

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Gregory A. Nichols, Anouk Déruaz-Luyet, Kimberly G. Brodovicz, Teresa M. Kimes, A. Gabriela Rosales and Sibylle J. Hauske

    Citation: BMC Nephrology 2020 21:200

    Content type: Correction

    Published on:

    The original article was published in BMC Nephrology 2020 21:167

  8. A large body mass index (BMI) has been considered as a relative contraindication for percutaneous catheter insertion, although this technique has many advantages. Up to now, there are few studies on peritoneal...

    Authors: Dayang Xie, Jianhui Zhou, Xueying Cao, Qingtao Zhang, Yanli Sun, Li Tang, Jing Huang, Juanli Zheng, Li Lin, Zhenzhen Li, Guangyan Cai and Xiangmei Chen

    Citation: BMC Nephrology 2020 21:199

    Content type: Research article

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  9. To examine the prevalence of chronic kidney disease (CKD) and its associations in a Russian population.

    Authors: Mukharram M. Bikbov, Rinat M. Zainullin, Gyulli M. Kazakbaeva, Timur R. Gilmanshin, Ellina M. Rakhimova, Iulia A. Rusakova, Natalia I. Bolshakova, Kamila R. Safiullina, Songhomitra Panda-Jonas, Dilya F. Yakupova, Nikolai A. Nikitin and Jost B. Jonas

    Citation: BMC Nephrology 2020 21:198

    Content type: Research article

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  10. Physical activity (PA) is typically lower on hemodialysis (HD) days. Albeit intradialytic inactivity is expected, it is unknown whether recovery after HD contributes to low PA. We investigated the impact of HD...

    Authors: John W. Larkin, Maggie Han, Hao Han, Murilo H. Guedes, Priscila Bezerra Gonçalves, Carlos Eduardo Poli-de-Figueiredo, Américo Lourenço Cuvello-Neto, Ana Beatriz L. Barra, Thyago Proença de Moraes, Len A. Usvyat, Peter Kotanko, Maria Eugenia F. Canziani, Jochen G. Raimann and Roberto Pecoits-Filho

    Citation: BMC Nephrology 2020 21:197

    Content type: Research article

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  11. The kidney is a major target in primary antiphospholipid syndrome. Several types of nephropathy have been reported, the most frequent being acute or chronic specific vascular nephropathies and membranous nephr...

    Authors: Maxime Teisseyre, Hélène Perrochia, Pascal Reboul, Sylvain Cariou, Sophie Renaud, Cédric Aglae and Olivier Moranne

    Citation: BMC Nephrology 2020 21:196

    Content type: Case report

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  12. Fibrillary glomerulonephritis (FGN) is distinguished from amyloidosis by thicker fibrils and the lack of staining with histochemical dyes typically reactive with amyloid. However, congophilic FGN has been prop...

    Authors: Misa Adachi, Mineaki Kitamura, Kumiko Muta, Akihiro Maekawa, Tadashi Uramatsu, Masato Tadokoro, Satoshi Funakoshi, Satoshi Hisano, Naomi Kuwahara, Akira Shimizu, Hiroshi Mukae and Tomoya Nishino

    Citation: BMC Nephrology 2020 21:195

    Content type: Case report

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  13. Accurate assessment of volume status to direct dialysis remains a clinical challenge. Despite current attempts at volume-directed dialysis, inadequate dialysis and intradialytic hypotension (IDH) are common oc...

    Authors: Bret D. Alvis, Monica Polcz, Merrick Miles, Donald Wright, Mohammad Shwetar, Phil Leisy, Rachel Forbes, Rachel Fissell, Jon Whitfield, Susan Eagle, Colleen Brophy and Kyle Hocking

    Citation: BMC Nephrology 2020 21:194

    Content type: Technical advance

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  15. Kidney transplantation remains the optimal therapy for patients with end stage kidney disease (ESKD), though a small fraction of patients on dialysis are on organ waitlists. An important barrier to both preemp...

    Authors: Samira S. Farouk, Sara Atallah, Kirk N. Campbell, Joseph A. Vassalotti and Jaime Uribarri

    Citation: BMC Nephrology 2020 21:192

    Content type: Research article

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  16. Currently, there is limited epidemiology data on acute kidney injury (AKI) in Indonesia. Therefore, we assessed the incidence of AKI and the utilization of renal replacement therapy (RRT) in Indonesia.

    Authors: Jonny Jonny, Moch Hasyim, Vedora Angelia, Ayu Nursantisuryani Jahya, Lydia Permata Hilman, Venna Febrian Kusumaningrum and Nattachai Srisawat

    Citation: BMC Nephrology 2020 21:191

    Content type: Research article

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  17. Arterial reconstruction is one of the paramount procedures in kidney transplantation (KT) and greatly important if the procured kidney has multiple renal arteries (MRA). Despite various established techniques ...

