- Research article
- Open Access
Barriers and enablers to detection and management of chronic kidney disease in primary healthcare: a systematic review
BMC Nephrology volume 21, Article number: 83 (2020)
Chronic kidney disease (CKD) is growing population health concern worldwide, and with early identification and effective management, kidney disease progression can be slowed or prevented. Most patients with risk factors for chronic kidney disease are treated within primary healthcare. Therefore, it is important to understand how best to support primary care providers (PC-P) to detect and manage chronic kidney disease. The aim of this systematic review was to evaluate barriers and enablers to the diagnosis and management of CKD in primary care.
A systematic review of qualitative research on the barriers and/or enablers to detection and/or management of CKD in adults within primary healthcare was conducted. The databases Medline (EBSCO), PubMed, Cochrane CENTRAL, CINAHL (EBSCO) and Joanna Briggs Institute Evidence Based Practice (Ovid) were searched until 27th August 2019. Barriers and/or enablers reported in each study were identified, classified into themes, and categorised according to the Theoretical Domains Framework.
A total of 20 studies were included in this review. The most commonly reported barriers related to detection and management of CKD in primary care were categorised into the ‘Environmental context and resources’ domain (n = 16 studies). Overall, the most common barrier identified was a lack of time (n = 13 studies), followed by a fear of delivering a diagnosis of CKD, and dissatisfaction with CKD guidelines (both n = 10 studies). Overall, the most common enabler identified was the presence of supportive technology to identify and manage CKD (n = 7 studies), followed by the presence of a collaborative relationship between members of the healthcare team (n = 5 studies).
This systematic review identified a number of barriers and enablers which PC-P face when identifying and managing CKD. The findings of this review suggest a need for time-efficient strategies that promote collaboration between members of the healthcare team, and practice guidelines which consider the frequently co-morbid nature of CKD. Enhanced collaboration between PC-P and nephrology services may also support PC-Ps when diagnosing CKD in primary care, and facilitate improved patient self-management.
Chronic kidney disease (CKD) is growing population health concern worldwide. The results of the Global Burden of Disease Study suggested that in 2015, 1.2 million deaths were associated with kidney failure, an increase of 32% since 2005 . Higher income countries typically spend 2–3% of their annual health budget on the treatment of end-stage kidney disease, however the percentage of the population which receives such treatment is less than 0.03% of the population . Even a moderate decline in kidney function is associated with significantly higher risk of cardiovascular events and mortality, while those who progress to end-stage kidney disease require specialist treatment, either transplantation, dialysis or palliation, all adding significant cost to the health budget .
With early identification and effective management, CKD progression to end-stage kidney disease can be slowed or prevented. Most patients with risk factors for, or early stages of CKD are treated in primary care [4,5,6]. Therefore, exploration of how best to support primary care providers (PC-P) to detect and manage CKD is needed. While several studies have explored factors impacting the management of CKD in the primary care setting [7,8,9,10], there is a need to identify common barriers and enablers in order to develop effective strategies to enhance CKD care. While a systematic review of barriers to CKD management in primary care has been published , this study did not explore enabling factors. In addition, as the search for the previous review was conducted almost 10 years ago, there is a need to explore the more recent evidence on this topic. Therefore, the present systematic review aimed to provide an expanded and more recent perspective on the topic of barriers and enablers to the diagnosis and management of CKD in primary care.
This systematic review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement . The review protocol was registered with the International Prospective Register of Systematic Reviews (CRD42018092364, http://www.crd.york.ac.uk/).
Systematic searches were performed using the Medline (EBSCO), PubMed, Cochrane CENTRAL, CINAHL (EBSCO) and Joanna Briggs Institute Evidence Based Practice (Ovid) databases to identify relevant articles (Supplementary Material 1). After initially being conducted in April 2018, the search was then updated on 27th August 2019. Studies which reported qualitative information on the barriers and/or enablers to detection and/or management of CKD (stages 1–5) in adults (over 18 years) within primary healthcare were eligible for inclusion in the review. Identification of primary healthcare settings was based on The Department of Health Australian Government  and Australian Institute of Health and Welfare  definitions of primary healthcare. Studies were limited to those which reported qualitative information in order to facilitate in-depth analysis of the reported barriers and enablers, in line with a previous systematic review conducted in CKD . Studies were excluded in the case they: reported barriers or enablers in both primary and secondary/tertiary healthcare where it was not possible to differentiate the two settings; where the study was a review/study protocol/case study; or where the study was undertaken in a developing country, in order to ensure findings were comparable across health systems. Eligible studies were also limited to those published in English.