    Authors: Mitsuru Tomizawa, Shunta Hori, Nobutaka Nishimura, Chihiro Omori, Yasushi Nakai, Makito Miyake, Tatsuo Yoneda and Kiyohide Fujimoto

    Citation: BMC Nephrology 2020 21:190

    Content type: Case report

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  18. Atypical hemolytic uremic syndrome (aHUS) can result in severe kidney dysfunction, secondary to thrombotic microangiopathy. Eculizumab has been used to treat this disorder, and has resulted in favourable outco...

    Authors: Sam Kant, Anshul Bhalla, Sami Alasfar and Nada Alachkar

    Citation: BMC Nephrology 2020 21:189

    Content type: Research article

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  19. There is a lack of empirical effort that systematically investigates the clustering of comorbidity among known risk factors (obesity, hypertension, diabetes, hypercholesterolemia, and elevated inflammation) of...

    Authors: Agus Surachman, Jonathan Daw, Bethany C. Bray, Lacy M. Alexander, Christopher L. Coe and David M. Almeida

    Citation: BMC Nephrology 2020 21:188

    Content type: Research article

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  20. T-type calcium channels (TTCC) are involved in mesangial cell proliferation. In acute thy-1 nephritis in the rat TTCC inhibition reduces glomerular damage and cell proliferation. This work is extended here by ...

    Authors: Andrea Cove-Smith, Claire C. Sharpe, Michael J. Shattock and Bruce M. Hendry

    Citation: BMC Nephrology 2020 21:187

    Content type: Research article

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  21. Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) a...

    Authors: Anas AlYousef, Ali AlSahow, Bassam AlHelal, Ahmed Alqallaf, Emad Abdallah, Mohammed Abdellatif, Hani Nawar and Riham Elmahalawy

    Citation: BMC Nephrology 2020 21:186

    Content type: Research article

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  22. Quality of life (QOL) is important to patients with end stage renal disease and their partners. Despite the first 12 weeks being a critical time in the treatment pathway, limited research exists which examines...

    Authors: Currie Moore, Lesley-Anne Carter, Sandip Mitra, Suzanne Skevington and Alison Wearden

    Citation: BMC Nephrology 2020 21:185

    Content type: Research article

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  23. Crystalglobulin-associated nephropathy (CAN), a rare subtype of monoclonal gammopathy, usually associated with multiple myeloma and occasionally monoclonal gammopathy of uncertain significance (MGUS), is chara...

    Authors: Rajib K. Gupta, Lois J. Arend, Anupama BK, Sriram Narsipur and Ramya Bhargava

    Citation: BMC Nephrology 2020 21:184

    Content type: Case report

    Published on:

  24. Continuous ambulatory peritoneal dialysis (CAPD) patients have a high incidence of stroke and commonly have increased parathyroid hormone levels and vitamin D insufficiency. We seek to investigate the incidenc...

    Authors: Xiaohan You, Ying Zhou, Jianna Zhang, Qiongxiu Zhou, Yanling Shi, Zhen Su, Chaoshen Chen, Rongrong Shao and Ji Zhang

    Citation: BMC Nephrology 2020 21:183

    Content type: Research article

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  25. Thalassemia is a group of hereditary diseases characterized by a common recessive monogenic hematological disorder, presenting a significant public health concern in the developing countries. Recent studies ha...

    Authors: Jun Ni, Caifeng Zhu, Xiaoqiu Ni and Jiazhen Yin

    Citation: BMC Nephrology 2020 21:182

    Content type: Case report

    Published on:

  26. We aimed to develop a nomogram based on preprocedural features for early prediction of acute kidney injury (AKI) and to assess the prognosis in patients after radical and partial nephrectomy.

    Authors: Lingyu Xu, Chenyu Li, Long Zhao, Bin Zhou, Congjuan Luo, Xiaofei Man, Hong Luan, Lin Che, Yanfei Wang and Yan Xu

    Citation: BMC Nephrology 2020 21:181

    Content type: Research article

    Published on:

  27. Peritoneal ultrafiltration (pUF) in refractory heart failure (HF) reduces the incidence of decompensation episodes, which is of particular significance as each episode incrementally adds to mortality. Neverthe...

    Authors: Leonie Grossekettler, Bastian Schmack, Carsten Brockmann, Reinhard Wanninger, Michael M. Kreusser, Lutz Frankenstein, Lars P. Kihm, Martin Zeier, Hugo A. Katus, Vedat Schwenger and Andrew Remppis

    Citation: BMC Nephrology 2020 21:179

    Content type: Research article

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  28. Induction therapy is crucial in kidney transplantation and constitutes an important cornerstone for long-term allograft survival. Alemtuzumab is a depleting CD52-specific antibody with T- and B-cell activity, ...