Retrieved studies were screened by title and abstract using the semi-automated citation screening tool Abstrackr . Full texts were retrieved for potentially relevant articles and reviewed against the inclusion/exclusion criteria. Contentious articles were discussed with another researcher (EN or KL) until consensus was reached.
Study context, data collection method, country, participant characteristics and sample size were extracted into summary tables. All included studies were assessed for their methodological quality using the Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research .
Barriers and/or enablers reported in each study were identified. Similar barriers/enablers were then grouped into themes , and categorised according to the Theoretical Domains Framework . The Theoretical Domains Framework consists of 12 theoretical domains related to behaviour change . These domains can be used to map potential areas to target for implementation challenges [20, 21]. In addition to the published domains, we created an additional domain (perceptions of patients) to fully encapsulate all barriers and enablers observed in the current study. Exemplar quotes were then identified for each theme.
Characteristics of included studies
Across the original and updated searches, a total of 20,840 results were obtained (Fig. 1). After removal of duplicates, 14,448 results were screened by title and abstract using the citation screening program Abstrackr . A total of 349 potentially relevant articles were retrieved for full text review, with 22 articles describing 20 studies included in the review.
Of the 20 included studies, 12 were interviews [7, 10, 22,23,24,25,26,27,28,29,30,31], six were focus groups [5, 6, 8, 32,33,34,35,36], and two were surveys with open-ended responses [9, 37] (Table 1). General practitioners, nurses, practice managers, pharmacists and medical assistants were represented across the 20 studies. Included studies were performed in the United Kingdom [6, 7, 10, 22, 32], United States [8, 23,24,25,26, 28, 29, 33, 34], Australia [5, 9, 30, 36], Canada [27, 31, 37], and the Netherlands .
The methodological quality according to the Joanna Briggs Institute critical appraisal checklist is summarised in Table 2. All studies were assessed as having congruity between the stated philosophical perspective and the research methodology used; the research methodology and research questions; the research methodology and methods used to collect data; and the methodology and the representation and analysis of data. A statement locating the researcher culturally/theoretically was reported in four studies and the influence of the researcher on the research was reported in two studies. Participant voices were adequately represented in all studies, meaning that study conclusions were demonstrated to be based on results, for example quotes from participants. Adequate conclusions were drawn from the analysis/interpretation of the data in all studies. All studies provided a statement of ethical approval.
Barriers to identification and management of CKD in primary care
The barriers to detection and management of CKD in primary care identified in this review could be categorised into seven domains of the Theoretical Domains Framework, outlined in detail below. The domains and corresponding themes are shown by study in Table 3, and exemplar quotes for each theme are listed in Table 4.
Environmental context and resources
The most commonly reported barriers related to detection and management of CKD in primary care were categorised into the ‘Environmental context and resources’ domain and were reported in 16 studies [5, 6, 8, 9, 22, 24, 26,27,28,29,30,31,32,33,34,35,36,37]. PC-Ps frequently perceived they lacked time to devote to this task [6, 8, 9, 22, 26,27,28,29,30,31,32,33,34,35] and this was exacerbated by the limited amount of time available for patient appointments. The complex nature of managing multiple co-morbidities also meant additional time was needed for these patients. Limited access to specialist nephrology services was also highlighted as a barrier [5, 8, 34,35,36,37], and was perceived to result in delays in patients being able to make appointments. Other factors included challenges interpreting laboratory measures [8, 31, 32, 34], for example a study conducted in the United States highlighted a barrier of laboratory results providing creatinine but not calculating eGFR . A lack of educational resources for patients [8, 33, 34, 37] was reported, although minimal detail was provided on the type of resources (for example brochures, online materials) that were desired. In addition, technological issues such as software not automatically flagging abnormal results [24, 28, 29]; and a lack of renumeration for tasks such as CKD screening within health system rebates [9, 22] were reported. Attempts to implement changes in the primary care setting were obstructed by variations in practice operations , as well as a lack of CKD-specific information in insurance reports and other performance data .