    Authors: Martina Guthoff, Kilian Berger, Karina Althaus, Thomas Mühlbacher, Tamam Bakchoul, Wolfgang Steurer, Silvio Nadalin, Alfred Königsrainer and Nils Heyne

    Citation: BMC Nephrology 2020 21:178

    Content type: Research article

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  29. Burnout syndrome in physicians is associated with adverse patient safety events, poorer quality of care and reduced patients’ satisfaction. There has been scarce information on the risk factors of burnout affe...

    Authors: Ewa Pawłowicz and Michał Nowicki

    Citation: BMC Nephrology 2020 21:177

    Content type: Research article

    Published on:

  30. phosphate homeostasis is mediated through complex counter regulatory feed-back balance between parathyroid hormone, FGF-23 and 1,25(OH)2D. Both parathyroid hormone and FGF-23 regulate proximal tubular phosphat...

    Authors: Forough Saki, Seyed Reza Kassaee, Azita Salehifar and Gholam Hossein Ranjbar Omrani

    Citation: BMC Nephrology 2020 21:176

    Content type: Research article

    Published on:

  31. Monoclonal immunoglobulin deposition disease (MIDD) is a rare condition accounting for < 1% of histopathological diagnoses made on kidney biopsy1. The best outcomes are seen in those diagnosed and treated promptl...

    Authors: Michael Turner, Anna Crawford, Claire Winterbottom, Oliver Flossmann, Bassam Alchi, Maria Soares and Umanath Bhandary

    Citation: BMC Nephrology 2020 21:175

    Content type: Case report

    Published on:

  32. Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes, and is the most important cause of death for diabetic patients. Baicalin (BAI) has anti-oxidative, anti-inflammatory a...

    Authors: Xiao-peng Zheng, Qing Nie, Jing Feng, Xiao-yan Fan, Yue-lei Jin, Guang Chen and Ji-wei Du

    Citation: BMC Nephrology 2020 21:174

    Content type: Research article

    Published on:

  33. Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingolipids and produced by sphingosine kinases (SphK1 and SphK2). SphK1/S1P pathway is implicated in the progression of chronic kidney disease. How...

    Authors: Bingqing Lyu, Weili Wang, Xin-Ying Ji, Joseph K. Ritter and Ningjun Li

    Citation: BMC Nephrology 2020 21:173

    Content type: Research article

    Published on:

  34. Rehabilitation effects of exercise training on adults with chronic kidney disease (CKD) have been generally recognised; however, the effects of exercise training on proteinuria have been underexplored. Our aim...

    Authors: Lei Yang, Xiaoxia Wu, Ying Wang, Chunfeng Wang, Rong Hu and Yong Wu

    Citation: BMC Nephrology 2020 21:172

    Content type: Research article

    Published on:

  35. Female Dent disease 1 patients with low-molecular-weight proteinuria (LMWP) due to CLCN5 gene mutation were rarely reported, and these cases that the people were also with Turner syndrome (TS) were even hardly do...

    Authors: Yuhong Ye, Jingjing Wang, Xiaofang Quan, Ke Xu, Haidong Fu, Weiyue Gu and Jianhua Mao

    Citation: BMC Nephrology 2020 21:171

    Content type: Case report

    Published on:

  36. Schimke immuno-osseous dysplasia (SIOD) is a rare autosomal recessive disorder characterized by spondyloepiphyseal dysplasia, progressive renal insufficiency and defective cellular immunity. Podocytic infoldin...

    Authors: Shiqiu Xiong, Lanjun Shuai, Xiaoyan Li, Xiqiang Dang, Xiaochuan Wu and Qingnan He

    Citation: BMC Nephrology 2020 21:170

    Content type: Case report

    Published on:

  37. Impaired kidney function is the hallmark of chronic kidney disease (CKD), and is associated with increased risk of all-cause mortality in the elderly. In the present cross-sectional population-based study, we ...

    Authors: Horng-Jinh Chang, Kuan-Reng Lin, Meng-Te Lin and Junn-Liang Chang

    Citation: BMC Nephrology 2020 21:169

    Content type: Research article

    Published on:

  38. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Daniela Gerges-Knafl, Peter Pichler, Alexander Zimprich, Christoph Hotzy, Wolfgang Barousch, Rita M. Lang, Elisabeth Lobmeyr, Sabina Baumgartner-Parzer, Ludwig Wagner and Wolfgang Winnicki

    Citation: BMC Nephrology 2020 21:168

    Content type: Correction

    Published on:

    The original article was published in BMC Nephrology 2020 21:117

  39. Studies of progression of kidney dysfunction typically focus on renal replacement therapy or percentage decline in estimated glomerular filtration rate (eGFR) as outcomes. Our aim was to compare real-world pat...