Beliefs about consequences
A total of 14 studies reported barriers related to ‘beliefs about consequences’ [5,6,7,8,9,10, 22, 24, 26, 29, 31,32,33,34,35,36]. The most commonly reported barrier within this domain was a fear of frightening patients by delivering a diagnosis of CKD. This was reported in 10 studies [6, 7, 9, 10, 22, 24, 26, 32, 33, 35]. The source of fear for practitioners in primary care appeared to frequently be due to the perception that patients did not understand CKD and therefore would not be able to cope with the diagnosis. Some studies also reported a perception that CKD was a lower priority clinical issue [7, 9, 22, 31, 33, 35], particularly in light of other co-morbidities which also required management. There was also a reported perception that declining kidney function was an expected part of aging [6, 7, 32, 35], and therefore it was more important to focus on overall quality of life rather than CKD. An additional barrier identified within this domain was the perceived cost to patients of managing CKDs [8, 29, 34], particularly the time and financial burden associated with attending multiple appointments and multiple blood tests. One study also reported that the current approach to healthcare was too reactive [5, 36], and did not prioritise preventative measures that might minimise the risk of developing CKD, such as weight management.
Thirteen studies reported barriers to the identification and management of CKD in the ‘knowledge’ domain [6, 8,9,10, 24, 25, 27,28,29, 31, 32, 34, 35, 37]. A commonly reported barrier was a dissatisfaction with the current evidence based guidelines for the management of CKD [6, 8, 10, 24, 25, 27, 28, 31, 32, 34, 35]. The theme of dissatisfaction with guidelines covered a range of concepts including where participants found guidelines confusing, or felt that they were not appropriate. Numerous studies reported that those in primary care felt the guidelines were confusing, difficult to use, or changed frequently. It was also identified that there was a perception that there is inadequate training or education for PC-P on the management of CKD [8,9,10, 27, 28, 32, 34, 35, 37], resulting in some practitioners feeling unprepared to diagnose or manage patients with CKD. Other studies reported that practitioners were unfamiliar with management guidelines for CKD [8, 28, 29, 32, 34] (categorised into the theme ‘lack of awareness of guidelines’), as well as available resources or support services, for example for conservative care [27, 37]. Finally, there was a perception that the definition of CKD was not clear and resulted in diagnostic challenges .
Social/professional role and identity
A number of barriers relating to the professional role of PC-Ps were reported. Six studies [5, 8, 9, 22, 23, 34,35,36] reported barriers that were related perceived misunderstanding about the role of PC-Ps in the management of CKD by other healthcare professionals (for example nephrologists). Some studies reported that general practitioners felt that other healthcare providers underestimated their role [5, 8, 23, 34,35,36], and did not appreciate their expertise or their ability to competently manage the disease. This was also reported by practice nurses who felt their ability to be involved in patient screening or management were restricted by the preferences of general practitioners [9, 22]. A lack of clear delineation about the role of PC-Ps in the management of CKD resulted in ambiguities and occasional duplication of tasks such as ordering blood tests [5, 7, 8, 27, 29, 31, 34, 36]. Perceptions held by patients about the roles of different healthcare providers was also reported in two studies [8, 9, 30, 34], with one study suggesting that patients could not always differentiate the role of the PC-P compared to nephrologist, and contributed to patient confusion and suboptimal adherence [8, 34].
Perceptions about patients
Barriers related to PC-P perceptions regarding patients were reported in eight studies [5, 8, 10, 28, 30,31,32,33,34, 36]. Low patient adherence to management strategies, particularly lifestyle strategies, were reported as a common barrier [5, 28, 30,31,32, 36]. In addition, PC-P felt that due to the asymptomatic nature of CKD, patients did not understand the seriousness of CKD and were unlikely to prioritise its management until the disease reached a more severe stage with symptoms [8, 10, 30, 33, 34].
Barriers relating to ‘beliefs about capabilities’ were reported in five studies [8, 10, 27, 33,34,35]. Within this domain, the challenging nature of managing CKD within the primary care setting was highlighted [8, 10, 27, 34], especially due to the nature of CKD as an incurable condition with multiple co-morbidities. In addition, educating patients about the management of CKD was reported to be difficult, in part due to limited health literacy of patients [33, 35]. Within the domain of ‘social influences’, insufficient communication between members of the healthcare team was identified as a barrier to the management of CKD in six studies [5, 8, 27, 30, 34,35,36,37]. PC-Ps felt that communication between primary care and nephrology services was poor, and there was a general lack of communication back to primary care.
Overall, the most common barrier described in 13 studies was a lack of time [6, 8, 9, 22, 26,27,28,29,30,31,32,33,34,35], followed by 10 studies citing a fear by PC-Ps of frightening patients with a diagnosis of CKD [6, 7, 9, 10, 22, 24, 26, 32, 33, 35], and 10 studies which referred to a dissatisfaction with CKD guidelines [6, 8, 10, 24, 25, 27, 28, 31, 32, 34, 35].
Enablers to identification and management of CKD in primary care
Enablers to the detection and management of CKD in primary care identified in this review were categorised into six domains of the Theoretical Domains Framework. The domains and corresponding themes are shown by study in Table 5, with exemplar quotes for each theme listed in Table 6.
Environmental context and resources
The most commonly reported enablers to the diagnosis and management of CKD in primary care were related to ‘Environmental context and resources’ and reported in 14 studies [5, 6, 8, 9, 22, 24,25,26,27, 30,31,32,33,34, 36, 37]. PC-Ps reported that technological improvements assisted them to identify and manage CKD [5, 8, 24,25,26, 31, 33, 34, 36]. In particular, shared electronic medical records facilitated collaboration between different healthcare providers, and software programs that automatically calculated eGFR were highlighted as being valuable. PC-Ps described having adequate access to specialists, including for their own professional support, as being highly valuable [6, 8, 27, 34, 37]. The availability of patient education resources [8, 26, 27, 33, 34], and funding for screening and management initiatives [8, 9, 22, 30, 34] were also considered to be enablers to effectively diagnosing and managing patients. Additional enablers included the presence of clear referral pathways to specialist care [5, 26, 32, 36], including guidelines of when to refer; improved access to support services, particularly in regional areas . Other enablers included access to laboratories ; raising patient awareness of available services ; and, amongst practice nurses, the presence of time to listen to and engage with the patient .
Ten studies reported enablers for the identification and management of CKD in primary care which aligned with the ‘knowledge’ domain [5,6,7,8,9, 27, 31, 32, 34,35,36,37]. PC-Ps highlighted that the value of CKD guidelines was in providing direction for patient care, which enabled PC-Ps to then individualise care [6, 8, 27, 31, 32, 34, 35, 37]. When training opportunities and educational resources were available, they were also considered an important enabler to support CKD management in primary care [5, 8, 34, 36]. Finally, the initial diagnosis of CKD was also identified as an enabler in two studies [7, 9], primarily because awareness of the diagnosis of CKD then facilitated the PC-P to develop a proactive treatment plan.
Within the ‘social influences’ domain, five studies [5, 8, 26, 27, 34, 36, 37] highlighted the value of collaboration between members of the healthcare team. In particular, collaboration and clear communication between PC-P and nephrology services was emphasised, although the importance of collaboration between all members of the healthcare team as well at the patient and their family was also highlighted. Three studies reported enablers that aligned with ‘social/professional role and identity’ [5, 30, 31, 36]. The importance of clear role delineation between members of the healthcare team was emphasised in three studies [5, 30, 31, 36]. One study  reported that there are opportunities to leverage on existing services, such as when developing a CKD risk assessment service in the community pharmacy setting. Within the ‘beliefs about capabilities’ domain, the importance of the relationship between the PC-P and the patient was described in three studies [9, 27, 31]. In particular the trust developed between the patient and PC-P was an important factor that enabled successful management of CKD. In addition, the importance of managing patient expectations about CKD management during education and ensuring they understood their care plan was also described [5, 27, 36]. Finally, within the ‘beliefs about consequences domain’, PC-Ps in two studies [27, 35] highlighted the value of considering the patient ‘as a whole’, including the impact of a CKD diagnosis on their quality of life, and was described as important to decisions about future management.
Overall, the most common enabler identified was the presence of supportive technology to identify and manage CKD, reported in seven studies [5, 8, 24,25,26, 31, 33, 34, 36], followed by having a collaborative relationship between members of the healthcare team (reported in five studies, [5, 8, 26, 27, 34, 36, 37]).