    Authors: Gregory A. Nichols, Anouk Déruaz-Luyet, Kimberly G. Brodovicz, Teresa M. Kimes, A. Gabriela Rosales and Sibylle J. Hauske

    Citation: BMC Nephrology 2020 21:167

    Content type: Research article

    Published on:

  40. Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commo...

    Authors: Yu Ho Lee, Jin Sug Kim, Su-Woong Jung, Hyeon Seok Hwang, Ju-Young Moon, Kyung-Hwan Jeong, Sang-Ho Lee, So-Young Lee, Gang Jee Ko, Dong-Young Lee, Hong joo Lee and Yang Gyun Kim

    Citation: BMC Nephrology 2020 21:166

    Content type: Research article

    Published on:

  41. Limited data suggest serum chloride levels associate with mortality in heart failure, chronic kidney disease (CKD), and pulmonary arterial hypertension. Randomized trials have also shown that administration of...

    Authors: Minesh Khatri, Joshua Zitovsky, Dale Lee, Kamal Nayyar, Melissa Fazzari and Candace Grant

    Citation: BMC Nephrology 2020 21:165

    Content type: Research article

    Published on:

  43. Twice-weekly maintenance hemodialysis sessions in patients with end stage renal disease are commonly practiced due to economic constraints in developing countries including Eritrea. To ameliorate the paucity o...

    Authors: Saud Mohammed Raja and Yemane Seyoum

    Citation: BMC Nephrology 2020 21:163

    Content type: Research article

    Published on:

  44. Patients who were diagnosed with hematologic malignancies (HM) had a higher risk of acute kidney injury (AKI). This study applies the Bayesian networks (BNs) to investigate the interrelationships between AKI a...

    Authors: Yang Li, Xiaohong Chen, Yimei Wang, Jiachang Hu, Ziyan Shen and Xiaoqiang Ding

    Citation: BMC Nephrology 2020 21:162

    Content type: Research article

    Published on:

  45. Chronic kidney disease (CKD) is a common chronic condition and a rising public health issue with increased morbidity and mortality, even at an early stage. Primary care has a pivotal role in the early detectio...

    Authors: Steve A. Van den Bulck, Patrik Vankrunkelsven, Geert Goderis, Gijs Van Pottelbergh, Jonathan Swerts, Karolien Panis and Rosella Hermens

    Citation: BMC Nephrology 2020 21:161

    Content type: Research article

    Published on:

  46. To measure health-related and care-related quality of life among informal caregivers of older people with end-stage kidney disease (ESKD), and to determine the association between caregiver quality of life and...

    Authors: Karan K. Shah, Fliss E. M. Murtagh, Kevin McGeechan, Susan M. Crail, Aine Burns and Rachael L. Morton

    Citation: BMC Nephrology 2020 21:160

    Content type: Research article

    Published on:

  48. The inflammatory mediator calprotectin (CPT, myeloid-related protein 8/14) is known as an endogenous ligand contributing to pathophysiology in inflammatory diseases. Serum CPT reportedly became a potential bio...

    Authors: Tomoko Kanki, Takashige Kuwabara, Jun Morinaga, Hirotaka Fukami, Shuro Umemoto, Daisuke Fujimoto, Teruhiko Mizumoto, Manabu Hayata, Yutaka Kakizoe, Yuichiro Izumi, Saeko Tajiri, Tetsuya Tajiri, Kenichiro Kitamura and Masashi Mukoyama

    Citation: BMC Nephrology 2020 21:158

    Content type: Research article

    Published on:

  49. Xylitol is an approved food additive that is widely used as a sweetener in many manufactured products. It is also used in pharmaceuticals. Secondary oxalosis resulting from high dietary oxalate has been report...

    Authors: Shinobu Takayasu, Aya Kamba, Kazutaka Yoshida, Ken Terui, Yutaka Watanuki, Noriko Ishigame, Satoru Mizushiri, Tetsu Tomita, Kazuhiko Nakamura, Norio Yasui-Furukori and Makoto Daimon

    Citation: BMC Nephrology 2020 21:157

    Content type: Case report

    Published on:

  50. Regarding lupus disease activity, morbidity and survival, limited literature concluded conflicting results when comparing hemodialysis versus peritoneal dialysis as initial renal replacement therapies (RRT) pr...

    Authors: Joel Swai, Xiexiong Zhao, Julie-Raisa Noube and Gui Ming

    Citation: BMC Nephrology 2020 21:156

    Content type: Research article

    Published on:

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