To the authors’ knowledge, this is the first systematic review to explore both the barriers and enablers reported by PC-P regarding the diagnosis and management of CKD in the primary healthcare setting. Common barriers included a lack of time for screening and management in the primary care setting, fear about increasing patient anxiety by delivering a diagnosis of CKD, and a perception that CKD guidelines were difficult to use, confusing, or changed frequently. Enablers included the presence of supportive technology for identifying and managing CKD, and a collaborative approach between the healthcare team. Given the high prevalence of CKD worldwide, and the important role of primary care in managing this condition, the findings highlight potential opportunities for improving the detection and management of CKD.
Barriers related to the ‘environmental context and resource’ domain were most commonly reported, particularly a perceived lack of time to treat CKD in the primary healthcare setting [6, 8, 9, 22, 26,27,28,29,30,31,32,33,34,35]. This finding aligns with previous systematic reviews relating to CKD specifically , and cardiometabolic diseases more broadly . The presence of a high workload and limited time availability in primary care have been previously highlighted in the literature . These barriers are likely to present particular challenges in the case of CKD, a disease known to be associated with multiple co-morbidities. Research suggests that of those individuals diagnosed with CKD, the majority have a least one co-morbid condition, and many patients may have multiple conditions [40, 41]. These conditions are often associated with complex management strategies and require referrals to multiple specialists, which substantially increases the workload associated with managing these conditions in primary care . Previous research has also highlighted the challenges associated with applying clinical practice guidelines to patients with multi-morbidity, given that such guidelines are typically designed for the management of an individual condition . Interestingly, the most common enabler to effective identification and management of CKD in primary care identified in the current review was the presence of supportive technology, for example shared electronic medical records and automatic calculation of risk markers. While limited time and the challenges associated with a multi-morbid condition such as CKD are likely to remain present in the primary care setting, these findings suggest that practical strategies around the use of electronic medical records may in part alleviate these issues, and therefore should be explored further.
As with any chronic condition, effective management of CKD is dependent on both the clinical expertise of the practitioner and appropriate self-management behaviours by patients. This is dependent on the patient being informed and knowledgeable about their condition. The present review highlighted a level of anxiety amongst PC-P about when or if to describe a diagnosis of CKD to patients, with PC-Ps subsequently underplaying the severity of the condition [6, 7, 9, 10, 22, 24, 26, 32, 33, 35]. Previous research conducted in patients with CKD further supports this finding. Daker-White et al.  interviewed patients with Stage 3 CKD, and found that limited or partial disclosure of the diagnosis of CKD was common, and the diagnosis of CKD frequently downplayed as ‘nothing to worry about’ or ‘nothing serious’. This approach can trivialise the condition, in turn limiting the ability of the patient to self-manage the condition and restricting their ability to make informed choices regarding their treatment . Previous research has also demonstrated that patient understanding of CKD supports improved outcomes [45, 46], suggesting that hesitation to inform patients may result in poorer health outcomes. Barriers related to knowledge of the diagnosis and management of CKD were also identified in the present review, including a dissatisfaction with existing CKD guidelines and a perceived lack of training on CKD management. The application of clinical practice guidelines to multi-morbid patients is particularly challenging [42, 43]. For patients and carers, managing multi-morbidity in CKD has been described as complex, exhausting and challenging . The timing of the research included in the present review should be considered when interpreting these results, with the majority of studies [5, 6, 8,9,10, 22,23,24,25, 27,28,29,30,31, 33,34,35,36,37] published after the release of global  and country-specific CKD management guidelines [49,50,51,52], suggesting challenges with guidelines persisted after the release of the most recent guidelines. Despite these challenges, guidelines for care were also described as useful in this review. Taken together, these results highlight the value of guidelines, but emphasise the need to ensure management guidelines consider the complexities of the condition. Furthermore, while a tendency to not disclose or provide limited disclosure about a diagnosis may be well-intentioned, it is vital for patients to make informed choices about the management of this chronic condition.
Due to the complex nature of CKD, the management of CKD requires input from a multi-disciplinary team spanning primary and specialist care. Research has suggested that identification of CKD and adherence to guidelines for management of advanced CKD is greater when a nephrologist is involved in patient care [53, 54], with early referral to nephrology associated with favourable patient outcomes . In addition, continuing of care from a PC-P has been associated with improved blood pressure control in patients with CKD . This highlights the importance of shared care which values the input of all members of the healthcare team. However, the current review identified a number of barriers associated with the functioning of this team, relating to issues pertaining to role identify and social influences. Common barriers described were a perception amongst PC-Ps that other healthcare providers, such as nephrologists, underestimated the importance of their role and their relationship with their patients [5, 8, 23, 34,35,36], as well as a lack of clear delineation of each provider’s role [5, 7, 8, 27, 29, 31, 34, 36]. Challenges pertaining to inadequate communication between members of the healthcare team was also an important barrier identified [5, 8, 27, 30, 34,35,36,37]. Poor collaboration between specialist and primary care providers has been reported previously , including in those with complex conditions , with CKD patients also reporting problems experienced with coordination of care . In order for effective patient management, there is a need for coordinated and collaborative care which spans all members of the healthcare team. Indeed, a collaborative relationship between members of the healthcare team was also identified as one of the most commonly reported enablers to effective CKD diagnosis and management in the current review [5, 8, 26, 27, 34, 36, 37].
Previous research has described effective strategies to improve collaboration and communication between primary care and nephrology. Haley et al.  implemented a quality improvement activity using modified tools from the Renal Physicians Association toolkit. These tools were designed for either the primary care clinician or the nephrologist, and included education on topics including CKD identification, communication between healthcare practitioners, and patient education. Provision of these tools was associated with greater identification of CKD, increased referral to nephrology services, increased communication, and development of co-management plans, and greater healthcare provider satisfaction with co-management. These findings highlight how existing resources can be used to enhance the primary care-nephrology relationship. Increasing access to specialists and support services has also been found to be effective. For example, an intervention involving phone access for PC-P to a range of healthcare providers including nurse navigator, community care resource coordinator, and general internal medicine, supplemented by online access to hospital laboratory results , allowed PC-Ps to clarify their role and encouraged collaborative care . Importantly, such interventions address the barriers and enablers to CKD identification and management identified here, such as the importance of role clarification and reciprocal communication, enhancing shared care.
The review had several limitations. A number of the studies included had small sample sizes, limiting the generalisability of their findings. Studies came from multiple countries with varied healthcare systems, meaning some of the findings may not be applicable to all countries. While the limited number of studies meant it was not possible to compare findings between countries, it was observed that commonly reported themes were similar between different countries. This was particularly evident in the case of barriers, although the enabler ‘presence of supportive technology’ appeared to be predominantly observed in studies conducted in the United States and Canada. This finding suggests the presence of common challenges facing primary health practitioners in a number of countries, although potential differences in enablers between countries require further investigation. Similarly, all included studies were limited to published data which focused specifically on primary healthcare, meaning some relevant studies may have not have been detected. All included studies were in the English language, which may have also resulted in the exclusion of potentially relevant articles.
This systematic review identified a number of barriers and enablers which PC-P face when identifying and managing CKD. Themes relating to ‘environmental context and resources’, ‘beliefs about consequences’ and ‘knowledge’ were the most commonly reported barriers, specifically a lack of time, anxiety communicating a diagnosis of CKD, and a dissatisfaction with current with CKD management guidelines. The presence of supportive technology within practices was the most commonly described enabler, followed by a collaborative relationship between members of the primary healthcare and nephrology team. The findings of this review suggest a need for time-efficient strategies that promote collaboration between members of the healthcare team, and practice guidelines which consider the frequently co-morbid nature of CKD. Enhanced collaboration between PC-P and nephrology services may also support PC-Ps when diagnosing CKD in primary care, and facilitate improved patient self-management.
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Chronic kidney disease
Primary care practitioners
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This project received funding from the Health Impacts Research Cluster, University of Wollongong.
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Supplementary Material 1: PRISMA 2009 Checklist. Supplementary Material 2: Example search strategy.
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Neale, E.P., Middleton, J. & Lambert, K. Barriers and enablers to detection and management of chronic kidney disease in primary healthcare: a systematic review. BMC Nephrol 21, 83 (2020). https://doi.org/10.1186/s12882-020-01731-x
- Chronic kidney disease
- Primary care
- Systematic review